Browse MT1X

Summary
SymbolMT1X
Namemetallothionein 1X
Aliases MT-1X; MT-IX; metallothionein-IX; Metallothionein-1X
Chromosomal Location16q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location -
Domain PF00131 Metallothionein
Function

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. May be involved in FAM168A anti-apoptotic signaling (PubMed:23251525).

> Gene Ontology
 
Biological Process GO:0006875 cellular metal ion homeostasis
GO:0006882 cellular zinc ion homeostasis
GO:0007263 nitric oxide mediated signal transduction
GO:0009636 response to toxic substance
GO:0010001 glial cell differentiation
GO:0010035 response to inorganic substance
GO:0010038 response to metal ion
GO:0010043 response to zinc ion
GO:0010273 detoxification of copper ion
GO:0014002 astrocyte development
GO:0019932 second-messenger-mediated signaling
GO:0021782 glial cell development
GO:0036017 response to erythropoietin
GO:0036018 cellular response to erythropoietin
GO:0042063 gliogenesis
GO:0045926 negative regulation of growth
GO:0046686 response to cadmium ion
GO:0046688 response to copper ion
GO:0046916 cellular transition metal ion homeostasis
GO:0048143 astrocyte activation
GO:0048708 astrocyte differentiation
GO:0055069 zinc ion homeostasis
GO:0055076 transition metal ion homeostasis
GO:0061687 detoxification of inorganic compound
GO:0071241 cellular response to inorganic substance
GO:0071248 cellular response to metal ion
GO:0071276 cellular response to cadmium ion
GO:0071294 cellular response to zinc ion
GO:0072503 cellular divalent inorganic cation homeostasis
GO:0072507 divalent inorganic cation homeostasis
GO:0097501 stress response to metal ion
GO:0098754 detoxification
GO:1990169 stress response to copper ion
GO:1990267 response to transition metal nanoparticle
Molecular Function GO:0046870 cadmium ion binding
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04978 Mineral absorption
Reactome R-HSA-1430728: Metabolism
R-HSA-5661231: Metallothioneins bind metals
R-HSA-5660526: Response to metal ions
Summary
SymbolMT1X
Namemetallothionein 1X
Aliases MT-1X; MT-IX; metallothionein-IX; Metallothionein-1X
Chromosomal Location16q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between MT1X and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolMT1X
Namemetallothionein 1X
Aliases MT-1X; MT-IX; metallothionein-IX; Metallothionein-1X
Chromosomal Location16q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of MT1X in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolMT1X
Namemetallothionein 1X
Aliases MT-1X; MT-IX; metallothionein-IX; Metallothionein-1X
Chromosomal Location16q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of MT1X in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.8690.0668
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.3430.922
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)871.2690.586
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.360.617
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.4220.793
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.2620.914
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0180.973
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.0140.99
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.0890.946
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.6310.784
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.7970.801
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.590.0107
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolMT1X
Namemetallothionein 1X
Aliases MT-1X; MT-IX; metallothionein-IX; Metallothionein-1X
Chromosomal Location16q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MT1X. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolMT1X
Namemetallothionein 1X
Aliases MT-1X; MT-IX; metallothionein-IX; Metallothionein-1X
Chromosomal Location16q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MT1X. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MT1X.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolMT1X
Namemetallothionein 1X
Aliases MT-1X; MT-IX; metallothionein-IX; Metallothionein-1X
Chromosomal Location16q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MT1X. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolMT1X
Namemetallothionein 1X
Aliases MT-1X; MT-IX; metallothionein-IX; Metallothionein-1X
Chromosomal Location16q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of MT1X expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolMT1X
Namemetallothionein 1X
Aliases MT-1X; MT-IX; metallothionein-IX; Metallothionein-1X
Chromosomal Location16q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between MT1X and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolMT1X
Namemetallothionein 1X
Aliases MT-1X; MT-IX; metallothionein-IX; Metallothionein-1X
Chromosomal Location16q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting MT1X collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.