Browse LARP4

Summary
SymbolLARP4
NameLa ribonucleoprotein domain family, member 4
Aliases PP13296; c-Mpl binding protein; La ribonucleoprotein domain family member 4; La-related protein 4
Chromosomal Location12q13.12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm, Stress granule Cytoplasm, cytosol Note=Localized throughout the cytosol. Partially localized in stress granules in response to arsenite treatment.
Domain PF05383 La domain
Function

RNA binding protein that binds to the poly-A tract of mRNA molecules (PubMed:21098120). Associates with the 40S ribosomal subunit and with polysomes (PubMed:21098120). Plays a role in the regulation of mRNA translation (PubMed:21098120). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987, PubMed:27615744).

> Gene Ontology
 
Biological Process GO:0022604 regulation of cell morphogenesis
Molecular Function -
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolLARP4
NameLa ribonucleoprotein domain family, member 4
Aliases PP13296; c-Mpl binding protein; La ribonucleoprotein domain family member 4; La-related protein 4
Chromosomal Location12q13.12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between LARP4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolLARP4
NameLa ribonucleoprotein domain family, member 4
Aliases PP13296; c-Mpl binding protein; La ribonucleoprotein domain family member 4; La-related protein 4
Chromosomal Location12q13.12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of LARP4 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell logFC: -2.30; FDR: 0.04170 Resistant to T cell-mediated killing
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell logFC: -2.06; FDR: 0.04110 Resistant to T cell-mediated killing
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolLARP4
NameLa ribonucleoprotein domain family, member 4
Aliases PP13296; c-Mpl binding protein; La ribonucleoprotein domain family member 4; La-related protein 4
Chromosomal Location12q13.12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of LARP4 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.240.444
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.5120.764
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.0420.974
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.5340.102
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.7910.696
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.2120.932
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0340.937
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.0620.974
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.1810.93
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.250.811
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.7940.614
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.040.446
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of LARP4 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277302.7-2.71
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275903.4-3.41
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolLARP4
NameLa ribonucleoprotein domain family, member 4
Aliases PP13296; c-Mpl binding protein; La ribonucleoprotein domain family member 4; La-related protein 4
Chromosomal Location12q13.12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of LARP4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolLARP4
NameLa ribonucleoprotein domain family, member 4
Aliases PP13296; c-Mpl binding protein; La ribonucleoprotein domain family member 4; La-related protein 4
Chromosomal Location12q13.12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of LARP4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by LARP4.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolLARP4
NameLa ribonucleoprotein domain family, member 4
Aliases PP13296; c-Mpl binding protein; La ribonucleoprotein domain family member 4; La-related protein 4
Chromosomal Location12q13.12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of LARP4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolLARP4
NameLa ribonucleoprotein domain family, member 4
Aliases PP13296; c-Mpl binding protein; La ribonucleoprotein domain family member 4; La-related protein 4
Chromosomal Location12q13.12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of LARP4 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolLARP4
NameLa ribonucleoprotein domain family, member 4
Aliases PP13296; c-Mpl binding protein; La ribonucleoprotein domain family member 4; La-related protein 4
Chromosomal Location12q13.12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between LARP4 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolLARP4
NameLa ribonucleoprotein domain family, member 4
Aliases PP13296; c-Mpl binding protein; La ribonucleoprotein domain family member 4; La-related protein 4
Chromosomal Location12q13.12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting LARP4 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.