TISIDB

Summary
Symbol	LRRK1
Name	leucine-rich repeat kinase 1
Aliases	FLJ23119; KIAA1790; Roco1; RIPK6; Leucine-rich repeat serine/threonine-protein kinase 1
Chromosomal Location	15q26.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cytoplasm
Domain	PF16095 C-terminal of Roc PF00069 Protein kinase domain
Function	-

> Gene Ontology [ TOP ]
Biological Process	GO:0001501 skeletal system development GO:0001894 tissue homeostasis GO:0001933 negative regulation of protein phosphorylation GO:0002521 leukocyte differentiation GO:0002573 myeloid leukocyte differentiation GO:0016055 Wnt signaling pathway GO:0018108 peptidyl-tyrosine phosphorylation GO:0018212 peptidyl-tyrosine modification GO:0030099 myeloid cell differentiation GO:0030111 regulation of Wnt signaling pathway GO:0030177 positive regulation of Wnt signaling pathway GO:0030316 osteoclast differentiation GO:0036035 osteoclast development GO:0042326 negative regulation of phosphorylation GO:0045453 bone resorption GO:0046849 bone remodeling GO:0048771 tissue remodeling GO:0048871 multicellular organismal homeostasis GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation GO:0060070 canonical Wnt signaling pathway GO:0060249 anatomical structure homeostasis GO:0060348 bone development GO:0060828 regulation of canonical Wnt signaling pathway GO:0061515 myeloid cell development GO:0090263 positive regulation of canonical Wnt signaling pathway GO:0098751 bone cell development GO:0198738 cell-cell signaling by wnt
Molecular Function	GO:0004674 protein serine/threonine kinase activity GO:0005525 GTP binding GO:0019001 guanyl nucleotide binding GO:0032561 guanyl ribonucleotide binding
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	-

Summary
Symbol	LRRK1
Name	leucine-rich repeat kinase 1
Aliases	FLJ23119; KIAA1790; Roco1; RIPK6; Leucine-rich repeat serine/threonine-protein kinase 1
Chromosomal Location	15q26.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between LRRK1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	LRRK1
Name	leucine-rich repeat kinase 1
Aliases	FLJ23119; KIAA1790; Roco1; RIPK6; Leucine-rich repeat serine/threonine-protein kinase 1
Chromosomal Location	15q26.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of LRRK1 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	LRRK1
Name	leucine-rich repeat kinase 1
Aliases	FLJ23119; KIAA1790; Roco1; RIPK6; Leucine-rich repeat serine/threonine-protein kinase 1
Chromosomal Location	15q26.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of LRRK1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.058	0.848
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.335	0.693
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.143	0.826
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.088	0.72
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.292	0.898
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.171	0.953
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.3	0.422
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.656	0.585
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.099	0.941
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.81	0.389
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	1.104	0.45
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.198	0.0741

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of LRRK1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	7.1	0	7.1	0.452
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	10	0	10	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	18.5	2.7	15.8	0.0147
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	18.5	3.4	15.1	0.0291
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	4.8	0	4.8	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	7.7	0	7.7	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	2.6	3.7	-1.1	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	4.5	0	4.5	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	7.1	-7.1	0.467
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	LRRK1
Name	leucine-rich repeat kinase 1
Aliases	FLJ23119; KIAA1790; Roco1; RIPK6; Leucine-rich repeat serine/threonine-protein kinase 1
Chromosomal Location	15q26.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of LRRK1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	LRRK1
Name	leucine-rich repeat kinase 1
Aliases	FLJ23119; KIAA1790; Roco1; RIPK6; Leucine-rich repeat serine/threonine-protein kinase 1
Chromosomal Location	15q26.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of LRRK1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by LRRK1. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	LRRK1
Name	leucine-rich repeat kinase 1
Aliases	FLJ23119; KIAA1790; Roco1; RIPK6; Leucine-rich repeat serine/threonine-protein kinase 1
Chromosomal Location	15q26.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of LRRK1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	LRRK1
Name	leucine-rich repeat kinase 1
Aliases	FLJ23119; KIAA1790; Roco1; RIPK6; Leucine-rich repeat serine/threonine-protein kinase 1
Chromosomal Location	15q26.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of LRRK1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	LRRK1
Name	leucine-rich repeat kinase 1
Aliases	FLJ23119; KIAA1790; Roco1; RIPK6; Leucine-rich repeat serine/threonine-protein kinase 1
Chromosomal Location	15q26.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between LRRK1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	LRRK1
Name	leucine-rich repeat kinase 1
Aliases	FLJ23119; KIAA1790; Roco1; RIPK6; Leucine-rich repeat serine/threonine-protein kinase 1
Chromosomal Location	15q26.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting LRRK1 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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