Browse KNDC1

Summary
SymbolKNDC1
Namekinase non-catalytic C-lobe domain (KIND) containing 1
Aliases KIAA1768; bB439H18.3; FLJ25027; RASGEF2; C10orf23; RasGEF domain family, member 2; KIND domain-containing pr ......
Chromosomal Location10q26.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell projection, dendrite Perikaryon
Domain PF16474 Kinase non-catalytic C-lobe domain
PF00617 RasGEF domain
PF00618 RasGEF N-terminal motif
Function

RAS-Guanine nucleotide exchange factor (GEF) that controls the negative regulation of neuronal dendrite growth by mediating a signaling pathway linking RAS and MAP2 (By similarity). May be involved in cellular senescence (PubMed:24788352).

> Gene Ontology
 
Biological Process GO:0010769 regulation of cell morphogenesis involved in differentiation
GO:0010975 regulation of neuron projection development
GO:0016358 dendrite development
GO:0021533 cell differentiation in hindbrain
GO:0021549 cerebellum development
GO:0021575 hindbrain morphogenesis
GO:0021587 cerebellum morphogenesis
GO:0021681 cerebellar granular layer development
GO:0021683 cerebellar granular layer morphogenesis
GO:0021684 cerebellar granular layer formation
GO:0021695 cerebellar cortex development
GO:0021696 cerebellar cortex morphogenesis
GO:0021697 cerebellar cortex formation
GO:0021707 cerebellar granule cell differentiation
GO:0021953 central nervous system neuron differentiation
GO:0022037 metencephalon development
GO:0022604 regulation of cell morphogenesis
GO:0030902 hindbrain development
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0048813 dendrite morphogenesis
GO:0048814 regulation of dendrite morphogenesis
GO:0050773 regulation of dendrite development
Molecular Function GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
Cellular Component GO:0030425 dendrite
GO:0032045 guanyl-nucleotide exchange factor complex
GO:0043025 neuronal cell body
GO:0044297 cell body
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolKNDC1
Namekinase non-catalytic C-lobe domain (KIND) containing 1
Aliases KIAA1768; bB439H18.3; FLJ25027; RASGEF2; C10orf23; RasGEF domain family, member 2; KIND domain-containing pr ......
Chromosomal Location10q26.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between KNDC1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolKNDC1
Namekinase non-catalytic C-lobe domain (KIND) containing 1
Aliases KIAA1768; bB439H18.3; FLJ25027; RASGEF2; C10orf23; RasGEF domain family, member 2; KIND domain-containing pr ......
Chromosomal Location10q26.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of KNDC1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolKNDC1
Namekinase non-catalytic C-lobe domain (KIND) containing 1
Aliases KIAA1768; bB439H18.3; FLJ25027; RASGEF2; C10orf23; RasGEF domain family, member 2; KIND domain-containing pr ......
Chromosomal Location10q26.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of KNDC1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.1670.415
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.1260.803
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.3830.371
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.2770.731
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-1.6790.228
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 471.4920.359
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.3870.645
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.5770.697
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.4120.772
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.8730.202
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.9980.268
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.9220.00207
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of KNDC1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.15.91.21
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 41407.1-7.11
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277311.1011.10.0181
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275911.1011.10.0286
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211714.35.98.40.613
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131115.49.16.31
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.118.8-7.71
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59022.2-22.20.505
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 472514.310.71
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.305.30.507
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolKNDC1
Namekinase non-catalytic C-lobe domain (KIND) containing 1
Aliases KIAA1768; bB439H18.3; FLJ25027; RASGEF2; C10orf23; RasGEF domain family, member 2; KIND domain-containing pr ......
Chromosomal Location10q26.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of KNDC1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolKNDC1
Namekinase non-catalytic C-lobe domain (KIND) containing 1
Aliases KIAA1768; bB439H18.3; FLJ25027; RASGEF2; C10orf23; RasGEF domain family, member 2; KIND domain-containing pr ......
Chromosomal Location10q26.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of KNDC1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by KNDC1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolKNDC1
Namekinase non-catalytic C-lobe domain (KIND) containing 1
Aliases KIAA1768; bB439H18.3; FLJ25027; RASGEF2; C10orf23; RasGEF domain family, member 2; KIND domain-containing pr ......
Chromosomal Location10q26.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of KNDC1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolKNDC1
Namekinase non-catalytic C-lobe domain (KIND) containing 1
Aliases KIAA1768; bB439H18.3; FLJ25027; RASGEF2; C10orf23; RasGEF domain family, member 2; KIND domain-containing pr ......
Chromosomal Location10q26.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of KNDC1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolKNDC1
Namekinase non-catalytic C-lobe domain (KIND) containing 1
Aliases KIAA1768; bB439H18.3; FLJ25027; RASGEF2; C10orf23; RasGEF domain family, member 2; KIND domain-containing pr ......
Chromosomal Location10q26.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between KNDC1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolKNDC1
Namekinase non-catalytic C-lobe domain (KIND) containing 1
Aliases KIAA1768; bB439H18.3; FLJ25027; RASGEF2; C10orf23; RasGEF domain family, member 2; KIND domain-containing pr ......
Chromosomal Location10q26.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting KNDC1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.