Browse NIPBL

Summary
SymbolNIPBL
NameNipped-B homolog (Drosophila)
Aliases IDN3; DKFZp434L1319; FLJ11203; FLJ12597; FLJ13354; FLJ13648; Scc2; sister chromatid cohesion 2 homolog (yeas ......
Chromosomal Location5p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus Chromosome
Domain PF12765 HEAT repeat associated with sister chromatid cohesion
PF12830 Sister chromatid cohesion C-terminus
Function

Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitement to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitement to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity).

> Gene Ontology
 
Biological Process GO:0000070 mitotic sister chromatid segregation
GO:0000819 sister chromatid segregation
GO:0001501 skeletal system development
GO:0001503 ossification
GO:0001654 eye development
GO:0001655 urogenital system development
GO:0001656 metanephros development
GO:0001822 kidney development
GO:0003007 heart morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0006476 protein deacetylation
GO:0007059 chromosome segregation
GO:0007062 sister chromatid cohesion
GO:0007064 mitotic sister chromatid cohesion
GO:0007067 mitotic nuclear division
GO:0007423 sensory organ development
GO:0007507 heart development
GO:0007548 sex differentiation
GO:0007605 sensory perception of sound
GO:0009314 response to radiation
GO:0010165 response to X-ray
GO:0010171 body morphogenesis
GO:0010212 response to ionizing radiation
GO:0016570 histone modification
GO:0016575 histone deacetylation
GO:0019827 stem cell population maintenance
GO:0030278 regulation of ossification
GO:0030326 embryonic limb morphogenesis
GO:0031056 regulation of histone modification
GO:0031058 positive regulation of histone modification
GO:0031063 regulation of histone deacetylation
GO:0031065 positive regulation of histone deacetylation
GO:0034086 maintenance of sister chromatid cohesion
GO:0034088 maintenance of mitotic sister chromatid cohesion
GO:0035107 appendage morphogenesis
GO:0035108 limb morphogenesis
GO:0035112 genitalia morphogenesis
GO:0035113 embryonic appendage morphogenesis
GO:0035115 embryonic forelimb morphogenesis
GO:0035136 forelimb morphogenesis
GO:0035239 tube morphogenesis
GO:0035261 external genitalia morphogenesis
GO:0035264 multicellular organism growth
GO:0035601 protein deacylation
GO:0040014 regulation of multicellular organism growth
GO:0040018 positive regulation of multicellular organism growth
GO:0042303 molting cycle
GO:0042471 ear morphogenesis
GO:0042633 hair cycle
GO:0042634 regulation of hair cycle
GO:0043583 ear development
GO:0045444 fat cell differentiation
GO:0045778 positive regulation of ossification
GO:0045927 positive regulation of growth
GO:0045995 regulation of embryonic development
GO:0048546 digestive tract morphogenesis
GO:0048557 embryonic digestive tract morphogenesis
GO:0048562 embryonic organ morphogenesis
GO:0048565 digestive tract development
GO:0048566 embryonic digestive tract development
GO:0048568 embryonic organ development
GO:0048592 eye morphogenesis
GO:0048608 reproductive structure development
GO:0048638 regulation of developmental growth
GO:0048639 positive regulation of developmental growth
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0048703 embryonic viscerocranium morphogenesis
GO:0048704 embryonic skeletal system morphogenesis
GO:0048705 skeletal system morphogenesis
GO:0048706 embryonic skeletal system development
GO:0048736 appendage development
GO:0048806 genitalia development
GO:0050890 cognition
GO:0050954 sensory perception of mechanical stimulus
GO:0055123 digestive system development
GO:0060065 uterus development
GO:0060173 limb development
GO:0060323 head morphogenesis
GO:0060324 face development
GO:0060325 face morphogenesis
GO:0061008 hepaticobiliary system development
GO:0061010 gall bladder development
GO:0061038 uterus morphogenesis
GO:0061458 reproductive system development
GO:0071214 cellular response to abiotic stimulus
GO:0071478 cellular response to radiation
GO:0071479 cellular response to ionizing radiation
GO:0071481 cellular response to X-ray
GO:0072001 renal system development
GO:0090311 regulation of protein deacetylation
GO:0090312 positive regulation of protein deacetylation
GO:0090596 sensory organ morphogenesis
GO:0098727 maintenance of cell number
GO:0098732 macromolecule deacylation
GO:0098813 nuclear chromosome segregation
GO:1902275 regulation of chromatin organization
GO:1904888 cranial skeletal system development
GO:1905269 positive regulation of chromatin organization
Molecular Function GO:0003682 chromatin binding
GO:0008022 protein C-terminus binding
GO:0036033 mediator complex binding
GO:0042826 histone deacetylase binding
GO:0047485 protein N-terminus binding
GO:0070087 chromo shadow domain binding
Cellular Component GO:0000785 chromatin
GO:0032116 SMC loading complex
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-1640170: Cell Cycle
R-HSA-69278: Cell Cycle, Mitotic
R-HSA-2470946: Cohesin Loading onto Chromatin
R-HSA-68886: M Phase
R-HSA-68884: Mitotic Telophase/Cytokinesis
Summary
SymbolNIPBL
NameNipped-B homolog (Drosophila)
Aliases IDN3; DKFZp434L1319; FLJ11203; FLJ12597; FLJ13354; FLJ13648; Scc2; sister chromatid cohesion 2 homolog (yeas ......
Chromosomal Location5p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between NIPBL and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolNIPBL
NameNipped-B homolog (Drosophila)
Aliases IDN3; DKFZp434L1319; FLJ11203; FLJ12597; FLJ13354; FLJ13648; Scc2; sister chromatid cohesion 2 homolog (yeas ......
Chromosomal Location5p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of NIPBL in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.9 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolNIPBL
NameNipped-B homolog (Drosophila)
Aliases IDN3; DKFZp434L1319; FLJ11203; FLJ12597; FLJ13354; FLJ13648; Scc2; sister chromatid cohesion 2 homolog (yeas ......
Chromosomal Location5p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of NIPBL in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.1020.663
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.1330.914
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.0850.932
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.0910.808
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.0590.984
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.2820.939
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.1570.683
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.2210.903
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.110.956
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.5460.641
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.0690.535
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0790.246
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of NIPBL in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141714.35.98.40.576
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 414257.117.90.405
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277311.11.49.70.0589
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275911.11.79.40.0895
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.85.9-1.11
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.79.1-1.41
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.16.24.91
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 472514.310.71
1329033130MelanomaallAnti-PD-1 (nivolumab) 382715.83.712.10.224
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221313.6013.60.279
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161418.87.111.70.602
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolNIPBL
NameNipped-B homolog (Drosophila)
Aliases IDN3; DKFZp434L1319; FLJ11203; FLJ12597; FLJ13354; FLJ13648; Scc2; sister chromatid cohesion 2 homolog (yeas ......
Chromosomal Location5p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NIPBL. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolNIPBL
NameNipped-B homolog (Drosophila)
Aliases IDN3; DKFZp434L1319; FLJ11203; FLJ12597; FLJ13354; FLJ13648; Scc2; sister chromatid cohesion 2 homolog (yeas ......
Chromosomal Location5p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NIPBL. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NIPBL.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolNIPBL
NameNipped-B homolog (Drosophila)
Aliases IDN3; DKFZp434L1319; FLJ11203; FLJ12597; FLJ13354; FLJ13648; Scc2; sister chromatid cohesion 2 homolog (yeas ......
Chromosomal Location5p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NIPBL. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolNIPBL
NameNipped-B homolog (Drosophila)
Aliases IDN3; DKFZp434L1319; FLJ11203; FLJ12597; FLJ13354; FLJ13648; Scc2; sister chromatid cohesion 2 homolog (yeas ......
Chromosomal Location5p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of NIPBL expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolNIPBL
NameNipped-B homolog (Drosophila)
Aliases IDN3; DKFZp434L1319; FLJ11203; FLJ12597; FLJ13354; FLJ13648; Scc2; sister chromatid cohesion 2 homolog (yeas ......
Chromosomal Location5p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between NIPBL and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolNIPBL
NameNipped-B homolog (Drosophila)
Aliases IDN3; DKFZp434L1319; FLJ11203; FLJ12597; FLJ13354; FLJ13648; Scc2; sister chromatid cohesion 2 homolog (yeas ......
Chromosomal Location5p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting NIPBL collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.