Summary | |
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Symbol | KNDC1 |
Name | kinase non-catalytic C-lobe domain (KIND) containing 1 |
Aliases | KIAA1768; bB439H18.3; FLJ25027; RASGEF2; C10orf23; RasGEF domain family, member 2; KIND domain-containing pr ...... |
Chromosomal Location | 10q26.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell projection, dendrite Perikaryon |
Domain |
PF16474 Kinase non-catalytic C-lobe domain PF00617 RasGEF domain PF00618 RasGEF N-terminal motif |
Function |
RAS-Guanine nucleotide exchange factor (GEF) that controls the negative regulation of neuronal dendrite growth by mediating a signaling pathway linking RAS and MAP2 (By similarity). May be involved in cellular senescence (PubMed:24788352). |
Biological Process |
GO:0010769 regulation of cell morphogenesis involved in differentiation GO:0010975 regulation of neuron projection development GO:0016358 dendrite development GO:0021533 cell differentiation in hindbrain GO:0021549 cerebellum development GO:0021575 hindbrain morphogenesis GO:0021587 cerebellum morphogenesis GO:0021681 cerebellar granular layer development GO:0021683 cerebellar granular layer morphogenesis GO:0021684 cerebellar granular layer formation GO:0021695 cerebellar cortex development GO:0021696 cerebellar cortex morphogenesis GO:0021697 cerebellar cortex formation GO:0021707 cerebellar granule cell differentiation GO:0021953 central nervous system neuron differentiation GO:0022037 metencephalon development GO:0022604 regulation of cell morphogenesis GO:0030902 hindbrain development GO:0048667 cell morphogenesis involved in neuron differentiation GO:0048813 dendrite morphogenesis GO:0048814 regulation of dendrite morphogenesis GO:0050773 regulation of dendrite development |
Molecular Function |
GO:0005085 guanyl-nucleotide exchange factor activity GO:0005088 Ras guanyl-nucleotide exchange factor activity |
Cellular Component |
GO:0030425 dendrite GO:0032045 guanyl-nucleotide exchange factor complex GO:0043025 neuronal cell body GO:0044297 cell body |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | KNDC1 |
Name | kinase non-catalytic C-lobe domain (KIND) containing 1 |
Aliases | KIAA1768; bB439H18.3; FLJ25027; RASGEF2; C10orf23; RasGEF domain family, member 2; KIND domain-containing pr ...... |
Chromosomal Location | 10q26.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between KNDC1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | KNDC1 |
Name | kinase non-catalytic C-lobe domain (KIND) containing 1 |
Aliases | KIAA1768; bB439H18.3; FLJ25027; RASGEF2; C10orf23; RasGEF domain family, member 2; KIND domain-containing pr ...... |
Chromosomal Location | 10q26.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of KNDC1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | KNDC1 |
Name | kinase non-catalytic C-lobe domain (KIND) containing 1 |
Aliases | KIAA1768; bB439H18.3; FLJ25027; RASGEF2; C10orf23; RasGEF domain family, member 2; KIND domain-containing pr ...... |
Chromosomal Location | 10q26.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of KNDC1 in various data sets.
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Points in the above scatter plot represent the mutation difference of KNDC1 in various data sets.
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Summary | |
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Symbol | KNDC1 |
Name | kinase non-catalytic C-lobe domain (KIND) containing 1 |
Aliases | KIAA1768; bB439H18.3; FLJ25027; RASGEF2; C10orf23; RasGEF domain family, member 2; KIND domain-containing pr ...... |
Chromosomal Location | 10q26.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of KNDC1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | KNDC1 |
Name | kinase non-catalytic C-lobe domain (KIND) containing 1 |
Aliases | KIAA1768; bB439H18.3; FLJ25027; RASGEF2; C10orf23; RasGEF domain family, member 2; KIND domain-containing pr ...... |
Chromosomal Location | 10q26.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of KNDC1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by KNDC1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | KNDC1 |
Name | kinase non-catalytic C-lobe domain (KIND) containing 1 |
Aliases | KIAA1768; bB439H18.3; FLJ25027; RASGEF2; C10orf23; RasGEF domain family, member 2; KIND domain-containing pr ...... |
Chromosomal Location | 10q26.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of KNDC1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | KNDC1 |
Name | kinase non-catalytic C-lobe domain (KIND) containing 1 |
Aliases | KIAA1768; bB439H18.3; FLJ25027; RASGEF2; C10orf23; RasGEF domain family, member 2; KIND domain-containing pr ...... |
Chromosomal Location | 10q26.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of KNDC1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | KNDC1 |
Name | kinase non-catalytic C-lobe domain (KIND) containing 1 |
Aliases | KIAA1768; bB439H18.3; FLJ25027; RASGEF2; C10orf23; RasGEF domain family, member 2; KIND domain-containing pr ...... |
Chromosomal Location | 10q26.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between KNDC1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | KNDC1 |
Name | kinase non-catalytic C-lobe domain (KIND) containing 1 |
Aliases | KIAA1768; bB439H18.3; FLJ25027; RASGEF2; C10orf23; RasGEF domain family, member 2; KIND domain-containing pr ...... |
Chromosomal Location | 10q26.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting KNDC1 collected from DrugBank database. |
There is no record. |