Browse MESP1

Summary
SymbolMESP1
Namemesoderm posterior bHLH transcription factor 1
Aliases MGC10676; bHLHc5; mesoderm posterior 1 homolog (mouse); mesoderm posterior basic helix-loop-helix transcript ......
Chromosomal Location15q26.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus
Domain PF00010 Helix-loop-helix DNA-binding domain
Function

Transcription factor. Plays a role in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. Defines the rostrocaudal patterning of the somites by participating in distinct Notch pathways (By similarity).

> Gene Ontology
 
Biological Process GO:0001667 ameboidal-type cell migration
GO:0001704 formation of primary germ layer
GO:0001706 endoderm formation
GO:0001707 mesoderm formation
GO:0001708 cell fate specification
GO:0001709 cell fate determination
GO:0001710 mesodermal cell fate commitment
GO:0001711 endodermal cell fate commitment
GO:0001714 endodermal cell fate specification
GO:0001759 organ induction
GO:0001889 liver development
GO:0001947 heart looping
GO:0003002 regionalization
GO:0003007 heart morphogenesis
GO:0003128 heart field specification
GO:0003129 heart induction
GO:0003137 Notch signaling pathway involved in heart induction
GO:0003139 secondary heart field specification
GO:0003143 embryonic heart tube morphogenesis
GO:0003156 regulation of animal organ formation
GO:0003158 endothelium development
GO:0003161 cardiac conduction system development
GO:0003163 sinoatrial node development
GO:0003205 cardiac chamber development
GO:0003206 cardiac chamber morphogenesis
GO:0003207 cardiac chamber formation
GO:0003208 cardiac ventricle morphogenesis
GO:0003209 cardiac atrium morphogenesis
GO:0003210 cardiac atrium formation
GO:0003211 cardiac ventricle formation
GO:0003230 cardiac atrium development
GO:0003231 cardiac ventricle development
GO:0003235 sinus venosus development
GO:0003236 sinus venosus morphogenesis
GO:0003241 growth involved in heart morphogenesis
GO:0003259 cardioblast anterior-lateral migration
GO:0003260 cardioblast migration
GO:0003306 Wnt signaling pathway involved in heart development
GO:0003307 regulation of Wnt signaling pathway involved in heart development
GO:0003308 negative regulation of Wnt signaling pathway involved in heart development
GO:0003318 cell migration to the midline involved in heart development
GO:0007219 Notch signaling pathway
GO:0007368 determination of left/right symmetry
GO:0007369 gastrulation
GO:0007389 pattern specification process
GO:0007492 endoderm development
GO:0007498 mesoderm development
GO:0007501 mesodermal cell fate specification
GO:0007507 heart development
GO:0008078 mesodermal cell migration
GO:0008593 regulation of Notch signaling pathway
GO:0009799 specification of symmetry
GO:0009855 determination of bilateral symmetry
GO:0009996 negative regulation of cell fate specification
GO:0010092 specification of animal organ identity
GO:0010453 regulation of cell fate commitment
GO:0010454 negative regulation of cell fate commitment
GO:0010470 regulation of gastrulation
GO:0014706 striated muscle tissue development
GO:0016055 Wnt signaling pathway
GO:0023019 signal transduction involved in regulation of gene expression
GO:0030111 regulation of Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030856 regulation of epithelial cell differentiation
GO:0030858 positive regulation of epithelial cell differentiation
GO:0031128 developmental induction
GO:0035050 embryonic heart tube development
GO:0035051 cardiocyte differentiation
GO:0035239 tube morphogenesis
GO:0035265 organ growth
GO:0035480 regulation of Notch signaling pathway involved in heart induction
GO:0035481 positive regulation of Notch signaling pathway involved in heart induction
GO:0035886 vascular smooth muscle cell differentiation
GO:0035987 endodermal cell differentiation
GO:0042659 regulation of cell fate specification
GO:0042661 regulation of mesodermal cell fate specification
GO:0042662 negative regulation of mesodermal cell fate specification
GO:0042663 regulation of endodermal cell fate specification
GO:0042664 negative regulation of endodermal cell fate specification
GO:0042692 muscle cell differentiation
GO:0045165 cell fate commitment
GO:0045446 endothelial cell differentiation
GO:0045747 positive regulation of Notch signaling pathway
GO:0045992 negative regulation of embryonic development
GO:0045995 regulation of embryonic development
GO:0048332 mesoderm morphogenesis
GO:0048333 mesodermal cell differentiation
GO:0048368 lateral mesoderm development
GO:0048562 embryonic organ morphogenesis
GO:0048568 embryonic organ development
GO:0048645 animal organ formation
GO:0048732 gland development
GO:0048738 cardiac muscle tissue development
GO:0051145 smooth muscle cell differentiation
GO:0051146 striated muscle cell differentiation
GO:0051147 regulation of muscle cell differentiation
GO:0051149 positive regulation of muscle cell differentiation
GO:0051153 regulation of striated muscle cell differentiation
GO:0051155 positive regulation of striated muscle cell differentiation
GO:0055007 cardiac muscle cell differentiation
GO:0060026 convergent extension
GO:0060029 convergent extension involved in organogenesis
GO:0060070 canonical Wnt signaling pathway
GO:0060419 heart growth
GO:0060485 mesenchyme development
GO:0060537 muscle tissue development
GO:0060560 developmental growth involved in morphogenesis
GO:0060562 epithelial tube morphogenesis
GO:0060795 cell fate commitment involved in formation of primary germ layer
GO:0060828 regulation of canonical Wnt signaling pathway
GO:0060911 cardiac cell fate commitment
GO:0060913 cardiac cell fate determination
GO:0060914 heart formation
GO:0060920 cardiac pacemaker cell differentiation
GO:0060921 sinoatrial node cell differentiation
GO:0060947 cardiac vascular smooth muscle cell differentiation
GO:0060973 cell migration involved in heart development
GO:0060974 cell migration involved in heart formation
GO:0060975 cardioblast migration to the midline involved in heart field formation
GO:0060976 coronary vasculature development
GO:0061008 hepaticobiliary system development
GO:0061311 cell surface receptor signaling pathway involved in heart development
GO:0061371 determination of heart left/right asymmetry
GO:0070365 hepatocyte differentiation
GO:0070366 regulation of hepatocyte differentiation
GO:0070368 positive regulation of hepatocyte differentiation
GO:0090081 regulation of heart induction by regulation of canonical Wnt signaling pathway
GO:0090082 positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090381 regulation of heart induction
GO:0100012 regulation of heart induction by canonical Wnt signaling pathway
GO:0198738 cell-cell signaling by wnt
GO:1901321 positive regulation of heart induction
GO:1903224 regulation of endodermal cell differentiation
GO:1903225 negative regulation of endodermal cell differentiation
GO:2000027 regulation of organ morphogenesis
GO:2000380 regulation of mesoderm development
GO:2000381 negative regulation of mesoderm development
GO:2000542 negative regulation of gastrulation
GO:2000826 regulation of heart morphogenesis
Molecular Function GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0000987 core promoter proximal region sequence-specific DNA binding
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001159 core promoter proximal region DNA binding
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0035326 enhancer binding
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolMESP1
Namemesoderm posterior bHLH transcription factor 1
Aliases MGC10676; bHLHc5; mesoderm posterior 1 homolog (mouse); mesoderm posterior basic helix-loop-helix transcript ......
Chromosomal Location15q26.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between MESP1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolMESP1
Namemesoderm posterior bHLH transcription factor 1
Aliases MGC10676; bHLHc5; mesoderm posterior 1 homolog (mouse); mesoderm posterior basic helix-loop-helix transcript ......
Chromosomal Location15q26.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of MESP1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolMESP1
Namemesoderm posterior bHLH transcription factor 1
Aliases MGC10676; bHLHc5; mesoderm posterior 1 homolog (mouse); mesoderm posterior basic helix-loop-helix transcript ......
Chromosomal Location15q26.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of MESP1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.2630.588
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.4080.662
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.1410.879
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.6160.468
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.9510.448
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 472.5990.0655
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.1730.704
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.870.228
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.5210.521
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.0610.934
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.6410.499
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.6840.0166
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of MESP1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolMESP1
Namemesoderm posterior bHLH transcription factor 1
Aliases MGC10676; bHLHc5; mesoderm posterior 1 homolog (mouse); mesoderm posterior basic helix-loop-helix transcript ......
Chromosomal Location15q26.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MESP1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolMESP1
Namemesoderm posterior bHLH transcription factor 1
Aliases MGC10676; bHLHc5; mesoderm posterior 1 homolog (mouse); mesoderm posterior basic helix-loop-helix transcript ......
Chromosomal Location15q26.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MESP1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MESP1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolMESP1
Namemesoderm posterior bHLH transcription factor 1
Aliases MGC10676; bHLHc5; mesoderm posterior 1 homolog (mouse); mesoderm posterior basic helix-loop-helix transcript ......
Chromosomal Location15q26.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MESP1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolMESP1
Namemesoderm posterior bHLH transcription factor 1
Aliases MGC10676; bHLHc5; mesoderm posterior 1 homolog (mouse); mesoderm posterior basic helix-loop-helix transcript ......
Chromosomal Location15q26.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of MESP1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolMESP1
Namemesoderm posterior bHLH transcription factor 1
Aliases MGC10676; bHLHc5; mesoderm posterior 1 homolog (mouse); mesoderm posterior basic helix-loop-helix transcript ......
Chromosomal Location15q26.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between MESP1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolMESP1
Namemesoderm posterior bHLH transcription factor 1
Aliases MGC10676; bHLHc5; mesoderm posterior 1 homolog (mouse); mesoderm posterior basic helix-loop-helix transcript ......
Chromosomal Location15q26.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting MESP1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.