Browse LAMA5

Summary
SymbolLAMA5
Namelaminin, alpha 5
Aliases laminin alpha-5 chain; laminin-10 subunit alpha; laminin-11 subunit alpha; laminin-15 subunit alpha; Laminin ......
Chromosomal Location20q13.2-q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.
Domain PF00052 Laminin B (Domain IV)
PF00053 Laminin EGF domain
PF02210 Laminin G domain
PF06008 Laminin Domain I
PF06009 Laminin Domain II
PF00055 Laminin N-terminal (Domain VI)
Function

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

> Gene Ontology
 
Biological Process GO:0001525 angiogenesis
GO:0001655 urogenital system development
GO:0001657 ureteric bud development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001667 ameboidal-type cell migration
GO:0001738 morphogenesis of a polarized epithelium
GO:0001755 neural crest cell migration
GO:0001763 morphogenesis of a branching structure
GO:0001822 kidney development
GO:0001823 mesonephros development
GO:0001942 hair follicle development
GO:0003158 endothelium development
GO:0007009 plasma membrane organization
GO:0007044 cell-substrate junction assembly
GO:0007045 cell-substrate adherens junction assembly
GO:0007160 cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0007431 salivary gland development
GO:0007435 salivary gland morphogenesis
GO:0007517 muscle organ development
GO:0008037 cell recognition
GO:0008544 epidermis development
GO:0010927 cellular component assembly involved in morphogenesis
GO:0014031 mesenchymal cell development
GO:0014032 neural crest cell development
GO:0014033 neural crest cell differentiation
GO:0016331 morphogenesis of embryonic epithelium
GO:0022404 molting cycle process
GO:0022405 hair cycle process
GO:0022612 gland morphogenesis
GO:0030031 cell projection assembly
GO:0030198 extracellular matrix organization
GO:0030323 respiratory tube development
GO:0030324 lung development
GO:0031589 cell-substrate adhesion
GO:0034329 cell junction assembly
GO:0034330 cell junction organization
GO:0034332 adherens junction organization
GO:0034333 adherens junction assembly
GO:0034446 substrate adhesion-dependent cell spreading
GO:0035239 tube morphogenesis
GO:0035272 exocrine system development
GO:0042303 molting cycle
GO:0042384 cilium assembly
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042476 odontogenesis
GO:0042633 hair cycle
GO:0043062 extracellular structure organization
GO:0043588 skin development
GO:0044782 cilium organization
GO:0045216 cell-cell junction organization
GO:0045446 endothelial cell differentiation
GO:0045995 regulation of embryonic development
GO:0048041 focal adhesion assembly
GO:0048514 blood vessel morphogenesis
GO:0048732 gland development
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048762 mesenchymal cell differentiation
GO:0048863 stem cell differentiation
GO:0048864 stem cell development
GO:0060271 cilium morphogenesis
GO:0060445 branching involved in salivary gland morphogenesis
GO:0060485 mesenchyme development
GO:0060541 respiratory system development
GO:0060562 epithelial tube morphogenesis
GO:0060675 ureteric bud morphogenesis
GO:0060993 kidney morphogenesis
GO:0061138 morphogenesis of a branching epithelium
GO:0061326 renal tubule development
GO:0061333 renal tubule morphogenesis
GO:0072001 renal system development
GO:0072006 nephron development
GO:0072009 nephron epithelium development
GO:0072028 nephron morphogenesis
GO:0072073 kidney epithelium development
GO:0072078 nephron tubule morphogenesis
GO:0072080 nephron tubule development
GO:0072088 nephron epithelium morphogenesis
GO:0072163 mesonephric epithelium development
GO:0072164 mesonephric tubule development
GO:0072171 mesonephric tubule morphogenesis
GO:0072657 protein localization to membrane
GO:0072659 protein localization to plasma membrane
GO:0090002 establishment of protein localization to plasma membrane
GO:0090150 establishment of protein localization to membrane
GO:0098773 skin epidermis development
GO:1990778 protein localization to cell periphery
Molecular Function GO:0005178 integrin binding
GO:0050839 cell adhesion molecule binding
Cellular Component GO:0005578 proteinaceous extracellular matrix
GO:0005604 basement membrane
GO:0005605 basal lamina
GO:0005610 laminin-5 complex
GO:0043256 laminin complex
GO:0043259 laminin-10 complex
GO:0043260 laminin-11 complex
GO:0044420 extracellular matrix component
> KEGG and Reactome Pathway
 
KEGG hsa04151 PI3K-Akt signaling pathway
hsa04510 Focal adhesion
hsa04512 ECM-receptor interaction
hsa01100 Metabolic pathways
Reactome R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-1474228: Degradation of the extracellular matrix
R-HSA-3000178: ECM proteoglycans
R-HSA-1474244: Extracellular matrix organization
R-HSA-168256: Immune System
R-HSA-6785807: Interleukin-4 and 13 signaling
R-HSA-3000157: Laminin interactions
R-HSA-8874081: MET activates PTK2 signaling
R-HSA-8875878: MET promotes cell motility
R-HSA-3000171: Non-integrin membrane-ECM interactions
R-HSA-162582: Signal Transduction
R-HSA-449147: Signaling by Interleukins
R-HSA-6806834: Signaling by MET
Summary
SymbolLAMA5
Namelaminin, alpha 5
Aliases laminin alpha-5 chain; laminin-10 subunit alpha; laminin-11 subunit alpha; laminin-15 subunit alpha; Laminin ......
Chromosomal Location20q13.2-q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between LAMA5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolLAMA5
Namelaminin, alpha 5
Aliases laminin alpha-5 chain; laminin-10 subunit alpha; laminin-11 subunit alpha; laminin-15 subunit alpha; Laminin ......
Chromosomal Location20q13.2-q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of LAMA5 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolLAMA5
Namelaminin, alpha 5
Aliases laminin alpha-5 chain; laminin-10 subunit alpha; laminin-11 subunit alpha; laminin-15 subunit alpha; Laminin ......
Chromosomal Location20q13.2-q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of LAMA5 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.8540.0337
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.7710.238
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.1750.862
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.5530.198
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.7470.831
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.3050.945
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.2550.643
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.2660.847
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.2890.844
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.4190.835
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.5360.852
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.1730.174
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of LAMA5 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141721.411.89.60.636
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103200201
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4142514.310.71
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277311.14.170.339
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275911.15.160.373
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.817.6-12.80.307
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.727.3-19.60.3
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.16.24.91
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 382710.511.1-0.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221318.27.710.50.63
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1614014.3-14.30.209
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolLAMA5
Namelaminin, alpha 5
Aliases laminin alpha-5 chain; laminin-10 subunit alpha; laminin-11 subunit alpha; laminin-15 subunit alpha; Laminin ......
Chromosomal Location20q13.2-q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of LAMA5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolLAMA5
Namelaminin, alpha 5
Aliases laminin alpha-5 chain; laminin-10 subunit alpha; laminin-11 subunit alpha; laminin-15 subunit alpha; Laminin ......
Chromosomal Location20q13.2-q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of LAMA5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by LAMA5.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolLAMA5
Namelaminin, alpha 5
Aliases laminin alpha-5 chain; laminin-10 subunit alpha; laminin-11 subunit alpha; laminin-15 subunit alpha; Laminin ......
Chromosomal Location20q13.2-q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of LAMA5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolLAMA5
Namelaminin, alpha 5
Aliases laminin alpha-5 chain; laminin-10 subunit alpha; laminin-11 subunit alpha; laminin-15 subunit alpha; Laminin ......
Chromosomal Location20q13.2-q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of LAMA5 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolLAMA5
Namelaminin, alpha 5
Aliases laminin alpha-5 chain; laminin-10 subunit alpha; laminin-11 subunit alpha; laminin-15 subunit alpha; Laminin ......
Chromosomal Location20q13.2-q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between LAMA5 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolLAMA5
Namelaminin, alpha 5
Aliases laminin alpha-5 chain; laminin-10 subunit alpha; laminin-11 subunit alpha; laminin-15 subunit alpha; Laminin ......
Chromosomal Location20q13.2-q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting LAMA5 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting LAMA5.
ID Name Drug Type Targets #Targets
DB06245LanoteplaseBiotechANXA2, CALR, CANX, CLEC3B, F10, FGA, FN1, KLK1, KRT8, LAMA1, LAMA3 ......17