Browse NEUROD1

Summary
SymbolNEUROD1
Nameneuronal differentiation 1
Aliases BHF-1; NeuroD; bHLHa3; MODY6; beta-cell E-box transactivator 2; neurogenic helix-loop-helix protein NEUROD; ......
Chromosomal Location2q32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm Nucleus Note=In pancreatic islet cells, shuttles to the nucleus in response to glucose stimulation (By similarity). Colocalizes with NR0B2 in the nucleus.
Domain PF00010 Helix-loop-helix DNA-binding domain
PF12533 Neuronal helix-loop-helix transcription factor
Function

Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity).

> Gene Ontology
 
Biological Process GO:0001654 eye development
GO:0001678 cellular glucose homeostasis
GO:0001894 tissue homeostasis
GO:0002065 columnar/cuboidal epithelial cell differentiation
GO:0002067 glandular epithelial cell differentiation
GO:0002790 peptide secretion
GO:0002791 regulation of peptide secretion
GO:0003002 regionalization
GO:0003310 pancreatic A cell differentiation
GO:0003312 pancreatic PP cell differentiation
GO:0003326 pancreatic A cell fate commitment
GO:0003329 pancreatic PP cell fate commitment
GO:0003407 neural retina development
GO:0006913 nucleocytoplasmic transport
GO:0007050 cell cycle arrest
GO:0007259 JAK-STAT cascade
GO:0007263 nitric oxide mediated signal transduction
GO:0007389 pattern specification process
GO:0007423 sensory organ development
GO:0007586 digestion
GO:0009306 protein secretion
GO:0009743 response to carbohydrate
GO:0009746 response to hexose
GO:0009749 response to glucose
GO:0009914 hormone transport
GO:0009952 anterior/posterior pattern specification
GO:0010669 epithelial structure maintenance
GO:0010720 positive regulation of cell development
GO:0010817 regulation of hormone levels
GO:0015833 peptide transport
GO:0019932 second-messenger-mediated signaling
GO:0021537 telencephalon development
GO:0021542 dentate gyrus development
GO:0021543 pallium development
GO:0021549 cerebellum development
GO:0021761 limbic system development
GO:0021766 hippocampus development
GO:0022037 metencephalon development
GO:0022600 digestive system process
GO:0023019 signal transduction involved in regulation of gene expression
GO:0023061 signal release
GO:0030072 peptide hormone secretion
GO:0030073 insulin secretion
GO:0030277 maintenance of gastrointestinal epithelium
GO:0030900 forebrain development
GO:0030902 hindbrain development
GO:0031016 pancreas development
GO:0031018 endocrine pancreas development
GO:0032844 regulation of homeostatic process
GO:0033500 carbohydrate homeostasis
GO:0034284 response to monosaccharide
GO:0035270 endocrine system development
GO:0035881 amacrine cell differentiation
GO:0035883 enteroendocrine cell differentiation
GO:0042493 response to drug
GO:0042593 glucose homeostasis
GO:0042886 amide transport
GO:0043010 camera-type eye development
GO:0043388 positive regulation of DNA binding
GO:0043583 ear development
GO:0044057 regulation of system process
GO:0044058 regulation of digestive system process
GO:0045165 cell fate commitment
GO:0045666 positive regulation of neuron differentiation
GO:0045786 negative regulation of cell cycle
GO:0046425 regulation of JAK-STAT cascade
GO:0046426 negative regulation of JAK-STAT cascade
GO:0046879 hormone secretion
GO:0046883 regulation of hormone secretion
GO:0048562 embryonic organ morphogenesis
GO:0048568 embryonic organ development
GO:0048839 inner ear development
GO:0048871 multicellular organismal homeostasis
GO:0050708 regulation of protein secretion
GO:0050769 positive regulation of neurogenesis
GO:0050796 regulation of insulin secretion
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051098 regulation of binding
GO:0051099 positive regulation of binding
GO:0051101 regulation of DNA binding
GO:0051169 nuclear transport
GO:0051962 positive regulation of nervous system development
GO:0060041 retina development in camera-type eye
GO:0060249 anatomical structure homeostasis
GO:0060729 intestinal epithelial structure maintenance
GO:0060730 regulation of intestinal epithelial structure maintenance
GO:0071156 regulation of cell cycle arrest
GO:0071322 cellular response to carbohydrate stimulus
GO:0071326 cellular response to monosaccharide stimulus
GO:0071331 cellular response to hexose stimulus
GO:0071333 cellular response to glucose stimulus
GO:0072148 epithelial cell fate commitment
GO:0090087 regulation of peptide transport
GO:0090276 regulation of peptide hormone secretion
GO:0097050 type B pancreatic cell apoptotic process
GO:0097696 STAT cascade
GO:1902532 negative regulation of intracellular signal transduction
GO:1904019 epithelial cell apoptotic process
GO:1904035 regulation of epithelial cell apoptotic process
GO:1904036 negative regulation of epithelial cell apoptotic process
GO:1904892 regulation of STAT cascade
GO:1904893 negative regulation of STAT cascade
GO:2000674 regulation of type B pancreatic cell apoptotic process
GO:2000675 negative regulation of type B pancreatic cell apoptotic process
GO:2000677 regulation of transcription regulatory region DNA binding
GO:2000679 positive regulation of transcription regulatory region DNA binding
Molecular Function GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0000987 core promoter proximal region sequence-specific DNA binding
GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001085 RNA polymerase II transcription factor binding
GO:0001102 RNA polymerase II activating transcription factor binding
GO:0001104 RNA polymerase II transcription cofactor activity
GO:0001105 RNA polymerase II transcription coactivator activity
GO:0001159 core promoter proximal region DNA binding
GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003682 chromatin binding
GO:0003713 transcription coactivator activity
GO:0008134 transcription factor binding
GO:0033613 activating transcription factor binding
GO:0046982 protein heterodimerization activity
GO:0070888 E-box binding
GO:0098811 transcriptional repressor activity, RNA polymerase II activating transcription factor binding
Cellular Component GO:0005667 transcription factor complex
GO:0044798 nuclear transcription factor complex
GO:0090575 RNA polymerase II transcription factor complex
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-1266738: Developmental Biology
R-HSA-186712: Regulation of beta-cell development
R-HSA-210745: Regulation of gene expression in beta cells
R-HSA-210746: Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells
Summary
SymbolNEUROD1
Nameneuronal differentiation 1
Aliases BHF-1; NeuroD; bHLHa3; MODY6; beta-cell E-box transactivator 2; neurogenic helix-loop-helix protein NEUROD; ......
Chromosomal Location2q32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between NEUROD1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolNEUROD1
Nameneuronal differentiation 1
Aliases BHF-1; NeuroD; bHLHa3; MODY6; beta-cell E-box transactivator 2; neurogenic helix-loop-helix protein NEUROD; ......
Chromosomal Location2q32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of NEUROD1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolNEUROD1
Nameneuronal differentiation 1
Aliases BHF-1; NeuroD; bHLHa3; MODY6; beta-cell E-box transactivator 2; neurogenic helix-loop-helix protein NEUROD; ......
Chromosomal Location2q32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of NEUROD1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)141201
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.1530.859
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.6920.654
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.5350.757
729033130MelanomaallAnti-PD-1 (nivolumab) 262301
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 151101
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 111201
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.2140.657
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.2140.761
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.6110.000373
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of NEUROD1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.407.40.0709
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.407.40.096
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59200200.357
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 111307.7-7.71
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 51208.3-8.31
Summary
SymbolNEUROD1
Nameneuronal differentiation 1
Aliases BHF-1; NeuroD; bHLHa3; MODY6; beta-cell E-box transactivator 2; neurogenic helix-loop-helix protein NEUROD; ......
Chromosomal Location2q32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NEUROD1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolNEUROD1
Nameneuronal differentiation 1
Aliases BHF-1; NeuroD; bHLHa3; MODY6; beta-cell E-box transactivator 2; neurogenic helix-loop-helix protein NEUROD; ......
Chromosomal Location2q32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NEUROD1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NEUROD1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolNEUROD1
Nameneuronal differentiation 1
Aliases BHF-1; NeuroD; bHLHa3; MODY6; beta-cell E-box transactivator 2; neurogenic helix-loop-helix protein NEUROD; ......
Chromosomal Location2q32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NEUROD1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolNEUROD1
Nameneuronal differentiation 1
Aliases BHF-1; NeuroD; bHLHa3; MODY6; beta-cell E-box transactivator 2; neurogenic helix-loop-helix protein NEUROD; ......
Chromosomal Location2q32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of NEUROD1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolNEUROD1
Nameneuronal differentiation 1
Aliases BHF-1; NeuroD; bHLHa3; MODY6; beta-cell E-box transactivator 2; neurogenic helix-loop-helix protein NEUROD; ......
Chromosomal Location2q32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between NEUROD1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolNEUROD1
Nameneuronal differentiation 1
Aliases BHF-1; NeuroD; bHLHa3; MODY6; beta-cell E-box transactivator 2; neurogenic helix-loop-helix protein NEUROD; ......
Chromosomal Location2q32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting NEUROD1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.