TISIDB

Summary
Symbol	NFKBIA
Name	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
Aliases	IKBA; MAD-3; IkappaBalpha; NFKBI; I-kappa-B-alpha; ikB-alpha; major histocompatibility complex enhancer-bind ......
Chromosomal Location	14q13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export.
Domain	PF00023 Ankyrin repeat PF12796 Ankyrin repeats (3 copies)
Function	Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.

> Gene Ontology [ TOP ]
Biological Process	GO:0000060 protein import into nucleus, translocation GO:0001889 liver development GO:0002218 activation of innate immune response GO:0002220 innate immune response activating cell surface receptor signaling pathway GO:0002221 pattern recognition receptor signaling pathway GO:0002223 stimulatory C-type lectin receptor signaling pathway GO:0002224 toll-like receptor signaling pathway GO:0002237 response to molecule of bacterial origin GO:0002429 immune response-activating cell surface receptor signaling pathway GO:0002683 negative regulation of immune system process GO:0002753 cytoplasmic pattern recognition receptor signaling pathway GO:0002757 immune response-activating signal transduction GO:0002758 innate immune response-activating signal transduction GO:0002764 immune response-regulating signaling pathway GO:0002768 immune response-regulating cell surface receptor signaling pathway GO:0006606 protein import into nucleus GO:0006869 lipid transport GO:0006913 nucleocytoplasmic transport GO:0007219 Notch signaling pathway GO:0007249 I-kappaB kinase/NF-kappaB signaling GO:0007253 cytoplasmic sequestering of NF-kappaB GO:0008593 regulation of Notch signaling pathway GO:0009266 response to temperature stimulus GO:0009409 response to cold GO:0009612 response to mechanical stimulus GO:0010742 macrophage derived foam cell differentiation GO:0010743 regulation of macrophage derived foam cell differentiation GO:0010745 negative regulation of macrophage derived foam cell differentiation GO:0010874 regulation of cholesterol efflux GO:0010875 positive regulation of cholesterol efflux GO:0010876 lipid localization GO:0010883 regulation of lipid storage GO:0010888 negative regulation of lipid storage GO:0015850 organic hydroxy compound transport GO:0015918 sterol transport GO:0017038 protein import GO:0019915 lipid storage GO:0030099 myeloid cell differentiation GO:0030301 cholesterol transport GO:0030522 intracellular receptor signaling pathway GO:0031099 regeneration GO:0031100 animal organ regeneration GO:0031349 positive regulation of defense response GO:0031503 protein complex localization GO:0031663 lipopolysaccharide-mediated signaling pathway GO:0032088 negative regulation of NF-kappaB transcription factor activity GO:0032368 regulation of lipid transport GO:0032370 positive regulation of lipid transport GO:0032371 regulation of sterol transport GO:0032373 positive regulation of sterol transport GO:0032374 regulation of cholesterol transport GO:0032376 positive regulation of cholesterol transport GO:0032386 regulation of intracellular transport GO:0032387 negative regulation of intracellular transport GO:0032495 response to muramyl dipeptide GO:0032496 response to lipopolysaccharide GO:0032507 maintenance of protein location in cell GO:0033157 regulation of intracellular protein transport GO:0033344 cholesterol efflux GO:0034142 toll-like receptor 4 signaling pathway GO:0034504 protein localization to nucleus GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway GO:0035994 response to muscle stretch GO:0038093 Fc receptor signaling pathway GO:0038095 Fc-epsilon receptor signaling pathway GO:0042306 regulation of protein import into nucleus GO:0042308 negative regulation of protein import into nucleus GO:0042345 regulation of NF-kappaB import into nucleus GO:0042347 negative regulation of NF-kappaB import into nucleus GO:0042348 NF-kappaB import into nucleus GO:0042990 regulation of transcription factor import into nucleus GO:0042991 transcription factor import into nucleus GO:0042992 negative regulation of transcription factor import into nucleus GO:0042994 cytoplasmic sequestering of transcription factor GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043330 response to exogenous dsRNA GO:0043331 response to dsRNA GO:0043392 negative regulation of DNA binding GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity GO:0044744 protein targeting to nucleus GO:0045088 regulation of innate immune response GO:0045089 positive regulation of innate immune response GO:0045185 maintenance of protein location GO:0045637 regulation of myeloid cell differentiation GO:0045638 negative regulation of myeloid cell differentiation GO:0045746 negative regulation of Notch signaling pathway GO:0046822 regulation of nucleocytoplasmic transport GO:0046823 negative regulation of nucleocytoplasmic transport GO:0048732 gland development GO:0050851 antigen receptor-mediated signaling pathway GO:0050852 T cell receptor signaling pathway GO:0051051 negative regulation of transport GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051092 positive regulation of NF-kappaB transcription factor activity GO:0051098 regulation of binding GO:0051100 negative regulation of binding GO:0051101 regulation of DNA binding GO:0051169 nuclear transport GO:0051170 nuclear import GO:0051220 cytoplasmic sequestering of protein GO:0051224 negative regulation of protein transport GO:0051235 maintenance of location GO:0051651 maintenance of location in cell GO:0061008 hepaticobiliary system development GO:0070417 cellular response to cold GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway GO:0071216 cellular response to biotic stimulus GO:0071219 cellular response to molecule of bacterial origin GO:0071222 cellular response to lipopolysaccharide GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0090077 foam cell differentiation GO:0090317 negative regulation of intracellular protein transport GO:0097421 liver regeneration GO:1900180 regulation of protein localization to nucleus GO:1900181 negative regulation of protein localization to nucleus GO:1901652 response to peptide GO:1902532 negative regulation of intracellular signal transduction GO:1902593 single-organism nuclear import GO:1903533 regulation of protein targeting GO:1903706 regulation of hemopoiesis GO:1903707 negative regulation of hemopoiesis GO:1903828 negative regulation of cellular protein localization GO:1904589 regulation of protein import GO:1904590 negative regulation of protein import GO:1904950 negative regulation of establishment of protein localization
Molecular Function	GO:0005048 signal sequence binding GO:0008134 transcription factor binding GO:0008139 nuclear localization sequence binding GO:0031072 heat shock protein binding GO:0031625 ubiquitin protein ligase binding GO:0033218 amide binding GO:0042277 peptide binding GO:0044389 ubiquitin-like protein ligase binding GO:0051059 NF-kappaB binding
Cellular Component	GO:0033256 I-kappaB/NF-kappaB complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04024 cAMP signaling pathway hsa04062 Chemokine signaling pathway hsa04064 NF-kappa B signaling pathway hsa04210 Apoptosis hsa04380 Osteoclast differentiation hsa04620 Toll-like receptor signaling pathway hsa04621 NOD-like receptor signaling pathway hsa04622 RIG-I-like receptor signaling pathway hsa04623 Cytosolic DNA-sensing pathway hsa04660 T cell receptor signaling pathway hsa04662 B cell receptor signaling pathway hsa04668 TNF signaling pathway hsa04722 Neurotrophin signaling pathway hsa04920 Adipocytokine signaling pathway
Reactome	R-HSA-166054: Activated TLR4 signalling R-HSA-1169091: Activation of NF-kappaB in B cells R-HSA-1280218: Adaptive Immune System R-HSA-5621481: C-type lectin receptors (CLRs) R-HSA-5607764: CLEC7A (Dectin-1) signaling R-HSA-1834949: Cytosolic sensors of pathogen-associated DNA R-HSA-5688426: Deubiquitination R-HSA-1643685: Disease R-HSA-5602358: Diseases associated with the TLR signaling cascade R-HSA-5260271: Diseases of Immune System R-HSA-202424: Downstream TCR signaling R-HSA-1168372: Downstream signaling events of B Cell Receptor (BCR) R-HSA-2871837: FCERI mediated NF-kB activation R-HSA-2454202: Fc epsilon receptor (FCERI) signaling R-HSA-5603027: IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603029: IkBA variant leads to EDA-ID R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-392499: Metabolism of proteins R-HSA-975871: MyD88 cascade initiated on plasma membrane R-HSA-975155: MyD88 dependent cascade initiated on endosome R-HSA-166166: MyD88-independent TLR3/TLR4 cascade R-HSA-166058: MyD88 R-HSA-209560: NF-kB is activated and signals survival R-HSA-597592: Post-translational protein modification R-HSA-168928: RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways R-HSA-1810476: RIP-mediated NFkB activation via ZBP1 R-HSA-162582: Signal Transduction R-HSA-983705: Signaling by the B Cell Receptor (BCR) R-HSA-166520: Signalling by NGF R-HSA-445989: TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-HSA-202403: TCR signaling R-HSA-168180: TRAF6 Mediated Induction of proinflammatory cytokines R-HSA-933542: TRAF6 mediated NF-kB activation R-HSA-975138: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-937061: TRIF-mediated TLR3/TLR4 signaling R-HSA-168142: Toll Like Receptor 10 (TLR10) Cascade R-HSA-181438: Toll Like Receptor 2 (TLR2) Cascade R-HSA-168164: Toll Like Receptor 3 (TLR3) Cascade R-HSA-166016: Toll Like Receptor 4 (TLR4) Cascade R-HSA-168176: Toll Like Receptor 5 (TLR5) Cascade R-HSA-168181: Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168138: Toll Like Receptor 9 (TLR9) Cascade R-HSA-168179: Toll Like Receptor TLR1 R-HSA-168188: Toll Like Receptor TLR6 R-HSA-168898: Toll-Like Receptors Cascades R-HSA-5689880: Ub-specific processing proteases R-HSA-1606322: ZBP1(DAI) mediated induction of type I IFNs R-HSA-193704: p75 NTR receptor-mediated signalling R-HSA-193639: p75NTR signals via NF-kB

> KEGG and Reactome Pathway

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KEGG

hsa04024 cAMP signaling pathway
hsa04062 Chemokine signaling pathway
hsa04064 NF-kappa B signaling pathway
hsa04210 Apoptosis
hsa04380 Osteoclast differentiation
hsa04620 Toll-like receptor signaling pathway
hsa04621 NOD-like receptor signaling pathway
hsa04622 RIG-I-like receptor signaling pathway
hsa04623 Cytosolic DNA-sensing pathway
hsa04660 T cell receptor signaling pathway
hsa04662 B cell receptor signaling pathway
hsa04668 TNF signaling pathway
hsa04722 Neurotrophin signaling pathway
hsa04920 Adipocytokine signaling pathway

Reactome

R-HSA-166054: Activated TLR4 signalling
R-HSA-1169091: Activation of NF-kappaB in B cells
R-HSA-1280218: Adaptive Immune System
R-HSA-5621481: C-type lectin receptors (CLRs)
R-HSA-5607764: CLEC7A (Dectin-1) signaling
R-HSA-1834949: Cytosolic sensors of pathogen-associated DNA
R-HSA-5688426: Deubiquitination
R-HSA-1643685: Disease
R-HSA-5602358: Diseases associated with the TLR signaling cascade
R-HSA-5260271: Diseases of Immune System
R-HSA-202424: Downstream TCR signaling
R-HSA-1168372: Downstream signaling events of B Cell Receptor (BCR)
R-HSA-2871837: FCERI mediated NF-kB activation
R-HSA-2454202: Fc epsilon receptor (FCERI) signaling
R-HSA-5603027: IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
R-HSA-5603029: IkBA variant leads to EDA-ID
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-392499: Metabolism of proteins
R-HSA-975871: MyD88 cascade initiated on plasma membrane
R-HSA-975155: MyD88 dependent cascade initiated on endosome
R-HSA-166166: MyD88-independent TLR3/TLR4 cascade
R-HSA-166058: MyD88
R-HSA-209560: NF-kB is activated and signals survival
R-HSA-597592: Post-translational protein modification
R-HSA-168928: RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
R-HSA-1810476: RIP-mediated NFkB activation via ZBP1
R-HSA-162582: Signal Transduction
R-HSA-983705: Signaling by the B Cell Receptor (BCR)
R-HSA-166520: Signalling by NGF
R-HSA-445989: TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-HSA-202403: TCR signaling
R-HSA-168180: TRAF6 Mediated Induction of proinflammatory cytokines
R-HSA-933542: TRAF6 mediated NF-kB activation
R-HSA-975138: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-HSA-937061: TRIF-mediated TLR3/TLR4 signaling
R-HSA-168142: Toll Like Receptor 10 (TLR10) Cascade
R-HSA-181438: Toll Like Receptor 2 (TLR2) Cascade
R-HSA-168164: Toll Like Receptor 3 (TLR3) Cascade
R-HSA-166016: Toll Like Receptor 4 (TLR4) Cascade
R-HSA-168176: Toll Like Receptor 5 (TLR5) Cascade
R-HSA-168181: Toll Like Receptor 7/8 (TLR7/8) Cascade
R-HSA-168138: Toll Like Receptor 9 (TLR9) Cascade
R-HSA-168179: Toll Like Receptor TLR1
R-HSA-168188: Toll Like Receptor TLR6
R-HSA-168898: Toll-Like Receptors Cascades
R-HSA-5689880: Ub-specific processing proteases
R-HSA-1606322: ZBP1(DAI) mediated induction of type I IFNs
R-HSA-193704: p75 NTR receptor-mediated signalling
R-HSA-193639: p75NTR signals via NF-kB

Summary
Symbol	NFKBIA
Name	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
Aliases	IKBA; MAD-3; IkappaBalpha; NFKBI; I-kappa-B-alpha; ikB-alpha; major histocompatibility complex enhancer-bind ......
Chromosomal Location	14q13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between NFKBIA and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining

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Literatures describing the relation between NFKBIA and anti-tumor immunity in human cancer.

PMID	Cancer type	Relation to immunity	Evidence sentences
17210719	Sacroma	Inhibit immunity (T cell function)	Tumor-induced oxidative stress increased cytosolic IkappaBalpha retention and inhibited NF-kappaB nuclear translocation in thymic T cells. These NF-kappaB-perturbed cells became vulnerable to tumor-secreted tumor necrosis factor (TNF)-alpha (TNF-alpha)-mediated apoptosis through the activation of TNF receptor-associated protein death domain-associated Fas-associated protein death domain and caspase-8.

Summary
Symbol	NFKBIA
Name	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
Aliases	IKBA; MAD-3; IkappaBalpha; NFKBI; I-kappa-B-alpha; ikB-alpha; major histocompatibility complex enhancer-bind ......
Chromosomal Location	14q13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of NFKBIA in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	NFKBIA
Name	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
Aliases	IKBA; MAD-3; IkappaBalpha; NFKBI; I-kappa-B-alpha; ikB-alpha; major histocompatibility complex enhancer-bind ......
Chromosomal Location	14q13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of NFKBIA in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.085	0.803
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.196	0.938
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.004	0.998
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.018	0.97
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.562	0.828
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.677	0.848
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.127	0.775
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.095	0.952
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.07	0.97
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.386	0.838
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.833	0.772
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.057	0.551

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of NFKBIA in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	0	0	0	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	0	0	0	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	4.8	0	4.8	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	7.7	0	7.7	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	9.1	15.4	-6.3	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	20	16.7	3.3	1

Summary
Symbol	NFKBIA
Name	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
Aliases	IKBA; MAD-3; IkappaBalpha; NFKBI; I-kappa-B-alpha; ikB-alpha; major histocompatibility complex enhancer-bind ......
Chromosomal Location	14q13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NFKBIA. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	NFKBIA
Name	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
Aliases	IKBA; MAD-3; IkappaBalpha; NFKBI; I-kappa-B-alpha; ikB-alpha; major histocompatibility complex enhancer-bind ......
Chromosomal Location	14q13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NFKBIA. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NFKBIA. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	NFKBIA
Name	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
Aliases	IKBA; MAD-3; IkappaBalpha; NFKBI; I-kappa-B-alpha; ikB-alpha; major histocompatibility complex enhancer-bind ......
Chromosomal Location	14q13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NFKBIA. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	NFKBIA
Name	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
Aliases	IKBA; MAD-3; IkappaBalpha; NFKBI; I-kappa-B-alpha; ikB-alpha; major histocompatibility complex enhancer-bind ......
Chromosomal Location	14q13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of NFKBIA expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	NFKBIA
Name	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
Aliases	IKBA; MAD-3; IkappaBalpha; NFKBI; I-kappa-B-alpha; ikB-alpha; major histocompatibility complex enhancer-bind ......
Chromosomal Location	14q13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between NFKBIA and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	NFKBIA
Name	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
Aliases	IKBA; MAD-3; IkappaBalpha; NFKBI; I-kappa-B-alpha; ikB-alpha; major histocompatibility complex enhancer-bind ......
Chromosomal Location	14q13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting NFKBIA collected from DrugBank database.

> Drugs from DrugBank database

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Details on drugs targeting NFKBIA.

ID	Name	Drug Type	Targets	#Targets
DB00945	Acetylsalicylic acid	Small Molecule	AKR1C1, EDNRA, HSPA5, IKBKB, NFKB1, NFKB2, NFKBIA, PRKAA1, PRKAA2, ......	18
DB05983	Bardoxolone methyl	Small Molecule	NFKBIA	1
DB06543	Astaxanthin	Small Molecule	NFKBIA	1

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