TISIDB

Summary
Symbol	LLGL2
Name	lethal giant larvae homolog 2 (Drosophila)
Aliases	Hugl-2; lethal giant larvae (Drosophila) homolog 2; human giant larvae homolog; Lethal(2) giant larvae prote ......
Chromosomal Location	17q25.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cytoplasm Note=Localized in the perinuclear structure and faintly at the cell-cell contacts sites in the interphase. Localized at the cell periphery during metaphase. Cortical localization in mitotic cells. Found in the lateral region of polarized epithelial cells.
Domain	PF08366 LLGL2 PF00400 WD domain
Function	Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity.

> Gene Ontology [ TOP ]
Biological Process	GO:0000226 microtubule cytoskeleton organization GO:0006887 exocytosis GO:0007163 establishment or maintenance of cell polarity GO:0007219 Notch signaling pathway GO:0008593 regulation of Notch signaling pathway GO:0009306 protein secretion GO:0030010 establishment of cell polarity GO:0030865 cortical cytoskeleton organization GO:0030866 cortical actin cytoskeleton organization GO:0032878 regulation of establishment or maintenance of cell polarity GO:0050708 regulation of protein secretion GO:0051293 establishment of spindle localization GO:0051294 establishment of spindle orientation GO:0051640 organelle localization GO:0051653 spindle localization GO:0051656 establishment of organelle localization
Molecular Function	GO:0005096 GTPase activator activity GO:0008047 enzyme activator activity GO:0017016 Ras GTPase binding GO:0017137 Rab GTPase binding GO:0030165 PDZ domain binding GO:0030695 GTPase regulator activity GO:0031267 small GTPase binding GO:0051020 GTPase binding GO:0060589 nucleoside-triphosphatase regulator activity
Cellular Component	GO:0005938 cell cortex GO:0015629 actin cytoskeleton GO:0030863 cortical cytoskeleton GO:0030864 cortical actin cytoskeleton GO:0044448 cell cortex part GO:0099568 cytoplasmic region

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04390 Hippo signaling pathway hsa04530 Tight junction
Reactome	-

Summary
Symbol	LLGL2
Name	lethal giant larvae homolog 2 (Drosophila)
Aliases	Hugl-2; lethal giant larvae (Drosophila) homolog 2; human giant larvae homolog; Lethal(2) giant larvae prote ......
Chromosomal Location	17q25.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between LLGL2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	LLGL2
Name	lethal giant larvae homolog 2 (Drosophila)
Aliases	Hugl-2; lethal giant larvae (Drosophila) homolog 2; human giant larvae homolog; Lethal(2) giant larvae prote ......
Chromosomal Location	17q25.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of LLGL2 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	LLGL2
Name	lethal giant larvae homolog 2 (Drosophila)
Aliases	Hugl-2; lethal giant larvae (Drosophila) homolog 2; human giant larvae homolog; Lethal(2) giant larvae prote ......
Chromosomal Location	17q25.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of LLGL2 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.667	0.117
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.111	0.921
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	1.246	0.0935
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	1.394	0.0357
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	1.122	0.622
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	1.748	0.573
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.377	0.411
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.717	0.37
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.132	0.894
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	-0.369	0.806
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.129	0.95
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.091	0.503

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of LLGL2 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	7.1	0	7.1	0.452
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	10	0	10	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	0	2.7	-2.7	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	0	3.4	-3.4	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	9.5	0	9.5	0.492
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	15.4	0	15.4	0.482
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	22.2	6.2	16	0.53
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	20	0	20	0.357
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	25	14.3	10.7	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	5.3	7.4	-2.1	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	9.1	7.7	1.4	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	7.1	-7.1	0.467
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	LLGL2
Name	lethal giant larvae homolog 2 (Drosophila)
Aliases	Hugl-2; lethal giant larvae (Drosophila) homolog 2; human giant larvae homolog; Lethal(2) giant larvae prote ......
Chromosomal Location	17q25.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of LLGL2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	LLGL2
Name	lethal giant larvae homolog 2 (Drosophila)
Aliases	Hugl-2; lethal giant larvae (Drosophila) homolog 2; human giant larvae homolog; Lethal(2) giant larvae prote ......
Chromosomal Location	17q25.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of LLGL2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by LLGL2. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	LLGL2
Name	lethal giant larvae homolog 2 (Drosophila)
Aliases	Hugl-2; lethal giant larvae (Drosophila) homolog 2; human giant larvae homolog; Lethal(2) giant larvae prote ......
Chromosomal Location	17q25.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of LLGL2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	LLGL2
Name	lethal giant larvae homolog 2 (Drosophila)
Aliases	Hugl-2; lethal giant larvae (Drosophila) homolog 2; human giant larvae homolog; Lethal(2) giant larvae prote ......
Chromosomal Location	17q25.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of LLGL2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	LLGL2
Name	lethal giant larvae homolog 2 (Drosophila)
Aliases	Hugl-2; lethal giant larvae (Drosophila) homolog 2; human giant larvae homolog; Lethal(2) giant larvae prote ......
Chromosomal Location	17q25.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between LLGL2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	LLGL2
Name	lethal giant larvae homolog 2 (Drosophila)
Aliases	Hugl-2; lethal giant larvae (Drosophila) homolog 2; human giant larvae homolog; Lethal(2) giant larvae prote ......
Chromosomal Location	17q25.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting LLGL2 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

Browse LLGL2