Browse KIF20B

Summary
SymbolKIF20B
Namekinesin family member 20B
Aliases KRMP1; cancer/testis antigen 90; MPHOSPH1; M-phase phosphoprotein 1; MPP-1; kinesin-related motor interactin ......
Chromosomal Location10q23.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Nucleus, nucleolus Nucleus, nucleoplasm Cytoplasm, cytoskeleton, spindle Cytoplasm, cytoskeleton, spindle pole Midbody Cell projection, axon Cell projection, growth cone Note=Localizes mainly in the nucleus during interphase although it is also detected in the cytoplasm without clear association with microtubules (PubMed:12740395). Localized to the central spindle during cytokinetic furrowing and with the midbody during abscission (PubMed:12740395, PubMed:17409436). A 2-3 fold expression increase is seen as cells progress from G1 to G2/M phase (PubMed:12740395). During prophase and metaphase it is found throughout the cytoplasm and at anaphase accumulates at the midplan of the cell and forms a distinct band extending across the spindle midzone (PubMed:12740395). At anaphase it is concentrated in the midbody (PubMed:12740395). Colocalized partially along microtubules in primary neurons. Colocalized with SHTN1 along microtubules to the tip of the growing cone in primary hippocampal neurons. Localized in midbodies between dividing radial progenitors in the ventricular zone (By similarity). Colocalized with PRC1 in the nucleus of bladder carcinoma cells at the interphase. Colocalized with PRC1 in bladder carcinoma cells at prophase, metaphase, early anaphase, at the midzone in late anaphase and at the contractile ring in telophase (PubMed:17409436).
Domain PF00225 Kinesin motor domain
Function

Plus-end-directed motor enzyme that is required for completion of cytokinesis (PubMed:11470801, PubMed:12740395). Required for proper midbody organization and abscission in polarized cortical stem cells. Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in cerebral cortex growth (By similarity). Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436).

> Gene Ontology
 
Biological Process GO:0000281 mitotic cytokinesis
GO:0000910 cytokinesis
GO:0001764 neuron migration
GO:0001838 embryonic epithelial tube formation
GO:0001841 neural tube formation
GO:0001843 neural tube closure
GO:0007018 microtubule-based movement
GO:0007050 cell cycle arrest
GO:0007067 mitotic nuclear division
GO:0007088 regulation of mitotic nuclear division
GO:0007163 establishment or maintenance of cell polarity
GO:0007346 regulation of mitotic cell cycle
GO:0010720 positive regulation of cell development
GO:0014020 primary neural tube formation
GO:0016331 morphogenesis of embryonic epithelium
GO:0021915 neural tube development
GO:0030010 establishment of cell polarity
GO:0030335 positive regulation of cell migration
GO:0032386 regulation of intracellular transport
GO:0032388 positive regulation of intracellular transport
GO:0032465 regulation of cytokinesis
GO:0032467 positive regulation of cytokinesis
GO:0032506 cytokinetic process
GO:0032878 regulation of establishment or maintenance of cell polarity
GO:0032954 regulation of cytokinetic process
GO:0033157 regulation of intracellular protein transport
GO:0035148 tube formation
GO:0035239 tube morphogenesis
GO:0035372 protein localization to microtubule
GO:0040017 positive regulation of locomotion
GO:0044380 protein localization to cytoskeleton
GO:0045786 negative regulation of cell cycle
GO:0045787 positive regulation of cell cycle
GO:0045931 positive regulation of mitotic cell cycle
GO:0050769 positive regulation of neurogenesis
GO:0051222 positive regulation of protein transport
GO:0051272 positive regulation of cellular component movement
GO:0051302 regulation of cell division
GO:0051781 positive regulation of cell division
GO:0051783 regulation of nuclear division
GO:0051962 positive regulation of nervous system development
GO:0060562 epithelial tube morphogenesis
GO:0060606 tube closure
GO:0061640 cytoskeleton-dependent cytokinesis
GO:0072175 epithelial tube formation
GO:0072698 protein localization to microtubule cytoskeleton
GO:0090068 positive regulation of cell cycle process
GO:0090316 positive regulation of intracellular protein transport
GO:1902410 mitotic cytokinetic process
GO:1902412 regulation of mitotic cytokinesis
GO:1903436 regulation of mitotic cytokinetic process
GO:1903438 positive regulation of mitotic cytokinetic process
GO:1903490 positive regulation of mitotic cytokinesis
GO:1903829 positive regulation of cellular protein localization
GO:1904951 positive regulation of establishment of protein localization
GO:2000114 regulation of establishment of cell polarity
GO:2000147 positive regulation of cell motility
GO:2001222 regulation of neuron migration
GO:2001224 positive regulation of neuron migration
Molecular Function GO:0003774 motor activity
GO:0003777 microtubule motor activity
GO:0008017 microtubule binding
GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed
GO:0015631 tubulin binding
GO:0016887 ATPase activity
GO:0050699 WW domain binding
GO:1990939 ATP-dependent microtubule motor activity
Cellular Component GO:0000922 spindle pole
GO:0005813 centrosome
GO:0005819 spindle
GO:0005871 kinesin complex
GO:0005874 microtubule
GO:0005875 microtubule associated complex
GO:0030424 axon
GO:0030426 growth cone
GO:0030427 site of polarized growth
GO:0030496 midbody
GO:0051233 spindle midzone
GO:0070938 contractile ring
GO:0072686 mitotic spindle
GO:0097431 mitotic spindle pole
GO:1990023 mitotic spindle midzone
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-6811434: COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983231: Factors involved in megakaryocyte development and platelet production
R-HSA-8856688: Golgi-to-ER retrograde transport
R-HSA-109582: Hemostasis
R-HSA-6811442: Intra-Golgi and retrograde Golgi-to-ER traffic
R-HSA-983189: Kinesins
R-HSA-199991: Membrane Trafficking
R-HSA-5653656: Vesicle-mediated transport
Summary
SymbolKIF20B
Namekinesin family member 20B
Aliases KRMP1; cancer/testis antigen 90; MPHOSPH1; M-phase phosphoprotein 1; MPP-1; kinesin-related motor interactin ......
Chromosomal Location10q23.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between KIF20B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolKIF20B
Namekinesin family member 20B
Aliases KRMP1; cancer/testis antigen 90; MPHOSPH1; M-phase phosphoprotein 1; MPP-1; kinesin-related motor interactin ......
Chromosomal Location10q23.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of KIF20B in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.51 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolKIF20B
Namekinesin family member 20B
Aliases KRMP1; cancer/testis antigen 90; MPHOSPH1; M-phase phosphoprotein 1; MPP-1; kinesin-related motor interactin ......
Chromosomal Location10q23.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of KIF20B in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.3880.203
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.2870.754
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.4660.537
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.1450.665
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.1290.939
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.4870.827
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.2380.463
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.0480.971
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.5440.69
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.2840.699
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.6380.527
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.2870.0027
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of KIF20B in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.15.91.21
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 41407.1-7.11
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277314.8014.80.00448
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275914.8014.80.00826
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.55.93.61
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.79.1-1.41
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.16.24.91
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.305.30.507
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolKIF20B
Namekinesin family member 20B
Aliases KRMP1; cancer/testis antigen 90; MPHOSPH1; M-phase phosphoprotein 1; MPP-1; kinesin-related motor interactin ......
Chromosomal Location10q23.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of KIF20B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolKIF20B
Namekinesin family member 20B
Aliases KRMP1; cancer/testis antigen 90; MPHOSPH1; M-phase phosphoprotein 1; MPP-1; kinesin-related motor interactin ......
Chromosomal Location10q23.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of KIF20B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by KIF20B.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolKIF20B
Namekinesin family member 20B
Aliases KRMP1; cancer/testis antigen 90; MPHOSPH1; M-phase phosphoprotein 1; MPP-1; kinesin-related motor interactin ......
Chromosomal Location10q23.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of KIF20B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolKIF20B
Namekinesin family member 20B
Aliases KRMP1; cancer/testis antigen 90; MPHOSPH1; M-phase phosphoprotein 1; MPP-1; kinesin-related motor interactin ......
Chromosomal Location10q23.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of KIF20B expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolKIF20B
Namekinesin family member 20B
Aliases KRMP1; cancer/testis antigen 90; MPHOSPH1; M-phase phosphoprotein 1; MPP-1; kinesin-related motor interactin ......
Chromosomal Location10q23.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between KIF20B and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolKIF20B
Namekinesin family member 20B
Aliases KRMP1; cancer/testis antigen 90; MPHOSPH1; M-phase phosphoprotein 1; MPP-1; kinesin-related motor interactin ......
Chromosomal Location10q23.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting KIF20B collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.