Browse MAS1

Summary
SymbolMAS1
NameMAS1 proto-oncogene, G protein-coupled receptor
Aliases MAS1 oncogene; MAS; MGRA; Mas-related G protein-coupled receptor A; Proto-oncogene Mas
Chromosomal Location6q24-q27
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Multi-pass membrane protein
Domain PF00001 7 transmembrane receptor (rhodopsin family)
Function

Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1.

> Gene Ontology
 
Biological Process GO:0001933 negative regulation of protein phosphorylation
GO:0006066 alcohol metabolic process
GO:0006109 regulation of carbohydrate metabolic process
GO:0006260 DNA replication
GO:0006275 regulation of DNA replication
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0007283 spermatogenesis
GO:0007548 sex differentiation
GO:0008406 gonad development
GO:0008584 male gonad development
GO:0010675 regulation of cellular carbohydrate metabolic process
GO:0010676 positive regulation of cellular carbohydrate metabolic process
GO:0010919 regulation of inositol phosphate biosynthetic process
GO:0014823 response to activity
GO:0016051 carbohydrate biosynthetic process
GO:0019751 polyol metabolic process
GO:0021537 telencephalon development
GO:0021543 pallium development
GO:0021761 limbic system development
GO:0021766 hippocampus development
GO:0030900 forebrain development
GO:0032147 activation of protein kinase activity
GO:0032958 inositol phosphate biosynthetic process
GO:0033674 positive regulation of kinase activity
GO:0034698 response to gonadotropin
GO:0038061 NIK/NF-kappaB signaling
GO:0038166 angiotensin-activated signaling pathway
GO:0042326 negative regulation of phosphorylation
GO:0042493 response to drug
GO:0043255 regulation of carbohydrate biosynthetic process
GO:0043434 response to peptide hormone
GO:0043647 inositol phosphate metabolic process
GO:0044262 cellular carbohydrate metabolic process
GO:0044283 small molecule biosynthetic process
GO:0044723 single-organism carbohydrate metabolic process
GO:0045137 development of primary sexual characteristics
GO:0045740 positive regulation of DNA replication
GO:0045860 positive regulation of protein kinase activity
GO:0045913 positive regulation of carbohydrate metabolic process
GO:0046165 alcohol biosynthetic process
GO:0046173 polyol biosynthetic process
GO:0046546 development of primary male sexual characteristics
GO:0046661 male sex differentiation
GO:0048232 male gamete generation
GO:0048608 reproductive structure development
GO:0050727 regulation of inflammatory response
GO:0051052 regulation of DNA metabolic process
GO:0051054 positive regulation of DNA metabolic process
GO:0060732 positive regulation of inositol phosphate biosynthetic process
GO:0061458 reproductive system development
GO:0070528 protein kinase C signaling
GO:0071375 cellular response to peptide hormone stimulus
GO:0071417 cellular response to organonitrogen compound
GO:0071900 regulation of protein serine/threonine kinase activity
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:1901222 regulation of NIK/NF-kappaB signaling
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1901615 organic hydroxy compound metabolic process
GO:1901617 organic hydroxy compound biosynthetic process
GO:1901652 response to peptide
GO:1901653 cellular response to peptide
GO:1902930 regulation of alcohol biosynthetic process
GO:1902932 positive regulation of alcohol biosynthetic process
GO:1904385 cellular response to angiotensin
GO:1990776 response to angiotensin
Molecular Function GO:0001595 angiotensin receptor activity
GO:0001653 peptide receptor activity
GO:0004945 angiotensin type II receptor activity
GO:0008528 G-protein coupled peptide receptor activity
GO:0017046 peptide hormone binding
GO:0033218 amide binding
GO:0042277 peptide binding
GO:0042562 hormone binding
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04080 Neuroactive ligand-receptor interaction
hsa04614 Renin-angiotensin system
Reactome -
Summary
SymbolMAS1
NameMAS1 proto-oncogene, G protein-coupled receptor
Aliases MAS1 oncogene; MAS; MGRA; Mas-related G protein-coupled receptor A; Proto-oncogene Mas
Chromosomal Location6q24-q27
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between MAS1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolMAS1
NameMAS1 proto-oncogene, G protein-coupled receptor
Aliases MAS1 oncogene; MAS; MGRA; Mas-related G protein-coupled receptor A; Proto-oncogene Mas
Chromosomal Location6q24-q27
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of MAS1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolMAS1
NameMAS1 proto-oncogene, G protein-coupled receptor
Aliases MAS1 oncogene; MAS; MGRA; Mas-related G protein-coupled receptor A; Proto-oncogene Mas
Chromosomal Location6q24-q27
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of MAS1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)141201
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-2.2060.0355
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-2.4440.0958
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-1.920.276
729033130MelanomaallAnti-PD-1 (nivolumab) 262301
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 151101
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 111201
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.1610.723
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.1610.81
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.1840.354
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of MAS1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277302.7-2.71
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275903.4-3.41
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211705.9-5.90.447
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131109.1-9.10.458
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolMAS1
NameMAS1 proto-oncogene, G protein-coupled receptor
Aliases MAS1 oncogene; MAS; MGRA; Mas-related G protein-coupled receptor A; Proto-oncogene Mas
Chromosomal Location6q24-q27
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MAS1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolMAS1
NameMAS1 proto-oncogene, G protein-coupled receptor
Aliases MAS1 oncogene; MAS; MGRA; Mas-related G protein-coupled receptor A; Proto-oncogene Mas
Chromosomal Location6q24-q27
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MAS1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MAS1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolMAS1
NameMAS1 proto-oncogene, G protein-coupled receptor
Aliases MAS1 oncogene; MAS; MGRA; Mas-related G protein-coupled receptor A; Proto-oncogene Mas
Chromosomal Location6q24-q27
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MAS1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolMAS1
NameMAS1 proto-oncogene, G protein-coupled receptor
Aliases MAS1 oncogene; MAS; MGRA; Mas-related G protein-coupled receptor A; Proto-oncogene Mas
Chromosomal Location6q24-q27
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of MAS1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolMAS1
NameMAS1 proto-oncogene, G protein-coupled receptor
Aliases MAS1 oncogene; MAS; MGRA; Mas-related G protein-coupled receptor A; Proto-oncogene Mas
Chromosomal Location6q24-q27
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between MAS1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolMAS1
NameMAS1 proto-oncogene, G protein-coupled receptor
Aliases MAS1 oncogene; MAS; MGRA; Mas-related G protein-coupled receptor A; Proto-oncogene Mas
Chromosomal Location6q24-q27
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting MAS1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.