TISIDB

Summary
Symbol	MYH11
Name	myosin, heavy chain 11, smooth muscle
Aliases	SMMHC; SMHC; myosin, heavy polypeptide 11, smooth muscle; AAT4; FAA4; myosin heavy chain 11; myosin heavy ch ......
Chromosomal Location	16p13.11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Melanosome Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Thick filaments of the myofibrils.
Domain	PF00063 Myosin head (motor domain) PF02736 Myosin N-terminal SH3-like domain PF01576 Myosin tail
Function	Muscle contraction.

> Gene Ontology [ TOP ]
Biological Process	GO:0003012 muscle system process GO:0006936 muscle contraction GO:0006939 smooth muscle contraction GO:0007507 heart development GO:0010927 cellular component assembly involved in morphogenesis GO:0014706 striated muscle tissue development GO:0014866 skeletal myofibril assembly GO:0030198 extracellular matrix organization GO:0030239 myofibril assembly GO:0030241 skeletal muscle myosin thick filament assembly GO:0031032 actomyosin structure organization GO:0031033 myosin filament organization GO:0031034 myosin filament assembly GO:0035051 cardiocyte differentiation GO:0042692 muscle cell differentiation GO:0043062 extracellular structure organization GO:0048251 elastic fiber assembly GO:0048738 cardiac muscle tissue development GO:0048739 cardiac muscle fiber development GO:0048747 muscle fiber development GO:0051146 striated muscle cell differentiation GO:0055001 muscle cell development GO:0055002 striated muscle cell development GO:0055006 cardiac cell development GO:0055007 cardiac muscle cell differentiation GO:0055013 cardiac muscle cell development GO:0060537 muscle tissue development GO:0071688 striated muscle myosin thick filament assembly GO:0085029 extracellular matrix assembly
Molecular Function	GO:0003774 motor activity GO:0003779 actin binding GO:0005516 calmodulin binding GO:0008307 structural constituent of muscle GO:0051015 actin filament binding
Cellular Component	GO:0005859 muscle myosin complex GO:0015629 actin cytoskeleton GO:0016459 myosin complex GO:0016460 myosin II complex GO:0032982 myosin filament GO:0042470 melanosome GO:0043292 contractile fiber GO:0044449 contractile fiber part GO:0048770 pigment granule

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04270 Vascular smooth muscle contraction hsa04530 Tight junction
Reactome	R-HSA-422475: Axon guidance R-HSA-1266738: Developmental Biology R-HSA-2682334: EPH-Ephrin signaling R-HSA-3928663: EPHA-mediated growth cone collapse R-HSA-397014: Muscle contraction R-HSA-195258: RHO GTPase Effectors R-HSA-5627117: RHO GTPases Activate ROCKs R-HSA-5625900: RHO GTPases activate CIT R-HSA-5627123: RHO GTPases activate PAKs R-HSA-5625740: RHO GTPases activate PKNs R-HSA-400685: Sema4D in semaphorin signaling R-HSA-416572: Sema4D induced cell migration and growth-cone collapse R-HSA-373755: Semaphorin interactions R-HSA-162582: Signal Transduction R-HSA-194315: Signaling by Rho GTPases R-HSA-445355: Smooth Muscle Contraction

> KEGG and Reactome Pathway

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KEGG

hsa04270 Vascular smooth muscle contraction
hsa04530 Tight junction

Reactome

R-HSA-422475: Axon guidance
R-HSA-1266738: Developmental Biology
R-HSA-2682334: EPH-Ephrin signaling
R-HSA-3928663: EPHA-mediated growth cone collapse
R-HSA-397014: Muscle contraction
R-HSA-195258: RHO GTPase Effectors
R-HSA-5627117: RHO GTPases Activate ROCKs
R-HSA-5625900: RHO GTPases activate CIT
R-HSA-5627123: RHO GTPases activate PAKs
R-HSA-5625740: RHO GTPases activate PKNs
R-HSA-400685: Sema4D in semaphorin signaling
R-HSA-416572: Sema4D induced cell migration and growth-cone collapse
R-HSA-373755: Semaphorin interactions
R-HSA-162582: Signal Transduction
R-HSA-194315: Signaling by Rho GTPases
R-HSA-445355: Smooth Muscle Contraction

Summary
Symbol	MYH11
Name	myosin, heavy chain 11, smooth muscle
Aliases	SMMHC; SMHC; myosin, heavy polypeptide 11, smooth muscle; AAT4; FAA4; myosin heavy chain 11; myosin heavy ch ......
Chromosomal Location	16p13.11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between MYH11 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	MYH11
Name	myosin, heavy chain 11, smooth muscle
Aliases	SMMHC; SMHC; myosin, heavy polypeptide 11, smooth muscle; AAT4; FAA4; myosin heavy chain 11; myosin heavy ch ......
Chromosomal Location	16p13.11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of MYH11 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	MYH11
Name	myosin, heavy chain 11, smooth muscle
Aliases	SMMHC; SMHC; myosin, heavy polypeptide 11, smooth muscle; AAT4; FAA4; myosin heavy chain 11; myosin heavy ch ......
Chromosomal Location	16p13.11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of MYH11 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.544	0.257
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.602	0.54
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.488	0.48
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.689	0.546
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.35	0.93
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-1.12	0.822
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.613	0.232
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	1.043	0.402
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.156	0.909
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.298	0.831
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	1.281	0.481
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.618	0.0387

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of MYH11 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	7.1	5.9	1.2	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	10	33.3	-23.3	0.423
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	22.2	6.8	15.4	0.0644
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	22.2	8.5	13.7	0.0918
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	14.3	5.9	8.4	0.613
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	12.5	0	12.5	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	15.4	9.1	6.3	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	22.2	0	22.2	0.12
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	20	0	20	0.357
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	25	0	25	0.364
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	7.9	3.7	4.2	0.636
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	13.6	0	13.6	0.279
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	7.1	-7.1	0.467
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	MYH11
Name	myosin, heavy chain 11, smooth muscle
Aliases	SMMHC; SMHC; myosin, heavy polypeptide 11, smooth muscle; AAT4; FAA4; myosin heavy chain 11; myosin heavy ch ......
Chromosomal Location	16p13.11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MYH11. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	MYH11
Name	myosin, heavy chain 11, smooth muscle
Aliases	SMMHC; SMHC; myosin, heavy polypeptide 11, smooth muscle; AAT4; FAA4; myosin heavy chain 11; myosin heavy ch ......
Chromosomal Location	16p13.11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MYH11. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MYH11. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	MYH11
Name	myosin, heavy chain 11, smooth muscle
Aliases	SMMHC; SMHC; myosin, heavy polypeptide 11, smooth muscle; AAT4; FAA4; myosin heavy chain 11; myosin heavy ch ......
Chromosomal Location	16p13.11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MYH11. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	MYH11
Name	myosin, heavy chain 11, smooth muscle
Aliases	SMMHC; SMHC; myosin, heavy polypeptide 11, smooth muscle; AAT4; FAA4; myosin heavy chain 11; myosin heavy ch ......
Chromosomal Location	16p13.11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of MYH11 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	MYH11
Name	myosin, heavy chain 11, smooth muscle
Aliases	SMMHC; SMHC; myosin, heavy polypeptide 11, smooth muscle; AAT4; FAA4; myosin heavy chain 11; myosin heavy ch ......
Chromosomal Location	16p13.11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between MYH11 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	MYH11
Name	myosin, heavy chain 11, smooth muscle
Aliases	SMMHC; SMHC; myosin, heavy polypeptide 11, smooth muscle; AAT4; FAA4; myosin heavy chain 11; myosin heavy ch ......
Chromosomal Location	16p13.11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting MYH11 collected from DrugBank database.

> Drugs from DrugBank database

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Details on drugs targeting MYH11.

ID	Name	Drug Type	Targets	#Targets
DB04444	Tetrafluoroaluminate Ion	Small Molecule	ATP2A1, CMPK1, GNAI1, GNAT1, MYH11, MYH14	6

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