TISIDB

Summary
Symbol	KIF23
Name	kinesin family member 23
Aliases	MKLP1; MKLP-1; KNSL5; kinesin-like 5 (mitotic kinesin-like protein 1); CHO1; Mitotic kinesin-like protein 1; ......
Chromosomal Location	15q23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Nucleus. Cytoplasm, cytoskeleton, spindle. Midbody, Midbody ring Note=Localizes to the interzone of mitotic spindles. Detected at the midbody during later stages of mitotic cytokinesis.
Domain	PF00225 Kinesin motor domain PF16540 Arf6-interacting domain of mitotic kinesin-like protein 1
Function	Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro.

> Gene Ontology [ TOP ]
Biological Process	GO:0000022 mitotic spindle elongation GO:0000070 mitotic sister chromatid segregation GO:0000226 microtubule cytoskeleton organization GO:0000281 mitotic cytokinesis GO:0000819 sister chromatid segregation GO:0000910 cytokinesis GO:0000912 assembly of actomyosin apparatus involved in cytokinesis GO:0000915 actomyosin contractile ring assembly GO:0002478 antigen processing and presentation of exogenous peptide antigen GO:0002495 antigen processing and presentation of peptide antigen via MHC class II GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0006890 retrograde vesicle-mediated transport, Golgi to ER GO:0007018 microtubule-based movement GO:0007051 spindle organization GO:0007052 mitotic spindle organization GO:0007059 chromosome segregation GO:0007067 mitotic nuclear division GO:0010970 transport along microtubule GO:0019882 antigen processing and presentation GO:0019884 antigen processing and presentation of exogenous antigen GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0030705 cytoskeleton-dependent intracellular transport GO:0030865 cortical cytoskeleton organization GO:0030866 cortical actin cytoskeleton organization GO:0031032 actomyosin structure organization GO:0032465 regulation of cytokinesis GO:0032467 positive regulation of cytokinesis GO:0032506 cytokinetic process GO:0044837 actomyosin contractile ring organization GO:0045787 positive regulation of cell cycle GO:0047496 vesicle transport along microtubule GO:0048002 antigen processing and presentation of peptide antigen GO:0048193 Golgi vesicle transport GO:0051225 spindle assembly GO:0051231 spindle elongation GO:0051255 spindle midzone assembly GO:0051256 mitotic spindle midzone assembly GO:0051302 regulation of cell division GO:0051640 organelle localization GO:0051648 vesicle localization GO:0051650 establishment of vesicle localization GO:0051656 establishment of organelle localization GO:0051781 positive regulation of cell division GO:0061640 cytoskeleton-dependent cytokinesis GO:0072383 plus-end-directed vesicle transport along microtubule GO:0072384 organelle transport along microtubule GO:0072386 plus-end-directed organelle transport along microtubule GO:0090068 positive regulation of cell cycle process GO:0090307 mitotic spindle assembly GO:0098813 nuclear chromosome segregation GO:0099518 vesicle cytoskeletal trafficking GO:1902850 microtubule cytoskeleton organization involved in mitosis
Molecular Function	GO:0003774 motor activity GO:0003777 microtubule motor activity GO:0008017 microtubule binding GO:0015631 tubulin binding GO:0016887 ATPase activity
Cellular Component	GO:0005813 centrosome GO:0005819 spindle GO:0005871 kinesin complex GO:0005874 microtubule GO:0005875 microtubule associated complex GO:0005924 cell-substrate adherens junction GO:0005925 focal adhesion GO:0030055 cell-substrate junction GO:0030496 midbody GO:0045171 intercellular bridge GO:0072686 mitotic spindle GO:0097149 centralspindlin complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-1280218: Adaptive Immune System R-HSA-6811434: COPI-dependent Golgi-to-ER retrograde traffic R-HSA-1640170: Cell Cycle R-HSA-69278: Cell Cycle, Mitotic R-HSA-983231: Factors involved in megakaryocyte development and platelet production R-HSA-8856688: Golgi-to-ER retrograde transport R-HSA-109582: Hemostasis R-HSA-168256: Immune System R-HSA-6811442: Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-983189: Kinesins R-HSA-68886: M Phase R-HSA-2132295: MHC class II antigen presentation R-HSA-199991: Membrane Trafficking R-HSA-68884: Mitotic Telophase/Cytokinesis R-HSA-5653656: Vesicle-mediated transport

> KEGG and Reactome Pathway

[ TOP ]

KEGG

Reactome

R-HSA-1280218: Adaptive Immune System
R-HSA-6811434: COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-1640170: Cell Cycle
R-HSA-69278: Cell Cycle, Mitotic
R-HSA-983231: Factors involved in megakaryocyte development and platelet production
R-HSA-8856688: Golgi-to-ER retrograde transport
R-HSA-109582: Hemostasis
R-HSA-168256: Immune System
R-HSA-6811442: Intra-Golgi and retrograde Golgi-to-ER traffic
R-HSA-983189: Kinesins
R-HSA-68886: M Phase
R-HSA-2132295: MHC class II antigen presentation
R-HSA-199991: Membrane Trafficking
R-HSA-68884: Mitotic Telophase/Cytokinesis
R-HSA-5653656: Vesicle-mediated transport

Summary
Symbol	KIF23
Name	kinesin family member 23
Aliases	MKLP1; MKLP-1; KNSL5; kinesin-like 5 (mitotic kinesin-like protein 1); CHO1; Mitotic kinesin-like protein 1; ......
Chromosomal Location	15q23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between KIF23 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	KIF23
Name	kinesin family member 23
Aliases	MKLP1; MKLP-1; KNSL5; kinesin-like 5 (mitotic kinesin-like protein 1); CHO1; Mitotic kinesin-like protein 1; ......
Chromosomal Location	15q23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of KIF23 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	KIF23
Name	kinesin family member 23
Aliases	MKLP1; MKLP-1; KNSL5; kinesin-like 5 (mitotic kinesin-like protein 1); CHO1; Mitotic kinesin-like protein 1; ......
Chromosomal Location	15q23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the expression difference of KIF23 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.032	0.913
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.377	0.794
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.333	0.764
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.146	0.688
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.236	0.881
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.035	0.986
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.036	0.927
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.227	0.881
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.276	0.858
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.229	0.781
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.388	0.752
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.469	0.000125

> Mutation difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the mutation difference of KIF23 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	11.1	11.1	0.0181
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	11.1	11.1	0.0286
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	11.1	11.1	0.36
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	25	25	0.364
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	2.6	2.6	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	4.5	4.5	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	1

Summary
Symbol	KIF23
Name	kinesin family member 23
Aliases	MKLP1; MKLP-1; KNSL5; kinesin-like 5 (mitotic kinesin-like protein 1); CHO1; Mitotic kinesin-like protein 1; ......
Chromosomal Location	15q23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of KIF23. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	KIF23
Name	kinesin family member 23
Aliases	MKLP1; MKLP-1; KNSL5; kinesin-like 5 (mitotic kinesin-like protein 1); CHO1; Mitotic kinesin-like protein 1; ......
Chromosomal Location	15q23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of KIF23. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by KIF23. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	KIF23
Name	kinesin family member 23
Aliases	MKLP1; MKLP-1; KNSL5; kinesin-like 5 (mitotic kinesin-like protein 1); CHO1; Mitotic kinesin-like protein 1; ......
Chromosomal Location	15q23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of KIF23. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	KIF23
Name	kinesin family member 23
Aliases	MKLP1; MKLP-1; KNSL5; kinesin-like 5 (mitotic kinesin-like protein 1); CHO1; Mitotic kinesin-like protein 1; ......
Chromosomal Location	15q23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of KIF23 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	KIF23
Name	kinesin family member 23
Aliases	MKLP1; MKLP-1; KNSL5; kinesin-like 5 (mitotic kinesin-like protein 1); CHO1; Mitotic kinesin-like protein 1; ......
Chromosomal Location	15q23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between KIF23 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	KIF23
Name	kinesin family member 23
Aliases	MKLP1; MKLP-1; KNSL5; kinesin-like 5 (mitotic kinesin-like protein 1); CHO1; Mitotic kinesin-like protein 1; ......
Chromosomal Location	15q23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting KIF23 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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