Browse NEK11

Summary
SymbolNEK11
NameNIMA-related kinase 11
Aliases FLJ23495; NIMA (never in mitosis gene a)- related kinase 11; NimA-related protein kinase 11; Never in mitosi ......
Chromosomal Location3q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus. Nucleus, nucleolus. Note=Nuclear during interphase but moves to the polar microtubules during prometaphase and metaphase. Accumulates in the nucleolus in G1/S-arrested cells.
Domain PF00069 Protein kinase domain
Function

Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation.

> Gene Ontology
 
Biological Process GO:0000075 cell cycle checkpoint
GO:0000077 DNA damage checkpoint
GO:0007093 mitotic cell cycle checkpoint
GO:0007346 regulation of mitotic cell cycle
GO:0016570 histone modification
GO:0016572 histone phosphorylation
GO:0031570 DNA integrity checkpoint
GO:0031572 G2 DNA damage checkpoint
GO:0031573 intra-S DNA damage checkpoint
GO:0044770 cell cycle phase transition
GO:0044772 mitotic cell cycle phase transition
GO:0044773 mitotic DNA damage checkpoint
GO:0044774 mitotic DNA integrity checkpoint
GO:0045786 negative regulation of cell cycle
GO:0045930 negative regulation of mitotic cell cycle
GO:1901987 regulation of cell cycle phase transition
GO:1901990 regulation of mitotic cell cycle phase transition
Molecular Function GO:0004674 protein serine/threonine kinase activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolNEK11
NameNIMA-related kinase 11
Aliases FLJ23495; NIMA (never in mitosis gene a)- related kinase 11; NimA-related protein kinase 11; Never in mitosi ......
Chromosomal Location3q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between NEK11 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolNEK11
NameNIMA-related kinase 11
Aliases FLJ23495; NIMA (never in mitosis gene a)- related kinase 11; NimA-related protein kinase 11; Never in mitosi ......
Chromosomal Location3q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of NEK11 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen Total # shRNA with >= 4-fold: 1 Resistant to T-cell proliferation
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolNEK11
NameNIMA-related kinase 11
Aliases FLJ23495; NIMA (never in mitosis gene a)- related kinase 11; NimA-related protein kinase 11; Never in mitosi ......
Chromosomal Location3q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of NEK11 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.2010.471
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.6120.379
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.1050.833
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.1670.566
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.4720.749
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.2210.902
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0790.773
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.1190.873
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.0880.92
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.050.963
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.4340.765
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.1780.0485
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of NEK11 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.41.460.177
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.41.75.70.231
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.509.50.492
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolNEK11
NameNIMA-related kinase 11
Aliases FLJ23495; NIMA (never in mitosis gene a)- related kinase 11; NimA-related protein kinase 11; Never in mitosi ......
Chromosomal Location3q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NEK11. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolNEK11
NameNIMA-related kinase 11
Aliases FLJ23495; NIMA (never in mitosis gene a)- related kinase 11; NimA-related protein kinase 11; Never in mitosi ......
Chromosomal Location3q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NEK11. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NEK11.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolNEK11
NameNIMA-related kinase 11
Aliases FLJ23495; NIMA (never in mitosis gene a)- related kinase 11; NimA-related protein kinase 11; Never in mitosi ......
Chromosomal Location3q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NEK11. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolNEK11
NameNIMA-related kinase 11
Aliases FLJ23495; NIMA (never in mitosis gene a)- related kinase 11; NimA-related protein kinase 11; Never in mitosi ......
Chromosomal Location3q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of NEK11 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolNEK11
NameNIMA-related kinase 11
Aliases FLJ23495; NIMA (never in mitosis gene a)- related kinase 11; NimA-related protein kinase 11; Never in mitosi ......
Chromosomal Location3q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between NEK11 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolNEK11
NameNIMA-related kinase 11
Aliases FLJ23495; NIMA (never in mitosis gene a)- related kinase 11; NimA-related protein kinase 11; Never in mitosi ......
Chromosomal Location3q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting NEK11 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting NEK11.
ID Name Drug Type Targets #Targets
DB08912DabrafenibSmall MoleculeBRAF, LIMK1, NEK11, RAF1, SIK15