TISIDB

Summary
Symbol	MST1R
Name	macrophage stimulating 1 receptor
Aliases	CDw136; CD136; c-met-related tyrosine kinase; RON; PTK8; PTK8 protein tyrosine kinase 8; MSP receptor; MST1R ......
Chromosomal Location	3p21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Membrane; Single-pass type I membrane protein.
Domain	PF07714 Protein tyrosine kinase PF01403 Sema domain PF01833 IPT/TIG domain
Function	Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.

> Gene Ontology [ TOP ]
Biological Process	GO:0007338 single fertilization GO:0009566 fertilization GO:0009615 response to virus GO:0018108 peptidyl-tyrosine phosphorylation GO:0018212 peptidyl-tyrosine modification GO:0033674 positive regulation of kinase activity GO:0036005 response to macrophage colony-stimulating factor GO:0036006 cellular response to macrophage colony-stimulating factor stimulus GO:0038145 macrophage colony-stimulating factor signaling pathway GO:0043405 regulation of MAP kinase activity GO:0043406 positive regulation of MAP kinase activity GO:0043410 positive regulation of MAPK cascade GO:0043491 protein kinase B signaling GO:0045860 positive regulation of protein kinase activity GO:0048012 hepatocyte growth factor receptor signaling pathway GO:0051896 regulation of protein kinase B signaling GO:0051897 positive regulation of protein kinase B signaling GO:0071900 regulation of protein serine/threonine kinase activity GO:0071902 positive regulation of protein serine/threonine kinase activity
Molecular Function	GO:0004713 protein tyrosine kinase activity GO:0004714 transmembrane receptor protein tyrosine kinase activity GO:0005011 macrophage colony-stimulating factor receptor activity GO:0019199 transmembrane receptor protein kinase activity
Cellular Component	GO:0001725 stress fiber GO:0015629 actin cytoskeleton GO:0032432 actin filament bundle GO:0042641 actomyosin GO:0097517 contractile actin filament bundle

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-162582: Signal Transduction R-HSA-8852405: Signaling by MST1

Summary
Symbol	MST1R
Name	macrophage stimulating 1 receptor
Aliases	CDw136; CD136; c-met-related tyrosine kinase; RON; PTK8; PTK8 protein tyrosine kinase 8; MSP receptor; MST1R ......
Chromosomal Location	3p21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between MST1R and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining

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Literatures describing the relation between MST1R and anti-tumor immunity in human cancer.

PMID	Cancer type	Relation to immunity	Evidence sentences
23612011	Lung Carcinoma	Inhibit immunity (T cell function)	Our data show that loss of Ron function promotes an effective antitumor CD8(+) T-cell response, which specifically inhibits outgrowth of seeded metastatic colonies.

Summary
Symbol	MST1R
Name	macrophage stimulating 1 receptor
Aliases	CDw136; CD136; c-met-related tyrosine kinase; RON; PTK8; PTK8 protein tyrosine kinase 8; MSP receptor; MST1R ......
Chromosomal Location	3p21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of MST1R in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	MST1R
Name	macrophage stimulating 1 receptor
Aliases	CDw136; CD136; c-met-related tyrosine kinase; RON; PTK8; PTK8 protein tyrosine kinase 8; MSP receptor; MST1R ......
Chromosomal Location	3p21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of MST1R in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.566	0.166
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.122	0.856
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	1.08	0.0546
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	1.005	0.138
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.642	0.778
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	1.458	0.594
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.303	0.568
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.743	0.355
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.117	0.889
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.547	0.342
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.515	0.496
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.831	0.000915

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of MST1R in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	7.1	5.9	1.2	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	33.3	-33.3	0.231
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	25	0	25	0.222
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	11.1	5.5	5.6	0.384
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	11.1	6.8	4.3	0.673
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	4.8	5.9	-1.1	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	7.7	9.1	-1.4	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	6.2	-6.2	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	11.1	-11.1	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	7.9	0	7.9	0.26
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	13.6	0	13.6	0.279
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	MST1R
Name	macrophage stimulating 1 receptor
Aliases	CDw136; CD136; c-met-related tyrosine kinase; RON; PTK8; PTK8 protein tyrosine kinase 8; MSP receptor; MST1R ......
Chromosomal Location	3p21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MST1R. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	MST1R
Name	macrophage stimulating 1 receptor
Aliases	CDw136; CD136; c-met-related tyrosine kinase; RON; PTK8; PTK8 protein tyrosine kinase 8; MSP receptor; MST1R ......
Chromosomal Location	3p21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MST1R. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MST1R. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	MST1R
Name	macrophage stimulating 1 receptor
Aliases	CDw136; CD136; c-met-related tyrosine kinase; RON; PTK8; PTK8 protein tyrosine kinase 8; MSP receptor; MST1R ......
Chromosomal Location	3p21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MST1R. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	MST1R
Name	macrophage stimulating 1 receptor
Aliases	CDw136; CD136; c-met-related tyrosine kinase; RON; PTK8; PTK8 protein tyrosine kinase 8; MSP receptor; MST1R ......
Chromosomal Location	3p21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of MST1R expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	MST1R
Name	macrophage stimulating 1 receptor
Aliases	CDw136; CD136; c-met-related tyrosine kinase; RON; PTK8; PTK8 protein tyrosine kinase 8; MSP receptor; MST1R ......
Chromosomal Location	3p21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between MST1R and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	MST1R
Name	macrophage stimulating 1 receptor
Aliases	CDw136; CD136; c-met-related tyrosine kinase; RON; PTK8; PTK8 protein tyrosine kinase 8; MSP receptor; MST1R ......
Chromosomal Location	3p21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting MST1R collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

Browse MST1R