Browse NFE2L2

Summary
SymbolNFE2L2
Namenuclear factor, erythroid 2-like 2
Aliases NF-E2-related factor 2; nuclear factor (erythroid-derived 2)-like 2; nuclear factor erythroid-derived 2-like ......
Chromosomal Location2q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm, cytosol. Nucleus. Note=Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electrophilic agents.
Domain PF03131 bZIP Maf transcription factor
Function

Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.

> Gene Ontology
 
Biological Process GO:0000302 response to reactive oxygen species
GO:0000303 response to superoxide
GO:0000305 response to oxygen radical
GO:0001525 angiogenesis
GO:0001666 response to hypoxia
GO:0001667 ameboidal-type cell migration
GO:0002244 hematopoietic progenitor cell differentiation
GO:0002683 negative regulation of immune system process
GO:0006575 cellular modified amino acid metabolic process
GO:0006749 glutathione metabolic process
GO:0006750 glutathione biosynthetic process
GO:0006790 sulfur compound metabolic process
GO:0006801 superoxide metabolic process
GO:0006979 response to oxidative stress
GO:0006984 ER-nucleus signaling pathway
GO:0006986 response to unfolded protein
GO:0007568 aging
GO:0007596 blood coagulation
GO:0007599 hemostasis
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0008643 carbohydrate transport
GO:0008645 hexose transport
GO:0009267 cellular response to starvation
GO:0009636 response to toxic substance
GO:0009894 regulation of catabolic process
GO:0009896 positive regulation of catabolic process
GO:0009991 response to extracellular stimulus
GO:0010035 response to inorganic substance
GO:0010498 proteasomal protein catabolic process
GO:0010499 proteasomal ubiquitin-independent protein catabolic process
GO:0010594 regulation of endothelial cell migration
GO:0010595 positive regulation of endothelial cell migration
GO:0010631 epithelial cell migration
GO:0010632 regulation of epithelial cell migration
GO:0010634 positive regulation of epithelial cell migration
GO:0010656 negative regulation of muscle cell apoptotic process
GO:0010657 muscle cell apoptotic process
GO:0010658 striated muscle cell apoptotic process
GO:0010659 cardiac muscle cell apoptotic process
GO:0010660 regulation of muscle cell apoptotic process
GO:0010662 regulation of striated muscle cell apoptotic process
GO:0010664 negative regulation of striated muscle cell apoptotic process
GO:0010665 regulation of cardiac muscle cell apoptotic process
GO:0010667 negative regulation of cardiac muscle cell apoptotic process
GO:0010720 positive regulation of cell development
GO:0010827 regulation of glucose transport
GO:0010828 positive regulation of glucose transport
GO:0010975 regulation of neuron projection development
GO:0010976 positive regulation of neuron projection development
GO:0014812 muscle cell migration
GO:0014909 smooth muscle cell migration
GO:0014910 regulation of smooth muscle cell migration
GO:0014912 negative regulation of smooth muscle cell migration
GO:0015749 monosaccharide transport
GO:0015758 glucose transport
GO:0019184 nonribosomal peptide biosynthetic process
GO:0019430 removal of superoxide radicals
GO:0030193 regulation of blood coagulation
GO:0030194 positive regulation of blood coagulation
GO:0030335 positive regulation of cell migration
GO:0030336 negative regulation of cell migration
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0031329 regulation of cellular catabolic process
GO:0031331 positive regulation of cellular catabolic process
GO:0031346 positive regulation of cell projection organization
GO:0031667 response to nutrient levels
GO:0031668 cellular response to extracellular stimulus
GO:0031669 cellular response to nutrient levels
GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034248 regulation of cellular amide metabolic process
GO:0034250 positive regulation of cellular amide metabolic process
GO:0034405 response to fluid shear stress
GO:0034599 cellular response to oxidative stress
GO:0034612 response to tumor necrosis factor
GO:0034614 cellular response to reactive oxygen species
GO:0034616 response to laminar fluid shear stress
GO:0034620 cellular response to unfolded protein
GO:0034976 response to endoplasmic reticulum stress
GO:0035690 cellular response to drug
GO:0035966 response to topologically incorrect protein
GO:0035967 cellular response to topologically incorrect protein
GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress
GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0036293 response to decreased oxygen levels
GO:0036294 cellular response to decreased oxygen levels
GO:0036473 cell death in response to oxidative stress
GO:0036474 cell death in response to hydrogen peroxide
GO:0036499 PERK-mediated unfolded protein response
GO:0036503 ERAD pathway
GO:0040013 negative regulation of locomotion
GO:0040017 positive regulation of locomotion
GO:0042149 cellular response to glucose starvation
GO:0042176 regulation of protein catabolic process
GO:0042398 cellular modified amino acid biosynthetic process
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0042594 response to starvation
GO:0042762 regulation of sulfur metabolic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043534 blood vessel endothelial cell migration
GO:0043535 regulation of blood vessel endothelial cell migration
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0043542 endothelial cell migration
GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress
GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0043620 regulation of DNA-templated transcription in response to stress
GO:0044272 sulfur compound biosynthetic process
GO:0045454 cell redox homeostasis
GO:0045666 positive regulation of neuron differentiation
GO:0045732 positive regulation of protein catabolic process
GO:0045765 regulation of angiogenesis
GO:0045766 positive regulation of angiogenesis
GO:0045862 positive regulation of proteolysis
GO:0045995 regulation of embryonic development
GO:0046323 glucose import
GO:0046324 regulation of glucose import
GO:0046326 positive regulation of glucose import
GO:0048514 blood vessel morphogenesis
GO:0048863 stem cell differentiation
GO:0050769 positive regulation of neurogenesis
GO:0050817 coagulation
GO:0050818 regulation of coagulation
GO:0050820 positive regulation of coagulation
GO:0050878 regulation of body fluid levels
GO:0051176 positive regulation of sulfur metabolic process
GO:0051271 negative regulation of cellular component movement
GO:0051272 positive regulation of cellular component movement
GO:0051962 positive regulation of nervous system development
GO:0060218 hematopoietic stem cell differentiation
GO:0061041 regulation of wound healing
GO:0061136 regulation of proteasomal protein catabolic process
GO:0070301 cellular response to hydrogen peroxide
GO:0070482 response to oxygen levels
GO:0071356 cellular response to tumor necrosis factor
GO:0071450 cellular response to oxygen radical
GO:0071451 cellular response to superoxide
GO:0071453 cellular response to oxygen levels
GO:0071456 cellular response to hypoxia
GO:0071496 cellular response to external stimulus
GO:0071498 cellular response to fluid shear stress
GO:0071499 cellular response to laminar fluid shear stress
GO:0072577 endothelial cell apoptotic process
GO:0072593 reactive oxygen species metabolic process
GO:0090130 tissue migration
GO:0090132 epithelium migration
GO:0090303 positive regulation of wound healing
GO:0090322 regulation of superoxide metabolic process
GO:0097193 intrinsic apoptotic signaling pathway
GO:0098754 detoxification
GO:0098869 cellular oxidant detoxification
GO:1900046 regulation of hemostasis
GO:1900048 positive regulation of hemostasis
GO:1900407 regulation of cellular response to oxidative stress
GO:1900408 negative regulation of cellular response to oxidative stress
GO:1901031 regulation of response to reactive oxygen species
GO:1901032 negative regulation of response to reactive oxygen species
GO:1901342 regulation of vasculature development
GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
GO:1901532 regulation of hematopoietic progenitor cell differentiation
GO:1901533 negative regulation of hematopoietic progenitor cell differentiation
GO:1901800 positive regulation of proteasomal protein catabolic process
GO:1902036 regulation of hematopoietic stem cell differentiation
GO:1902037 negative regulation of hematopoietic stem cell differentiation
GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:1902532 negative regulation of intracellular signal transduction
GO:1902882 regulation of response to oxidative stress
GO:1902883 negative regulation of response to oxidative stress
GO:1903034 regulation of response to wounding
GO:1903036 positive regulation of response to wounding
GO:1903050 regulation of proteolysis involved in cellular protein catabolic process
GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process
GO:1903069 regulation of ER-associated ubiquitin-dependent protein catabolic process
GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process
GO:1903201 regulation of oxidative stress-induced cell death
GO:1903202 negative regulation of oxidative stress-induced cell death
GO:1903205 regulation of hydrogen peroxide-induced cell death
GO:1903206 negative regulation of hydrogen peroxide-induced cell death
GO:1903362 regulation of cellular protein catabolic process
GO:1903364 positive regulation of cellular protein catabolic process
GO:1903706 regulation of hemopoiesis
GO:1903707 negative regulation of hemopoiesis
GO:1903786 regulation of glutathione biosynthetic process
GO:1903788 positive regulation of glutathione biosynthetic process
GO:1904018 positive regulation of vasculature development
GO:1904019 epithelial cell apoptotic process
GO:1904035 regulation of epithelial cell apoptotic process
GO:1904036 negative regulation of epithelial cell apoptotic process
GO:1904292 regulation of ERAD pathway
GO:1904294 positive regulation of ERAD pathway
GO:1904738 vascular associated smooth muscle cell migration
GO:1904752 regulation of vascular associated smooth muscle cell migration
GO:1904753 negative regulation of vascular associated smooth muscle cell migration
GO:1990748 cellular detoxification
GO:2000121 regulation of removal of superoxide radicals
GO:2000146 negative regulation of cell motility
GO:2000147 positive regulation of cell motility
GO:2000351 regulation of endothelial cell apoptotic process
GO:2000352 negative regulation of endothelial cell apoptotic process
GO:2000377 regulation of reactive oxygen species metabolic process
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2000736 regulation of stem cell differentiation
GO:2000737 negative regulation of stem cell differentiation
GO:2001233 regulation of apoptotic signaling pathway
GO:2001234 negative regulation of apoptotic signaling pathway
GO:2001242 regulation of intrinsic apoptotic signaling pathway
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Molecular Function GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001085 RNA polymerase II transcription factor binding
GO:0001102 RNA polymerase II activating transcription factor binding
GO:0001158 enhancer sequence-specific DNA binding
GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0001221 transcription cofactor binding
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0008134 transcription factor binding
GO:0033613 activating transcription factor binding
GO:0035326 enhancer binding
Cellular Component GO:0000785 chromatin
GO:0005813 centrosome
GO:0032993 protein-DNA complex
> KEGG and Reactome Pathway
 
KEGG hsa04141 Protein processing in endoplasmic reticulum
Reactome -
Summary
SymbolNFE2L2
Namenuclear factor, erythroid 2-like 2
Aliases NF-E2-related factor 2; nuclear factor (erythroid-derived 2)-like 2; nuclear factor erythroid-derived 2-like ......
Chromosomal Location2q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between NFE2L2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between NFE2L2 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
26936880Breast Carcinoma; Colon CarcinomaInhibit immunity (T cell function)Nrf2 enhanced MDSC suppressive activity by increasing MDSC production of H2O2, and it increased the quantity of tumor-infiltrating MDSC by reducing their oxidative stress and rate of apoptosis.
29786078MelanomaInhibit immunity (infiltration)Depletion of NRF2 significantly induces tumor infiltration by both CD8+ and CD4+ T cells to suppress melanoma progression, and combining NRF2 inhibition with anti-PD-1 treatment enhanced its anti-tumor function.
Summary
SymbolNFE2L2
Namenuclear factor, erythroid 2-like 2
Aliases NF-E2-related factor 2; nuclear factor (erythroid-derived 2)-like 2; nuclear factor erythroid-derived 2-like ......
Chromosomal Location2q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of NFE2L2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolNFE2L2
Namenuclear factor, erythroid 2-like 2
Aliases NF-E2-related factor 2; nuclear factor (erythroid-derived 2)-like 2; nuclear factor erythroid-derived 2-like ......
Chromosomal Location2q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of NFE2L2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.1030.699
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.0390.988
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.1560.933
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.2230.511
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.7030.791
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.380.909
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0790.857
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.0480.982
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.1250.957
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.2020.912
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.5590.843
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.2180.00628
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of NFE2L2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.42.74.70.294
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.41.75.70.231
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolNFE2L2
Namenuclear factor, erythroid 2-like 2
Aliases NF-E2-related factor 2; nuclear factor (erythroid-derived 2)-like 2; nuclear factor erythroid-derived 2-like ......
Chromosomal Location2q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NFE2L2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolNFE2L2
Namenuclear factor, erythroid 2-like 2
Aliases NF-E2-related factor 2; nuclear factor (erythroid-derived 2)-like 2; nuclear factor erythroid-derived 2-like ......
Chromosomal Location2q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NFE2L2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NFE2L2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolNFE2L2
Namenuclear factor, erythroid 2-like 2
Aliases NF-E2-related factor 2; nuclear factor (erythroid-derived 2)-like 2; nuclear factor erythroid-derived 2-like ......
Chromosomal Location2q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NFE2L2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolNFE2L2
Namenuclear factor, erythroid 2-like 2
Aliases NF-E2-related factor 2; nuclear factor (erythroid-derived 2)-like 2; nuclear factor erythroid-derived 2-like ......
Chromosomal Location2q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of NFE2L2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolNFE2L2
Namenuclear factor, erythroid 2-like 2
Aliases NF-E2-related factor 2; nuclear factor (erythroid-derived 2)-like 2; nuclear factor erythroid-derived 2-like ......
Chromosomal Location2q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between NFE2L2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolNFE2L2
Namenuclear factor, erythroid 2-like 2
Aliases NF-E2-related factor 2; nuclear factor (erythroid-derived 2)-like 2; nuclear factor erythroid-derived 2-like ......
Chromosomal Location2q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting NFE2L2 collected from DrugBank database.
> Drugs from DrugBank database
 

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