Browse NEURL1

Summary
SymbolNEURL1
Nameneuralized E3 ubiquitin protein ligase 1
Aliases h-neu; RNF67; neu-1; NEURL; neuralized (Drosophila)-like; neuralized-like (Drosophila); neuralized homolog ( ......
Chromosomal Location10q25.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm, perinuclear region Cell membrane Peripheral membrane protein Perikaryon Cell projection, dendrite Cell junction, synapse, postsynaptic cell membrane, postsynaptic density Note=Localized in the cell bodies of the pyramidal neurons and distributed along their apical dendrites. Colocalized with PSD95 in postsynaptic sites. Colocalized with CPEB3 at apical dendrites of CA1 neurons (By similarity). Colocalized with JAG1 at the cell surface.
Domain PF07177 Neuralized
Function

Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway.

> Gene Ontology
 
Biological Process GO:0000226 microtubule cytoskeleton organization
GO:0001101 response to acid chemical
GO:0001578 microtubule bundle formation
GO:0006417 regulation of translation
GO:0006513 protein monoubiquitination
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007176 regulation of epidermal growth factor-activated receptor activity
GO:0007219 Notch signaling pathway
GO:0007281 germ cell development
GO:0007283 spermatogenesis
GO:0007286 spermatid development
GO:0007288 sperm axoneme assembly
GO:0007517 muscle organ development
GO:0007519 skeletal muscle tissue development
GO:0007589 body fluid secretion
GO:0007595 lactation
GO:0008593 regulation of Notch signaling pathway
GO:0010469 regulation of receptor activity
GO:0010608 posttranscriptional regulation of gene expression
GO:0010720 positive regulation of cell development
GO:0010927 cellular component assembly involved in morphogenesis
GO:0010975 regulation of neuron projection development
GO:0010976 positive regulation of neuron projection development
GO:0014706 striated muscle tissue development
GO:0016358 dendrite development
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0018212 peptidyl-tyrosine modification
GO:0021700 developmental maturation
GO:0022412 cellular process involved in reproduction in multicellular organism
GO:0030031 cell projection assembly
GO:0030317 flagellated sperm motility
GO:0030879 mammary gland development
GO:0031346 positive regulation of cell projection organization
GO:0032941 secretion by tissue
GO:0033674 positive regulation of kinase activity
GO:0034248 regulation of cellular amide metabolic process
GO:0035082 axoneme assembly
GO:0038127 ERBB signaling pathway
GO:0042058 regulation of epidermal growth factor receptor signaling pathway
GO:0042384 cilium assembly
GO:0043200 response to amino acid
GO:0044089 positive regulation of cellular component biogenesis
GO:0044782 cilium organization
GO:0045666 positive regulation of neuron differentiation
GO:0045741 positive regulation of epidermal growth factor-activated receptor activity
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway
GO:0045746 negative regulation of Notch signaling pathway
GO:0045860 positive regulation of protein kinase activity
GO:0046847 filopodium assembly
GO:0048167 regulation of synaptic plasticity
GO:0048168 regulation of neuronal synaptic plasticity
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0048170 positive regulation of long-term neuronal synaptic plasticity
GO:0048232 male gamete generation
GO:0048515 spermatid differentiation
GO:0048732 gland development
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050769 positive regulation of neurogenesis
GO:0050773 regulation of dendrite development
GO:0050803 regulation of synapse structure or activity
GO:0050804 modulation of synaptic transmission
GO:0050807 regulation of synapse organization
GO:0050808 synapse organization
GO:0050878 regulation of body fluid levels
GO:0051489 regulation of filopodium assembly
GO:0051491 positive regulation of filopodium assembly
GO:0051962 positive regulation of nervous system development
GO:0060074 synapse maturation
GO:0060271 cilium morphogenesis
GO:0060491 regulation of cell projection assembly
GO:0060537 muscle tissue development
GO:0060538 skeletal muscle organ development
GO:0060996 dendritic spine development
GO:0060998 regulation of dendritic spine development
GO:0060999 positive regulation of dendritic spine development
GO:0061097 regulation of protein tyrosine kinase activity
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0071229 cellular response to acid chemical
GO:0071230 cellular response to amino acid stimulus
GO:0071417 cellular response to organonitrogen compound
GO:0090128 regulation of synapse maturation
GO:0090129 positive regulation of synapse maturation
GO:0097722 sperm motility
GO:1900006 positive regulation of dendrite development
GO:1901184 regulation of ERBB signaling pathway
GO:1901186 positive regulation of ERBB signaling pathway
GO:2000273 positive regulation of receptor activity
Molecular Function GO:0004842 ubiquitin-protein transferase activity
GO:0016874 ligase activity
GO:0019787 ubiquitin-like protein transferase activity
GO:0045182 translation regulator activity
GO:0045183 translation factor activity, non-nucleic acid binding
GO:0061630 ubiquitin protein ligase activity
GO:0061659 ubiquitin-like protein ligase activity
Cellular Component GO:0014069 postsynaptic density
GO:0030425 dendrite
GO:0043025 neuronal cell body
GO:0043197 dendritic spine
GO:0043204 perikaryon
GO:0044297 cell body
GO:0044309 neuron spine
GO:0045211 postsynaptic membrane
GO:0060076 excitatory synapse
GO:0097060 synaptic membrane
GO:0097440 apical dendrite
GO:0098794 postsynapse
GO:0099572 postsynaptic specialization
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-2122948: Activated NOTCH1 Transmits Signal to the Nucleus
R-HSA-2691232: Constitutive Signaling by NOTCH1 HD Domain Mutants
R-HSA-2894862: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-2644606: Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-1643685: Disease
R-HSA-5663202: Diseases of signal transduction
R-HSA-2979096: NOTCH2 Activation and Transmission of Signal to the Nucleus
R-HSA-162582: Signal Transduction
R-HSA-157118: Signaling by NOTCH
R-HSA-1980143: Signaling by NOTCH1
R-HSA-2691230: Signaling by NOTCH1 HD Domain Mutants in Cancer
R-HSA-2894858: Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
R-HSA-2644602: Signaling by NOTCH1 PEST Domain Mutants in Cancer
R-HSA-2644603: Signaling by NOTCH1 in Cancer
R-HSA-1980145: Signaling by NOTCH2
Summary
SymbolNEURL1
Nameneuralized E3 ubiquitin protein ligase 1
Aliases h-neu; RNF67; neu-1; NEURL; neuralized (Drosophila)-like; neuralized-like (Drosophila); neuralized homolog ( ......
Chromosomal Location10q25.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between NEURL1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolNEURL1
Nameneuralized E3 ubiquitin protein ligase 1
Aliases h-neu; RNF67; neu-1; NEURL; neuralized (Drosophila)-like; neuralized-like (Drosophila); neuralized homolog ( ......
Chromosomal Location10q25.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of NEURL1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolNEURL1
Nameneuralized E3 ubiquitin protein ligase 1
Aliases h-neu; RNF67; neu-1; NEURL; neuralized (Drosophila)-like; neuralized-like (Drosophila); neuralized homolog ( ......
Chromosomal Location10q25.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of NEURL1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.8740.0444
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.3450.0609
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.5320.396
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.5210.356
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.4960.768
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-1.8050.378
729033130MelanomaallAnti-PD-1 (nivolumab) 26231.1380.0678
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15111.3240.149
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11121.0370.298
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.3740.471
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.6290.368
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.4770.104
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of NEURL1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277302.7-2.71
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275903.4-3.41
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.305.30.507
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolNEURL1
Nameneuralized E3 ubiquitin protein ligase 1
Aliases h-neu; RNF67; neu-1; NEURL; neuralized (Drosophila)-like; neuralized-like (Drosophila); neuralized homolog ( ......
Chromosomal Location10q25.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NEURL1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolNEURL1
Nameneuralized E3 ubiquitin protein ligase 1
Aliases h-neu; RNF67; neu-1; NEURL; neuralized (Drosophila)-like; neuralized-like (Drosophila); neuralized homolog ( ......
Chromosomal Location10q25.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NEURL1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NEURL1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolNEURL1
Nameneuralized E3 ubiquitin protein ligase 1
Aliases h-neu; RNF67; neu-1; NEURL; neuralized (Drosophila)-like; neuralized-like (Drosophila); neuralized homolog ( ......
Chromosomal Location10q25.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NEURL1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolNEURL1
Nameneuralized E3 ubiquitin protein ligase 1
Aliases h-neu; RNF67; neu-1; NEURL; neuralized (Drosophila)-like; neuralized-like (Drosophila); neuralized homolog ( ......
Chromosomal Location10q25.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of NEURL1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolNEURL1
Nameneuralized E3 ubiquitin protein ligase 1
Aliases h-neu; RNF67; neu-1; NEURL; neuralized (Drosophila)-like; neuralized-like (Drosophila); neuralized homolog ( ......
Chromosomal Location10q25.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between NEURL1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolNEURL1
Nameneuralized E3 ubiquitin protein ligase 1
Aliases h-neu; RNF67; neu-1; NEURL; neuralized (Drosophila)-like; neuralized-like (Drosophila); neuralized homolog ( ......
Chromosomal Location10q25.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting NEURL1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.