TISIDB

Summary
Symbol	KIF3A
Name	kinesin family member 3A
Aliases	FLA10; KLP-20; kinesin family protein 3A; microtubule plus end-directed kinesin motor 3A; Kinesin-like prote ......
Chromosomal Location	5q31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cytoplasm, cytoskeleton Cell projection, cilium Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Note=Localizes to the subdistal appendage region of the centriole.
Domain	PF00225 Kinesin motor domain
Function	Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation. Plays a role in centriole cohesion and subdistal appendage organization and function. Regulates the formation of the subdistal appendage via recruitement of DCTN1 to the centriole. Also required for ciliary basal feet formation and microtubule anchoring to mother centriole.

> Gene Ontology [ TOP ]
Biological Process	GO:0002478 antigen processing and presentation of exogenous peptide antigen GO:0002495 antigen processing and presentation of peptide antigen via MHC class II GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0006890 retrograde vesicle-mediated transport, Golgi to ER GO:0007018 microtubule-based movement GO:0010927 cellular component assembly involved in morphogenesis GO:0010970 transport along microtubule GO:0019882 antigen processing and presentation GO:0019884 antigen processing and presentation of exogenous antigen GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0030031 cell projection assembly GO:0030705 cytoskeleton-dependent intracellular transport GO:0042384 cilium assembly GO:0044782 cilium organization GO:0047496 vesicle transport along microtubule GO:0048002 antigen processing and presentation of peptide antigen GO:0048193 Golgi vesicle transport GO:0051640 organelle localization GO:0051648 vesicle localization GO:0051650 establishment of vesicle localization GO:0051656 establishment of organelle localization GO:0060271 cilium morphogenesis GO:0072383 plus-end-directed vesicle transport along microtubule GO:0072384 organelle transport along microtubule GO:0072386 plus-end-directed organelle transport along microtubule GO:0099518 vesicle cytoskeletal trafficking
Molecular Function	GO:0003774 motor activity GO:0003777 microtubule motor activity GO:0008017 microtubule binding GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed GO:0015631 tubulin binding GO:0016887 ATPase activity GO:0017016 Ras GTPase binding GO:0017137 Rab GTPase binding GO:0030507 spectrin binding GO:0031267 small GTPase binding GO:0051020 GTPase binding GO:1990939 ATP-dependent microtubule motor activity
Cellular Component	GO:0005813 centrosome GO:0005819 spindle GO:0005871 kinesin complex GO:0005874 microtubule GO:0005875 microtubule associated complex GO:0005876 spindle microtubule GO:0005929 cilium GO:0016939 kinesin II complex GO:0044441 ciliary part GO:0072372 primary cilium GO:0097542 ciliary tip

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04340 Hedgehog signaling pathway
Reactome	R-HSA-5635838: Activation of SMO R-HSA-1280218: Adaptive Immune System R-HSA-6811434: COPI-dependent Golgi-to-ER retrograde traffic R-HSA-5617833: Cilium Assembly R-HSA-983231: Factors involved in megakaryocyte development and platelet production R-HSA-8856688: Golgi-to-ER retrograde transport R-HSA-5610787: Hedgehog 'off' state R-HSA-5632684: Hedgehog 'on' state R-HSA-109582: Hemostasis R-HSA-168256: Immune System R-HSA-6811442: Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-5620924: Intraflagellar transport R-HSA-983189: Kinesins R-HSA-2132295: MHC class II antigen presentation R-HSA-199991: Membrane Trafficking R-HSA-1852241: Organelle biogenesis and maintenance R-HSA-162582: Signal Transduction R-HSA-5358351: Signaling by Hedgehog R-HSA-1445148: Translocation of GLUT4 to the plasma membrane R-HSA-5653656: Vesicle-mediated transport

> KEGG and Reactome Pathway

[ TOP ]

KEGG

hsa04340 Hedgehog signaling pathway

Reactome

R-HSA-5635838: Activation of SMO
R-HSA-1280218: Adaptive Immune System
R-HSA-6811434: COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-5617833: Cilium Assembly
R-HSA-983231: Factors involved in megakaryocyte development and platelet production
R-HSA-8856688: Golgi-to-ER retrograde transport
R-HSA-5610787: Hedgehog 'off' state
R-HSA-5632684: Hedgehog 'on' state
R-HSA-109582: Hemostasis
R-HSA-168256: Immune System
R-HSA-6811442: Intra-Golgi and retrograde Golgi-to-ER traffic
R-HSA-5620924: Intraflagellar transport
R-HSA-983189: Kinesins
R-HSA-2132295: MHC class II antigen presentation
R-HSA-199991: Membrane Trafficking
R-HSA-1852241: Organelle biogenesis and maintenance
R-HSA-162582: Signal Transduction
R-HSA-5358351: Signaling by Hedgehog
R-HSA-1445148: Translocation of GLUT4 to the plasma membrane
R-HSA-5653656: Vesicle-mediated transport

Summary
Symbol	KIF3A
Name	kinesin family member 3A
Aliases	FLA10; KLP-20; kinesin family protein 3A; microtubule plus end-directed kinesin motor 3A; Kinesin-like prote ......
Chromosomal Location	5q31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between KIF3A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	KIF3A
Name	kinesin family member 3A
Aliases	FLA10; KLP-20; kinesin family protein 3A; microtubule plus end-directed kinesin motor 3A; Kinesin-like prote ......
Chromosomal Location	5q31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of KIF3A in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	logFC: 0.77; FDR: 0.036300	Sensitive to T cell-mediated killing
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	KIF3A
Name	kinesin family member 3A
Aliases	FLA10; KLP-20; kinesin family protein 3A; microtubule plus end-directed kinesin motor 3A; Kinesin-like prote ......
Chromosomal Location	5q31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the expression difference of KIF3A in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.25	0.291
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.628	0.545
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.032	0.97
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.334	0.228
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.135	0.931
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-0.586	0.763
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0	1
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.057	0.969
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.116	0.94
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	-0.27	0.754
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.214	0.851
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.035	0.549

> Mutation difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the mutation difference of KIF3A in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	5.9	-5.9	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	7.1	-7.1	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	11.1	1.4	9.7	0.0589
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	11.1	1.7	9.4	0.0895
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	4.8	5.9	-1.1	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	16.7	-16.7	0.429
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	7.7	0	7.7	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	KIF3A
Name	kinesin family member 3A
Aliases	FLA10; KLP-20; kinesin family protein 3A; microtubule plus end-directed kinesin motor 3A; Kinesin-like prote ......
Chromosomal Location	5q31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of KIF3A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	KIF3A
Name	kinesin family member 3A
Aliases	FLA10; KLP-20; kinesin family protein 3A; microtubule plus end-directed kinesin motor 3A; Kinesin-like prote ......
Chromosomal Location	5q31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of KIF3A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by KIF3A. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	KIF3A
Name	kinesin family member 3A
Aliases	FLA10; KLP-20; kinesin family protein 3A; microtubule plus end-directed kinesin motor 3A; Kinesin-like prote ......
Chromosomal Location	5q31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of KIF3A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	KIF3A
Name	kinesin family member 3A
Aliases	FLA10; KLP-20; kinesin family protein 3A; microtubule plus end-directed kinesin motor 3A; Kinesin-like prote ......
Chromosomal Location	5q31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of KIF3A expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	KIF3A
Name	kinesin family member 3A
Aliases	FLA10; KLP-20; kinesin family protein 3A; microtubule plus end-directed kinesin motor 3A; Kinesin-like prote ......
Chromosomal Location	5q31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between KIF3A and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	KIF3A
Name	kinesin family member 3A
Aliases	FLA10; KLP-20; kinesin family protein 3A; microtubule plus end-directed kinesin motor 3A; Kinesin-like prote ......
Chromosomal Location	5q31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting KIF3A collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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