Browse KLF2

Summary
SymbolKLF2
NameKruppel-like factor 2
Aliases LKLF; Kruppel-like factor 2 (lung); Kruppel-like factor LKLF; lung Kruppel-like zinc finger transcription fa ......
Chromosomal Location19p13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus
Domain -
Function

Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription.

> Gene Ontology
 
Biological Process GO:0000302 response to reactive oxygen species
GO:0001701 in utero embryonic development
GO:0001818 negative regulation of cytokine production
GO:0002262 myeloid cell homeostasis
GO:0006809 nitric oxide biosynthetic process
GO:0006979 response to oxidative stress
GO:0010035 response to inorganic substance
GO:0021700 developmental maturation
GO:0030099 myeloid cell differentiation
GO:0030218 erythrocyte differentiation
GO:0030323 respiratory tube development
GO:0030324 lung development
GO:0032635 interleukin-6 production
GO:0032675 regulation of interleukin-6 production
GO:0032715 negative regulation of interleukin-6 production
GO:0034101 erythrocyte homeostasis
GO:0034405 response to fluid shear stress
GO:0034599 cellular response to oxidative stress
GO:0034612 response to tumor necrosis factor
GO:0034614 cellular response to reactive oxygen species
GO:0034616 response to laminar fluid shear stress
GO:0035264 multicellular organism growth
GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress
GO:0040029 regulation of gene expression, epigenetic
GO:0042542 response to hydrogen peroxide
GO:0043249 erythrocyte maturation
GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress
GO:0043620 regulation of DNA-templated transcription in response to stress
GO:0045428 regulation of nitric oxide biosynthetic process
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0046209 nitric oxide metabolic process
GO:0046898 response to cycloheximide
GO:0048469 cell maturation
GO:0048821 erythrocyte development
GO:0048872 homeostasis of number of cells
GO:0060428 lung epithelium development
GO:0060479 lung cell differentiation
GO:0060487 lung epithelial cell differentiation
GO:0060509 Type I pneumocyte differentiation
GO:0060541 respiratory system development
GO:0061515 myeloid cell development
GO:0070301 cellular response to hydrogen peroxide
GO:0070555 response to interleukin-1
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0071407 cellular response to organic cyclic compound
GO:0071409 cellular response to cycloheximide
GO:0071417 cellular response to organonitrogen compound
GO:0071498 cellular response to fluid shear stress
GO:0071499 cellular response to laminar fluid shear stress
GO:0072593 reactive oxygen species metabolic process
GO:0097305 response to alcohol
GO:0097306 cellular response to alcohol
GO:1901652 response to peptide
GO:1901653 cellular response to peptide
GO:1901654 response to ketone
GO:1901655 cellular response to ketone
GO:1903409 reactive oxygen species biosynthetic process
GO:1903426 regulation of reactive oxygen species biosynthetic process
GO:1903428 positive regulation of reactive oxygen species biosynthetic process
GO:1904407 positive regulation of nitric oxide metabolic process
GO:2000377 regulation of reactive oxygen species metabolic process
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2001057 reactive nitrogen species metabolic process
Molecular Function -
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04068 FoxO signaling pathway
Reactome -
Summary
SymbolKLF2
NameKruppel-like factor 2
Aliases LKLF; Kruppel-like factor 2 (lung); Kruppel-like factor LKLF; lung Kruppel-like zinc finger transcription fa ......
Chromosomal Location19p13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between KLF2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolKLF2
NameKruppel-like factor 2
Aliases LKLF; Kruppel-like factor 2 (lung); Kruppel-like factor LKLF; lung Kruppel-like zinc finger transcription fa ......
Chromosomal Location19p13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of KLF2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.59 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolKLF2
NameKruppel-like factor 2
Aliases LKLF; Kruppel-like factor 2 (lung); Kruppel-like factor LKLF; lung Kruppel-like zinc finger transcription fa ......
Chromosomal Location19p13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of KLF2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.0580.911
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.6330.763
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.5670.727
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.0650.934
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.4230.846
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.3910.889
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.3230.45
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.3660.732
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.2480.837
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.4340.232
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.4170.409
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.4840.00662
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of KLF2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277301.4-1.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275901.7-1.71
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolKLF2
NameKruppel-like factor 2
Aliases LKLF; Kruppel-like factor 2 (lung); Kruppel-like factor LKLF; lung Kruppel-like zinc finger transcription fa ......
Chromosomal Location19p13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of KLF2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolKLF2
NameKruppel-like factor 2
Aliases LKLF; Kruppel-like factor 2 (lung); Kruppel-like factor LKLF; lung Kruppel-like zinc finger transcription fa ......
Chromosomal Location19p13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of KLF2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by KLF2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolKLF2
NameKruppel-like factor 2
Aliases LKLF; Kruppel-like factor 2 (lung); Kruppel-like factor LKLF; lung Kruppel-like zinc finger transcription fa ......
Chromosomal Location19p13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of KLF2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolKLF2
NameKruppel-like factor 2
Aliases LKLF; Kruppel-like factor 2 (lung); Kruppel-like factor LKLF; lung Kruppel-like zinc finger transcription fa ......
Chromosomal Location19p13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of KLF2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolKLF2
NameKruppel-like factor 2
Aliases LKLF; Kruppel-like factor 2 (lung); Kruppel-like factor LKLF; lung Kruppel-like zinc finger transcription fa ......
Chromosomal Location19p13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between KLF2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolKLF2
NameKruppel-like factor 2
Aliases LKLF; Kruppel-like factor 2 (lung); Kruppel-like factor LKLF; lung Kruppel-like zinc finger transcription fa ......
Chromosomal Location19p13.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting KLF2 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.