Browse KRTAP5-1

Summary
SymbolKRTAP5-1
Namekeratin associated protein 5-1
Aliases KRTAP5.1; KRN1L; keratin, cuticle, ultrahigh sulphur 1-like; keratin-associated protein 5.1; ultrahigh sulfu ......
Chromosomal Location11p15.5
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location -
Domain -
Function

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

> Gene Ontology
 
Biological Process -
Molecular Function -
Cellular Component GO:0005882 intermediate filament
GO:0045095 keratin filament
GO:0045111 intermediate filament cytoskeleton
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-1266738: Developmental Biology
R-HSA-6805567: Keratinization
Summary
SymbolKRTAP5-1
Namekeratin associated protein 5-1
Aliases KRTAP5.1; KRN1L; keratin, cuticle, ultrahigh sulphur 1-like; keratin-associated protein 5.1; ultrahigh sulfu ......
Chromosomal Location11p15.5
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between KRTAP5-1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolKRTAP5-1
Namekeratin associated protein 5-1
Aliases KRTAP5.1; KRN1L; keratin, cuticle, ultrahigh sulphur 1-like; keratin-associated protein 5.1; ultrahigh sulfu ......
Chromosomal Location11p15.5
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of KRTAP5-1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.56 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolKRTAP5-1
Namekeratin associated protein 5-1
Aliases KRTAP5.1; KRN1L; keratin, cuticle, ultrahigh sulphur 1-like; keratin-associated protein 5.1; ultrahigh sulfu ......
Chromosomal Location11p15.5
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of KRTAP5-1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.1690.566
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.3150.602
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.070.874
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.9830.266
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.0560.972
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 472.160.281
729033130MelanomaallAnti-PD-1 (nivolumab) 262301
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 151101
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 111201
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 4801
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 2801
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0060.969
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of KRTAP5-1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277311.14.170.339
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275911.13.47.70.176
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211714.311.82.51
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)862533.3-8.31
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38277.907.90.26
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221313.6013.60.279
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolKRTAP5-1
Namekeratin associated protein 5-1
Aliases KRTAP5.1; KRN1L; keratin, cuticle, ultrahigh sulphur 1-like; keratin-associated protein 5.1; ultrahigh sulfu ......
Chromosomal Location11p15.5
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of KRTAP5-1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolKRTAP5-1
Namekeratin associated protein 5-1
Aliases KRTAP5.1; KRN1L; keratin, cuticle, ultrahigh sulphur 1-like; keratin-associated protein 5.1; ultrahigh sulfu ......
Chromosomal Location11p15.5
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of KRTAP5-1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by KRTAP5-1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolKRTAP5-1
Namekeratin associated protein 5-1
Aliases KRTAP5.1; KRN1L; keratin, cuticle, ultrahigh sulphur 1-like; keratin-associated protein 5.1; ultrahigh sulfu ......
Chromosomal Location11p15.5
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of KRTAP5-1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolKRTAP5-1
Namekeratin associated protein 5-1
Aliases KRTAP5.1; KRN1L; keratin, cuticle, ultrahigh sulphur 1-like; keratin-associated protein 5.1; ultrahigh sulfu ......
Chromosomal Location11p15.5
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of KRTAP5-1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolKRTAP5-1
Namekeratin associated protein 5-1
Aliases KRTAP5.1; KRN1L; keratin, cuticle, ultrahigh sulphur 1-like; keratin-associated protein 5.1; ultrahigh sulfu ......
Chromosomal Location11p15.5
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between KRTAP5-1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolKRTAP5-1
Namekeratin associated protein 5-1
Aliases KRTAP5.1; KRN1L; keratin, cuticle, ultrahigh sulphur 1-like; keratin-associated protein 5.1; ultrahigh sulfu ......
Chromosomal Location11p15.5
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting KRTAP5-1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.