Browse MMP23B

Summary
SymbolMMP23B
Namematrix metallopeptidase 23B
Aliases matrix metalloproteinase 22; MMP22; matrix metalloproteinase 23B
Chromosomal Location1p36.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Endoplasmic reticulum membrane Single-pass type II membrane protein Membrane Single-pass type II membrane protein Note=A secreted form produced by proteolytic cleavage may also exist.
Domain PF00413 Matrixin
PF01549 ShK domain-like
Function

Protease. May regulate the surface expression of some potassium channels by retaining them in the endoplasmic reticulum (By similarity).

> Gene Ontology
 
Biological Process -
Molecular Function GO:0004175 endopeptidase activity
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
Cellular Component GO:0005578 proteinaceous extracellular matrix
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolMMP23B
Namematrix metallopeptidase 23B
Aliases matrix metalloproteinase 22; MMP22; matrix metalloproteinase 23B
Chromosomal Location1p36.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between MMP23B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolMMP23B
Namematrix metallopeptidase 23B
Aliases matrix metalloproteinase 22; MMP22; matrix metalloproteinase 23B
Chromosomal Location1p36.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of MMP23B in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolMMP23B
Namematrix metallopeptidase 23B
Aliases matrix metalloproteinase 22; MMP22; matrix metalloproteinase 23B
Chromosomal Location1p36.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of MMP23B in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-1.30.0121
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.5150.151
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-1.1390.163
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.0020.998
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.2830.864
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.3670.86
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.5090.354
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.1890.822
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.6140.455
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.3440.697
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.5740.611
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0550.786
> Mutation difference between responders and non-responders
 

There is no record.

Summary
SymbolMMP23B
Namematrix metallopeptidase 23B
Aliases matrix metalloproteinase 22; MMP22; matrix metalloproteinase 23B
Chromosomal Location1p36.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MMP23B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolMMP23B
Namematrix metallopeptidase 23B
Aliases matrix metalloproteinase 22; MMP22; matrix metalloproteinase 23B
Chromosomal Location1p36.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MMP23B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MMP23B.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolMMP23B
Namematrix metallopeptidase 23B
Aliases matrix metalloproteinase 22; MMP22; matrix metalloproteinase 23B
Chromosomal Location1p36.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MMP23B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolMMP23B
Namematrix metallopeptidase 23B
Aliases matrix metalloproteinase 22; MMP22; matrix metalloproteinase 23B
Chromosomal Location1p36.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of MMP23B expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolMMP23B
Namematrix metallopeptidase 23B
Aliases matrix metalloproteinase 22; MMP22; matrix metalloproteinase 23B
Chromosomal Location1p36.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between MMP23B and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolMMP23B
Namematrix metallopeptidase 23B
Aliases matrix metalloproteinase 22; MMP22; matrix metalloproteinase 23B
Chromosomal Location1p36.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting MMP23B collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting MMP23B.
ID Name Drug Type Targets #Targets
DB00786MarimastatSmall MoleculeMMP1, MMP10, MMP11, MMP12, MMP13, MMP14, MMP15, MMP16, MMP17, MMP1 ......23