TISIDB

Summary
Symbol	MPP5
Name	membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
Aliases	PALS1; FLJ12615; stardust; protein associated with lin seven 1; MAGUK p55 subfamily member 5
Chromosomal Location	14q23.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cell membrane; Peripheral membrane protein. Endomembrane system; Peripheral membrane protein. Cell junction, tight junction. Note=Localized to the tight junctions of epithelial cells and a subset of intracellular vesicles. In the retina, detected at the outer limiting membrane (OLM), apical to the adherens junction (AJ), where it colocalizes with CRB1. Colocalizes with MPP1 in the retina at the outer limiting membrane (OLM). Localized to the Purkinje cell body and axon.
Domain	PF00625 Guanylate kinase PF02828 L27 domain PF09060 L27_N PF00595 PDZ domain (Also known as DHR or GLGF) PF07653 Variant SH3 domain
Function	May play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter. Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity).

> Gene Ontology [ TOP ]
Biological Process	GO:0002011 morphogenesis of an epithelial sheet GO:0007009 plasma membrane organization GO:0007043 cell-cell junction assembly GO:0007163 establishment or maintenance of cell polarity GO:0007272 ensheathment of neurons GO:0007422 peripheral nervous system development GO:0008105 asymmetric protein localization GO:0008366 axon ensheathment GO:0010001 glial cell differentiation GO:0010927 cellular component assembly involved in morphogenesis GO:0014037 Schwann cell differentiation GO:0014044 Schwann cell development GO:0021782 glial cell development GO:0022011 myelination in peripheral nervous system GO:0030010 establishment of cell polarity GO:0032287 peripheral nervous system myelin maintenance GO:0032288 myelin assembly GO:0032292 peripheral nervous system axon ensheathment GO:0034329 cell junction assembly GO:0034330 cell junction organization GO:0035750 protein localization to myelin sheath abaxonal region GO:0042063 gliogenesis GO:0042552 myelination GO:0043217 myelin maintenance GO:0043297 apical junction assembly GO:0045216 cell-cell junction organization GO:0070830 bicellular tight junction assembly GO:0072657 protein localization to membrane GO:0072659 protein localization to plasma membrane GO:0090002 establishment of protein localization to plasma membrane GO:0090150 establishment of protein localization to membrane GO:0090162 establishment of epithelial cell polarity GO:1990778 protein localization to cell periphery
Molecular Function	-
Cellular Component	GO:0005923 bicellular tight junction GO:0035749 myelin sheath adaxonal region GO:0043209 myelin sheath GO:0043218 compact myelin GO:0043219 lateral loop GO:0043220 Schmidt-Lanterman incisure GO:0043296 apical junction complex GO:0070160 occluding junction

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04390 Hippo signaling pathway hsa04530 Tight junction
Reactome	R-HSA-446728: Cell junction organization R-HSA-1500931: Cell-Cell communication R-HSA-421270: Cell-cell junction organization R-HSA-420029: Tight junction interactions

Summary
Symbol	MPP5
Name	membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
Aliases	PALS1; FLJ12615; stardust; protein associated with lin seven 1; MAGUK p55 subfamily member 5
Chromosomal Location	14q23.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between MPP5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	MPP5
Name	membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
Aliases	PALS1; FLJ12615; stardust; protein associated with lin seven 1; MAGUK p55 subfamily member 5
Chromosomal Location	14q23.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of MPP5 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	MPP5
Name	membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
Aliases	PALS1; FLJ12615; stardust; protein associated with lin seven 1; MAGUK p55 subfamily member 5
Chromosomal Location	14q23.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of MPP5 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.226	0.497
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.617	0.638
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.052	0.953
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.25	0.422
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.021	0.991
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.596	0.808
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.053	0.882
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.056	0.971
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.161	0.923
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	-0.247	0.805
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.128	0.929
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.073	0.339

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of MPP5 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	11.1	11.1	0.0181
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	11.1	11.1	0.0286
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	9.5	9.5	0.492
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	12.5	12.5	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	7.7	7.7	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	1

Summary
Symbol	MPP5
Name	membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
Aliases	PALS1; FLJ12615; stardust; protein associated with lin seven 1; MAGUK p55 subfamily member 5
Chromosomal Location	14q23.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MPP5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	MPP5
Name	membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
Aliases	PALS1; FLJ12615; stardust; protein associated with lin seven 1; MAGUK p55 subfamily member 5
Chromosomal Location	14q23.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MPP5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MPP5. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	MPP5
Name	membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
Aliases	PALS1; FLJ12615; stardust; protein associated with lin seven 1; MAGUK p55 subfamily member 5
Chromosomal Location	14q23.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MPP5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	MPP5
Name	membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
Aliases	PALS1; FLJ12615; stardust; protein associated with lin seven 1; MAGUK p55 subfamily member 5
Chromosomal Location	14q23.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of MPP5 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	MPP5
Name	membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
Aliases	PALS1; FLJ12615; stardust; protein associated with lin seven 1; MAGUK p55 subfamily member 5
Chromosomal Location	14q23.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between MPP5 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	MPP5
Name	membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
Aliases	PALS1; FLJ12615; stardust; protein associated with lin seven 1; MAGUK p55 subfamily member 5
Chromosomal Location	14q23.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting MPP5 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

Browse MPP5