Browse MC1R

Summary
SymbolMC1R
Namemelanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
Aliases MSH-R; CMM5; SHEP2; MC1-R; melanotropin receptor; Melanocortin receptor 1; Melanocyte-stimulating hormone re ......
Chromosomal Location16q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane; Multi-pass membrane protein.
Domain PF00001 7 transmembrane receptor (rhodopsin family)
Function

Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

> Gene Ontology
 
Biological Process GO:0001818 negative regulation of cytokine production
GO:0006140 regulation of nucleotide metabolic process
GO:0006164 purine nucleotide biosynthetic process
GO:0006171 cAMP biosynthetic process
GO:0006582 melanin metabolic process
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0009150 purine ribonucleotide metabolic process
GO:0009152 purine ribonucleotide biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0009187 cyclic nucleotide metabolic process
GO:0009190 cyclic nucleotide biosynthetic process
GO:0009260 ribonucleotide biosynthetic process
GO:0009314 response to radiation
GO:0009411 response to UV
GO:0009416 response to light stimulus
GO:0009650 UV protection
GO:0010737 protein kinase A signaling
GO:0010738 regulation of protein kinase A signaling
GO:0010739 positive regulation of protein kinase A signaling
GO:0018958 phenol-containing compound metabolic process
GO:0019233 sensory perception of pain
GO:0019748 secondary metabolic process
GO:0030799 regulation of cyclic nucleotide metabolic process
GO:0030801 positive regulation of cyclic nucleotide metabolic process
GO:0030802 regulation of cyclic nucleotide biosynthetic process
GO:0030804 positive regulation of cyclic nucleotide biosynthetic process
GO:0030808 regulation of nucleotide biosynthetic process
GO:0030810 positive regulation of nucleotide biosynthetic process
GO:0030814 regulation of cAMP metabolic process
GO:0030816 positive regulation of cAMP metabolic process
GO:0030817 regulation of cAMP biosynthetic process
GO:0030819 positive regulation of cAMP biosynthetic process
GO:0032640 tumor necrosis factor production
GO:0032680 regulation of tumor necrosis factor production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0034644 cellular response to UV
GO:0042438 melanin biosynthetic process
GO:0042440 pigment metabolic process
GO:0043473 pigmentation
GO:0043491 protein kinase B signaling
GO:0044550 secondary metabolite biosynthetic process
GO:0045981 positive regulation of nucleotide metabolic process
GO:0046058 cAMP metabolic process
GO:0046148 pigment biosynthetic process
GO:0046189 phenol-containing compound biosynthetic process
GO:0046390 ribose phosphate biosynthetic process
GO:0051896 regulation of protein kinase B signaling
GO:0051897 positive regulation of protein kinase B signaling
GO:0052652 cyclic purine nucleotide metabolic process
GO:0070528 protein kinase C signaling
GO:0070914 UV-damage excision repair
GO:0071214 cellular response to abiotic stimulus
GO:0071478 cellular response to radiation
GO:0071482 cellular response to light stimulus
GO:0071706 tumor necrosis factor superfamily cytokine production
GO:0072522 purine-containing compound biosynthetic process
GO:0090036 regulation of protein kinase C signaling
GO:0090037 positive regulation of protein kinase C signaling
GO:1900371 regulation of purine nucleotide biosynthetic process
GO:1900373 positive regulation of purine nucleotide biosynthetic process
GO:1900542 regulation of purine nucleotide metabolic process
GO:1900544 positive regulation of purine nucleotide metabolic process
GO:1901293 nucleoside phosphate biosynthetic process
GO:1901615 organic hydroxy compound metabolic process
GO:1901617 organic hydroxy compound biosynthetic process
GO:1903555 regulation of tumor necrosis factor superfamily cytokine production
GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production
Molecular Function GO:0001653 peptide receptor activity
GO:0004977 melanocortin receptor activity
GO:0004980 melanocyte-stimulating hormone receptor activity
GO:0008528 G-protein coupled peptide receptor activity
GO:0031625 ubiquitin protein ligase binding
GO:0044389 ubiquitin-like protein ligase binding
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04080 Neuroactive ligand-receptor interaction
hsa04916 Melanogenesis
Reactome R-HSA-373076: Class A/1 (Rhodopsin-like receptors)
R-HSA-418555: G alpha (s) signalling events
R-HSA-388396: GPCR downstream signaling
R-HSA-500792: GPCR ligand binding
R-HSA-375276: Peptide ligand-binding receptors
R-HSA-162582: Signal Transduction
R-HSA-372790: Signaling by GPCR
Summary
SymbolMC1R
Namemelanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
Aliases MSH-R; CMM5; SHEP2; MC1-R; melanotropin receptor; Melanocortin receptor 1; Melanocyte-stimulating hormone re ......
Chromosomal Location16q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between MC1R and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolMC1R
Namemelanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
Aliases MSH-R; CMM5; SHEP2; MC1-R; melanotropin receptor; Melanocortin receptor 1; Melanocyte-stimulating hormone re ......
Chromosomal Location16q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of MC1R in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell logFC: -1.99; FDR: 0.02150 Resistant to T cell-mediated killing
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolMC1R
Namemelanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
Aliases MSH-R; CMM5; SHEP2; MC1-R; melanotropin receptor; Melanocortin receptor 1; Melanocyte-stimulating hormone re ......
Chromosomal Location16q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of MC1R in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.7070.22
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.8250.673
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.6110.654
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.1390.748
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.7360.579
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.6130.717
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.1080.8
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.6410.392
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.4420.595
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.0980.899
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.1180.91
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.1690.238
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of MC1R in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.305.30.507
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.109.10.519
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolMC1R
Namemelanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
Aliases MSH-R; CMM5; SHEP2; MC1-R; melanotropin receptor; Melanocortin receptor 1; Melanocyte-stimulating hormone re ......
Chromosomal Location16q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MC1R. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolMC1R
Namemelanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
Aliases MSH-R; CMM5; SHEP2; MC1-R; melanotropin receptor; Melanocortin receptor 1; Melanocyte-stimulating hormone re ......
Chromosomal Location16q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MC1R. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MC1R.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolMC1R
Namemelanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
Aliases MSH-R; CMM5; SHEP2; MC1-R; melanotropin receptor; Melanocortin receptor 1; Melanocyte-stimulating hormone re ......
Chromosomal Location16q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MC1R. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolMC1R
Namemelanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
Aliases MSH-R; CMM5; SHEP2; MC1-R; melanotropin receptor; Melanocortin receptor 1; Melanocyte-stimulating hormone re ......
Chromosomal Location16q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of MC1R expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolMC1R
Namemelanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
Aliases MSH-R; CMM5; SHEP2; MC1-R; melanotropin receptor; Melanocortin receptor 1; Melanocyte-stimulating hormone re ......
Chromosomal Location16q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between MC1R and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolMC1R
Namemelanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
Aliases MSH-R; CMM5; SHEP2; MC1-R; melanotropin receptor; Melanocortin receptor 1; Melanocyte-stimulating hormone re ......
Chromosomal Location16q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting MC1R collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting MC1R.
ID Name Drug Type Targets #Targets
DB04931AfamelanotideSmall MoleculeMC1R1
DB05479CZEN 002Small MoleculeMC1R1