TISIDB

Summary
Symbol	NCOR1
Name	nuclear receptor corepressor 1
Aliases	N-CoR; hCIT529I10; hN-CoR; KIAA1047; MGC104216; PPP1R109; thyroid hormone- and retinoic acid receptor-associ ......
Chromosomal Location	17p11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Nucleus
Domain	PF15784 G-protein pathway suppressor 2-interacting domain PF00249 Myb-like DNA-binding domain
Function	Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6.

> Gene Ontology [ TOP ]
Biological Process	GO:0000226 microtubule cytoskeleton organization GO:0001933 negative regulation of protein phosphorylation GO:0006090 pyruvate metabolic process GO:0006091 generation of precursor metabolites and energy GO:0006096 glycolytic process GO:0006109 regulation of carbohydrate metabolic process GO:0006110 regulation of glycolytic process GO:0006140 regulation of nucleotide metabolic process GO:0006165 nucleoside diphosphate phosphorylation GO:0006417 regulation of translation GO:0006732 coenzyme metabolic process GO:0006733 oxidoreduction coenzyme metabolic process GO:0006757 ATP generation from ADP GO:0006820 anion transport GO:0006869 lipid transport GO:0007051 spindle organization GO:0007254 JNK cascade GO:0007623 circadian rhythm GO:0009116 nucleoside metabolic process GO:0009118 regulation of nucleoside metabolic process GO:0009119 ribonucleoside metabolic process GO:0009123 nucleoside monophosphate metabolic process GO:0009126 purine nucleoside monophosphate metabolic process GO:0009132 nucleoside diphosphate metabolic process GO:0009135 purine nucleoside diphosphate metabolic process GO:0009141 nucleoside triphosphate metabolic process GO:0009144 purine nucleoside triphosphate metabolic process GO:0009150 purine ribonucleotide metabolic process GO:0009161 ribonucleoside monophosphate metabolic process GO:0009167 purine ribonucleoside monophosphate metabolic process GO:0009179 purine ribonucleoside diphosphate metabolic process GO:0009185 ribonucleoside diphosphate metabolic process GO:0009199 ribonucleoside triphosphate metabolic process GO:0009205 purine ribonucleoside triphosphate metabolic process GO:0009894 regulation of catabolic process GO:0010608 posttranscriptional regulation of gene expression GO:0010876 lipid localization GO:0015711 organic anion transport GO:0015718 monocarboxylic acid transport GO:0015908 fatty acid transport GO:0016052 carbohydrate catabolic process GO:0016441 posttranscriptional gene silencing GO:0016458 gene silencing GO:0017148 negative regulation of translation GO:0019362 pyridine nucleotide metabolic process GO:0031047 gene silencing by RNA GO:0031050 dsRNA fragmentation GO:0031098 stress-activated protein kinase signaling cascade GO:0032368 regulation of lipid transport GO:0032872 regulation of stress-activated MAPK cascade GO:0032873 negative regulation of stress-activated MAPK cascade GO:0034248 regulation of cellular amide metabolic process GO:0034249 negative regulation of cellular amide metabolic process GO:0034250 positive regulation of cellular amide metabolic process GO:0035194 posttranscriptional gene silencing by RNA GO:0035195 gene silencing by miRNA GO:0035196 production of miRNAs involved in gene silencing by miRNA GO:0040029 regulation of gene expression, epigenetic GO:0042278 purine nucleoside metabolic process GO:0042326 negative regulation of phosphorylation GO:0043331 response to dsRNA GO:0043409 negative regulation of MAPK cascade GO:0043467 regulation of generation of precursor metabolites and energy GO:0043470 regulation of carbohydrate catabolic process GO:0044070 regulation of anion transport GO:0044723 single-organism carbohydrate metabolic process GO:0044724 single-organism carbohydrate catabolic process GO:0045727 positive regulation of translation GO:0046031 ADP metabolic process GO:0046034 ATP metabolic process GO:0046128 purine ribonucleoside metabolic process GO:0046328 regulation of JNK cascade GO:0046329 negative regulation of JNK cascade GO:0046496 nicotinamide nucleotide metabolic process GO:0046939 nucleotide phosphorylation GO:0046942 carboxylic acid transport GO:0048511 rhythmic process GO:0051186 cofactor metabolic process GO:0051193 regulation of cofactor metabolic process GO:0051196 regulation of coenzyme metabolic process GO:0051225 spindle assembly GO:0051403 stress-activated MAPK cascade GO:0060147 regulation of posttranscriptional gene silencing GO:0060149 negative regulation of posttranscriptional gene silencing GO:0060964 regulation of gene silencing by miRNA GO:0060965 negative regulation of gene silencing by miRNA GO:0060966 regulation of gene silencing by RNA GO:0060967 negative regulation of gene silencing by RNA GO:0060968 regulation of gene silencing GO:0060969 negative regulation of gene silencing GO:0070302 regulation of stress-activated protein kinase signaling cascade GO:0070303 negative regulation of stress-activated protein kinase signaling cascade GO:0070918 production of small RNA involved in gene silencing by RNA GO:0070920 regulation of production of small RNA involved in gene silencing by RNA GO:0071359 cellular response to dsRNA GO:0071407 cellular response to organic cyclic compound GO:0072361 regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter GO:0072362 regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter GO:0072367 regulation of lipid transport by regulation of transcription from RNA polymerase II promoter GO:0072368 regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter GO:0072524 pyridine-containing compound metabolic process GO:1900542 regulation of purine nucleotide metabolic process GO:1901657 glycosyl compound metabolic process GO:1902532 negative regulation of intracellular signal transduction GO:1903578 regulation of ATP metabolic process GO:1903798 regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:2000191 regulation of fatty acid transport
Molecular Function	GO:0001085 RNA polymerase II transcription factor binding GO:0001102 RNA polymerase II activating transcription factor binding GO:0003714 transcription corepressor activity GO:0008134 transcription factor binding GO:0016922 ligand-dependent nuclear receptor binding GO:0033613 activating transcription factor binding GO:0035257 nuclear hormone receptor binding GO:0042826 histone deacetylase binding GO:0046966 thyroid hormone receptor binding GO:0051427 hormone receptor binding
Cellular Component	GO:0000118 histone deacetylase complex GO:0000785 chromatin GO:0000790 nuclear chromatin GO:0005819 spindle GO:0005874 microtubule GO:0005876 spindle microtubule GO:0016580 Sin3 complex GO:0017053 transcriptional repressor complex GO:0044454 nuclear chromosome part GO:0070822 Sin3-type complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04919 Thyroid hormone signaling pathway
Reactome	R-HSA-5619507: Activation of HOX genes during differentiation R-HSA-5617472: Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-1368108: BMAL1 R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-400253: Circadian Clock R-HSA-2894862: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2644606: Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-1266738: Developmental Biology R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-2173795: Downregulation of SMAD2/3 R-HSA-535734: Fatty acid, triacylglycerol, and ketone body metabolism R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-3214815: HDACs deacetylate histones R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-1592230: Mitochondrial biogenesis R-HSA-2122947: NOTCH1 Intracellular Domain Regulates Transcription R-HSA-1368071: NR1D1 (REV-ERBA) represses gene expression R-HSA-1251985: Nuclear signaling by ERBB4 R-HSA-1852241: Organelle biogenesis and maintenance R-HSA-1989781: PPARA activates gene expression R-HSA-1368082: RORA activates gene expression R-HSA-400206: Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) R-HSA-162582: Signal Transduction R-HSA-1236394: Signaling by ERBB4 R-HSA-157118: Signaling by NOTCH R-HSA-1980143: Signaling by NOTCH1 R-HSA-2894858: Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2644602: Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644603: Signaling by NOTCH1 in Cancer R-HSA-170834: Signaling by TGF-beta Receptor Complex R-HSA-2151201: Transcriptional activation of mitochondrial biogenesis R-HSA-2173793: Transcriptional activity of SMAD2/SMAD3 R-HSA-381340: Transcriptional regulation of white adipocyte differentiation

> KEGG and Reactome Pathway

[ TOP ]

KEGG

hsa04919 Thyroid hormone signaling pathway

Reactome

R-HSA-5619507: Activation of HOX genes during differentiation
R-HSA-5617472: Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-1368108: BMAL1
R-HSA-3247509: Chromatin modifying enzymes
R-HSA-4839726: Chromatin organization
R-HSA-400253: Circadian Clock
R-HSA-2894862: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-2644606: Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-1266738: Developmental Biology
R-HSA-1643685: Disease
R-HSA-5663202: Diseases of signal transduction
R-HSA-2173795: Downregulation of SMAD2/3
R-HSA-535734: Fatty acid, triacylglycerol, and ketone body metabolism
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-3214815: HDACs deacetylate histones
R-HSA-1430728: Metabolism
R-HSA-556833: Metabolism of lipids and lipoproteins
R-HSA-1592230: Mitochondrial biogenesis
R-HSA-2122947: NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-1368071: NR1D1 (REV-ERBA) represses gene expression
R-HSA-1251985: Nuclear signaling by ERBB4
R-HSA-1852241: Organelle biogenesis and maintenance
R-HSA-1989781: PPARA activates gene expression
R-HSA-1368082: RORA activates gene expression
R-HSA-400206: Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-HSA-162582: Signal Transduction
R-HSA-1236394: Signaling by ERBB4
R-HSA-157118: Signaling by NOTCH
R-HSA-1980143: Signaling by NOTCH1
R-HSA-2894858: Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
R-HSA-2644602: Signaling by NOTCH1 PEST Domain Mutants in Cancer
R-HSA-2644603: Signaling by NOTCH1 in Cancer
R-HSA-170834: Signaling by TGF-beta Receptor Complex
R-HSA-2151201: Transcriptional activation of mitochondrial biogenesis
R-HSA-2173793: Transcriptional activity of SMAD2/SMAD3
R-HSA-381340: Transcriptional regulation of white adipocyte differentiation

Summary
Symbol	NCOR1
Name	nuclear receptor corepressor 1
Aliases	N-CoR; hCIT529I10; hN-CoR; KIAA1047; MGC104216; PPP1R109; thyroid hormone- and retinoic acid receptor-associ ......
Chromosomal Location	17p11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between NCOR1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining

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Literatures describing the relation between NCOR1 and anti-tumor immunity in human cancer.

PMID	Cancer type	Relation to immunity	Evidence sentences
23312906	Glioma; Mesothelioma	Promote immunity	In two non epithelial cancers (glioma and mesothelioma), we found that the epigenetic regulation of the NY-ESO1 gene requires the sequential recruitment of the HDAC1-mSin3a-NCOR, Dnmt3b-HDAC1-Egr1 and Dnmt1-PCNA-UHRF1-G9a complexes.The NY-ESO1 gene is a cancer/testis antigen considered to be suitable target for the immunotherapy of human malignancies.

Summary
Symbol	NCOR1
Name	nuclear receptor corepressor 1
Aliases	N-CoR; hCIT529I10; hN-CoR; KIAA1047; MGC104216; PPP1R109; thyroid hormone- and retinoic acid receptor-associ ......
Chromosomal Location	17p11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of NCOR1 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	NCOR1
Name	nuclear receptor corepressor 1
Aliases	N-CoR; hCIT529I10; hN-CoR; KIAA1047; MGC104216; PPP1R109; thyroid hormone- and retinoic acid receptor-associ ......
Chromosomal Location	17p11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of NCOR1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.118	0.669
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.051	0.973
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.175	0.89
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.178	0.534
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.076	0.978
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.309	0.932
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.233	0.543
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.46	0.805
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.05	0.981
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.054	0.974
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	-0.346	0.895
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.008	0.878

> Mutation difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the mutation difference of NCOR1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	7.1	5.9	1.2	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	10	33.3	-23.3	0.423
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	7.4	4.1	3.3	0.61
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	7.4	5.1	2.3	0.647
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	9.5	0	9.5	0.492
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	12.5	0	12.5	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	7.7	0	7.7	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	11.1	0	11.1	0.36
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	25	0	25	0.364
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	10.5	0	10.5	0.135
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	9.1	0	9.1	0.519
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	12.5	0	12.5	0.485
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	NCOR1
Name	nuclear receptor corepressor 1
Aliases	N-CoR; hCIT529I10; hN-CoR; KIAA1047; MGC104216; PPP1R109; thyroid hormone- and retinoic acid receptor-associ ......
Chromosomal Location	17p11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NCOR1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	NCOR1
Name	nuclear receptor corepressor 1
Aliases	N-CoR; hCIT529I10; hN-CoR; KIAA1047; MGC104216; PPP1R109; thyroid hormone- and retinoic acid receptor-associ ......
Chromosomal Location	17p11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NCOR1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NCOR1. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	NCOR1
Name	nuclear receptor corepressor 1
Aliases	N-CoR; hCIT529I10; hN-CoR; KIAA1047; MGC104216; PPP1R109; thyroid hormone- and retinoic acid receptor-associ ......
Chromosomal Location	17p11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NCOR1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	NCOR1
Name	nuclear receptor corepressor 1
Aliases	N-CoR; hCIT529I10; hN-CoR; KIAA1047; MGC104216; PPP1R109; thyroid hormone- and retinoic acid receptor-associ ......
Chromosomal Location	17p11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of NCOR1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	NCOR1
Name	nuclear receptor corepressor 1
Aliases	N-CoR; hCIT529I10; hN-CoR; KIAA1047; MGC104216; PPP1R109; thyroid hormone- and retinoic acid receptor-associ ......
Chromosomal Location	17p11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between NCOR1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	NCOR1
Name	nuclear receptor corepressor 1
Aliases	N-CoR; hCIT529I10; hN-CoR; KIAA1047; MGC104216; PPP1R109; thyroid hormone- and retinoic acid receptor-associ ......
Chromosomal Location	17p11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting NCOR1 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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