Browse LEP

Summary
SymbolLEP
Nameleptin
Aliases OBS; leptin (murine obesity homolog); leptin (obesity homolog, mouse); LEPD; obese protein; obese, mouse, ho ......
Chromosomal Location7q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted
Domain PF02024 Leptin
Function

Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (PubMed:17344214, PubMed:15899045, PubMed:19688109). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity (By similarity) (PubMed:8589726, PubMed:11460888, PubMed:19688109, PubMed:24340098, PubMed:25060689). In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides (By similarity). In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption (PubMed:24340098). Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways (By similarity) (PubMed:17344214). May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression (PubMed:18242580). Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) (PubMed:11460888). In innate immunity, modulates the activity and function of neutrophils by increasing chemotaxis and the secretion of oxygen radicals. Increases phagocytosis by macrophages and enhances secretion of pro-inflammatory mediators. Increases cytotoxic ability of NK cells (PubMed:12504075). Plays a pro-inflammatory role, in synergy with IL1B, by inducing NOS2 wich promotes the production of IL6, IL8 and Prostaglandin E2, through a signaling pathway that involves JAK2, PI3K, MAP2K1/MEK1 and MAPK14/p38 (PubMed:15899045, PubMed:19688109). In adaptive immunity, promotes the switch of memory T-cells towards T helper-1 cell immune responses (By similarity). Increases CD4(+)CD25(-) T-cell proliferation and reduces autophagy during TCR (T-cell receptor) stimulation, through MTOR signaling pathway activation and BCL2 up-regulation (PubMed:25060689).

> Gene Ontology
 
Biological Process GO:0001101 response to acid chemical
GO:0001501 skeletal system development
GO:0001503 ossification
GO:0001525 angiogenesis
GO:0001542 ovulation from ovarian follicle
GO:0001666 response to hypoxia
GO:0001787 natural killer cell proliferation
GO:0001819 positive regulation of cytokine production
GO:0001890 placenta development
GO:0001906 cell killing
GO:0001909 leukocyte mediated cytotoxicity
GO:0001910 regulation of leukocyte mediated cytotoxicity
GO:0001935 endothelial cell proliferation
GO:0001936 regulation of endothelial cell proliferation
GO:0002021 response to dietary excess
GO:0002228 natural killer cell mediated immunity
GO:0002443 leukocyte mediated immunity
GO:0002449 lymphocyte mediated immunity
GO:0002521 leukocyte differentiation
GO:0002532 production of molecular mediator involved in inflammatory response
GO:0002534 cytokine production involved in inflammatory response
GO:0002694 regulation of leukocyte activation
GO:0002696 positive regulation of leukocyte activation
GO:0002697 regulation of immune effector process
GO:0002703 regulation of leukocyte mediated immunity
GO:0002706 regulation of lymphocyte mediated immunity
GO:0002715 regulation of natural killer cell mediated immunity
GO:0002790 peptide secretion
GO:0002791 regulation of peptide secretion
GO:0002792 negative regulation of peptide secretion
GO:0003012 muscle system process
GO:0003013 circulatory system process
GO:0003018 vascular process in circulatory system
GO:0003300 cardiac muscle hypertrophy
GO:0005996 monosaccharide metabolic process
GO:0006006 glucose metabolic process
GO:0006066 alcohol metabolic process
GO:0006071 glycerol metabolic process
GO:0006091 generation of precursor metabolites and energy
GO:0006094 gluconeogenesis
GO:0006109 regulation of carbohydrate metabolic process
GO:0006111 regulation of gluconeogenesis
GO:0006112 energy reserve metabolic process
GO:0006114 glycerol biosynthetic process
GO:0006606 protein import into nucleus
GO:0006631 fatty acid metabolic process
GO:0006635 fatty acid beta-oxidation
GO:0006694 steroid biosynthetic process
GO:0006820 anion transport
GO:0006865 amino acid transport
GO:0006868 glutamine transport
GO:0006869 lipid transport
GO:0006909 phagocytosis
GO:0006913 nucleocytoplasmic transport
GO:0006914 autophagy
GO:0007159 leukocyte cell-cell adhesion
GO:0007259 JAK-STAT cascade
GO:0007260 tyrosine phosphorylation of STAT protein
GO:0007262 STAT protein import into nucleus
GO:0007292 female gamete generation
GO:0007548 sex differentiation
GO:0007565 female pregnancy
GO:0007584 response to nutrient
GO:0007586 digestion
GO:0007623 circadian rhythm
GO:0007631 feeding behavior
GO:0008015 blood circulation
GO:0008202 steroid metabolic process
GO:0008203 cholesterol metabolic process
GO:0008206 bile acid metabolic process
GO:0008217 regulation of blood pressure
GO:0008286 insulin receptor signaling pathway
GO:0008343 adult feeding behavior
GO:0008406 gonad development
GO:0008585 female gonad development
GO:0008643 carbohydrate transport
GO:0008645 hexose transport
GO:0009062 fatty acid catabolic process
GO:0009306 protein secretion
GO:0009914 hormone transport
GO:0009991 response to extracellular stimulus
GO:0010506 regulation of autophagy
GO:0010507 negative regulation of autophagy
GO:0010675 regulation of cellular carbohydrate metabolic process
GO:0010817 regulation of hormone levels
GO:0010827 regulation of glucose transport
GO:0010829 negative regulation of glucose transport
GO:0010876 lipid localization
GO:0010883 regulation of lipid storage
GO:0010888 negative regulation of lipid storage
GO:0010906 regulation of glucose metabolic process
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014823 response to activity
GO:0014896 muscle hypertrophy
GO:0014897 striated muscle hypertrophy
GO:0015711 organic anion transport
GO:0015718 monocarboxylic acid transport
GO:0015732 prostaglandin transport
GO:0015749 monosaccharide transport
GO:0015758 glucose transport
GO:0015804 neutral amino acid transport
GO:0015833 peptide transport
GO:0015837 amine transport
GO:0015849 organic acid transport
GO:0015850 organic hydroxy compound transport
GO:0015908 fatty acid transport
GO:0015918 sterol transport
GO:0015980 energy derivation by oxidation of organic compounds
GO:0016042 lipid catabolic process
GO:0016051 carbohydrate biosynthetic process
GO:0016054 organic acid catabolic process
GO:0016125 sterol metabolic process
GO:0017038 protein import
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0018212 peptidyl-tyrosine modification
GO:0019216 regulation of lipid metabolic process
GO:0019218 regulation of steroid metabolic process
GO:0019229 regulation of vasoconstriction
GO:0019318 hexose metabolic process
GO:0019319 hexose biosynthetic process
GO:0019395 fatty acid oxidation
GO:0019400 alditol metabolic process
GO:0019401 alditol biosynthetic process
GO:0019751 polyol metabolic process
GO:0019915 lipid storage
GO:0021700 developmental maturation
GO:0021953 central nervous system neuron differentiation
GO:0021954 central nervous system neuron development
GO:0022407 regulation of cell-cell adhesion
GO:0022409 positive regulation of cell-cell adhesion
GO:0022600 digestive system process
GO:0022602 ovulation cycle process
GO:0023061 signal release
GO:0030072 peptide hormone secretion
GO:0030073 insulin secretion
GO:0030098 lymphocyte differentiation
GO:0030099 myeloid cell differentiation
GO:0030101 natural killer cell activation
GO:0030217 T cell differentiation
GO:0030258 lipid modification
GO:0030282 bone mineralization
GO:0030299 intestinal cholesterol absorption
GO:0030300 regulation of intestinal cholesterol absorption
GO:0030301 cholesterol transport
GO:0030522 intracellular receptor signaling pathway
GO:0030534 adult behavior
GO:0030728 ovulation
GO:0031098 stress-activated protein kinase signaling cascade
GO:0031214 biomineral tissue development
GO:0031341 regulation of cell killing
GO:0031667 response to nutrient levels
GO:0031929 TOR signaling
GO:0032006 regulation of TOR signaling
GO:0032008 positive regulation of TOR signaling
GO:0032094 response to food
GO:0032095 regulation of response to food
GO:0032096 negative regulation of response to food
GO:0032098 regulation of appetite
GO:0032099 negative regulation of appetite
GO:0032102 negative regulation of response to external stimulus
GO:0032104 regulation of response to extracellular stimulus
GO:0032105 negative regulation of response to extracellular stimulus
GO:0032107 regulation of response to nutrient levels
GO:0032108 negative regulation of response to nutrient levels
GO:0032147 activation of protein kinase activity
GO:0032274 gonadotropin secretion
GO:0032275 luteinizing hormone secretion
GO:0032276 regulation of gonadotropin secretion
GO:0032278 positive regulation of gonadotropin secretion
GO:0032309 icosanoid secretion
GO:0032310 prostaglandin secretion
GO:0032355 response to estradiol
GO:0032368 regulation of lipid transport
GO:0032371 regulation of sterol transport
GO:0032374 regulation of cholesterol transport
GO:0032386 regulation of intracellular transport
GO:0032388 positive regulation of intracellular transport
GO:0032526 response to retinoic acid
GO:0032615 interleukin-12 production
GO:0032635 interleukin-6 production
GO:0032637 interleukin-8 production
GO:0032640 tumor necrosis factor production
GO:0032680 regulation of tumor necrosis factor production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032768 regulation of monooxygenase activity
GO:0032814 regulation of natural killer cell activation
GO:0032817 regulation of natural killer cell proliferation
GO:0032868 response to insulin
GO:0032869 cellular response to insulin stimulus
GO:0032872 regulation of stress-activated MAPK cascade
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0032890 regulation of organic acid transport
GO:0032891 negative regulation of organic acid transport
GO:0032943 mononuclear cell proliferation
GO:0032944 regulation of mononuclear cell proliferation
GO:0032946 positive regulation of mononuclear cell proliferation
GO:0033157 regulation of intracellular protein transport
GO:0033197 response to vitamin E
GO:0033210 leptin-mediated signaling pathway
GO:0033273 response to vitamin
GO:0033500 carbohydrate homeostasis
GO:0033674 positive regulation of kinase activity
GO:0033684 regulation of luteinizing hormone secretion
GO:0033686 positive regulation of luteinizing hormone secretion
GO:0034103 regulation of tissue remodeling
GO:0034439 lipoprotein lipid oxidation
GO:0034440 lipid oxidation
GO:0034442 regulation of lipoprotein oxidation
GO:0034504 protein localization to nucleus
GO:0034637 cellular carbohydrate biosynthetic process
GO:0035150 regulation of tube size
GO:0035265 organ growth
GO:0035357 peroxisome proliferator activated receptor signaling pathway
GO:0035358 regulation of peroxisome proliferator activated receptor signaling pathway
GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway
GO:0035630 bone mineralization involved in bone maturation
GO:0035733 hepatic stellate cell activation
GO:0036293 response to decreased oxygen levels
GO:0038066 p38MAPK cascade
GO:0038108 negative regulation of appetite by leptin-mediated signaling pathway
GO:0042098 T cell proliferation
GO:0042102 positive regulation of T cell proliferation
GO:0042110 T cell activation
GO:0042129 regulation of T cell proliferation
GO:0042157 lipoprotein metabolic process
GO:0042160 lipoprotein modification
GO:0042161 lipoprotein oxidation
GO:0042267 natural killer cell mediated cytotoxicity
GO:0042269 regulation of natural killer cell mediated cytotoxicity
GO:0042306 regulation of protein import into nucleus
GO:0042307 positive regulation of protein import into nucleus
GO:0042310 vasoconstriction
GO:0042445 hormone metabolic process
GO:0042503 tyrosine phosphorylation of Stat3 protein
GO:0042509 regulation of tyrosine phosphorylation of STAT protein
GO:0042516 regulation of tyrosine phosphorylation of Stat3 protein
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042593 glucose homeostasis
GO:0042698 ovulation cycle
GO:0042755 eating behavior
GO:0042886 amide transport
GO:0043255 regulation of carbohydrate biosynthetic process
GO:0043270 positive regulation of ion transport
GO:0043271 negative regulation of ion transport
GO:0043410 positive regulation of MAPK cascade
GO:0043434 response to peptide hormone
GO:0043491 protein kinase B signaling
GO:0043931 ossification involved in bone maturation
GO:0044057 regulation of system process
GO:0044058 regulation of digestive system process
GO:0044060 regulation of endocrine process
GO:0044070 regulation of anion transport
GO:0044241 lipid digestion
GO:0044242 cellular lipid catabolic process
GO:0044262 cellular carbohydrate metabolic process
GO:0044282 small molecule catabolic process
GO:0044283 small molecule biosynthetic process
GO:0044320 cellular response to leptin stimulus
GO:0044321 response to leptin
GO:0044706 multi-multicellular organism process
GO:0044708 single-organism behavior
GO:0044723 single-organism carbohydrate metabolic process
GO:0044744 protein targeting to nucleus
GO:0045088 regulation of innate immune response
GO:0045123 cellular extravasation
GO:0045137 development of primary sexual characteristics
GO:0045444 fat cell differentiation
GO:0045471 response to ethanol
GO:0045598 regulation of fat cell differentiation
GO:0045637 regulation of myeloid cell differentiation
GO:0045639 positive regulation of myeloid cell differentiation
GO:0045765 regulation of angiogenesis
GO:0045785 positive regulation of cell adhesion
GO:0045860 positive regulation of protein kinase activity
GO:0045906 negative regulation of vasoconstriction
GO:0045927 positive regulation of growth
GO:0046165 alcohol biosynthetic process
GO:0046173 polyol biosynthetic process
GO:0046323 glucose import
GO:0046324 regulation of glucose import
GO:0046325 negative regulation of glucose import
GO:0046364 monosaccharide biosynthetic process
GO:0046395 carboxylic acid catabolic process
GO:0046425 regulation of JAK-STAT cascade
GO:0046427 positive regulation of JAK-STAT cascade
GO:0046545 development of primary female sexual characteristics
GO:0046626 regulation of insulin receptor signaling pathway
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0046651 lymphocyte proliferation
GO:0046660 female sex differentiation
GO:0046822 regulation of nucleocytoplasmic transport
GO:0046824 positive regulation of nucleocytoplasmic transport
GO:0046849 bone remodeling
GO:0046850 regulation of bone remodeling
GO:0046879 hormone secretion
GO:0046880 regulation of follicle-stimulating hormone secretion
GO:0046881 positive regulation of follicle-stimulating hormone secretion
GO:0046883 regulation of hormone secretion
GO:0046884 follicle-stimulating hormone secretion
GO:0046887 positive regulation of hormone secretion
GO:0046888 negative regulation of hormone secretion
GO:0046890 regulation of lipid biosynthetic process
GO:0046942 carboxylic acid transport
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048017 inositol lipid-mediated signaling
GO:0048511 rhythmic process
GO:0048514 blood vessel morphogenesis
GO:0048608 reproductive structure development
GO:0048638 regulation of developmental growth
GO:0048639 positive regulation of developmental growth
GO:0048771 tissue remodeling
GO:0048799 animal organ maturation
GO:0050663 cytokine secretion
GO:0050670 regulation of lymphocyte proliferation
GO:0050671 positive regulation of lymphocyte proliferation
GO:0050673 epithelial cell proliferation
GO:0050678 regulation of epithelial cell proliferation
GO:0050708 regulation of protein secretion
GO:0050727 regulation of inflammatory response
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050746 regulation of lipoprotein metabolic process
GO:0050796 regulation of insulin secretion
GO:0050810 regulation of steroid biosynthetic process
GO:0050863 regulation of T cell activation
GO:0050865 regulation of cell activation
GO:0050867 positive regulation of cell activation
GO:0050870 positive regulation of T cell activation
GO:0050873 brown fat cell differentiation
GO:0050880 regulation of blood vessel size
GO:0050886 endocrine process
GO:0050892 intestinal absorption
GO:0050900 leukocyte migration
GO:0050901 leukocyte tethering or rolling
GO:0050999 regulation of nitric-oxide synthase activity
GO:0051047 positive regulation of secretion
GO:0051048 negative regulation of secretion
GO:0051051 negative regulation of transport
GO:0051169 nuclear transport
GO:0051170 nuclear import
GO:0051216 cartilage development
GO:0051222 positive regulation of protein transport
GO:0051235 maintenance of location
GO:0051249 regulation of lymphocyte activation
GO:0051251 positive regulation of lymphocyte activation
GO:0051341 regulation of oxidoreductase activity
GO:0051403 stress-activated MAPK cascade
GO:0051896 regulation of protein kinase B signaling
GO:0051897 positive regulation of protein kinase B signaling
GO:0051952 regulation of amine transport
GO:0051953 negative regulation of amine transport
GO:0051955 regulation of amino acid transport
GO:0051956 negative regulation of amino acid transport
GO:0060348 bone development
GO:0060587 regulation of lipoprotein lipid oxidation
GO:0060612 adipose tissue development
GO:0060986 endocrine hormone secretion
GO:0061035 regulation of cartilage development
GO:0061037 negative regulation of cartilage development
GO:0061448 connective tissue development
GO:0061458 reproductive system development
GO:0061756 leukocyte adhesion to vascular endothelial cell
GO:0070091 glucagon secretion
GO:0070092 regulation of glucagon secretion
GO:0070093 negative regulation of glucagon secretion
GO:0070302 regulation of stress-activated protein kinase signaling cascade
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade
GO:0070482 response to oxygen levels
GO:0070486 leukocyte aggregation
GO:0070489 T cell aggregation
GO:0070661 leukocyte proliferation
GO:0070663 regulation of leukocyte proliferation
GO:0070665 positive regulation of leukocyte proliferation
GO:0070977 bone maturation
GO:0071229 cellular response to acid chemical
GO:0071298 cellular response to L-ascorbic acid
GO:0071300 cellular response to retinoic acid
GO:0071375 cellular response to peptide hormone stimulus
GO:0071396 cellular response to lipid
GO:0071417 cellular response to organonitrogen compound
GO:0071593 lymphocyte aggregation
GO:0071695 anatomical structure maturation
GO:0071706 tumor necrosis factor superfamily cytokine production
GO:0071715 icosanoid transport
GO:0072329 monocarboxylic acid catabolic process
GO:0072537 fibroblast activation
GO:0072593 reactive oxygen species metabolic process
GO:0072604 interleukin-6 secretion
GO:0072606 interleukin-8 secretion
GO:0090066 regulation of anatomical structure size
GO:0090087 regulation of peptide transport
GO:0090276 regulation of peptide hormone secretion
GO:0090278 negative regulation of peptide hormone secretion
GO:0090316 positive regulation of intracellular protein transport
GO:0090335 regulation of brown fat cell differentiation
GO:0097305 response to alcohol
GO:0097696 STAT cascade
GO:0098856 intestinal lipid absorption
GO:0098868 bone growth
GO:1900015 regulation of cytokine production involved in inflammatory response
GO:1900076 regulation of cellular response to insulin stimulus
GO:1900078 positive regulation of cellular response to insulin stimulus
GO:1900180 regulation of protein localization to nucleus
GO:1900182 positive regulation of protein localization to nucleus
GO:1900744 regulation of p38MAPK cascade
GO:1900745 positive regulation of p38MAPK cascade
GO:1901342 regulation of vasculature development
GO:1901615 organic hydroxy compound metabolic process
GO:1901617 organic hydroxy compound biosynthetic process
GO:1901652 response to peptide
GO:1901653 cellular response to peptide
GO:1902593 single-organism nuclear import
GO:1902652 secondary alcohol metabolic process
GO:1903037 regulation of leukocyte cell-cell adhesion
GO:1903039 positive regulation of leukocyte cell-cell adhesion
GO:1903522 regulation of blood circulation
GO:1903523 negative regulation of blood circulation
GO:1903531 negative regulation of secretion by cell
GO:1903532 positive regulation of secretion by cell
GO:1903533 regulation of protein targeting
GO:1903555 regulation of tumor necrosis factor superfamily cytokine production
GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production
GO:1903706 regulation of hemopoiesis
GO:1903708 positive regulation of hemopoiesis
GO:1903792 negative regulation of anion transport
GO:1903829 positive regulation of cellular protein localization
GO:1904478 regulation of intestinal absorption
GO:1904589 regulation of protein import
GO:1904591 positive regulation of protein import
GO:1904606 fat cell apoptotic process
GO:1904649 regulation of fat cell apoptotic process
GO:1904651 positive regulation of fat cell apoptotic process
GO:1904729 regulation of intestinal lipid absorption
GO:1904892 regulation of STAT cascade
GO:1904894 positive regulation of STAT cascade
GO:1904951 positive regulation of establishment of protein localization
GO:1990051 activation of protein kinase C activity
GO:2000364 regulation of STAT protein import into nucleus
GO:2000366 positive regulation of STAT protein import into nucleus
GO:2000377 regulation of reactive oxygen species metabolic process
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2000485 regulation of glutamine transport
GO:2000486 negative regulation of glutamine transport
GO:2000489 regulation of hepatic stellate cell activation
GO:2000491 positive regulation of hepatic stellate cell activation
Molecular Function GO:0005179 hormone activity
GO:0008083 growth factor activity
GO:0051427 hormone receptor binding
GO:0051428 peptide hormone receptor binding
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04060 Cytokine-cytokine receptor interaction
hsa04080 Neuroactive ligand-receptor interaction
hsa04152 AMPK signaling pathway
hsa04630 Jak-STAT signaling pathway
hsa04920 Adipocytokine signaling pathway
Reactome R-HSA-1266738: Developmental Biology
R-HSA-400508: Incretin synthesis, secretion, and inactivation
R-HSA-392499: Metabolism of proteins
R-HSA-2980736: Peptide hormone metabolism
R-HSA-162582: Signal Transduction
R-HSA-2586552: Signaling by Leptin
R-HSA-422085: Synthesis, secretion, and deacylation of Ghrelin
R-HSA-381771: Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
R-HSA-381340: Transcriptional regulation of white adipocyte differentiation
Summary
SymbolLEP
Nameleptin
Aliases OBS; leptin (murine obesity homolog); leptin (obesity homolog, mouse); LEPD; obese protein; obese, mouse, ho ......
Chromosomal Location7q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between LEP and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between LEP and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
26639061Hepatocellular CarcinomaPromote immunity (T cell function)Hepatoma cell-derived leptin downregulates the immunosuppressive function of regulatory T-cells to enhance the anti-tumor activity of CD8+ T-cells.
19010917Colorectal CarcinomaPromote immunity (T cell function)Systemic leptin enhanced the proinflammatory cytokines in normal colonocytes and in HT29 xenografted tumor colonocytes. Colonocyte-derived products after leptin treatment stimulated perforin and granzyme B expressions in normal CD8(+) T cells in vitro.
Summary
SymbolLEP
Nameleptin
Aliases OBS; leptin (murine obesity homolog); leptin (obesity homolog, mouse); LEPD; obese protein; obese, mouse, ho ......
Chromosomal Location7q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of LEP in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolLEP
Nameleptin
Aliases OBS; leptin (murine obesity homolog); leptin (obesity homolog, mouse); LEPD; obese protein; obese, mouse, ho ......
Chromosomal Location7q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of LEP in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.1550.616
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.5450.295
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.1390.78
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.540.37
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-1.6010.0974
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.7990.476
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-1.3470.146
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.2580.842
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-2.2530.11
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.4580.369
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.0980.121
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.3530.329
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of LEP in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.703.70.27
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.703.70.314
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolLEP
Nameleptin
Aliases OBS; leptin (murine obesity homolog); leptin (obesity homolog, mouse); LEPD; obese protein; obese, mouse, ho ......
Chromosomal Location7q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of LEP. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolLEP
Nameleptin
Aliases OBS; leptin (murine obesity homolog); leptin (obesity homolog, mouse); LEPD; obese protein; obese, mouse, ho ......
Chromosomal Location7q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of LEP. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by LEP.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolLEP
Nameleptin
Aliases OBS; leptin (murine obesity homolog); leptin (obesity homolog, mouse); LEPD; obese protein; obese, mouse, ho ......
Chromosomal Location7q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of LEP. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolLEP
Nameleptin
Aliases OBS; leptin (murine obesity homolog); leptin (obesity homolog, mouse); LEPD; obese protein; obese, mouse, ho ......
Chromosomal Location7q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of LEP expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolLEP
Nameleptin
Aliases OBS; leptin (murine obesity homolog); leptin (obesity homolog, mouse); LEPD; obese protein; obese, mouse, ho ......
Chromosomal Location7q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between LEP and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolLEP
Nameleptin
Aliases OBS; leptin (murine obesity homolog); leptin (obesity homolog, mouse); LEPD; obese protein; obese, mouse, ho ......
Chromosomal Location7q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting LEP collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.