TISIDB

Summary
Symbol	LILRB4
Name	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
Aliases	LIR-5; ILT3; HM18; LIR5; CD85k; ILT-3; CD85 antigen-like family member K; immunoglobulin-like transcript 3; ......
Chromosomal Location	19q13.4
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cell membrane Single-pass type I membrane protein Note=Ligand binding leads to internalization and translocation to an antigen-processing compartment.
Domain	PF00047 Immunoglobulin domain PF13895 Immunoglobulin domain
Function	Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.

> Gene Ontology [ TOP ]
Biological Process	GO:0002250 adaptive immune response GO:0002521 leukocyte differentiation GO:0002573 myeloid leukocyte differentiation GO:0002683 negative regulation of immune system process GO:0002761 regulation of myeloid leukocyte differentiation GO:0002762 negative regulation of myeloid leukocyte differentiation GO:0030099 myeloid cell differentiation GO:0030316 osteoclast differentiation GO:0045637 regulation of myeloid cell differentiation GO:0045638 negative regulation of myeloid cell differentiation GO:0045670 regulation of osteoclast differentiation GO:0045671 negative regulation of osteoclast differentiation GO:0061614 pri-miRNA transcription from RNA polymerase II promoter GO:1902105 regulation of leukocyte differentiation GO:1902106 negative regulation of leukocyte differentiation GO:1902893 regulation of pri-miRNA transcription from RNA polymerase II promoter GO:1902894 negative regulation of pri-miRNA transcription from RNA polymerase II promoter GO:1903706 regulation of hemopoiesis GO:1903707 negative regulation of hemopoiesis
Molecular Function	GO:0003823 antigen binding
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04380 Osteoclast differentiation
Reactome	R-HSA-1280218: Adaptive Immune System R-HSA-168256: Immune System R-HSA-198933: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Summary
Symbol	LILRB4
Name	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
Aliases	LIR-5; ILT3; HM18; LIR5; CD85k; ILT-3; CD85 antigen-like family member K; immunoglobulin-like transcript 3; ......
Chromosomal Location	19q13.4
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between LILRB4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining

[ TOP ]

Literatures describing the relation between LILRB4 and anti-tumor immunity in human cancer.

PMID	Cancer type	Relation to immunity	Evidence sentences
17513794	Colorectal Carcinoma; Pancreatic Carcinoma; Melanoma	Inhibit immunity	Furthermore, we found that patients with melanoma, and carcinomas of the colon, rectum, and pancreas produce the soluble ILT3 protein, which induces the differentiation of CD8(+) T suppressor cells and impairs T cell responses in MLC. These responses are restored by anti-ILT3 mAb or by depletion of soluble ILT3 from the serum.

Summary
Symbol	LILRB4
Name	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
Aliases	LIR-5; ILT3; HM18; LIR5; CD85k; ILT-3; CD85 antigen-like family member K; immunoglobulin-like transcript 3; ......
Chromosomal Location	19q13.4
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of LILRB4 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	LILRB4
Name	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
Aliases	LIR-5; ILT3; HM18; LIR5; CD85k; ILT-3; CD85 antigen-like family member K; immunoglobulin-like transcript 3; ......
Chromosomal Location	19q13.4
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the expression difference of LILRB4 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.086	0.839
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.332	0.826
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.388	0.723
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.174	0.768
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.87	0.592
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.711	0.74
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.378	0.519
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.826	0.566
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.186	0.911
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	1.525	0.347
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	1.561	0.548
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.128	0.566

> Mutation difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the mutation difference of LILRB4 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	14.3	5.9	8.4	0.576
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	20	33.3	-13.3	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	11.1	8.2	2.9	0.699
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	11.1	10.2	0.9	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	4.8	11.8	-7	0.577
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	12.5	0	12.5	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	18.2	-18.2	0.199
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	6.2	-6.2	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	11.1	-11.1	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	7.9	3.7	4.2	0.636
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	9.1	0	9.1	0.519
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	6.2	7.1	-0.9	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	LILRB4
Name	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
Aliases	LIR-5; ILT3; HM18; LIR5; CD85k; ILT-3; CD85 antigen-like family member K; immunoglobulin-like transcript 3; ......
Chromosomal Location	19q13.4
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of LILRB4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	LILRB4
Name	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
Aliases	LIR-5; ILT3; HM18; LIR5; CD85k; ILT-3; CD85 antigen-like family member K; immunoglobulin-like transcript 3; ......
Chromosomal Location	19q13.4
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of LILRB4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by LILRB4. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	LILRB4
Name	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
Aliases	LIR-5; ILT3; HM18; LIR5; CD85k; ILT-3; CD85 antigen-like family member K; immunoglobulin-like transcript 3; ......
Chromosomal Location	19q13.4
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of LILRB4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	LILRB4
Name	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
Aliases	LIR-5; ILT3; HM18; LIR5; CD85k; ILT-3; CD85 antigen-like family member K; immunoglobulin-like transcript 3; ......
Chromosomal Location	19q13.4
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of LILRB4 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	LILRB4
Name	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
Aliases	LIR-5; ILT3; HM18; LIR5; CD85k; ILT-3; CD85 antigen-like family member K; immunoglobulin-like transcript 3; ......
Chromosomal Location	19q13.4
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between LILRB4 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	LILRB4
Name	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
Aliases	LIR-5; ILT3; HM18; LIR5; CD85k; ILT-3; CD85 antigen-like family member K; immunoglobulin-like transcript 3; ......
Chromosomal Location	19q13.4
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting LILRB4 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

Browse LILRB4