TISIDB

Summary
Symbol	ITPK1
Name	inositol-tetrakisphosphate 1-kinase
Aliases	inositol 1,3,4-triphosphate 5/6 kinase; ITRPK1; inositol 1,3,4-trisphosphate 5/6 kinase; inositol 1,3,4-tris ......
Chromosomal Location	14q32.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	-
Domain	PF05770 Inositol 1
Function	Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain.

> Gene Ontology [ TOP ]
Biological Process	GO:0006066 alcohol metabolic process GO:0007596 blood coagulation GO:0007599 hemostasis GO:0016311 dephosphorylation GO:0019751 polyol metabolic process GO:0021915 neural tube development GO:0032957 inositol trisphosphate metabolic process GO:0043647 inositol phosphate metabolic process GO:0050817 coagulation GO:0050878 regulation of body fluid levels GO:1901615 organic hydroxy compound metabolic process
Molecular Function	GO:0000287 magnesium ion binding GO:0016791 phosphatase activity GO:0016853 isomerase activity GO:0042578 phosphoric ester hydrolase activity GO:0047325 inositol tetrakisphosphate 1-kinase activity GO:0051765 inositol tetrakisphosphate kinase activity GO:0051766 inositol trisphosphate kinase activity GO:0052659 inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity GO:0052725 inositol-1,3,4-trisphosphate 6-kinase activity GO:0052726 inositol-1,3,4-trisphosphate 5-kinase activity GO:0052743 inositol tetrakisphosphate phosphatase activity GO:0052745 inositol phosphate phosphatase activity GO:0052825 inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity GO:0052827 inositol pentakisphosphate phosphatase activity GO:0052830 inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity GO:0052831 inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity GO:0052835 inositol-3,4,6-trisphosphate 1-kinase activity
Cellular Component	GO:0016324 apical plasma membrane GO:0045177 apical part of cell

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04070 Phosphatidylinositol signaling system hsa00562 Inositol phosphate metabolism hsa01100 Metabolic pathways
Reactome	R-HSA-983231: Factors involved in megakaryocyte development and platelet production R-HSA-109582: Hemostasis R-HSA-1483249: Inositol phosphate metabolism R-HSA-1430728: Metabolism R-HSA-1855204: Synthesis of IP3 and IP4 in the cytosol R-HSA-1855167: Synthesis of pyrophosphates in the cytosol

Summary
Symbol	ITPK1
Name	inositol-tetrakisphosphate 1-kinase
Aliases	inositol 1,3,4-triphosphate 5/6 kinase; ITRPK1; inositol 1,3,4-trisphosphate 5/6 kinase; inositol 1,3,4-tris ......
Chromosomal Location	14q32.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between ITPK1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	ITPK1
Name	inositol-tetrakisphosphate 1-kinase
Aliases	inositol 1,3,4-triphosphate 5/6 kinase; ITRPK1; inositol 1,3,4-trisphosphate 5/6 kinase; inositol 1,3,4-tris ......
Chromosomal Location	14q32.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of ITPK1 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	Total # shRNA with >= 4-fold: 1	Resistant to T-cell proliferation
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	ITPK1
Name	inositol-tetrakisphosphate 1-kinase
Aliases	inositol 1,3,4-triphosphate 5/6 kinase; ITRPK1; inositol 1,3,4-trisphosphate 5/6 kinase; inositol 1,3,4-tris ......
Chromosomal Location	14q32.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the expression difference of ITPK1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.58	0.0751
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.815	0.747
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.412	0.819
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.51	0.221
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.619	0.785
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.375	0.899
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.023	0.953
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.284	0.87
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.422	0.834
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.321	0.836
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.412	0.859
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.062	0.46

> Mutation difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the mutation difference of ITPK1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	0	1.4	-1.4	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	0	1.7	-1.7	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	6.2	-6.2	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	11.1	-11.1	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	2.6	0	2.6	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	4.5	0	4.5	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	ITPK1
Name	inositol-tetrakisphosphate 1-kinase
Aliases	inositol 1,3,4-triphosphate 5/6 kinase; ITRPK1; inositol 1,3,4-trisphosphate 5/6 kinase; inositol 1,3,4-tris ......
Chromosomal Location	14q32.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ITPK1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	ITPK1
Name	inositol-tetrakisphosphate 1-kinase
Aliases	inositol 1,3,4-triphosphate 5/6 kinase; ITRPK1; inositol 1,3,4-trisphosphate 5/6 kinase; inositol 1,3,4-tris ......
Chromosomal Location	14q32.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ITPK1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ITPK1. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	ITPK1
Name	inositol-tetrakisphosphate 1-kinase
Aliases	inositol 1,3,4-triphosphate 5/6 kinase; ITRPK1; inositol 1,3,4-trisphosphate 5/6 kinase; inositol 1,3,4-tris ......
Chromosomal Location	14q32.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ITPK1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	ITPK1
Name	inositol-tetrakisphosphate 1-kinase
Aliases	inositol 1,3,4-triphosphate 5/6 kinase; ITRPK1; inositol 1,3,4-trisphosphate 5/6 kinase; inositol 1,3,4-tris ......
Chromosomal Location	14q32.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of ITPK1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	ITPK1
Name	inositol-tetrakisphosphate 1-kinase
Aliases	inositol 1,3,4-triphosphate 5/6 kinase; ITRPK1; inositol 1,3,4-trisphosphate 5/6 kinase; inositol 1,3,4-tris ......
Chromosomal Location	14q32.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between ITPK1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	ITPK1
Name	inositol-tetrakisphosphate 1-kinase
Aliases	inositol 1,3,4-triphosphate 5/6 kinase; ITRPK1; inositol 1,3,4-trisphosphate 5/6 kinase; inositol 1,3,4-tris ......
Chromosomal Location	14q32.12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting ITPK1 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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