Browse MZB1

Summary
SymbolMZB1
Namemarginal zone B and B1 cell-specific protein
Aliases MGC29506; HSPC190; pERp1; MEDA-7; plasma cell-induced ER protein 1; proapoptotic caspase adaptor protein; me ......
Chromosomal Location5q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Isoform 1: Endoplasmic reticulum lumen Secreted ; SUBCELLULAR LOCATION: Isoform 2: Cytoplasm Note=Diffuse granular localization in the cytoplasm surrounding the nucleus (PubMed:11350957).
Domain PF11938 TLR4 regulator and MIR-interacting MSAP
Function

Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity (By similarity). Isoform 2 may be involved in regulation of apoptosis. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation. ; FUNCTION: Acts as a hormone-regulated adipokine/proinflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance.

> Gene Ontology
 
Biological Process GO:0002377 immunoglobulin production
GO:0002378 immunoglobulin biosynthetic process
GO:0002440 production of molecular mediator of immune response
GO:0002637 regulation of immunoglobulin production
GO:0002639 positive regulation of immunoglobulin production
GO:0002640 regulation of immunoglobulin biosynthetic process
GO:0002642 positive regulation of immunoglobulin biosynthetic process
GO:0002694 regulation of leukocyte activation
GO:0002697 regulation of immune effector process
GO:0002699 positive regulation of immune effector process
GO:0002700 regulation of production of molecular mediator of immune response
GO:0002702 positive regulation of production of molecular mediator of immune response
GO:0008643 carbohydrate transport
GO:0008645 hexose transport
GO:0010827 regulation of glucose transport
GO:0010829 negative regulation of glucose transport
GO:0015749 monosaccharide transport
GO:0015758 glucose transport
GO:0030888 regulation of B cell proliferation
GO:0032868 response to insulin
GO:0032869 cellular response to insulin stimulus
GO:0032943 mononuclear cell proliferation
GO:0032944 regulation of mononuclear cell proliferation
GO:0033622 integrin activation
GO:0042100 B cell proliferation
GO:0042113 B cell activation
GO:0043434 response to peptide hormone
GO:0044381 glucose import in response to insulin stimulus
GO:0046323 glucose import
GO:0046324 regulation of glucose import
GO:0046325 negative regulation of glucose import
GO:0046651 lymphocyte proliferation
GO:0050670 regulation of lymphocyte proliferation
GO:0050864 regulation of B cell activation
GO:0050865 regulation of cell activation
GO:0051051 negative regulation of transport
GO:0051249 regulation of lymphocyte activation
GO:0070661 leukocyte proliferation
GO:0070663 regulation of leukocyte proliferation
GO:0071375 cellular response to peptide hormone stimulus
GO:0071417 cellular response to organonitrogen compound
GO:1900076 regulation of cellular response to insulin stimulus
GO:1900077 negative regulation of cellular response to insulin stimulus
GO:1901652 response to peptide
GO:1901653 cellular response to peptide
GO:2001273 regulation of glucose import in response to insulin stimulus
GO:2001274 negative regulation of glucose import in response to insulin stimulus
Molecular Function -
Cellular Component GO:0005788 endoplasmic reticulum lumen
GO:0034663 endoplasmic reticulum chaperone complex
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolMZB1
Namemarginal zone B and B1 cell-specific protein
Aliases MGC29506; HSPC190; pERp1; MEDA-7; plasma cell-induced ER protein 1; proapoptotic caspase adaptor protein; me ......
Chromosomal Location5q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between MZB1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between MZB1 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
23986581Kaposi SarcomaInhibit immunityPlasma cell-induced-endoplasmic reticulum (ER)-resident protein 1 (pERP1) is a cellular chaperone that is preferentially expressed in marginal-zone B cells and is highly upregulated during plasma cell differentiation. While initially identified as a dedicated factor for the assembly of secreted IgM, pERP1 has since been implicated in suppressing calcium mobilization, and its expression is misregulated in multiple tumors.
Summary
SymbolMZB1
Namemarginal zone B and B1 cell-specific protein
Aliases MGC29506; HSPC190; pERp1; MEDA-7; plasma cell-induced ER protein 1; proapoptotic caspase adaptor protein; me ......
Chromosomal Location5q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of MZB1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolMZB1
Namemarginal zone B and B1 cell-specific protein
Aliases MGC29506; HSPC190; pERp1; MEDA-7; plasma cell-induced ER protein 1; proapoptotic caspase adaptor protein; me ......
Chromosomal Location5q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of MZB1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.2230.829
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)651.3090.513
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-1.340.4
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.4470.503
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.6330.658
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.2160.907
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.6490.486
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15112.2150.11
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.9670.503
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 483.0820.0823
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 282.740.281
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0590.869
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolMZB1
Namemarginal zone B and B1 cell-specific protein
Aliases MGC29506; HSPC190; pERp1; MEDA-7; plasma cell-induced ER protein 1; proapoptotic caspase adaptor protein; me ......
Chromosomal Location5q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MZB1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolMZB1
Namemarginal zone B and B1 cell-specific protein
Aliases MGC29506; HSPC190; pERp1; MEDA-7; plasma cell-induced ER protein 1; proapoptotic caspase adaptor protein; me ......
Chromosomal Location5q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MZB1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MZB1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolMZB1
Namemarginal zone B and B1 cell-specific protein
Aliases MGC29506; HSPC190; pERp1; MEDA-7; plasma cell-induced ER protein 1; proapoptotic caspase adaptor protein; me ......
Chromosomal Location5q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MZB1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolMZB1
Namemarginal zone B and B1 cell-specific protein
Aliases MGC29506; HSPC190; pERp1; MEDA-7; plasma cell-induced ER protein 1; proapoptotic caspase adaptor protein; me ......
Chromosomal Location5q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of MZB1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolMZB1
Namemarginal zone B and B1 cell-specific protein
Aliases MGC29506; HSPC190; pERp1; MEDA-7; plasma cell-induced ER protein 1; proapoptotic caspase adaptor protein; me ......
Chromosomal Location5q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between MZB1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolMZB1
Namemarginal zone B and B1 cell-specific protein
Aliases MGC29506; HSPC190; pERp1; MEDA-7; plasma cell-induced ER protein 1; proapoptotic caspase adaptor protein; me ......
Chromosomal Location5q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting MZB1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.