Browse MAN2A1

Summary
SymbolMAN2A1
Namemannosidase, alpha, class 2A, member 1
Aliases GOLIM7; golgi integral membrane protein 7; MANA2; AMan II; MANII; Golgi alpha-mannosidase II; mannosidase, a ......
Chromosomal Location5q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Golgi apparatus membrane Single-pass type II membrane protein
Domain PF09261 Alpha mannosidase middle domain
PF01074 Glycosyl hydrolases family 38 N-terminal domain
PF07748 Glycosyl hydrolases family 38 C-terminal domain
Function

Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.

> Gene Ontology
 
Biological Process GO:0001654 eye development
GO:0001701 in utero embryonic development
GO:0001889 liver development
GO:0005996 monosaccharide metabolic process
GO:0006013 mannose metabolic process
GO:0006486 protein glycosylation
GO:0006487 protein N-linked glycosylation
GO:0006491 N-glycan processing
GO:0006517 protein deglycosylation
GO:0007033 vacuole organization
GO:0007423 sensory organ development
GO:0007585 respiratory gaseous exchange
GO:0009100 glycoprotein metabolic process
GO:0009101 glycoprotein biosynthetic process
GO:0009311 oligosaccharide metabolic process
GO:0010720 positive regulation of cell development
GO:0019318 hexose metabolic process
GO:0030323 respiratory tube development
GO:0030324 lung development
GO:0043010 camera-type eye development
GO:0043413 macromolecule glycosylation
GO:0044723 single-organism carbohydrate metabolic process
GO:0048286 lung alveolus development
GO:0048592 eye morphogenesis
GO:0048593 camera-type eye morphogenesis
GO:0048732 gland development
GO:0050769 positive regulation of neurogenesis
GO:0051962 positive regulation of nervous system development
GO:0060041 retina development in camera-type eye
GO:0060042 retina morphogenesis in camera-type eye
GO:0060541 respiratory system development
GO:0061008 hepaticobiliary system development
GO:0070085 glycosylation
GO:0090596 sensory organ morphogenesis
Molecular Function GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004559 alpha-mannosidase activity
GO:0004572 mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity
GO:0015923 mannosidase activity
GO:0015924 mannosyl-oligosaccharide mannosidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0030246 carbohydrate binding
Cellular Component GO:0005801 cis-Golgi network
> KEGG and Reactome Pathway
 
KEGG hsa00510 N-Glycan biosynthesis
hsa01100 Metabolic pathways
Reactome R-HSA-446203: Asparagine N-linked glycosylation
R-HSA-6811442: Intra-Golgi and retrograde Golgi-to-ER traffic
R-HSA-6811438: Intra-Golgi traffic
R-HSA-199991: Membrane Trafficking
R-HSA-392499: Metabolism of proteins
R-HSA-975576: N-glycan antennae elongation in the medial/trans-Golgi
R-HSA-597592: Post-translational protein modification
R-HSA-975578: Reactions specific to the complex N-glycan synthesis pathway
R-HSA-948021: Transport to the Golgi and subsequent modification
R-HSA-5653656: Vesicle-mediated transport
Summary
SymbolMAN2A1
Namemannosidase, alpha, class 2A, member 1
Aliases GOLIM7; golgi integral membrane protein 7; MANA2; AMan II; MANII; Golgi alpha-mannosidase II; mannosidase, a ......
Chromosomal Location5q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between MAN2A1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolMAN2A1
Namemannosidase, alpha, class 2A, member 1
Aliases GOLIM7; golgi integral membrane protein 7; MANA2; AMan II; MANII; Golgi alpha-mannosidase II; mannosidase, a ......
Chromosomal Location5q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of MAN2A1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell logFC: -2.80; FDR: 0.00979 Resistant to T cell-mediated killing
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolMAN2A1
Namemannosidase, alpha, class 2A, member 1
Aliases GOLIM7; golgi integral membrane protein 7; MANA2; AMan II; MANII; Golgi alpha-mannosidase II; mannosidase, a ......
Chromosomal Location5q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of MAN2A1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.1370.648
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.0640.963
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.1820.842
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.0060.984
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.2030.919
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.2440.924
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.4140.323
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.5570.704
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.2020.906
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.4270.771
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.2650.898
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.080.272
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of MAN2A1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277311.14.170.339
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275911.15.160.373
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.509.50.492
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131115.4015.40.482
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 382703.7-3.70.415
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161407.1-7.10.467
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolMAN2A1
Namemannosidase, alpha, class 2A, member 1
Aliases GOLIM7; golgi integral membrane protein 7; MANA2; AMan II; MANII; Golgi alpha-mannosidase II; mannosidase, a ......
Chromosomal Location5q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MAN2A1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolMAN2A1
Namemannosidase, alpha, class 2A, member 1
Aliases GOLIM7; golgi integral membrane protein 7; MANA2; AMan II; MANII; Golgi alpha-mannosidase II; mannosidase, a ......
Chromosomal Location5q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MAN2A1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MAN2A1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolMAN2A1
Namemannosidase, alpha, class 2A, member 1
Aliases GOLIM7; golgi integral membrane protein 7; MANA2; AMan II; MANII; Golgi alpha-mannosidase II; mannosidase, a ......
Chromosomal Location5q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MAN2A1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolMAN2A1
Namemannosidase, alpha, class 2A, member 1
Aliases GOLIM7; golgi integral membrane protein 7; MANA2; AMan II; MANII; Golgi alpha-mannosidase II; mannosidase, a ......
Chromosomal Location5q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of MAN2A1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolMAN2A1
Namemannosidase, alpha, class 2A, member 1
Aliases GOLIM7; golgi integral membrane protein 7; MANA2; AMan II; MANII; Golgi alpha-mannosidase II; mannosidase, a ......
Chromosomal Location5q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between MAN2A1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolMAN2A1
Namemannosidase, alpha, class 2A, member 1
Aliases GOLIM7; golgi integral membrane protein 7; MANA2; AMan II; MANII; Golgi alpha-mannosidase II; mannosidase, a ......
Chromosomal Location5q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting MAN2A1 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting MAN2A1.
ID Name Drug Type Targets #Targets
DB02034TridolgosirSmall MoleculeMAN2A11
DB023182-deoxy-2-fluoro-alpha-D-mannosyl fluorideSmall MoleculeMAN2A11
DB02492GhavamiolSmall MoleculeMAN2A11
DB02742KifunensineSmall MoleculeMAN1B1, MAN2A12
DB030085-fluoro-beta-L-gulosyl fluorideSmall MoleculeMAN2A11
DB034145-Thio-a/B-D-MannopyranosylamineSmall MoleculeMAN2A11
DB039551-deoxymannojirimycinSmall MoleculeMAN2A11
DB06984(1R,2R,3R,4S,5R)-4-(BENZYLAMINO)-5-(METHYLTHIO)CYCLOPENTANE-1,2,3-TRIOLSmall MoleculeMAN2A11
DB08321(1S,2S,3R,6R)-4-(hydroxymethyl)-6-(octylamino)cyclohex-4-ene-1,2,3-triolSmall MoleculeMAN2A11