TISIDB

Summary
Symbol	MYO5B
Name	myosin VB
Aliases	KIAA1119; MYO5B variant protein; myosin-Vb; Unconventional myosin-Vb
Chromosomal Location	18q
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cytoplasm
Domain	PF01843 DIL domain PF00612 IQ calmodulin-binding motif PF00063 Myosin head (motor domain)
Function	May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis.

> Gene Ontology [ TOP ]
Biological Process	GO:0003014 renal system process GO:0003091 renal water homeostasis GO:0030104 water homeostasis GO:0032439 endosome localization GO:0048871 multicellular organismal homeostasis GO:0050878 regulation of body fluid levels GO:0050891 multicellular organismal water homeostasis GO:0051640 organelle localization
Molecular Function	GO:0000146 microfilament motor activity GO:0003774 motor activity GO:0003779 actin binding GO:0005516 calmodulin binding GO:0017016 Ras GTPase binding GO:0017137 Rab GTPase binding GO:0031267 small GTPase binding GO:0051020 GTPase binding
Cellular Component	GO:0005938 cell cortex GO:0015629 actin cytoskeleton GO:0016459 myosin complex GO:0030659 cytoplasmic vesicle membrane GO:0044448 cell cortex part GO:0045177 apical part of cell GO:0045179 apical cortex GO:0055037 recycling endosome GO:0099568 cytoplasmic region GO:0099738 cell cortex region

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-445717: Aquaporin-mediated transport R-HSA-382551: Transmembrane transport of small molecules R-HSA-432040: Vasopressin regulates renal water homeostasis via Aquaporins

Summary
Symbol	MYO5B
Name	myosin VB
Aliases	KIAA1119; MYO5B variant protein; myosin-Vb; Unconventional myosin-Vb
Chromosomal Location	18q
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between MYO5B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	MYO5B
Name	myosin VB
Aliases	KIAA1119; MYO5B variant protein; myosin-Vb; Unconventional myosin-Vb
Chromosomal Location	18q
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of MYO5B in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	MYO5B
Name	myosin VB
Aliases	KIAA1119; MYO5B variant protein; myosin-Vb; Unconventional myosin-Vb
Chromosomal Location	18q
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the expression difference of MYO5B in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	1.034	0.0264
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.988	0.266
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	1.074	0.12
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.7	0.165
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.306	0.889
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	1.201	0.673
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.91	0.109
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	1.323	0.286
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.567	0.654
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	-0.304	0.778
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	-1.256	0.463
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.389	0.00971

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of MYO5B in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	7.1	0	7.1	0.452
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	25	0	25	0.222
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	22.2	5.5	16.7	0.0222
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	22.2	6.8	15.4	0.0651
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	23.8	11.8	12	0.427
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	25	0	25	0.473
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	23.1	18.2	4.9	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	11.1	6.2	4.9	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	20	11.1	8.9	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	13.2	7.4	5.8	0.69
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	13.6	7.7	5.9	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	12.5	7.1	5.4	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	MYO5B
Name	myosin VB
Aliases	KIAA1119; MYO5B variant protein; myosin-Vb; Unconventional myosin-Vb
Chromosomal Location	18q
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MYO5B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	MYO5B
Name	myosin VB
Aliases	KIAA1119; MYO5B variant protein; myosin-Vb; Unconventional myosin-Vb
Chromosomal Location	18q
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MYO5B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MYO5B. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	MYO5B
Name	myosin VB
Aliases	KIAA1119; MYO5B variant protein; myosin-Vb; Unconventional myosin-Vb
Chromosomal Location	18q
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MYO5B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	MYO5B
Name	myosin VB
Aliases	KIAA1119; MYO5B variant protein; myosin-Vb; Unconventional myosin-Vb
Chromosomal Location	18q
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of MYO5B expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	MYO5B
Name	myosin VB
Aliases	KIAA1119; MYO5B variant protein; myosin-Vb; Unconventional myosin-Vb
Chromosomal Location	18q
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between MYO5B and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	MYO5B
Name	myosin VB
Aliases	KIAA1119; MYO5B variant protein; myosin-Vb; Unconventional myosin-Vb
Chromosomal Location	18q
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting MYO5B collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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