TISIDB

Summary
Symbol	KIT
Name	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Aliases	CD117; SCFR; C-Kit; PBT; piebald trait; p145 c-kit; piebald trait protein; proto-oncogene c-Kit; proto-oncog ......
Chromosomal Location	4q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Isoform 1: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: Isoform 2: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: Isoform 3: Cytoplasm. Note=Detected in the cytoplasm of spermatozoa, especially in the equatorial and subacrosomal region of the sperm head.
Domain	PF00047 Immunoglobulin domain PF07714 Protein tyrosine kinase
Function	Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1.

> Gene Ontology [ TOP ]
Biological Process	GO:0000187 activation of MAPK activity GO:0001501 skeletal system development GO:0001541 ovarian follicle development GO:0001667 ameboidal-type cell migration GO:0002244 hematopoietic progenitor cell differentiation GO:0002262 myeloid cell homeostasis GO:0002263 cell activation involved in immune response GO:0002274 myeloid leukocyte activation GO:0002275 myeloid cell activation involved in immune response GO:0002279 mast cell activation involved in immune response GO:0002318 myeloid progenitor cell differentiation GO:0002320 lymphoid progenitor cell differentiation GO:0002327 immature B cell differentiation GO:0002366 leukocyte activation involved in immune response GO:0002367 cytokine production involved in immune response GO:0002371 dendritic cell cytokine production GO:0002440 production of molecular mediator of immune response GO:0002443 leukocyte mediated immunity GO:0002444 myeloid leukocyte mediated immunity GO:0002448 mast cell mediated immunity GO:0002521 leukocyte differentiation GO:0002551 mast cell chemotaxis GO:0002573 myeloid leukocyte differentiation GO:0002764 immune response-regulating signaling pathway GO:0002768 immune response-regulating cell surface receptor signaling pathway GO:0006643 membrane lipid metabolic process GO:0006644 phospholipid metabolic process GO:0006650 glycerophospholipid metabolic process GO:0006664 glycolipid metabolic process GO:0006665 sphingolipid metabolic process GO:0006687 glycosphingolipid metabolic process GO:0006887 exocytosis GO:0007159 leukocyte cell-cell adhesion GO:0007219 Notch signaling pathway GO:0007259 JAK-STAT cascade GO:0007260 tyrosine phosphorylation of STAT protein GO:0007281 germ cell development GO:0007283 spermatogenesis GO:0007286 spermatid development GO:0007548 sex differentiation GO:0007605 sensory perception of sound GO:0007611 learning or memory GO:0007612 learning GO:0007632 visual behavior GO:0008306 associative learning GO:0008354 germ cell migration GO:0008360 regulation of cell shape GO:0008406 gonad development GO:0008542 visual learning GO:0008584 male gonad development GO:0008585 female gonad development GO:0008593 regulation of Notch signaling pathway GO:0009314 response to radiation GO:0009416 response to light stimulus GO:0009581 detection of external stimulus GO:0009582 detection of abiotic stimulus GO:0009612 response to mechanical stimulus GO:0010517 regulation of phospholipase activity GO:0010518 positive regulation of phospholipase activity GO:0010623 programmed cell death involved in cell development GO:0010631 epithelial cell migration GO:0010720 positive regulation of cell development GO:0010863 positive regulation of phospholipase C activity GO:0014065 phosphatidylinositol 3-kinase signaling GO:0014066 regulation of phosphatidylinositol 3-kinase signaling GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling GO:0017145 stem cell division GO:0018108 peptidyl-tyrosine phosphorylation GO:0018212 peptidyl-tyrosine modification GO:0019216 regulation of lipid metabolic process GO:0019827 stem cell population maintenance GO:0022412 cellular process involved in reproduction in multicellular organism GO:0022602 ovulation cycle process GO:0022604 regulation of cell morphogenesis GO:0030031 cell projection assembly GO:0030032 lamellipodium assembly GO:0030098 lymphocyte differentiation GO:0030099 myeloid cell differentiation GO:0030183 B cell differentiation GO:0030217 T cell differentiation GO:0030218 erythrocyte differentiation GO:0030219 megakaryocyte differentiation GO:0030258 lipid modification GO:0030318 melanocyte differentiation GO:0030335 positive regulation of cell migration GO:0030595 leukocyte chemotaxis GO:0031268 pseudopodium organization GO:0031269 pseudopodium assembly GO:0031272 regulation of pseudopodium assembly GO:0031274 positive regulation of pseudopodium assembly GO:0031346 positive regulation of cell projection organization GO:0031532 actin cytoskeleton reorganization GO:0032147 activation of protein kinase activity GO:0032418 lysosome localization GO:0032762 mast cell cytokine production GO:0033674 positive regulation of kinase activity GO:0034101 erythrocyte homeostasis GO:0035019 somatic stem cell population maintenance GO:0035162 embryonic hemopoiesis GO:0035234 ectopic germ cell programmed cell death GO:0035701 hematopoietic stem cell migration GO:0035855 megakaryocyte development GO:0035886 vascular smooth muscle cell differentiation GO:0036017 response to erythropoietin GO:0036018 cellular response to erythropoietin GO:0036215 response to stem cell factor GO:0036216 cellular response to stem cell factor stimulus GO:0038093 Fc receptor signaling pathway GO:0038109 Kit signaling pathway GO:0038162 erythropoietin-mediated signaling pathway GO:0040017 positive regulation of locomotion GO:0042110 T cell activation GO:0042113 B cell activation GO:0042503 tyrosine phosphorylation of Stat3 protein GO:0042506 tyrosine phosphorylation of Stat5 protein GO:0042508 tyrosine phosphorylation of Stat1 protein GO:0042509 regulation of tyrosine phosphorylation of STAT protein GO:0042510 regulation of tyrosine phosphorylation of Stat1 protein GO:0042511 positive regulation of tyrosine phosphorylation of Stat1 protein GO:0042516 regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042522 regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein GO:0042692 muscle cell differentiation GO:0042698 ovulation cycle GO:0043299 leukocyte degranulation GO:0043303 mast cell degranulation GO:0043405 regulation of MAP kinase activity GO:0043406 positive regulation of MAP kinase activity GO:0043410 positive regulation of MAPK cascade GO:0043473 pigmentation GO:0043550 regulation of lipid kinase activity GO:0043551 regulation of phosphatidylinositol 3-kinase activity GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity GO:0044089 positive regulation of cellular component biogenesis GO:0044708 single-organism behavior GO:0045055 regulated exocytosis GO:0045137 development of primary sexual characteristics GO:0045576 mast cell activation GO:0045747 positive regulation of Notch signaling pathway GO:0045834 positive regulation of lipid metabolic process GO:0045860 positive regulation of protein kinase activity GO:0046425 regulation of JAK-STAT cascade GO:0046427 positive regulation of JAK-STAT cascade GO:0046486 glycerolipid metabolic process GO:0046488 phosphatidylinositol metabolic process GO:0046545 development of primary female sexual characteristics GO:0046546 development of primary male sexual characteristics GO:0046660 female sex differentiation GO:0046661 male sex differentiation GO:0046777 protein autophosphorylation GO:0046834 lipid phosphorylation GO:0046854 phosphatidylinositol phosphorylation GO:0048015 phosphatidylinositol-mediated signaling GO:0048017 inositol lipid-mediated signaling GO:0048066 developmental pigmentation GO:0048070 regulation of developmental pigmentation GO:0048103 somatic stem cell division GO:0048167 regulation of synaptic plasticity GO:0048168 regulation of neuronal synaptic plasticity GO:0048169 regulation of long-term neuronal synaptic plasticity GO:0048170 positive regulation of long-term neuronal synaptic plasticity GO:0048232 male gamete generation GO:0048511 rhythmic process GO:0048515 spermatid differentiation GO:0048565 digestive tract development GO:0048568 embryonic organ development GO:0048608 reproductive structure development GO:0048863 stem cell differentiation GO:0048872 homeostasis of number of cells GO:0050673 epithelial cell proliferation GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0050769 positive regulation of neurogenesis GO:0050804 modulation of synaptic transmission GO:0050890 cognition GO:0050900 leukocyte migration GO:0050910 detection of mechanical stimulus involved in sensory perception of sound GO:0050931 pigment cell differentiation GO:0050954 sensory perception of mechanical stimulus GO:0050974 detection of mechanical stimulus involved in sensory perception GO:0050982 detection of mechanical stimulus GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051145 smooth muscle cell differentiation GO:0051147 regulation of muscle cell differentiation GO:0051149 positive regulation of muscle cell differentiation GO:0051150 regulation of smooth muscle cell differentiation GO:0051152 positive regulation of smooth muscle cell differentiation GO:0051272 positive regulation of cellular component movement GO:0051640 organelle localization GO:0051656 establishment of organelle localization GO:0051962 positive regulation of nervous system development GO:0055123 digestive system development GO:0060191 regulation of lipase activity GO:0060193 positive regulation of lipase activity GO:0060326 cell chemotaxis GO:0060348 bone development GO:0060374 mast cell differentiation GO:0060491 regulation of cell projection assembly GO:0061082 myeloid leukocyte cytokine production GO:0061458 reproductive system development GO:0061515 myeloid cell development GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070661 leukocyte proliferation GO:0070662 mast cell proliferation GO:0071593 lymphocyte aggregation GO:0071900 regulation of protein serine/threonine kinase activity GO:0071902 positive regulation of protein serine/threonine kinase activity GO:0090130 tissue migration GO:0090132 epithelium migration GO:0090136 epithelial cell-cell adhesion GO:0090218 positive regulation of lipid kinase activity GO:0097066 response to thyroid hormone GO:0097067 cellular response to thyroid hormone stimulus GO:0097324 melanocyte migration GO:0097326 melanocyte adhesion GO:0097529 myeloid leukocyte migration GO:0097531 mast cell migration GO:0097581 lamellipodium organization GO:0097696 STAT cascade GO:0098727 maintenance of cell number GO:0098751 bone cell development GO:1900274 regulation of phospholipase C activity GO:1901342 regulation of vasculature development GO:1903509 liposaccharide metabolic process GO:1903725 regulation of phospholipid metabolic process GO:1903727 positive regulation of phospholipid metabolic process GO:1904018 positive regulation of vasculature development GO:1904892 regulation of STAT cascade GO:1904894 positive regulation of STAT cascade GO:1905063 regulation of vascular smooth muscle cell differentiation GO:1905065 positive regulation of vascular smooth muscle cell differentiation GO:2000147 positive regulation of cell motility
Molecular Function	GO:0002020 protease binding GO:0004713 protein tyrosine kinase activity GO:0004714 transmembrane receptor protein tyrosine kinase activity GO:0004716 receptor signaling protein tyrosine kinase activity GO:0005020 stem cell factor receptor activity GO:0005057 receptor signaling protein activity GO:0005085 guanyl-nucleotide exchange factor activity GO:0005088 Ras guanyl-nucleotide exchange factor activity GO:0019199 transmembrane receptor protein kinase activity GO:0019955 cytokine binding GO:0035004 phosphatidylinositol 3-kinase activity GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0052813 phosphatidylinositol bisphosphate kinase activity
Cellular Component	GO:0001669 acrosomal vesicle GO:0009897 external side of plasma membrane GO:0009898 cytoplasmic side of plasma membrane GO:0030141 secretory granule GO:0042629 mast cell granule GO:0097223 sperm part GO:0098552 side of membrane GO:0098562 cytoplasmic side of membrane GO:0099503 secretory vesicle

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04014 Ras signaling pathway hsa04015 Rap1 signaling pathway hsa04060 Cytokine-cytokine receptor interaction hsa04144 Endocytosis hsa04151 PI3K-Akt signaling pathway hsa04640 Hematopoietic cell lineage hsa04916 Melanogenesis
Reactome	R-HSA-170984: ARMS-mediated activation R-HSA-1280218: Adaptive Immune System R-HSA-422475: Axon guidance R-HSA-2219530: Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-2172127: DAP12 interactions R-HSA-2424491: DAP12 signaling R-HSA-1266738: Developmental Biology R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-186763: Downstream signal transduction R-HSA-1168372: Downstream signaling events of B Cell Receptor (BCR) R-HSA-2871796: FCERI mediated MAPK activation R-HSA-2454202: Fc epsilon receptor (FCERI) signaling R-HSA-170968: Frs2-mediated activation R-HSA-180292: GAB1 signalosome R-HSA-179812: GRB2 events in EGFR signaling R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-2428924: IGF1R signaling cascade R-HSA-112399: IRS-mediated signalling R-HSA-2428928: IRS-related events triggered by IGF1R R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-74751: Insulin receptor signalling cascade R-HSA-912526: Interleukin receptor SHC signaling R-HSA-451927: Interleukin-2 signaling R-HSA-512988: Interleukin-3, 5 and GM-CSF signaling R-HSA-5683057: MAPK family signaling cascades R-HSA-5684996: MAPK1/MAPK3 signaling R-HSA-375165: NCAM signaling for neurite out-growth R-HSA-187037: NGF signalling via TRKA from the plasma membrane R-HSA-199418: Negative regulation of the PI3K/AKT network R-HSA-2219528: PI3K/AKT Signaling in Cancer R-HSA-198203: PI3K/AKT activation R-HSA-6811558: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-1257604: PIP3 activates AKT signaling R-HSA-169893: Prolonged ERK activation events R-HSA-5673001: RAF/MAP kinase cascade R-HSA-8853659: RET signaling R-HSA-1433559: Regulation of KIT signaling R-HSA-2730905: Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-180336: SHC1 events in EGFR signaling R-HSA-112412: SOS-mediated signalling R-HSA-162582: Signal Transduction R-HSA-177929: Signaling by EGFR R-HSA-372790: Signaling by GPCR R-HSA-74752: Signaling by Insulin receptor R-HSA-449147: Signaling by Interleukins R-HSA-2586552: Signaling by Leptin R-HSA-186797: Signaling by PDGF R-HSA-1433557: Signaling by SCF-KIT R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-194138: Signaling by VEGF R-HSA-983705: Signaling by the B Cell Receptor (BCR) R-HSA-166520: Signalling by NGF R-HSA-187687: Signalling to ERKs R-HSA-167044: Signalling to RAS R-HSA-187706: Signalling to p38 via RIT and RIN R-HSA-8866910: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8864260: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-4420097: VEGFA-VEGFR2 Pathway R-HSA-5218921: VEGFR2 mediated cell proliferation

> KEGG and Reactome Pathway

[ TOP ]

KEGG

hsa04014 Ras signaling pathway
hsa04015 Rap1 signaling pathway
hsa04060 Cytokine-cytokine receptor interaction
hsa04144 Endocytosis
hsa04151 PI3K-Akt signaling pathway
hsa04640 Hematopoietic cell lineage
hsa04916 Melanogenesis

Reactome

R-HSA-170984: ARMS-mediated activation
R-HSA-1280218: Adaptive Immune System
R-HSA-422475: Axon guidance
R-HSA-2219530: Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-2172127: DAP12 interactions
R-HSA-2424491: DAP12 signaling
R-HSA-1266738: Developmental Biology
R-HSA-1643685: Disease
R-HSA-5663202: Diseases of signal transduction
R-HSA-186763: Downstream signal transduction
R-HSA-1168372: Downstream signaling events of B Cell Receptor (BCR)
R-HSA-2871796: FCERI mediated MAPK activation
R-HSA-2454202: Fc epsilon receptor (FCERI) signaling
R-HSA-170968: Frs2-mediated activation
R-HSA-180292: GAB1 signalosome
R-HSA-179812: GRB2 events in EGFR signaling
R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-2428924: IGF1R signaling cascade
R-HSA-112399: IRS-mediated signalling
R-HSA-2428928: IRS-related events triggered by IGF1R
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-74751: Insulin receptor signalling cascade
R-HSA-912526: Interleukin receptor SHC signaling
R-HSA-451927: Interleukin-2 signaling
R-HSA-512988: Interleukin-3, 5 and GM-CSF signaling
R-HSA-5683057: MAPK family signaling cascades
R-HSA-5684996: MAPK1/MAPK3 signaling
R-HSA-375165: NCAM signaling for neurite out-growth
R-HSA-187037: NGF signalling via TRKA from the plasma membrane
R-HSA-199418: Negative regulation of the PI3K/AKT network
R-HSA-2219528: PI3K/AKT Signaling in Cancer
R-HSA-198203: PI3K/AKT activation
R-HSA-6811558: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-1257604: PIP3 activates AKT signaling
R-HSA-169893: Prolonged ERK activation events
R-HSA-5673001: RAF/MAP kinase cascade
R-HSA-8853659: RET signaling
R-HSA-1433559: Regulation of KIT signaling
R-HSA-2730905: Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-180336: SHC1 events in EGFR signaling
R-HSA-112412: SOS-mediated signalling
R-HSA-162582: Signal Transduction
R-HSA-177929: Signaling by EGFR
R-HSA-372790: Signaling by GPCR
R-HSA-74752: Signaling by Insulin receptor
R-HSA-449147: Signaling by Interleukins
R-HSA-2586552: Signaling by Leptin
R-HSA-186797: Signaling by PDGF
R-HSA-1433557: Signaling by SCF-KIT
R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
R-HSA-194138: Signaling by VEGF
R-HSA-983705: Signaling by the B Cell Receptor (BCR)
R-HSA-166520: Signalling by NGF
R-HSA-187687: Signalling to ERKs
R-HSA-167044: Signalling to RAS
R-HSA-187706: Signalling to p38 via RIT and RIN
R-HSA-8866910: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
R-HSA-8864260: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
R-HSA-4420097: VEGFA-VEGFR2 Pathway
R-HSA-5218921: VEGFR2 mediated cell proliferation

Summary
Symbol	KIT
Name	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Aliases	CD117; SCFR; C-Kit; PBT; piebald trait; p145 c-kit; piebald trait protein; proto-oncogene c-Kit; proto-oncog ......
Chromosomal Location	4q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between KIT and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining

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Literatures describing the relation between KIT and anti-tumor immunity in human cancer.

PMID	Cancer type	Relation to immunity	Evidence sentences
27470968	Gastrointestinal Stromal Tumor	Inhibit immunity (T cell function); immunotherapy target	PD-1 and PD-L1 blockade in vivo each had no efficacy alone but enhanced the antitumor effects of imatinib by increasing T-cell effector function in the presence of KIT and IDO inhibition.
17885078	Colon Carcinoma	Inhibit immunity (T cell function)	More importantly, blockade of SCF receptor (ckit)-SCF interaction by anti-ckit prevented tumor-specific T-cell anergy, Treg development, and tumor angiogenesis. Furthermore, the prevention of MDSC accumulation in conjunction with immune activation therapy showed synergistic therapeutic effect when treating mice bearing large tumors.
16056250	Ovarian Dysgerminoma	Inhibit immunity	Although the prognosis of patients with dysgerminoma is generally good, this receptor could potentially serve as a target for site-specific immunotherapy as an alternative and/or complement to conventional treatment options.
22936666	Mastocytoma	Inhibit immunity	In this study, we report that the in vivo antitumor effects of the c-KIT inhibitor, dasatinib, on the c-KIT mutant P815 mastocytoma tumor were substantially dependent on T cell-mediated immunity. We found that dasatinib treatment significantly decreased levels of Tregs while specifically enhancing tumor antigen-specific T-cell responses.

Summary
Symbol	KIT
Name	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Aliases	CD117; SCFR; C-Kit; PBT; piebald trait; p145 c-kit; piebald trait protein; proto-oncogene c-Kit; proto-oncog ......
Chromosomal Location	4q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of KIT in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	KIT
Name	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Aliases	CD117; SCFR; C-Kit; PBT; piebald trait; p145 c-kit; piebald trait protein; proto-oncogene c-Kit; proto-oncog ......
Chromosomal Location	4q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of KIT in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.475	0.552
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.871	0.564
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.202	0.884
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.363	0.522
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.748	0.676
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.113	0.954
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.268	0.725
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	1.338	0.442
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.832	0.648
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	-0.349	0.637
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.735	0.411
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.64	0.00213

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of KIT in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	0	4.1	-4.1	0.561
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	0	5.1	-5.1	0.549
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	5.3	0	5.3	0.507
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	9.1	0	9.1	0.519
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	9.1	0	9.1	0.458
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	16.7	0	16.7	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	KIT
Name	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Aliases	CD117; SCFR; C-Kit; PBT; piebald trait; p145 c-kit; piebald trait protein; proto-oncogene c-Kit; proto-oncog ......
Chromosomal Location	4q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of KIT. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	KIT
Name	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Aliases	CD117; SCFR; C-Kit; PBT; piebald trait; p145 c-kit; piebald trait protein; proto-oncogene c-Kit; proto-oncog ......
Chromosomal Location	4q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of KIT. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by KIT. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	KIT
Name	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Aliases	CD117; SCFR; C-Kit; PBT; piebald trait; p145 c-kit; piebald trait protein; proto-oncogene c-Kit; proto-oncog ......
Chromosomal Location	4q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of KIT. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	KIT
Name	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Aliases	CD117; SCFR; C-Kit; PBT; piebald trait; p145 c-kit; piebald trait protein; proto-oncogene c-Kit; proto-oncog ......
Chromosomal Location	4q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of KIT expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	KIT
Name	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Aliases	CD117; SCFR; C-Kit; PBT; piebald trait; p145 c-kit; piebald trait protein; proto-oncogene c-Kit; proto-oncog ......
Chromosomal Location	4q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between KIT and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	KIT
Name	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Aliases	CD117; SCFR; C-Kit; PBT; piebald trait; p145 c-kit; piebald trait protein; proto-oncogene c-Kit; proto-oncog ......
Chromosomal Location	4q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting KIT collected from DrugBank database.

> Drugs from DrugBank database

[ TOP ]

Details on drugs targeting KIT.

ID	Name	Drug Type	Targets	#Targets
DB00398	Sorafenib	Small Molecule	BRAF, FGFR1, FLT1, FLT3, FLT4, KDR, KIT, PDGFRB, RAF1, RET	10
DB00619	Imatinib	Small Molecule	ABL1, CSF1R, DDR1, KIT, NTRK1, PDGFRA, PDGFRB	7
DB01254	Dasatinib	Small Molecule	ABL1, ABL2, BCR, BTK, CSK, EPHA2, EPHA5, EPHB4, FGR, FRK, FYN, HSP ......	22
DB01268	Sunitinib	Small Molecule	CSF1R, FLT1, FLT3, FLT4, KDR, KIT, PDGFRA, PDGFRB	8
DB01962	Phosphonotyrosine	Small Molecule	HCK, KIT, SRC	3
DB04868	Nilotinib	Small Molecule	ABL1, KIT	2
DB05146	XL820	Small Molecule	KDR, KIT, PDGFRA, PDGFRB	4
DB05913	OSI-930	Small Molecule	FLT1, KIT	2
DB06080	ABT-869	Small Molecule	CSF1R, FLT1, FLT3, FLT4, KDR, KIT	6
DB06589	Pazopanib	Small Molecule	FGF1, FGFR3, FLT1, FLT4, ITK, KDR, KIT, PDGFRA, PDGFRB, SH2B3	10
DB06595	Midostaurin	Small Molecule	FLT3, KDR, KIT, PDGFRA, PDGFRB, PRKCA	6
DB08896	Regorafenib	Small Molecule	ABL1, BRAF, DDR2, EPHA2, FGFR1, FGFR2, FLT1, FLT4, FRK, KDR, KIT, ......	18
DB08901	Ponatinib	Small Molecule	ABL1, BCR, FGFR1, FGFR2, FGFR3, FGFR4, FLT3, KDR, KIT, LCK, LYN, P ......	15
DB09078	Lenvatinib	Small Molecule	FGFR1, FGFR2, FGFR3, FGFR4, FLT1, FLT4, KDR, KIT	8
DB09103	Ancestim	Biotech	KIT	1
DB12742	Amuvatinib	Small Molecule	FLT3, KIT, MET, PDGFRA, RAD51, RET	6

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