Browse LYN

Summary
SymbolLYN
NameLYN proto-oncogene, Src family tyrosine kinase
Aliases JTK8; v-yes-1 Yamaguchi sarcoma viral related oncogene homolog; p53Lyn; p56Lyn; lck/Yes-related novel protei ......
Chromosomal Location8q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane. Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus. Membrane Lipid-anchor Note=Accumulates in the nucleus by inhibition of CRM1-mediated nuclear export. Nuclear accumulation is increased by inhibition of its kinase activity. The trafficking from the Golgi apparatus to the plasma membrane occurs in a kinase domain-dependent but kinase activity independent manner and is mediated by exocytic vesicular transport. Detected on plasma membrane lipid rafts.
Domain PF07714 Protein tyrosine kinase
PF00017 SH2 domain
PF00018 SH3 domain
Function

Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, PTK2B/PYK2, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr-72'. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation.

> Gene Ontology
 
Biological Process GO:0001101 response to acid chemical
GO:0001776 leukocyte homeostasis
GO:0001782 B cell homeostasis
GO:0001783 B cell apoptotic process
GO:0001821 histamine secretion
GO:0001933 negative regulation of protein phosphorylation
GO:0002218 activation of innate immune response
GO:0002220 innate immune response activating cell surface receptor signaling pathway
GO:0002221 pattern recognition receptor signaling pathway
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0002224 toll-like receptor signaling pathway
GO:0002237 response to molecule of bacterial origin
GO:0002250 adaptive immune response
GO:0002260 lymphocyte homeostasis
GO:0002262 myeloid cell homeostasis
GO:0002263 cell activation involved in immune response
GO:0002274 myeloid leukocyte activation
GO:0002275 myeloid cell activation involved in immune response
GO:0002279 mast cell activation involved in immune response
GO:0002349 histamine production involved in inflammatory response
GO:0002366 leukocyte activation involved in immune response
GO:0002429 immune response-activating cell surface receptor signaling pathway
GO:0002431 Fc receptor mediated stimulatory signaling pathway
GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis
GO:0002441 histamine secretion involved in inflammatory response
GO:0002443 leukocyte mediated immunity
GO:0002444 myeloid leukocyte mediated immunity
GO:0002448 mast cell mediated immunity
GO:0002507 tolerance induction
GO:0002513 tolerance induction to self antigen
GO:0002521 leukocyte differentiation
GO:0002532 production of molecular mediator involved in inflammatory response
GO:0002548 monocyte chemotaxis
GO:0002553 histamine secretion by mast cell
GO:0002573 myeloid leukocyte differentiation
GO:0002576 platelet degranulation
GO:0002683 negative regulation of immune system process
GO:0002685 regulation of leukocyte migration
GO:0002688 regulation of leukocyte chemotaxis
GO:0002694 regulation of leukocyte activation
GO:0002695 negative regulation of leukocyte activation
GO:0002696 positive regulation of leukocyte activation
GO:0002697 regulation of immune effector process
GO:0002699 positive regulation of immune effector process
GO:0002703 regulation of leukocyte mediated immunity
GO:0002757 immune response-activating signal transduction
GO:0002758 innate immune response-activating signal transduction
GO:0002761 regulation of myeloid leukocyte differentiation
GO:0002762 negative regulation of myeloid leukocyte differentiation
GO:0002764 immune response-regulating signaling pathway
GO:0002765 immune response-inhibiting signal transduction
GO:0002767 immune response-inhibiting cell surface receptor signaling pathway
GO:0002768 immune response-regulating cell surface receptor signaling pathway
GO:0002774 Fc receptor mediated inhibitory signaling pathway
GO:0002886 regulation of myeloid leukocyte mediated immunity
GO:0002902 regulation of B cell apoptotic process
GO:0006469 negative regulation of protein kinase activity
GO:0006644 phospholipid metabolic process
GO:0006816 calcium ion transport
GO:0006874 cellular calcium ion homeostasis
GO:0006875 cellular metal ion homeostasis
GO:0006887 exocytosis
GO:0006909 phagocytosis
GO:0006991 response to sterol depletion
GO:0007159 leukocyte cell-cell adhesion
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007259 JAK-STAT cascade
GO:0007260 tyrosine phosphorylation of STAT protein
GO:0007596 blood coagulation
GO:0007599 hemostasis
GO:0009266 response to temperature stimulus
GO:0009306 protein secretion
GO:0009408 response to heat
GO:0009636 response to toxic substance
GO:0009743 response to carbohydrate
GO:0009914 hormone transport
GO:0009991 response to extracellular stimulus
GO:0010001 glial cell differentiation
GO:0010522 regulation of calcium ion transport into cytosol
GO:0010543 regulation of platelet activation
GO:0010720 positive regulation of cell development
GO:0010817 regulation of hormone levels
GO:0010959 regulation of metal ion transport
GO:0010975 regulation of neuron projection development
GO:0010976 positive regulation of neuron projection development
GO:0014003 oligodendrocyte development
GO:0014009 glial cell proliferation
GO:0014013 regulation of gliogenesis
GO:0014015 positive regulation of gliogenesis
GO:0017157 regulation of exocytosis
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0018212 peptidyl-tyrosine modification
GO:0019216 regulation of lipid metabolic process
GO:0021782 glial cell development
GO:0022407 regulation of cell-cell adhesion
GO:0022409 positive regulation of cell-cell adhesion
GO:0023061 signal release
GO:0030099 myeloid cell differentiation
GO:0030168 platelet activation
GO:0030193 regulation of blood coagulation
GO:0030218 erythrocyte differentiation
GO:0030335 positive regulation of cell migration
GO:0030595 leukocyte chemotaxis
GO:0030888 regulation of B cell proliferation
GO:0030889 negative regulation of B cell proliferation
GO:0031098 stress-activated protein kinase signaling cascade
GO:0031294 lymphocyte costimulation
GO:0031295 T cell costimulation
GO:0031346 positive regulation of cell projection organization
GO:0031349 positive regulation of defense response
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0031668 cellular response to extracellular stimulus
GO:0032386 regulation of intracellular transport
GO:0032418 lysosome localization
GO:0032496 response to lipopolysaccharide
GO:0032526 response to retinoic acid
GO:0032844 regulation of homeostatic process
GO:0032845 negative regulation of homeostatic process
GO:0032868 response to insulin
GO:0032943 mononuclear cell proliferation
GO:0032944 regulation of mononuclear cell proliferation
GO:0032945 negative regulation of mononuclear cell proliferation
GO:0033003 regulation of mast cell activation
GO:0033006 regulation of mast cell activation involved in immune response
GO:0033627 cell adhesion mediated by integrin
GO:0033628 regulation of cell adhesion mediated by integrin
GO:0033673 negative regulation of kinase activity
GO:0033674 positive regulation of kinase activity
GO:0034101 erythrocyte homeostasis
GO:0034109 homotypic cell-cell adhesion
GO:0034110 regulation of homotypic cell-cell adhesion
GO:0034121 regulation of toll-like receptor signaling pathway
GO:0034122 negative regulation of toll-like receptor signaling pathway
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034135 regulation of toll-like receptor 2 signaling pathway
GO:0034136 negative regulation of toll-like receptor 2 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034143 regulation of toll-like receptor 4 signaling pathway
GO:0034144 negative regulation of toll-like receptor 4 signaling pathway
GO:0034605 cellular response to heat
GO:0034762 regulation of transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0038083 peptidyl-tyrosine autophosphorylation
GO:0038093 Fc receptor signaling pathway
GO:0038094 Fc-gamma receptor signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0040017 positive regulation of locomotion
GO:0042063 gliogenesis
GO:0042100 B cell proliferation
GO:0042110 T cell activation
GO:0042113 B cell activation
GO:0042326 negative regulation of phosphorylation
GO:0042493 response to drug
GO:0042509 regulation of tyrosine phosphorylation of STAT protein
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0043200 response to amino acid
GO:0043299 leukocyte degranulation
GO:0043300 regulation of leukocyte degranulation
GO:0043303 mast cell degranulation
GO:0043304 regulation of mast cell degranulation
GO:0043405 regulation of MAP kinase activity
GO:0043407 negative regulation of MAP kinase activity
GO:0043409 negative regulation of MAPK cascade
GO:0043434 response to peptide hormone
GO:0043550 regulation of lipid kinase activity
GO:0043551 regulation of phosphatidylinositol 3-kinase activity
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0045055 regulated exocytosis
GO:0045088 regulation of innate immune response
GO:0045089 positive regulation of innate immune response
GO:0045117 azole transport
GO:0045576 mast cell activation
GO:0045637 regulation of myeloid cell differentiation
GO:0045638 negative regulation of myeloid cell differentiation
GO:0045646 regulation of erythrocyte differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045785 positive regulation of cell adhesion
GO:0045834 positive regulation of lipid metabolic process
GO:0046425 regulation of JAK-STAT cascade
GO:0046427 positive regulation of JAK-STAT cascade
GO:0046651 lymphocyte proliferation
GO:0046777 protein autophosphorylation
GO:0046879 hormone secretion
GO:0048013 ephrin receptor signaling pathway
GO:0048678 response to axon injury
GO:0048709 oligodendrocyte differentiation
GO:0048872 homeostasis of number of cells
GO:0050663 cytokine secretion
GO:0050670 regulation of lymphocyte proliferation
GO:0050672 negative regulation of lymphocyte proliferation
GO:0050707 regulation of cytokine secretion
GO:0050708 regulation of protein secretion
GO:0050727 regulation of inflammatory response
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050769 positive regulation of neurogenesis
GO:0050777 negative regulation of immune response
GO:0050817 coagulation
GO:0050818 regulation of coagulation
GO:0050851 antigen receptor-mediated signaling pathway
GO:0050853 B cell receptor signaling pathway
GO:0050854 regulation of antigen receptor-mediated signaling pathway
GO:0050855 regulation of B cell receptor signaling pathway
GO:0050857 positive regulation of antigen receptor-mediated signaling pathway
GO:0050861 positive regulation of B cell receptor signaling pathway
GO:0050863 regulation of T cell activation
GO:0050864 regulation of B cell activation
GO:0050865 regulation of cell activation
GO:0050866 negative regulation of cell activation
GO:0050867 positive regulation of cell activation
GO:0050869 negative regulation of B cell activation
GO:0050870 positive regulation of T cell activation
GO:0050878 regulation of body fluid levels
GO:0050900 leukocyte migration
GO:0050920 regulation of chemotaxis
GO:0051208 sequestering of calcium ion
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051235 maintenance of location
GO:0051238 sequestering of metal ion
GO:0051249 regulation of lymphocyte activation
GO:0051250 negative regulation of lymphocyte activation
GO:0051251 positive regulation of lymphocyte activation
GO:0051272 positive regulation of cellular component movement
GO:0051279 regulation of release of sequestered calcium ion into cytosol
GO:0051282 regulation of sequestering of calcium ion
GO:0051283 negative regulation of sequestering of calcium ion
GO:0051348 negative regulation of transferase activity
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0051608 histamine transport
GO:0051640 organelle localization
GO:0051656 establishment of organelle localization
GO:0051924 regulation of calcium ion transport
GO:0051962 positive regulation of nervous system development
GO:0055074 calcium ion homeostasis
GO:0060251 regulation of glial cell proliferation
GO:0060252 positive regulation of glial cell proliferation
GO:0060326 cell chemotaxis
GO:0060368 regulation of Fc receptor mediated stimulatory signaling pathway
GO:0060369 positive regulation of Fc receptor mediated stimulatory signaling pathway
GO:0060396 growth hormone receptor signaling pathway
GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway
GO:0060401 cytosolic calcium ion transport
GO:0060402 calcium ion transport into cytosol
GO:0060416 response to growth hormone
GO:0060627 regulation of vesicle-mediated transport
GO:0061041 regulation of wound healing
GO:0061351 neural precursor cell proliferation
GO:0070227 lymphocyte apoptotic process
GO:0070228 regulation of lymphocyte apoptotic process
GO:0070302 regulation of stress-activated protein kinase signaling cascade
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade
GO:0070371 ERK1 and ERK2 cascade
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0070444 oligodendrocyte progenitor proliferation
GO:0070445 regulation of oligodendrocyte progenitor proliferation
GO:0070447 positive regulation of oligodendrocyte progenitor proliferation
GO:0070486 leukocyte aggregation
GO:0070489 T cell aggregation
GO:0070509 calcium ion import
GO:0070527 platelet aggregation
GO:0070588 calcium ion transmembrane transport
GO:0070661 leukocyte proliferation
GO:0070662 mast cell proliferation
GO:0070663 regulation of leukocyte proliferation
GO:0070664 negative regulation of leukocyte proliferation
GO:0070665 positive regulation of leukocyte proliferation
GO:0070666 regulation of mast cell proliferation
GO:0070667 negative regulation of mast cell proliferation
GO:0070668 positive regulation of mast cell proliferation
GO:0070838 divalent metal ion transport
GO:0071216 cellular response to biotic stimulus
GO:0071219 cellular response to molecule of bacterial origin
GO:0071222 cellular response to lipopolysaccharide
GO:0071229 cellular response to acid chemical
GO:0071300 cellular response to retinoic acid
GO:0071375 cellular response to peptide hormone stimulus
GO:0071378 cellular response to growth hormone stimulus
GO:0071396 cellular response to lipid
GO:0071417 cellular response to organonitrogen compound
GO:0071496 cellular response to external stimulus
GO:0071593 lymphocyte aggregation
GO:0071674 mononuclear cell migration
GO:0071675 regulation of mononuclear cell migration
GO:0071887 leukocyte apoptotic process
GO:0071900 regulation of protein serine/threonine kinase activity
GO:0071901 negative regulation of protein serine/threonine kinase activity
GO:0072503 cellular divalent inorganic cation homeostasis
GO:0072507 divalent inorganic cation homeostasis
GO:0072511 divalent inorganic cation transport
GO:0090025 regulation of monocyte chemotaxis
GO:0090218 positive regulation of lipid kinase activity
GO:0090279 regulation of calcium ion import
GO:0090330 regulation of platelet aggregation
GO:0097028 dendritic cell differentiation
GO:0097048 dendritic cell apoptotic process
GO:0097529 myeloid leukocyte migration
GO:0097553 calcium ion transmembrane import into cytosol
GO:0097696 STAT cascade
GO:1900046 regulation of hemostasis
GO:1901652 response to peptide
GO:1901653 cellular response to peptide
GO:1902105 regulation of leukocyte differentiation
GO:1902106 negative regulation of leukocyte differentiation
GO:1902532 negative regulation of intracellular signal transduction
GO:1902656 calcium ion import into cytosol
GO:1903034 regulation of response to wounding
GO:1903037 regulation of leukocyte cell-cell adhesion
GO:1903039 positive regulation of leukocyte cell-cell adhesion
GO:1903169 regulation of calcium ion transmembrane transport
GO:1903305 regulation of regulated secretory pathway
GO:1903706 regulation of hemopoiesis
GO:1903707 negative regulation of hemopoiesis
GO:1903725 regulation of phospholipid metabolic process
GO:1903727 positive regulation of phospholipid metabolic process
GO:1904062 regulation of cation transmembrane transport
GO:1904892 regulation of STAT cascade
GO:1904894 positive regulation of STAT cascade
GO:2000021 regulation of ion homeostasis
GO:2000106 regulation of leukocyte apoptotic process
GO:2000108 positive regulation of leukocyte apoptotic process
GO:2000147 positive regulation of cell motility
GO:2000177 regulation of neural precursor cell proliferation
GO:2000179 positive regulation of neural precursor cell proliferation
GO:2000668 regulation of dendritic cell apoptotic process
GO:2000670 positive regulation of dendritic cell apoptotic process
Molecular Function GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0004716 receptor signaling protein tyrosine kinase activity
GO:0005057 receptor signaling protein activity
GO:0005161 platelet-derived growth factor receptor binding
GO:0005178 integrin binding
GO:0015631 tubulin binding
GO:0017124 SH3 domain binding
GO:0031625 ubiquitin protein ligase binding
GO:0043015 gamma-tubulin binding
GO:0043208 glycosphingolipid binding
GO:0044325 ion channel binding
GO:0044389 ubiquitin-like protein ligase binding
GO:0046625 sphingolipid binding
GO:0050839 cell adhesion molecule binding
GO:0051219 phosphoprotein binding
GO:0051861 glycolipid binding
GO:0070851 growth factor receptor binding
Cellular Component GO:0005743 mitochondrial inner membrane
GO:0005758 mitochondrial intermembrane space
GO:0005913 cell-cell adherens junction
GO:0008305 integrin complex
GO:0009898 cytoplasmic side of plasma membrane
GO:0014069 postsynaptic density
GO:0019897 extrinsic component of plasma membrane
GO:0019898 extrinsic component of membrane
GO:0030061 mitochondrial crista
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031970 organelle envelope lumen
GO:0034666 integrin alpha2-beta1 complex
GO:0042629 mast cell granule
GO:0043235 receptor complex
GO:0044455 mitochondrial membrane part
GO:0045121 membrane raft
GO:0060076 excitatory synapse
GO:0098552 side of membrane
GO:0098562 cytoplasmic side of membrane
GO:0098589 membrane region
GO:0098636 protein complex involved in cell adhesion
GO:0098794 postsynapse
GO:0098802 plasma membrane receptor complex
GO:0098857 membrane microdomain
GO:0099572 postsynaptic specialization
> KEGG and Reactome Pathway
 
KEGG hsa04062 Chemokine signaling pathway
hsa04064 NF-kappa B signaling pathway
hsa04611 Platelet activation
hsa04662 B cell receptor signaling pathway
hsa04664 Fc epsilon RI signaling pathway
hsa04666 Fc gamma R-mediated phagocytosis
hsa04730 Long-term depression
Reactome R-HSA-1280218: Adaptive Immune System
R-HSA-983695: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
R-HSA-422475: Axon guidance
R-HSA-5621481: C-type lectin receptors (CLRs)
R-HSA-5621575: CD209 (DC-SIGN) signaling
R-HSA-5690714: CD22 mediated BCR regulation
R-HSA-389356: CD28 co-stimulation
R-HSA-389513: CTLA4 inhibitory signaling
R-HSA-202733: Cell surface interactions at the vascular wall
R-HSA-388841: Costimulation by the CD28 family
R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-5621480: Dectin-2 family
R-HSA-1266738: Developmental Biology
R-HSA-2682334: EPH-Ephrin signaling
R-HSA-3928665: EPH-ephrin mediated repulsion of cells
R-HSA-3928663: EPHA-mediated growth cone collapse
R-HSA-3928662: EPHB-mediated forward signaling
R-HSA-2871809: FCERI mediated Ca+2 mobilization
R-HSA-2871796: FCERI mediated MAPK activation
R-HSA-2871837: FCERI mediated NF-kB activation
R-HSA-2029481: FCGR activation
R-HSA-2454202: Fc epsilon receptor (FCERI) signaling
R-HSA-2029480: Fcgamma receptor (FCGR) dependent phagocytosis
R-HSA-114604: GPVI-mediated activation cascade
R-HSA-982772: Growth hormone receptor signaling
R-HSA-109582: Hemostasis
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-512988: Interleukin-3, 5 and GM-CSF signaling
R-HSA-210990: PECAM1 interactions
R-HSA-75892: Platelet Adhesion to exposed collagen
R-HSA-76002: Platelet activation, signaling and aggregation
R-HSA-1433559: Regulation of KIT signaling
R-HSA-912631: Regulation of signaling by CBL
R-HSA-2730905: Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-162582: Signal Transduction
R-HSA-449147: Signaling by Interleukins
R-HSA-1433557: Signaling by SCF-KIT
R-HSA-983705: Signaling by the B Cell Receptor (BCR)
Summary
SymbolLYN
NameLYN proto-oncogene, Src family tyrosine kinase
Aliases JTK8; v-yes-1 Yamaguchi sarcoma viral related oncogene homolog; p53Lyn; p56Lyn; lck/Yes-related novel protei ......
Chromosomal Location8q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between LYN and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between LYN and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
27256566Head and Neck Squamous Cell CarcinomaInhibit immunityNext, we analyzed LYN expression by immunostaining and found that it was overexpressed in the human HNSCC specimens. Moreover, LYN expression in stromal cells positively correlated with myeloid-derived suppressor cells (MDSCs) makers CD11b and CD33 in human HNSCC. The dual positive expression of LYN in epithelial and stromal cells (EPI+ SRT+ ) was associated with unfavorable overall survival of HNSCC patients.
Summary
SymbolLYN
NameLYN proto-oncogene, Src family tyrosine kinase
Aliases JTK8; v-yes-1 Yamaguchi sarcoma viral related oncogene homolog; p53Lyn; p56Lyn; lck/Yes-related novel protei ......
Chromosomal Location8q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of LYN in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolLYN
NameLYN proto-oncogene, Src family tyrosine kinase
Aliases JTK8; v-yes-1 Yamaguchi sarcoma viral related oncogene homolog; p53Lyn; p56Lyn; lck/Yes-related novel protei ......
Chromosomal Location8q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of LYN in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.1520.683
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.0170.992
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.2760.819
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.0480.916
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.7550.634
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.8560.705
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.320.485
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.4930.767
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.140.939
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.050.456
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.2190.605
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0640.58
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of LYN in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277301.4-1.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.305.30.507
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolLYN
NameLYN proto-oncogene, Src family tyrosine kinase
Aliases JTK8; v-yes-1 Yamaguchi sarcoma viral related oncogene homolog; p53Lyn; p56Lyn; lck/Yes-related novel protei ......
Chromosomal Location8q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of LYN. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolLYN
NameLYN proto-oncogene, Src family tyrosine kinase
Aliases JTK8; v-yes-1 Yamaguchi sarcoma viral related oncogene homolog; p53Lyn; p56Lyn; lck/Yes-related novel protei ......
Chromosomal Location8q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of LYN. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by LYN.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolLYN
NameLYN proto-oncogene, Src family tyrosine kinase
Aliases JTK8; v-yes-1 Yamaguchi sarcoma viral related oncogene homolog; p53Lyn; p56Lyn; lck/Yes-related novel protei ......
Chromosomal Location8q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of LYN. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolLYN
NameLYN proto-oncogene, Src family tyrosine kinase
Aliases JTK8; v-yes-1 Yamaguchi sarcoma viral related oncogene homolog; p53Lyn; p56Lyn; lck/Yes-related novel protei ......
Chromosomal Location8q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of LYN expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolLYN
NameLYN proto-oncogene, Src family tyrosine kinase
Aliases JTK8; v-yes-1 Yamaguchi sarcoma viral related oncogene homolog; p53Lyn; p56Lyn; lck/Yes-related novel protei ......
Chromosomal Location8q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between LYN and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolLYN
NameLYN proto-oncogene, Src family tyrosine kinase
Aliases JTK8; v-yes-1 Yamaguchi sarcoma viral related oncogene homolog; p53Lyn; p56Lyn; lck/Yes-related novel protei ......
Chromosomal Location8q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting LYN collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting LYN.
ID Name Drug Type Targets #Targets
DB01254DasatinibSmall MoleculeABL1, ABL2, BCR, BTK, CSK, EPHA2, EPHA5, EPHB4, FGR, FRK, FYN, HSP ......22
DB030231-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-YlamineSmall MoleculeLCK, LYN, SRC3
DB06616BosutinibSmall MoleculeABL1, BCR, CAMK2G, CDK2, HCK, LYN, MAP2K1, MAP2K2, MAP3K2, SRC10
DB08901PonatinibSmall MoleculeABL1, BCR, FGFR1, FGFR2, FGFR3, FGFR4, FLT3, KDR, KIT, LCK, LYN, P ......15
DB09079NintedanibSmall MoleculeFGFR1, FGFR2, FGFR3, FLT1, FLT3, FLT4, KDR, LCK, LYN, SRC10