Summary | |
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Symbol | MYH13 |
Name | myosin, heavy chain 13, skeletal muscle |
Aliases | MyHC-eo; extraocular muscle myosin heavy chain; extraocular myosin heavy chain; myosin, heavy polypeptide 13 ...... |
Chromosomal Location | 17p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm, myofibril. Note=Thick filaments of the myofibrils. |
Domain |
PF00063 Myosin head (motor domain) PF02736 Myosin N-terminal SH3-like domain PF01576 Myosin tail |
Function |
Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated muscles. |
Biological Process |
GO:0003012 muscle system process GO:0006936 muscle contraction GO:0009267 cellular response to starvation GO:0009991 response to extracellular stimulus GO:0031667 response to nutrient levels GO:0031668 cellular response to extracellular stimulus GO:0031669 cellular response to nutrient levels GO:0042594 response to starvation GO:0071496 cellular response to external stimulus |
Molecular Function |
GO:0000146 microfilament motor activity GO:0003774 motor activity GO:0003779 actin binding GO:0005516 calmodulin binding |
Cellular Component |
GO:0005859 muscle myosin complex GO:0015629 actin cytoskeleton GO:0016459 myosin complex GO:0016460 myosin II complex GO:0030016 myofibril GO:0032982 myosin filament GO:0043292 contractile fiber GO:0044449 contractile fiber part |
KEGG |
hsa04530 Tight junction |
Reactome |
R-HSA-199991: Membrane Trafficking R-HSA-1445148: Translocation of GLUT4 to the plasma membrane R-HSA-5653656: Vesicle-mediated transport |
Summary | |
---|---|
Symbol | MYH13 |
Name | myosin, heavy chain 13, skeletal muscle |
Aliases | MyHC-eo; extraocular muscle myosin heavy chain; extraocular myosin heavy chain; myosin, heavy polypeptide 13 ...... |
Chromosomal Location | 17p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between MYH13 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | MYH13 |
Name | myosin, heavy chain 13, skeletal muscle |
Aliases | MyHC-eo; extraocular muscle myosin heavy chain; extraocular myosin heavy chain; myosin, heavy polypeptide 13 ...... |
Chromosomal Location | 17p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of MYH13 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | MYH13 |
Name | myosin, heavy chain 13, skeletal muscle |
Aliases | MyHC-eo; extraocular muscle myosin heavy chain; extraocular myosin heavy chain; myosin, heavy polypeptide 13 ...... |
Chromosomal Location | 17p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of MYH13 in various data sets.
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Points in the above scatter plot represent the mutation difference of MYH13 in various data sets.
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Summary | |
---|---|
Symbol | MYH13 |
Name | myosin, heavy chain 13, skeletal muscle |
Aliases | MyHC-eo; extraocular muscle myosin heavy chain; extraocular myosin heavy chain; myosin, heavy polypeptide 13 ...... |
Chromosomal Location | 17p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MYH13. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | MYH13 |
Name | myosin, heavy chain 13, skeletal muscle |
Aliases | MyHC-eo; extraocular muscle myosin heavy chain; extraocular myosin heavy chain; myosin, heavy polypeptide 13 ...... |
Chromosomal Location | 17p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MYH13. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MYH13. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | MYH13 |
Name | myosin, heavy chain 13, skeletal muscle |
Aliases | MyHC-eo; extraocular muscle myosin heavy chain; extraocular myosin heavy chain; myosin, heavy polypeptide 13 ...... |
Chromosomal Location | 17p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MYH13. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | MYH13 |
Name | myosin, heavy chain 13, skeletal muscle |
Aliases | MyHC-eo; extraocular muscle myosin heavy chain; extraocular myosin heavy chain; myosin, heavy polypeptide 13 ...... |
Chromosomal Location | 17p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of MYH13 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | MYH13 |
Name | myosin, heavy chain 13, skeletal muscle |
Aliases | MyHC-eo; extraocular muscle myosin heavy chain; extraocular myosin heavy chain; myosin, heavy polypeptide 13 ...... |
Chromosomal Location | 17p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between MYH13 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | MYH13 |
Name | myosin, heavy chain 13, skeletal muscle |
Aliases | MyHC-eo; extraocular muscle myosin heavy chain; extraocular myosin heavy chain; myosin, heavy polypeptide 13 ...... |
Chromosomal Location | 17p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting MYH13 collected from DrugBank database. |
There is no record. |