Summary | |
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Symbol | MAP6 |
Name | microtubule-associated protein 6 |
Aliases | KIAA1878; STOP; FLJ41346; MAP6-N; MTAP6; N-STOP; CTD-2530H12.7; MAP-6; stable tubule-only polypeptide |
Chromosomal Location | 11q13.5 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm, cytoskeleton Golgi apparatus Cell projection, axon Cell projection, dendrite Cytoplasmic vesicle, secretory vesicle membrane Lipid-anchor Cytoplasmic side Note=Localizes predominantly in the proximal part of the axon (By similarity). Preferentially is concentrated on a portion of the microtubule polymer in which tubulin is modified by detyrosination and acetylation and is also resistant to depolymerization induced by both nocodazole and cold (By similarity). In unpolarized neurons, localizes to the Golgi and to secretory vesicles accumulating transiently at the tips of a subset of neurites (By similarity). Following neuronal polarization and during axon outgrowth, accumulates in the axonal growth cone and subsequently localizes throughout the axon (By similarity). Partially localizes to dendrites in mature neurons (By similarity). Colocalizes with neurofilament (NF)-rich inclusions in spinal chord and brain neurons of patients with amyotrophic lateral sclerosis (ALS) (PubMed:14692697). |
Domain | - |
Function |
Involved in microtubule stabilization in many cell types, including neuronal cells (By similarity). Specifically has microtubule cold stabilizing activity (By similarity). Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B (PubMed:24357581). Regulates KIF5A-mediated axonal cargo transport (By similarity). Regulates axonal growth during neuron polarization (By similarity). |
Biological Process |
GO:0000226 microtubule cytoskeleton organization GO:0016358 dendrite development GO:0032418 lysosome localization GO:0048667 cell morphogenesis involved in neuron differentiation GO:0048813 dendrite morphogenesis GO:0051640 organelle localization |
Molecular Function |
GO:0005516 calmodulin binding GO:0008017 microtubule binding GO:0015631 tubulin binding |
Cellular Component |
GO:0005874 microtubule |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | MAP6 |
Name | microtubule-associated protein 6 |
Aliases | KIAA1878; STOP; FLJ41346; MAP6-N; MTAP6; N-STOP; CTD-2530H12.7; MAP-6; stable tubule-only polypeptide |
Chromosomal Location | 11q13.5 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between MAP6 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | MAP6 |
Name | microtubule-associated protein 6 |
Aliases | KIAA1878; STOP; FLJ41346; MAP6-N; MTAP6; N-STOP; CTD-2530H12.7; MAP-6; stable tubule-only polypeptide |
Chromosomal Location | 11q13.5 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of MAP6 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | MAP6 |
Name | microtubule-associated protein 6 |
Aliases | KIAA1878; STOP; FLJ41346; MAP6-N; MTAP6; N-STOP; CTD-2530H12.7; MAP-6; stable tubule-only polypeptide |
Chromosomal Location | 11q13.5 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of MAP6 in various data sets.
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Points in the above scatter plot represent the mutation difference of MAP6 in various data sets.
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Summary | |
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Symbol | MAP6 |
Name | microtubule-associated protein 6 |
Aliases | KIAA1878; STOP; FLJ41346; MAP6-N; MTAP6; N-STOP; CTD-2530H12.7; MAP-6; stable tubule-only polypeptide |
Chromosomal Location | 11q13.5 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MAP6. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | MAP6 |
Name | microtubule-associated protein 6 |
Aliases | KIAA1878; STOP; FLJ41346; MAP6-N; MTAP6; N-STOP; CTD-2530H12.7; MAP-6; stable tubule-only polypeptide |
Chromosomal Location | 11q13.5 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MAP6. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MAP6. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | MAP6 |
Name | microtubule-associated protein 6 |
Aliases | KIAA1878; STOP; FLJ41346; MAP6-N; MTAP6; N-STOP; CTD-2530H12.7; MAP-6; stable tubule-only polypeptide |
Chromosomal Location | 11q13.5 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MAP6. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | MAP6 |
Name | microtubule-associated protein 6 |
Aliases | KIAA1878; STOP; FLJ41346; MAP6-N; MTAP6; N-STOP; CTD-2530H12.7; MAP-6; stable tubule-only polypeptide |
Chromosomal Location | 11q13.5 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of MAP6 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | MAP6 |
Name | microtubule-associated protein 6 |
Aliases | KIAA1878; STOP; FLJ41346; MAP6-N; MTAP6; N-STOP; CTD-2530H12.7; MAP-6; stable tubule-only polypeptide |
Chromosomal Location | 11q13.5 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between MAP6 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | MAP6 |
Name | microtubule-associated protein 6 |
Aliases | KIAA1878; STOP; FLJ41346; MAP6-N; MTAP6; N-STOP; CTD-2530H12.7; MAP-6; stable tubule-only polypeptide |
Chromosomal Location | 11q13.5 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting MAP6 collected from DrugBank database. |
There is no record. |