Browse MLYCD

Summary
SymbolMLYCD
Namemalonyl-CoA decarboxylase
Aliases hMCD; malonyl coenzyme A decarboxylase; Malonyl-CoA decarboxylase, mitochondrial
Chromosomal Location16q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm Mitochondrion matrix Peroxisome Peroxisome matrix Note=Enzymatically active in all three subcellular compartments.
Domain PF05292 Malonyl-CoA decarboxylase (MCD)
character(0) character(0)
Function

Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids. Plays a role in the metabolic balance between glucose and lipid oxidation in muscle independent of alterations in insulin signaling. May play a role in controlling the extent of ischemic injury by promoting glucose oxidation.

> Gene Ontology
 
Biological Process GO:0002931 response to ischemia
GO:0005996 monosaccharide metabolic process
GO:0006006 glucose metabolic process
GO:0006084 acetyl-CoA metabolic process
GO:0006085 acetyl-CoA biosynthetic process
GO:0006109 regulation of carbohydrate metabolic process
GO:0006631 fatty acid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0006637 acyl-CoA metabolic process
GO:0006732 coenzyme metabolic process
GO:0006790 sulfur compound metabolic process
GO:0009108 coenzyme biosynthetic process
GO:0010565 regulation of cellular ketone metabolic process
GO:0010675 regulation of cellular carbohydrate metabolic process
GO:0010906 regulation of glucose metabolic process
GO:0016053 organic acid biosynthetic process
GO:0019216 regulation of lipid metabolic process
GO:0019217 regulation of fatty acid metabolic process
GO:0019318 hexose metabolic process
GO:0019395 fatty acid oxidation
GO:0030258 lipid modification
GO:0034440 lipid oxidation
GO:0035383 thioester metabolic process
GO:0035384 thioester biosynthetic process
GO:0042180 cellular ketone metabolic process
GO:0044262 cellular carbohydrate metabolic process
GO:0044272 sulfur compound biosynthetic process
GO:0044273 sulfur compound catabolic process
GO:0044283 small molecule biosynthetic process
GO:0044723 single-organism carbohydrate metabolic process
GO:0045834 positive regulation of lipid metabolic process
GO:0045923 positive regulation of fatty acid metabolic process
GO:0046320 regulation of fatty acid oxidation
GO:0046321 positive regulation of fatty acid oxidation
GO:0046394 carboxylic acid biosynthetic process
GO:0051186 cofactor metabolic process
GO:0051188 cofactor biosynthetic process
GO:0071616 acyl-CoA biosynthetic process
GO:0072330 monocarboxylic acid biosynthetic process
GO:2001293 malonyl-CoA metabolic process
GO:2001294 malonyl-CoA catabolic process
Molecular Function GO:0016829 lyase activity
GO:0016830 carbon-carbon lyase activity
GO:0016831 carboxy-lyase activity
GO:0050080 malonyl-CoA decarboxylase activity
Cellular Component GO:0005759 mitochondrial matrix
GO:0005777 peroxisome
GO:0005782 peroxisomal matrix
GO:0031907 microbody lumen
GO:0042579 microbody
GO:0044438 microbody part
GO:0044439 peroxisomal part
> KEGG and Reactome Pathway
 
KEGG hsa04146 Peroxisome
hsa04152 AMPK signaling pathway
hsa00410 beta-Alanine metabolism
hsa00640 Propanoate metabolism
hsa01100 Metabolic pathways
Reactome R-HSA-1430728: Metabolism
R-HSA-556833: Metabolism of lipids and lipoproteins
R-HSA-390918: Peroxisomal lipid metabolism
Summary
SymbolMLYCD
Namemalonyl-CoA decarboxylase
Aliases hMCD; malonyl coenzyme A decarboxylase; Malonyl-CoA decarboxylase, mitochondrial
Chromosomal Location16q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between MLYCD and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolMLYCD
Namemalonyl-CoA decarboxylase
Aliases hMCD; malonyl coenzyme A decarboxylase; Malonyl-CoA decarboxylase, mitochondrial
Chromosomal Location16q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of MLYCD in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.53 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolMLYCD
Namemalonyl-CoA decarboxylase
Aliases hMCD; malonyl coenzyme A decarboxylase; Malonyl-CoA decarboxylase, mitochondrial
Chromosomal Location16q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of MLYCD in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.3230.0779
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.2020.886
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.4130.685
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.3330.259
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.3350.841
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.3310.875
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0030.99
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.1090.917
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.1120.924
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.1970.865
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.4730.793
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0430.528
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of MLYCD in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolMLYCD
Namemalonyl-CoA decarboxylase
Aliases hMCD; malonyl coenzyme A decarboxylase; Malonyl-CoA decarboxylase, mitochondrial
Chromosomal Location16q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MLYCD. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolMLYCD
Namemalonyl-CoA decarboxylase
Aliases hMCD; malonyl coenzyme A decarboxylase; Malonyl-CoA decarboxylase, mitochondrial
Chromosomal Location16q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MLYCD. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MLYCD.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolMLYCD
Namemalonyl-CoA decarboxylase
Aliases hMCD; malonyl coenzyme A decarboxylase; Malonyl-CoA decarboxylase, mitochondrial
Chromosomal Location16q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MLYCD. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolMLYCD
Namemalonyl-CoA decarboxylase
Aliases hMCD; malonyl coenzyme A decarboxylase; Malonyl-CoA decarboxylase, mitochondrial
Chromosomal Location16q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of MLYCD expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolMLYCD
Namemalonyl-CoA decarboxylase
Aliases hMCD; malonyl coenzyme A decarboxylase; Malonyl-CoA decarboxylase, mitochondrial
Chromosomal Location16q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between MLYCD and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolMLYCD
Namemalonyl-CoA decarboxylase
Aliases hMCD; malonyl coenzyme A decarboxylase; Malonyl-CoA decarboxylase, mitochondrial
Chromosomal Location16q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting MLYCD collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.