Browse LRRK2

Summary
SymbolLRRK2
Nameleucine-rich repeat kinase 2
Aliases ROCO2; DKFZp434H2111; FLJ45829; RIPK7; PARK8; Parkinson disease (autosomal dominant) 8; AURA17; DARDARIN; au ......
Chromosomal Location12q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Membrane; Peripheral membrane protein. Cytoplasm. Perikaryon. Mitochondrion. Golgi apparatus. Cell projection, axon. Cell projection, dendrite. Endoplasmic reticulum Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane Peripheral membrane protein Cytoplasmic side Endosome Lysosome Mitochondrion outer membrane Mitochondrion inner membrane Mitochondrion matrix Note=Predominantly associated with intracytoplasmic vesicular and membranous structures (By similarity). Localized in the cytoplasm and associated with cellular membrane structures. Predominantly associated with the mitochondrial outer membrane of the mitochondria. Colocalized with RAB29 along tubular structures emerging from Golgi apparatus. Localizes in intracytoplasmic punctate structures of neuronal perikarya and dendritic and axonal processes.
Domain PF16095 C-terminal of Roc
PF12799 Leucine Rich repeats (2 copies)
PF13855 Leucine rich repeat
PF00069 Protein kinase domain
Function

Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). Plays a role in synaptic vesicle trafficking. Phosphorylates PRDX3. Has GTPase activity. May play a role in the phosphorylation of proteins central to Parkinson disease.

> Gene Ontology
 
Biological Process GO:0000045 autophagosome assembly
GO:0000186 activation of MAPKK activity
GO:0000187 activation of MAPK activity
GO:0000266 mitochondrial fission
GO:0000302 response to reactive oxygen species
GO:0001505 regulation of neurotransmitter levels
GO:0001655 urogenital system development
GO:0001763 morphogenesis of a branching structure
GO:0001822 kidney development
GO:0001933 negative regulation of protein phosphorylation
GO:0003254 regulation of membrane depolarization
GO:0006626 protein targeting to mitochondrion
GO:0006627 protein processing involved in protein targeting to mitochondrion
GO:0006836 neurotransmitter transport
GO:0006839 mitochondrial transport
GO:0006885 regulation of pH
GO:0006887 exocytosis
GO:0006914 autophagy
GO:0006979 response to oxidative stress
GO:0007030 Golgi organization
GO:0007033 vacuole organization
GO:0007034 vacuolar transport
GO:0007040 lysosome organization
GO:0007041 lysosomal transport
GO:0007212 dopamine receptor signaling pathway
GO:0007269 neurotransmitter secretion
GO:0007270 neuron-neuron synaptic transmission
GO:0007405 neuroblast proliferation
GO:0007528 neuromuscular junction development
GO:0007568 aging
GO:0007626 locomotory behavior
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0008340 determination of adult lifespan
GO:0009116 nucleoside metabolic process
GO:0009119 ribonucleoside metabolic process
GO:0009141 nucleoside triphosphate metabolic process
GO:0009144 purine nucleoside triphosphate metabolic process
GO:0009150 purine ribonucleotide metabolic process
GO:0009199 ribonucleoside triphosphate metabolic process
GO:0009205 purine ribonucleoside triphosphate metabolic process
GO:0009267 cellular response to starvation
GO:0009894 regulation of catabolic process
GO:0009896 positive regulation of catabolic process
GO:0009991 response to extracellular stimulus
GO:0010035 response to inorganic substance
GO:0010038 response to metal ion
GO:0010042 response to manganese ion
GO:0010259 multicellular organism aging
GO:0010498 proteasomal protein catabolic process
GO:0010506 regulation of autophagy
GO:0010507 negative regulation of autophagy
GO:0010508 positive regulation of autophagy
GO:0010639 negative regulation of organelle organization
GO:0010737 protein kinase A signaling
GO:0010738 regulation of protein kinase A signaling
GO:0010769 regulation of cell morphogenesis involved in differentiation
GO:0010821 regulation of mitochondrion organization
GO:0010823 negative regulation of mitochondrion organization
GO:0010955 negative regulation of protein processing
GO:0010975 regulation of neuron projection development
GO:0014041 regulation of neuron maturation
GO:0016055 Wnt signaling pathway
GO:0016079 synaptic vesicle exocytosis
GO:0016197 endosomal transport
GO:0016236 macroautophagy
GO:0016241 regulation of macroautophagy
GO:0016242 negative regulation of macroautophagy
GO:0016358 dendrite development
GO:0016482 cytosolic transport
GO:0016485 protein processing
GO:0017156 calcium ion regulated exocytosis
GO:0017157 regulation of exocytosis
GO:0017158 regulation of calcium ion-dependent exocytosis
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0018209 peptidyl-serine modification
GO:0018210 peptidyl-threonine modification
GO:0019722 calcium-mediated signaling
GO:0019932 second-messenger-mediated signaling
GO:0021537 telencephalon development
GO:0021700 developmental maturation
GO:0021772 olfactory bulb development
GO:0021885 forebrain cell migration
GO:0021988 olfactory lobe development
GO:0022028 tangential migration from the subventricular zone to the olfactory bulb
GO:0022029 telencephalon cell migration
GO:0022604 regulation of cell morphogenesis
GO:0023061 signal release
GO:0030004 cellular monovalent inorganic cation homeostasis
GO:0030111 regulation of Wnt signaling pathway
GO:0030177 positive regulation of Wnt signaling pathway
GO:0030641 regulation of cellular pH
GO:0030900 forebrain development
GO:0031329 regulation of cellular catabolic process
GO:0031331 positive regulation of cellular catabolic process
GO:0031396 regulation of protein ubiquitination
GO:0031398 positive regulation of protein ubiquitination
GO:0031667 response to nutrient levels
GO:0031668 cellular response to extracellular stimulus
GO:0031669 cellular response to nutrient levels
GO:0032091 negative regulation of protein binding
GO:0032092 positive regulation of protein binding
GO:0032147 activation of protein kinase activity
GO:0032386 regulation of intracellular transport
GO:0032387 negative regulation of intracellular transport
GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032844 regulation of homeostatic process
GO:0033157 regulation of intracellular protein transport
GO:0033674 positive regulation of kinase activity
GO:0034260 negative regulation of GTPase activity
GO:0034599 cellular response to oxidative stress
GO:0034614 cellular response to reactive oxygen species
GO:0034976 response to endoplasmic reticulum stress
GO:0034982 mitochondrial protein processing
GO:0035249 synaptic transmission, glutamatergic
GO:0035564 regulation of kidney size
GO:0035640 exploration behavior
GO:0035641 locomotory exploration behavior
GO:0035751 regulation of lysosomal lumen pH
GO:0036473 cell death in response to oxidative stress
GO:0036474 cell death in response to hydrogen peroxide
GO:0042147 retrograde transport, endosome to Golgi
GO:0042176 regulation of protein catabolic process
GO:0042278 purine nucleoside metabolic process
GO:0042326 negative regulation of phosphorylation
GO:0042391 regulation of membrane potential
GO:0042542 response to hydrogen peroxide
GO:0042551 neuron maturation
GO:0042594 response to starvation
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043393 regulation of protein binding
GO:0043405 regulation of MAP kinase activity
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0044088 regulation of vacuole organization
GO:0044708 single-organism behavior
GO:0045055 regulated exocytosis
GO:0045324 late endosome to vacuole transport
GO:0045732 positive regulation of protein catabolic process
GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway
GO:0045860 positive regulation of protein kinase activity
GO:0045861 negative regulation of proteolysis
GO:0045862 positive regulation of proteolysis
GO:0046039 GTP metabolic process
GO:0046128 purine ribonucleoside metabolic process
GO:0046777 protein autophosphorylation
GO:0046928 regulation of neurotransmitter secretion
GO:0048311 mitochondrion distribution
GO:0048312 intracellular distribution of mitochondria
GO:0048469 cell maturation
GO:0048489 synaptic vesicle transport
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0048755 branching morphogenesis of a nerve
GO:0048813 dendrite morphogenesis
GO:0048814 regulation of dendrite morphogenesis
GO:0050773 regulation of dendrite development
GO:0050804 modulation of synaptic transmission
GO:0050805 negative regulation of synaptic transmission
GO:0050808 synapse organization
GO:0050848 regulation of calcium-mediated signaling
GO:0051051 negative regulation of transport
GO:0051098 regulation of binding
GO:0051099 positive regulation of binding
GO:0051100 negative regulation of binding
GO:0051224 negative regulation of protein transport
GO:0051341 regulation of oxidoreductase activity
GO:0051346 negative regulation of hydrolase activity
GO:0051354 negative regulation of oxidoreductase activity
GO:0051453 regulation of intracellular pH
GO:0051588 regulation of neurotransmitter transport
GO:0051604 protein maturation
GO:0051640 organelle localization
GO:0051646 mitochondrion localization
GO:0051648 vesicle localization
GO:0051650 establishment of vesicle localization
GO:0051656 establishment of organelle localization
GO:0051865 protein autoubiquitination
GO:0051881 regulation of mitochondrial membrane potential
GO:0051882 mitochondrial depolarization
GO:0051899 membrane depolarization
GO:0051900 regulation of mitochondrial depolarization
GO:0051966 regulation of synaptic transmission, glutamatergic
GO:0055067 monovalent inorganic cation homeostasis
GO:0060070 canonical Wnt signaling pathway
GO:0060078 regulation of postsynaptic membrane potential
GO:0060079 excitatory postsynaptic potential
GO:0060159 regulation of dopamine receptor signaling pathway
GO:0060161 positive regulation of dopamine receptor signaling pathway
GO:0060627 regulation of vesicle-mediated transport
GO:0060688 regulation of morphogenesis of a branching structure
GO:0060828 regulation of canonical Wnt signaling pathway
GO:0060993 kidney morphogenesis
GO:0060996 dendritic spine development
GO:0060997 dendritic spine morphogenesis
GO:0060998 regulation of dendritic spine development
GO:0061001 regulation of dendritic spine morphogenesis
GO:0061136 regulation of proteasomal protein catabolic process
GO:0061351 neural precursor cell proliferation
GO:0061762 CAMKK-AMPK signaling cascade
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070301 cellular response to hydrogen peroxide
GO:0070585 protein localization to mitochondrion
GO:0070613 regulation of protein processing
GO:0070997 neuron death
GO:0071241 cellular response to inorganic substance
GO:0071248 cellular response to metal ion
GO:0071287 cellular response to manganese ion
GO:0071407 cellular response to organic cyclic compound
GO:0071417 cellular response to organonitrogen compound
GO:0071496 cellular response to external stimulus
GO:0071867 response to monoamine
GO:0071868 cellular response to monoamine stimulus
GO:0071869 response to catecholamine
GO:0071870 cellular response to catecholamine stimulus
GO:0071900 regulation of protein serine/threonine kinase activity
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0072001 renal system development
GO:0072089 stem cell proliferation
GO:0072091 regulation of stem cell proliferation
GO:0072593 reactive oxygen species metabolic process
GO:0072655 establishment of protein localization to mitochondrion
GO:0080171 lytic vacuole organization
GO:0090066 regulation of anatomical structure size
GO:0090140 regulation of mitochondrial fission
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0090317 negative regulation of intracellular protein transport
GO:0090394 negative regulation of excitatory postsynaptic potential
GO:0097061 dendritic spine organization
GO:0097193 intrinsic apoptotic signaling pathway
GO:0097479 synaptic vesicle localization
GO:0097480 establishment of synaptic vesicle localization
GO:0098815 modulation of excitatory postsynaptic potential
GO:0099003 vesicle-mediated transport in synapse
GO:0099004 calmodulin dependent kinase signaling pathway
GO:0099504 synaptic vesicle cycle
GO:0099531 presynaptic process involved in chemical synaptic transmission
GO:0099565 chemical synaptic transmission, postsynaptic
GO:0099643 signal release from synapse
GO:0198738 cell-cell signaling by wnt
GO:1900407 regulation of cellular response to oxidative stress
GO:1900408 negative regulation of cellular response to oxidative stress
GO:1901031 regulation of response to reactive oxygen species
GO:1901032 negative regulation of response to reactive oxygen species
GO:1901068 guanosine-containing compound metabolic process
GO:1901214 regulation of neuron death
GO:1901215 negative regulation of neuron death
GO:1901657 glycosyl compound metabolic process
GO:1901800 positive regulation of proteasomal protein catabolic process
GO:1902115 regulation of organelle assembly
GO:1902116 negative regulation of organelle assembly
GO:1902235 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1902498 regulation of protein autoubiquitination
GO:1902499 positive regulation of protein autoubiquitination
GO:1902532 negative regulation of intracellular signal transduction
GO:1902692 regulation of neuroblast proliferation
GO:1902774 late endosome to lysosome transport
GO:1902803 regulation of synaptic vesicle transport
GO:1902822 regulation of late endosome to lysosome transport
GO:1902823 negative regulation of late endosome to lysosome transport
GO:1902882 regulation of response to oxidative stress
GO:1902883 negative regulation of response to oxidative stress
GO:1902902 negative regulation of autophagosome assembly
GO:1903050 regulation of proteolysis involved in cellular protein catabolic process
GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process
GO:1903123 regulation of thioredoxin peroxidase activity
GO:1903124 negative regulation of thioredoxin peroxidase activity
GO:1903125 negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation
GO:1903201 regulation of oxidative stress-induced cell death
GO:1903202 negative regulation of oxidative stress-induced cell death
GO:1903205 regulation of hydrogen peroxide-induced cell death
GO:1903206 negative regulation of hydrogen peroxide-induced cell death
GO:1903214 regulation of protein targeting to mitochondrion
GO:1903215 negative regulation of protein targeting to mitochondrion
GO:1903216 regulation of protein processing involved in protein targeting to mitochondrion
GO:1903217 negative regulation of protein processing involved in protein targeting to mitochondrion
GO:1903305 regulation of regulated secretory pathway
GO:1903317 regulation of protein maturation
GO:1903318 negative regulation of protein maturation
GO:1903320 regulation of protein modification by small protein conjugation or removal
GO:1903322 positive regulation of protein modification by small protein conjugation or removal
GO:1903335 regulation of vacuolar transport
GO:1903336 negative regulation of vacuolar transport
GO:1903350 response to dopamine
GO:1903351 cellular response to dopamine
GO:1903362 regulation of cellular protein catabolic process
GO:1903364 positive regulation of cellular protein catabolic process
GO:1903429 regulation of cell maturation
GO:1903533 regulation of protein targeting
GO:1903573 negative regulation of response to endoplasmic reticulum stress
GO:1903649 regulation of cytoplasmic transport
GO:1903747 regulation of establishment of protein localization to mitochondrion
GO:1903748 negative regulation of establishment of protein localization to mitochondrion
GO:1903828 negative regulation of cellular protein localization
GO:1904887 Wnt signalosome assembly
GO:1904950 negative regulation of establishment of protein localization
GO:1905037 autophagosome organization
GO:1905279 regulation of retrograde transport, endosome to Golgi
GO:1905289 regulation of CAMKK-AMPK signaling cascade
GO:1990267 response to transition metal nanoparticle
GO:2000021 regulation of ion homeostasis
GO:2000172 regulation of branching morphogenesis of a nerve
GO:2000177 regulation of neural precursor cell proliferation
GO:2000300 regulation of synaptic vesicle exocytosis
GO:2000468 regulation of peroxidase activity
GO:2000469 negative regulation of peroxidase activity
GO:2000785 regulation of autophagosome assembly
GO:2001233 regulation of apoptotic signaling pathway
GO:2001234 negative regulation of apoptotic signaling pathway
GO:2001242 regulation of intrinsic apoptotic signaling pathway
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Molecular Function GO:0000149 SNARE binding
GO:0001948 glycoprotein binding
GO:0003779 actin binding
GO:0003924 GTPase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004857 enzyme inhibitor activity
GO:0005096 GTPase activator activity
GO:0005525 GTP binding
GO:0008017 microtubule binding
GO:0008047 enzyme activator activity
GO:0015631 tubulin binding
GO:0017016 Ras GTPase binding
GO:0017048 Rho GTPase binding
GO:0017075 syntaxin-1 binding
GO:0019001 guanyl nucleotide binding
GO:0019905 syntaxin binding
GO:0030159 receptor signaling complex scaffold activity
GO:0030276 clathrin binding
GO:0030695 GTPase regulator activity
GO:0031267 small GTPase binding
GO:0032561 guanyl ribonucleotide binding
GO:0032947 protein complex scaffold
GO:0034211 GTP-dependent protein kinase activity
GO:0036479 peroxidase inhibitor activity
GO:0039706 co-receptor binding
GO:0044325 ion channel binding
GO:0051018 protein kinase A binding
GO:0051020 GTPase binding
GO:0060589 nucleoside-triphosphatase regulator activity
GO:1904713 beta-catenin destruction complex binding
Cellular Component GO:0005741 mitochondrial outer membrane
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
GO:0005767 secondary lysosome
GO:0005770 late endosome
GO:0005771 multivesicular body
GO:0005776 autophagosome
GO:0005798 Golgi-associated vesicle
GO:0005802 trans-Golgi network
GO:0005901 caveola
GO:0005902 microvillus
GO:0008021 synaptic vesicle
GO:0016234 inclusion body
GO:0019867 outer membrane
GO:0030133 transport vesicle
GO:0030424 axon
GO:0030425 dendrite
GO:0030426 growth cone
GO:0030427 site of polarized growth
GO:0030658 transport vesicle membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0030672 synaptic vesicle membrane
GO:0031968 organelle outer membrane
GO:0031984 organelle subcompartment
GO:0032473 cytoplasmic side of mitochondrial outer membrane
GO:0032838 cell projection cytoplasm
GO:0032839 dendrite cytoplasm
GO:0033267 axon part
GO:0043025 neuronal cell body
GO:0043195 terminal bouton
GO:0043204 perikaryon
GO:0043679 axon terminus
GO:0044297 cell body
GO:0044306 neuron projection terminus
GO:0044440 endosomal part
GO:0044455 mitochondrial membrane part
GO:0044753 amphisome
GO:0044754 autolysosome
GO:0044853 plasma membrane raft
GO:0045121 membrane raft
GO:0070382 exocytic vesicle
GO:0097487 multivesicular body, internal vesicle
GO:0098552 side of membrane
GO:0098562 cytoplasmic side of membrane
GO:0098589 membrane region
GO:0098791 Golgi subcompartment
GO:0098793 presynapse
GO:0098794 postsynapse
GO:0098857 membrane microdomain
GO:0098858 actin-based cell projection
GO:0099400 caveola neck
GO:0099501 exocytic vesicle membrane
GO:0099503 secretory vesicle
GO:0099568 cytoplasmic region
GO:1990909 Wnt signalosome
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-8857538: PTK6 promotes HIF1A stabilization
R-HSA-162582: Signal Transduction
R-HSA-8848021: Signaling by PTK6
Summary
SymbolLRRK2
Nameleucine-rich repeat kinase 2
Aliases ROCO2; DKFZp434H2111; FLJ45829; RIPK7; PARK8; Parkinson disease (autosomal dominant) 8; AURA17; DARDARIN; au ......
Chromosomal Location12q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between LRRK2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolLRRK2
Nameleucine-rich repeat kinase 2
Aliases ROCO2; DKFZp434H2111; FLJ45829; RIPK7; PARK8; Parkinson disease (autosomal dominant) 8; AURA17; DARDARIN; au ......
Chromosomal Location12q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of LRRK2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolLRRK2
Nameleucine-rich repeat kinase 2
Aliases ROCO2; DKFZp434H2111; FLJ45829; RIPK7; PARK8; Parkinson disease (autosomal dominant) 8; AURA17; DARDARIN; au ......
Chromosomal Location12q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of LRRK2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.410.386
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.1480.862
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.5970.416
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.0670.855
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.4250.839
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.3850.884
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.2630.567
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.4380.764
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.1070.946
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.5470.69
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.270.507
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.3020.0912
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of LRRK2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141705.9-5.91
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 41407.1-7.11
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277314.84.110.70.0828
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275914.85.19.70.199
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211714.3014.30.238
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131115.4015.40.482
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916012.5-12.50.52
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59022.2-22.20.505
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 382715.8015.80.037
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221318.2018.20.274
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161412.5012.50.485
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 111307.7-7.71
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610100-1000.143
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolLRRK2
Nameleucine-rich repeat kinase 2
Aliases ROCO2; DKFZp434H2111; FLJ45829; RIPK7; PARK8; Parkinson disease (autosomal dominant) 8; AURA17; DARDARIN; au ......
Chromosomal Location12q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of LRRK2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolLRRK2
Nameleucine-rich repeat kinase 2
Aliases ROCO2; DKFZp434H2111; FLJ45829; RIPK7; PARK8; Parkinson disease (autosomal dominant) 8; AURA17; DARDARIN; au ......
Chromosomal Location12q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of LRRK2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by LRRK2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolLRRK2
Nameleucine-rich repeat kinase 2
Aliases ROCO2; DKFZp434H2111; FLJ45829; RIPK7; PARK8; Parkinson disease (autosomal dominant) 8; AURA17; DARDARIN; au ......
Chromosomal Location12q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of LRRK2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolLRRK2
Nameleucine-rich repeat kinase 2
Aliases ROCO2; DKFZp434H2111; FLJ45829; RIPK7; PARK8; Parkinson disease (autosomal dominant) 8; AURA17; DARDARIN; au ......
Chromosomal Location12q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of LRRK2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolLRRK2
Nameleucine-rich repeat kinase 2
Aliases ROCO2; DKFZp434H2111; FLJ45829; RIPK7; PARK8; Parkinson disease (autosomal dominant) 8; AURA17; DARDARIN; au ......
Chromosomal Location12q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between LRRK2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolLRRK2
Nameleucine-rich repeat kinase 2
Aliases ROCO2; DKFZp434H2111; FLJ45829; RIPK7; PARK8; Parkinson disease (autosomal dominant) 8; AURA17; DARDARIN; au ......
Chromosomal Location12q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting LRRK2 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.