Browse MAOB

Summary
SymbolMAOB
Namemonoamine oxidase B
Aliases MAO, brain; MAO, platelet; MAO-B; adrenalin oxidase; monoamine oxidase type B; tyramine oxidase; Amine oxida ......
Chromosomal LocationXp11.4-p11.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side.
Domain PF01593 Flavin containing amine oxidoreductase
Function

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.

> Gene Ontology
 
Biological Process GO:0001505 regulation of neurotransmitter levels
GO:0001820 serotonin secretion
GO:0002237 response to molecule of bacterial origin
GO:0006584 catecholamine metabolic process
GO:0006837 serotonin transport
GO:0009308 amine metabolic process
GO:0009636 response to toxic substance
GO:0009712 catechol-containing compound metabolic process
GO:0010035 response to inorganic substance
GO:0010038 response to metal ion
GO:0010044 response to aluminum ion
GO:0010269 response to selenium ion
GO:0014062 regulation of serotonin secretion
GO:0014063 negative regulation of serotonin secretion
GO:0015844 monoamine transport
GO:0015850 organic hydroxy compound transport
GO:0018958 phenol-containing compound metabolic process
GO:0019336 phenol-containing compound catabolic process
GO:0019439 aromatic compound catabolic process
GO:0019614 catechol-containing compound catabolic process
GO:0021762 substantia nigra development
GO:0030901 midbrain development
GO:0031960 response to corticosteroid
GO:0032496 response to lipopolysaccharide
GO:0033238 regulation of cellular amine metabolic process
GO:0033240 positive regulation of cellular amine metabolic process
GO:0042053 regulation of dopamine metabolic process
GO:0042069 regulation of catecholamine metabolic process
GO:0042133 neurotransmitter metabolic process
GO:0042135 neurotransmitter catabolic process
GO:0042417 dopamine metabolic process
GO:0042420 dopamine catabolic process
GO:0042424 catecholamine catabolic process
GO:0042493 response to drug
GO:0042743 hydrogen peroxide metabolic process
GO:0044106 cellular amine metabolic process
GO:0045471 response to ethanol
GO:0045915 positive regulation of catecholamine metabolic process
GO:0045964 positive regulation of dopamine metabolic process
GO:0048545 response to steroid hormone
GO:0048857 neural nucleus development
GO:0050665 hydrogen peroxide biosynthetic process
GO:0051048 negative regulation of secretion
GO:0051051 negative regulation of transport
GO:0051384 response to glucocorticoid
GO:0051385 response to mineralocorticoid
GO:0051412 response to corticosterone
GO:0072593 reactive oxygen species metabolic process
GO:0097305 response to alcohol
GO:1901361 organic cyclic compound catabolic process
GO:1901565 organonitrogen compound catabolic process
GO:1901615 organic hydroxy compound metabolic process
GO:1901616 organic hydroxy compound catabolic process
GO:1901654 response to ketone
GO:1903409 reactive oxygen species biosynthetic process
GO:1903531 negative regulation of secretion by cell
Molecular Function GO:0008131 primary amine oxidase activity
GO:0009055 electron carrier activity
GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors
GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
GO:0048037 cofactor binding
GO:0050660 flavin adenine dinucleotide binding
GO:0050662 coenzyme binding
Cellular Component GO:0005741 mitochondrial outer membrane
GO:0005743 mitochondrial inner membrane
GO:0019867 outer membrane
GO:0031968 organelle outer membrane
> KEGG and Reactome Pathway
 
KEGG hsa04726 Serotonergic synapse
hsa04728 Dopaminergic synapse
hsa00260 Glycine, serine and threonine metabolism
hsa00330 Arginine and proline metabolism
hsa00340 Histidine metabolism
hsa00350 Tyrosine metabolism
hsa00360 Phenylalanine metabolism
hsa00380 Tryptophan metabolism
hsa00982 Drug metabolism - cytochrome P450
hsa01100 Metabolic pathways
Reactome R-HSA-140179: Amine Oxidase reactions
R-HSA-141333: Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB
R-HSA-211859: Biological oxidations
R-HSA-1430728: Metabolism
R-HSA-211945: Phase 1 - Functionalization of compounds
Summary
SymbolMAOB
Namemonoamine oxidase B
Aliases MAO, brain; MAO, platelet; MAO-B; adrenalin oxidase; monoamine oxidase type B; tyramine oxidase; Amine oxida ......
Chromosomal LocationXp11.4-p11.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between MAOB and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolMAOB
Namemonoamine oxidase B
Aliases MAO, brain; MAO, platelet; MAO-B; adrenalin oxidase; monoamine oxidase type B; tyramine oxidase; Amine oxida ......
Chromosomal LocationXp11.4-p11.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of MAOB in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolMAOB
Namemonoamine oxidase B
Aliases MAO, brain; MAO, platelet; MAO-B; adrenalin oxidase; monoamine oxidase type B; tyramine oxidase; Amine oxida ......
Chromosomal LocationXp11.4-p11.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of MAOB in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.7570.265
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.9160.513
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.6530.521
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.0410.948
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.2740.864
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.2470.893
729033130MelanomaallAnti-PD-1 (nivolumab) 26231.0990.151
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15111.7680.181
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.4230.762
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.590.747
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.6740.82
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.7830.000926
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of MAOB in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.703.70.27
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.703.70.314
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211714.3014.30.238
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131115.4015.40.482
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.305.30.507
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161412.5012.50.485
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolMAOB
Namemonoamine oxidase B
Aliases MAO, brain; MAO, platelet; MAO-B; adrenalin oxidase; monoamine oxidase type B; tyramine oxidase; Amine oxida ......
Chromosomal LocationXp11.4-p11.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MAOB. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolMAOB
Namemonoamine oxidase B
Aliases MAO, brain; MAO, platelet; MAO-B; adrenalin oxidase; monoamine oxidase type B; tyramine oxidase; Amine oxida ......
Chromosomal LocationXp11.4-p11.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MAOB. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MAOB.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolMAOB
Namemonoamine oxidase B
Aliases MAO, brain; MAO, platelet; MAO-B; adrenalin oxidase; monoamine oxidase type B; tyramine oxidase; Amine oxida ......
Chromosomal LocationXp11.4-p11.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MAOB. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolMAOB
Namemonoamine oxidase B
Aliases MAO, brain; MAO, platelet; MAO-B; adrenalin oxidase; monoamine oxidase type B; tyramine oxidase; Amine oxida ......
Chromosomal LocationXp11.4-p11.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of MAOB expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolMAOB
Namemonoamine oxidase B
Aliases MAO, brain; MAO, platelet; MAO-B; adrenalin oxidase; monoamine oxidase type B; tyramine oxidase; Amine oxida ......
Chromosomal LocationXp11.4-p11.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between MAOB and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolMAOB
Namemonoamine oxidase B
Aliases MAO, brain; MAO, platelet; MAO-B; adrenalin oxidase; monoamine oxidase type B; tyramine oxidase; Amine oxida ......
Chromosomal LocationXp11.4-p11.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting MAOB collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting MAOB.
ID Name Drug Type Targets #Targets
DB00182AmphetamineSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB ......19
DB00182AmphetamineSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB ......19
DB00191PhentermineSmall MoleculeMAOA, MAOB, SLC6A2, SLC6A3, SLC6A45
DB00721ProcaineSmall MoleculeCHRNA2, GRIN3A, HTR3A, KCNMA1, KCNMB1, KCNMB2, KCNMB3, KCNMB4, KCN ......16
DB00752TranylcypromineSmall MoleculeMAOA, MAOB2
DB00780PhenelzineSmall MoleculeABAT, AOC3, GPT, GPT2, MAOA, MAOB6
DB00909ZonisamideSmall MoleculeCA1, CA10, CA11, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, ......31
DB01037SelegilineSmall MoleculeMAOA, MAOB2
DB01132PioglitazoneSmall MoleculeMAOB, PPARA, PPARD, PPARG4
DB01168ProcarbazineSmall MoleculeMAOA, MAOB2
DB01171MoclobemideSmall MoleculeMAOA, MAOA, MAOB, MAOB4
DB01171MoclobemideSmall MoleculeMAOA, MAOA, MAOB, MAOB4
DB01247IsocarboxazidSmall MoleculeMAOA, MAOB2
DB01363EphedraSmall MoleculeADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, MAOA, MAOB, SLC18A1, ......13
DB01367RasagilineSmall MoleculeBCL2, MAOB2
DB01442MMDASmall MoleculeHTR2A, MAOA, MAOB, SLC18A1, SLC18A2, SLC6A2, SLC6A3, SLC6A48
DB014724-MethoxyamphetamineSmall MoleculeADRA1A, ADRA2A, MAOA, MAOB, SLC18A2, SLC6A3, SLC6A47
DB01577MethamphetamineSmall MoleculeADRA2A, ADRA2B, ADRA2C, MAOA, MAOB, SLC18A1, SLC18A2, SLC6A2, SLC6 ......11
DB01626PargylineSmall MoleculeMAOA, MAOB2
DB02095IsatinSmall MoleculeMAOB1
DB02211N-Methyl-N-Propargyl-1(R)-AminoindanSmall MoleculeMAOB1
DB02509FarnesolSmall MoleculeMAOB, NR1H42
DB02643N-Dodecyl-N,N-Dimethyl-3-Ammonio-1-PropanesulfonateSmall MoleculeIGF1, MAOB2
DB03147Flavin adenine dinucleotideSmall MoleculeACAD8, ACADM, ACADS, ACOX1, AIFM1, CYB5R1, CYB5R3, DAO, DLD, DPYD, ......26
DB03894N-Propargyl-1(S)-AminoindanSmall MoleculeMAOB1
DB04147Lauryl Dimethylamine-N-OxideSmall MoleculeCFL1, DHODH, DSTN, MAOB, NFE2L1, PMP2, RHO7
DB043075-Hydroxy-N-Propargyl-1(R)-AminoindanSmall MoleculeMAOB1
DB04677N-METHYL-N-[(1R)-1-METHYL-2-PHENYLETHYL]PROP-2-EN-1-AMINESmall MoleculeMAOB1
DB04820NialamideSmall MoleculeCOMT, MAOA, MAOB3
DB04821NomifensineSmall MoleculeMAOA, MAOB, MPO, SLC18A2, SLC6A2, SLC6A3, SLC6A47
DB04832ZimelidineSmall MoleculeMAOA, MAOB, SLC6A43
DB06654SafinamideSmall MoleculeMAOB1
DB075127-[(3-CHLOROBENZYL)OXY]-2-OXO-2H-CHROMENE-4-CARBALDEHYDESmall MoleculeMAOB1
DB075137-[(3-CHLOROBENZYL)OXY]-4-[(METHYLAMINO)METHYL]-2H-CHROMEN-2-ONESmall MoleculeMAOB1
DB08082N-(2-AMINOETHYL)-P-CHLOROBENZAMIDESmall MoleculeMAOB1
DB08176(1Z)-4-(4-FLUOROPHENYL)-2-METHYLIDENEBUTAN-1-IMINESmall MoleculeMAOB1
DB084804-HYDROXY-N-PROPARGYL-1(R)-AMINOINDANSmall MoleculeMAOB1
DB08516(S)-(+)-2-[4-(FLUOROBENZYLOXY-BENZYLAMINO)PROPIONAMIDE]Small MoleculeMAOB1