Browse NCMAP

Summary
SymbolNCMAP
Namenoncompact myelin associated protein
Aliases FLJ42528; MP11; myelin protein of 11 kDa; C1orf130; chromosome 1 open reading frame 130; Noncompact myelin-a ......
Chromosomal Location1p36.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Single-pass type I membrane protein Note=Localized mainly in the Schmidt-Lanterman incisures and paranodes of noncompact peripheral nerve myelin.
Domain -
Function

Plays a role in myelin formation.

> Gene Ontology
 
Biological Process GO:0007272 ensheathment of neurons
GO:0007422 peripheral nervous system development
GO:0008366 axon ensheathment
GO:0010001 glial cell differentiation
GO:0010927 cellular component assembly involved in morphogenesis
GO:0014037 Schwann cell differentiation
GO:0014044 Schwann cell development
GO:0021782 glial cell development
GO:0022011 myelination in peripheral nervous system
GO:0031641 regulation of myelination
GO:0031643 positive regulation of myelination
GO:0031644 regulation of neurological system process
GO:0031646 positive regulation of neurological system process
GO:0032288 myelin assembly
GO:0032290 peripheral nervous system myelin formation
GO:0032292 peripheral nervous system axon ensheathment
GO:0042063 gliogenesis
GO:0042552 myelination
GO:0044057 regulation of system process
GO:0051962 positive regulation of nervous system development
Molecular Function GO:0019911 structural constituent of myelin sheath
Cellular Component GO:0030424 axon
GO:0033267 axon part
GO:0033270 paranode region of axon
GO:0043209 myelin sheath
GO:0043218 compact myelin
GO:0043220 Schmidt-Lanterman incisure
GO:0044304 main axon
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolNCMAP
Namenoncompact myelin associated protein
Aliases FLJ42528; MP11; myelin protein of 11 kDa; C1orf130; chromosome 1 open reading frame 130; Noncompact myelin-a ......
Chromosomal Location1p36.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between NCMAP and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolNCMAP
Namenoncompact myelin associated protein
Aliases FLJ42528; MP11; myelin protein of 11 kDa; C1orf130; chromosome 1 open reading frame 130; Noncompact myelin-a ......
Chromosomal Location1p36.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of NCMAP in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolNCMAP
Namenoncompact myelin associated protein
Aliases FLJ42528; MP11; myelin protein of 11 kDa; C1orf130; chromosome 1 open reading frame 130; Noncompact myelin-a ......
Chromosomal Location1p36.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of NCMAP in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.4770.129
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.9620.0911
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.1210.805
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.0870.786
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.5110.548
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.4470.66
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.6850.463
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.0770.96
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-1.4880.374
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.1440.779
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.2790.689
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.7380.00972
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolNCMAP
Namenoncompact myelin associated protein
Aliases FLJ42528; MP11; myelin protein of 11 kDa; C1orf130; chromosome 1 open reading frame 130; Noncompact myelin-a ......
Chromosomal Location1p36.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NCMAP. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolNCMAP
Namenoncompact myelin associated protein
Aliases FLJ42528; MP11; myelin protein of 11 kDa; C1orf130; chromosome 1 open reading frame 130; Noncompact myelin-a ......
Chromosomal Location1p36.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NCMAP. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NCMAP.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolNCMAP
Namenoncompact myelin associated protein
Aliases FLJ42528; MP11; myelin protein of 11 kDa; C1orf130; chromosome 1 open reading frame 130; Noncompact myelin-a ......
Chromosomal Location1p36.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NCMAP. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolNCMAP
Namenoncompact myelin associated protein
Aliases FLJ42528; MP11; myelin protein of 11 kDa; C1orf130; chromosome 1 open reading frame 130; Noncompact myelin-a ......
Chromosomal Location1p36.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of NCMAP expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolNCMAP
Namenoncompact myelin associated protein
Aliases FLJ42528; MP11; myelin protein of 11 kDa; C1orf130; chromosome 1 open reading frame 130; Noncompact myelin-a ......
Chromosomal Location1p36.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between NCMAP and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolNCMAP
Namenoncompact myelin associated protein
Aliases FLJ42528; MP11; myelin protein of 11 kDa; C1orf130; chromosome 1 open reading frame 130; Noncompact myelin-a ......
Chromosomal Location1p36.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting NCMAP collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.