Browse NF1

Summary
SymbolNF1
Nameneurofibromin 1
Aliases neurofibromatosis; von Recklinghausen disease; Watson disease; NFNS; VRNF; neurofibromatosis-related protein ......
Chromosomal Location17q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus Nucleus, nucleolus
Domain PF13716 Divergent CRAL/TRIO domain
PF00616 GTPase-activator protein for Ras-like GTPase
Function

Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity.

> Gene Ontology
 
Biological Process GO:0001503 ossification
GO:0001505 regulation of neurotransmitter levels
GO:0001525 angiogenesis
GO:0001649 osteoblast differentiation
GO:0001654 eye development
GO:0001655 urogenital system development
GO:0001656 metanephros development
GO:0001666 response to hypoxia
GO:0001667 ameboidal-type cell migration
GO:0001822 kidney development
GO:0001889 liver development
GO:0001894 tissue homeostasis
GO:0001933 negative regulation of protein phosphorylation
GO:0001935 endothelial cell proliferation
GO:0001936 regulation of endothelial cell proliferation
GO:0001937 negative regulation of endothelial cell proliferation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0001952 regulation of cell-matrix adhesion
GO:0001953 negative regulation of cell-matrix adhesion
GO:0002521 leukocyte differentiation
GO:0002573 myeloid leukocyte differentiation
GO:0002683 negative regulation of immune system process
GO:0002761 regulation of myeloid leukocyte differentiation
GO:0002762 negative regulation of myeloid leukocyte differentiation
GO:0006140 regulation of nucleotide metabolic process
GO:0006164 purine nucleotide biosynthetic process
GO:0006171 cAMP biosynthetic process
GO:0006469 negative regulation of protein kinase activity
GO:0006606 protein import into nucleus
GO:0006820 anion transport
GO:0006835 dicarboxylic acid transport
GO:0006836 neurotransmitter transport
GO:0006913 nucleocytoplasmic transport
GO:0007160 cell-matrix adhesion
GO:0007162 negative regulation of cell adhesion
GO:0007265 Ras protein signal transduction
GO:0007269 neurotransmitter secretion
GO:0007270 neuron-neuron synaptic transmission
GO:0007272 ensheathment of neurons
GO:0007405 neuroblast proliferation
GO:0007406 negative regulation of neuroblast proliferation
GO:0007422 peripheral nervous system development
GO:0007423 sensory organ development
GO:0007507 heart development
GO:0007517 muscle organ development
GO:0007519 skeletal muscle tissue development
GO:0007611 learning or memory
GO:0007612 learning
GO:0007632 visual behavior
GO:0008306 associative learning
GO:0008366 axon ensheathment
GO:0008542 visual learning
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0009150 purine ribonucleotide metabolic process
GO:0009152 purine ribonucleotide biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0009187 cyclic nucleotide metabolic process
GO:0009190 cyclic nucleotide biosynthetic process
GO:0009260 ribonucleotide biosynthetic process
GO:0009266 response to temperature stimulus
GO:0009314 response to radiation
GO:0009408 response to heat
GO:0009416 response to light stimulus
GO:0010001 glial cell differentiation
GO:0010594 regulation of endothelial cell migration
GO:0010631 epithelial cell migration
GO:0010632 regulation of epithelial cell migration
GO:0010721 negative regulation of cell development
GO:0010810 regulation of cell-substrate adhesion
GO:0010812 negative regulation of cell-substrate adhesion
GO:0014002 astrocyte development
GO:0014013 regulation of gliogenesis
GO:0014014 negative regulation of gliogenesis
GO:0014037 Schwann cell differentiation
GO:0014044 Schwann cell development
GO:0014047 glutamate secretion
GO:0014051 gamma-aminobutyric acid secretion
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0014706 striated muscle tissue development
GO:0015711 organic anion transport
GO:0015812 gamma-aminobutyric acid transport
GO:0016525 negative regulation of angiogenesis
GO:0016601 Rac protein signal transduction
GO:0017038 protein import
GO:0021510 spinal cord development
GO:0021537 telencephalon development
GO:0021543 pallium development
GO:0021761 limbic system development
GO:0021764 amygdala development
GO:0021782 glial cell development
GO:0021896 forebrain astrocyte differentiation
GO:0021897 forebrain astrocyte development
GO:0021915 neural tube development
GO:0021987 cerebral cortex development
GO:0022011 myelination in peripheral nervous system
GO:0023061 signal release
GO:0030099 myeloid cell differentiation
GO:0030198 extracellular matrix organization
GO:0030199 collagen fibril organization
GO:0030316 osteoclast differentiation
GO:0030325 adrenal gland development
GO:0030336 negative regulation of cell migration
GO:0030799 regulation of cyclic nucleotide metabolic process
GO:0030801 positive regulation of cyclic nucleotide metabolic process
GO:0030802 regulation of cyclic nucleotide biosynthetic process
GO:0030804 positive regulation of cyclic nucleotide biosynthetic process
GO:0030808 regulation of nucleotide biosynthetic process
GO:0030810 positive regulation of nucleotide biosynthetic process
GO:0030814 regulation of cAMP metabolic process
GO:0030816 positive regulation of cAMP metabolic process
GO:0030817 regulation of cAMP biosynthetic process
GO:0030819 positive regulation of cAMP biosynthetic process
GO:0030900 forebrain development
GO:0031279 regulation of cyclase activity
GO:0031281 positive regulation of cyclase activity
GO:0031589 cell-substrate adhesion
GO:0032228 regulation of synaptic transmission, GABAergic
GO:0032292 peripheral nervous system axon ensheathment
GO:0032386 regulation of intracellular transport
GO:0032387 negative regulation of intracellular transport
GO:0032844 regulation of homeostatic process
GO:0033157 regulation of intracellular protein transport
GO:0033673 negative regulation of kinase activity
GO:0034103 regulation of tissue remodeling
GO:0034504 protein localization to nucleus
GO:0034605 cellular response to heat
GO:0035020 regulation of Rac protein signal transduction
GO:0035021 negative regulation of Rac protein signal transduction
GO:0035249 synaptic transmission, glutamatergic
GO:0035270 endocrine system development
GO:0036293 response to decreased oxygen levels
GO:0038034 signal transduction in absence of ligand
GO:0040013 negative regulation of locomotion
GO:0042063 gliogenesis
GO:0042306 regulation of protein import into nucleus
GO:0042308 negative regulation of protein import into nucleus
GO:0042326 negative regulation of phosphorylation
GO:0042552 myelination
GO:0042990 regulation of transcription factor import into nucleus
GO:0042991 transcription factor import into nucleus
GO:0042992 negative regulation of transcription factor import into nucleus
GO:0043010 camera-type eye development
GO:0043062 extracellular structure organization
GO:0043405 regulation of MAP kinase activity
GO:0043407 negative regulation of MAP kinase activity
GO:0043409 negative regulation of MAPK cascade
GO:0043473 pigmentation
GO:0043523 regulation of neuron apoptotic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0043534 blood vessel endothelial cell migration
GO:0043535 regulation of blood vessel endothelial cell migration
GO:0043542 endothelial cell migration
GO:0044708 single-organism behavior
GO:0044744 protein targeting to nucleus
GO:0045124 regulation of bone resorption
GO:0045453 bone resorption
GO:0045637 regulation of myeloid cell differentiation
GO:0045638 negative regulation of myeloid cell differentiation
GO:0045670 regulation of osteoclast differentiation
GO:0045671 negative regulation of osteoclast differentiation
GO:0045685 regulation of glial cell differentiation
GO:0045686 negative regulation of glial cell differentiation
GO:0045761 regulation of adenylate cyclase activity
GO:0045762 positive regulation of adenylate cyclase activity
GO:0045765 regulation of angiogenesis
GO:0045981 positive regulation of nucleotide metabolic process
GO:0046058 cAMP metabolic process
GO:0046390 ribose phosphate biosynthetic process
GO:0046578 regulation of Ras protein signal transduction
GO:0046580 negative regulation of Ras protein signal transduction
GO:0046717 acid secretion
GO:0046822 regulation of nucleocytoplasmic transport
GO:0046823 negative regulation of nucleocytoplasmic transport
GO:0046849 bone remodeling
GO:0046850 regulation of bone remodeling
GO:0046928 regulation of neurotransmitter secretion
GO:0046929 negative regulation of neurotransmitter secretion
GO:0046942 carboxylic acid transport
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048017 inositol lipid-mediated signaling
GO:0048144 fibroblast proliferation
GO:0048145 regulation of fibroblast proliferation
GO:0048147 negative regulation of fibroblast proliferation
GO:0048167 regulation of synaptic plasticity
GO:0048168 regulation of neuronal synaptic plasticity
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0048483 autonomic nervous system development
GO:0048485 sympathetic nervous system development
GO:0048514 blood vessel morphogenesis
GO:0048592 eye morphogenesis
GO:0048593 camera-type eye morphogenesis
GO:0048708 astrocyte differentiation
GO:0048709 oligodendrocyte differentiation
GO:0048710 regulation of astrocyte differentiation
GO:0048712 negative regulation of astrocyte differentiation
GO:0048713 regulation of oligodendrocyte differentiation
GO:0048715 negative regulation of oligodendrocyte differentiation
GO:0048732 gland development
GO:0048745 smooth muscle tissue development
GO:0048771 tissue remodeling
GO:0048844 artery morphogenesis
GO:0048853 forebrain morphogenesis
GO:0048854 brain morphogenesis
GO:0048871 multicellular organismal homeostasis
GO:0050673 epithelial cell proliferation
GO:0050678 regulation of epithelial cell proliferation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050768 negative regulation of neurogenesis
GO:0050804 modulation of synaptic transmission
GO:0050805 negative regulation of synaptic transmission
GO:0050806 positive regulation of synaptic transmission
GO:0050890 cognition
GO:0051048 negative regulation of secretion
GO:0051051 negative regulation of transport
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051058 negative regulation of small GTPase mediated signal transduction
GO:0051169 nuclear transport
GO:0051170 nuclear import
GO:0051224 negative regulation of protein transport
GO:0051271 negative regulation of cellular component movement
GO:0051339 regulation of lyase activity
GO:0051348 negative regulation of transferase activity
GO:0051349 positive regulation of lyase activity
GO:0051402 neuron apoptotic process
GO:0051588 regulation of neurotransmitter transport
GO:0051589 negative regulation of neurotransmitter transport
GO:0051932 synaptic transmission, GABAergic
GO:0051961 negative regulation of nervous system development
GO:0052652 cyclic purine nucleotide metabolic process
GO:0060249 anatomical structure homeostasis
GO:0060291 long-term synaptic potentiation
GO:0060537 muscle tissue development
GO:0060538 skeletal muscle organ development
GO:0060840 artery development
GO:0061008 hepaticobiliary system development
GO:0061351 neural precursor cell proliferation
GO:0061534 gamma-aminobutyric acid secretion, neurotransmission
GO:0061535 glutamate secretion, neurotransmission
GO:0070482 response to oxygen levels
GO:0070997 neuron death
GO:0071900 regulation of protein serine/threonine kinase activity
GO:0071901 negative regulation of protein serine/threonine kinase activity
GO:0072001 renal system development
GO:0072089 stem cell proliferation
GO:0072091 regulation of stem cell proliferation
GO:0072522 purine-containing compound biosynthetic process
GO:0090130 tissue migration
GO:0090132 epithelium migration
GO:0090317 negative regulation of intracellular protein transport
GO:0090596 sensory organ morphogenesis
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0098597 observational learning
GO:0099531 presynaptic process involved in chemical synaptic transmission
GO:0099643 signal release from synapse
GO:1900180 regulation of protein localization to nucleus
GO:1900181 negative regulation of protein localization to nucleus
GO:1900271 regulation of long-term synaptic potentiation
GO:1900371 regulation of purine nucleotide biosynthetic process
GO:1900373 positive regulation of purine nucleotide biosynthetic process
GO:1900542 regulation of purine nucleotide metabolic process
GO:1900544 positive regulation of purine nucleotide metabolic process
GO:1901214 regulation of neuron death
GO:1901216 positive regulation of neuron death
GO:1901293 nucleoside phosphate biosynthetic process
GO:1901342 regulation of vasculature development
GO:1901343 negative regulation of vasculature development
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902105 regulation of leukocyte differentiation
GO:1902106 negative regulation of leukocyte differentiation
GO:1902532 negative regulation of intracellular signal transduction
GO:1902593 single-organism nuclear import
GO:1902692 regulation of neuroblast proliferation
GO:1903531 negative regulation of secretion by cell
GO:1903533 regulation of protein targeting
GO:1903706 regulation of hemopoiesis
GO:1903707 negative regulation of hemopoiesis
GO:1903828 negative regulation of cellular protein localization
GO:1904589 regulation of protein import
GO:1904590 negative regulation of protein import
GO:1904950 negative regulation of establishment of protein localization
GO:2000146 negative regulation of cell motility
GO:2000177 regulation of neural precursor cell proliferation
GO:2000178 negative regulation of neural precursor cell proliferation
GO:2000181 negative regulation of blood vessel morphogenesis
GO:2000647 negative regulation of stem cell proliferation
GO:2001233 regulation of apoptotic signaling pathway
GO:2001235 positive regulation of apoptotic signaling pathway
GO:2001236 regulation of extrinsic apoptotic signaling pathway
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
Molecular Function GO:0005096 GTPase activator activity
GO:0005543 phospholipid binding
GO:0008047 enzyme activator activity
GO:0008429 phosphatidylethanolamine binding
GO:0030695 GTPase regulator activity
GO:0031210 phosphatidylcholine binding
GO:0060589 nucleoside-triphosphatase regulator activity
GO:0070405 ammonium ion binding
Cellular Component GO:0009898 cytoplasmic side of plasma membrane
GO:0030424 axon
GO:0030425 dendrite
GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane
GO:0098552 side of membrane
GO:0098562 cytoplasmic side of membrane
GO:0098793 presynapse
> KEGG and Reactome Pathway
 
KEGG hsa04010 MAPK signaling pathway
hsa04014 Ras signaling pathway
Reactome R-HSA-170984: ARMS-mediated activation
R-HSA-422475: Axon guidance
R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-2172127: DAP12 interactions
R-HSA-2424491: DAP12 signaling
R-HSA-1266738: Developmental Biology
R-HSA-1643685: Disease
R-HSA-5663202: Diseases of signal transduction
R-HSA-186763: Downstream signal transduction
R-HSA-2871796: FCERI mediated MAPK activation
R-HSA-2454202: Fc epsilon receptor (FCERI) signaling
R-HSA-170968: Frs2-mediated activation
R-HSA-179812: GRB2 events in EGFR signaling
R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK
R-HSA-2428924: IGF1R signaling cascade
R-HSA-112399: IRS-mediated signalling
R-HSA-2428928: IRS-related events triggered by IGF1R
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-74751: Insulin receptor signalling cascade
R-HSA-912526: Interleukin receptor SHC signaling
R-HSA-451927: Interleukin-2 signaling
R-HSA-512988: Interleukin-3, 5 and GM-CSF signaling
R-HSA-5683057: MAPK family signaling cascades
R-HSA-5684996: MAPK1/MAPK3 signaling
R-HSA-375165: NCAM signaling for neurite out-growth
R-HSA-187037: NGF signalling via TRKA from the plasma membrane
R-HSA-6802957: Oncogenic MAPK signaling
R-HSA-8849471: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
R-HSA-169893: Prolonged ERK activation events
R-HSA-5673001: RAF/MAP kinase cascade
R-HSA-6802953: RAS signaling downstream of NF1 loss-of-function variants
R-HSA-8853659: RET signaling
R-HSA-5658442: Regulation of RAS by GAPs
R-HSA-180336: SHC1 events in EGFR signaling
R-HSA-112412: SOS-mediated signalling
R-HSA-162582: Signal Transduction
R-HSA-177929: Signaling by EGFR
R-HSA-372790: Signaling by GPCR
R-HSA-74752: Signaling by Insulin receptor
R-HSA-449147: Signaling by Interleukins
R-HSA-2586552: Signaling by Leptin
R-HSA-186797: Signaling by PDGF
R-HSA-8848021: Signaling by PTK6
R-HSA-6802949: Signaling by RAS mutants
R-HSA-1433557: Signaling by SCF-KIT
R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
R-HSA-194138: Signaling by VEGF
R-HSA-166520: Signalling by NGF
R-HSA-187687: Signalling to ERKs
R-HSA-167044: Signalling to RAS
R-HSA-187706: Signalling to p38 via RIT and RIN
R-HSA-4420097: VEGFA-VEGFR2 Pathway
R-HSA-5218921: VEGFR2 mediated cell proliferation
Summary
SymbolNF1
Nameneurofibromin 1
Aliases neurofibromatosis; von Recklinghausen disease; Watson disease; NFNS; VRNF; neurofibromatosis-related protein ......
Chromosomal Location17q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between NF1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolNF1
Nameneurofibromin 1
Aliases neurofibromatosis; von Recklinghausen disease; Watson disease; NFNS; VRNF; neurofibromatosis-related protein ......
Chromosomal Location17q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of NF1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell logFC: 2.23; FDR: 0.000150 Sensitive to T cell-mediated killing
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell logFC: 1.27; FDR: 0.000381 Sensitive to T cell-mediated killing
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolNF1
Nameneurofibromin 1
Aliases neurofibromatosis; von Recklinghausen disease; Watson disease; NFNS; VRNF; neurofibromatosis-related protein ......
Chromosomal Location17q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of NF1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.1130.696
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.1610.902
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.0780.936
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.0420.888
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.10.971
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.0320.993
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0310.943
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.0150.993
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.0890.964
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.0190.987
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.710.656
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0030.964
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of NF1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.111.8-4.71
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1031033.3-23.30.423
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 41407.1-7.11
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277322.212.39.90.224
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275922.213.68.60.353
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211728.611.816.80.257
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8637.5037.50.209
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131123.118.24.91
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.16.24.91
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 382715.8015.80.037
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221318.2018.20.274
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161412.5012.50.485
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11139.115.4-6.31
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 6116.7016.71
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 512016.7-16.71
Summary
SymbolNF1
Nameneurofibromin 1
Aliases neurofibromatosis; von Recklinghausen disease; Watson disease; NFNS; VRNF; neurofibromatosis-related protein ......
Chromosomal Location17q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NF1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolNF1
Nameneurofibromin 1
Aliases neurofibromatosis; von Recklinghausen disease; Watson disease; NFNS; VRNF; neurofibromatosis-related protein ......
Chromosomal Location17q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NF1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NF1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolNF1
Nameneurofibromin 1
Aliases neurofibromatosis; von Recklinghausen disease; Watson disease; NFNS; VRNF; neurofibromatosis-related protein ......
Chromosomal Location17q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NF1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolNF1
Nameneurofibromin 1
Aliases neurofibromatosis; von Recklinghausen disease; Watson disease; NFNS; VRNF; neurofibromatosis-related protein ......
Chromosomal Location17q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of NF1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolNF1
Nameneurofibromin 1
Aliases neurofibromatosis; von Recklinghausen disease; Watson disease; NFNS; VRNF; neurofibromatosis-related protein ......
Chromosomal Location17q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between NF1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolNF1
Nameneurofibromin 1
Aliases neurofibromatosis; von Recklinghausen disease; Watson disease; NFNS; VRNF; neurofibromatosis-related protein ......
Chromosomal Location17q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting NF1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.