TISIDB

Summary
Symbol	NKD2
Name	naked cuticle homolog 2 (Drosophila)
Aliases	Naked2; naked cuticle-2; Dvl-binding protein NKD2; hNkd2; Naked-2; Protein naked cuticle homolog 2
Chromosomal Location	5p15.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cell membrane Cytoplasm Cytoplasmic vesicle
Domain	-
Function	Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity). Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells.

> Gene Ontology [ TOP ]
Biological Process	GO:0006612 protein targeting to membrane GO:0006887 exocytosis GO:0006906 vesicle fusion GO:0007009 plasma membrane organization GO:0009894 regulation of catabolic process GO:0009896 positive regulation of catabolic process GO:0010498 proteasomal protein catabolic process GO:0010954 positive regulation of protein processing GO:0016050 vesicle organization GO:0016055 Wnt signaling pathway GO:0016485 protein processing GO:0030111 regulation of Wnt signaling pathway GO:0030178 negative regulation of Wnt signaling pathway GO:0031329 regulation of cellular catabolic process GO:0031331 positive regulation of cellular catabolic process GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0042176 regulation of protein catabolic process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0044801 single-organism membrane fusion GO:0045732 positive regulation of protein catabolic process GO:0045862 positive regulation of proteolysis GO:0048193 Golgi vesicle transport GO:0048210 Golgi vesicle fusion to target membrane GO:0048284 organelle fusion GO:0051604 protein maturation GO:0060070 canonical Wnt signaling pathway GO:0060828 regulation of canonical Wnt signaling pathway GO:0061025 membrane fusion GO:0061136 regulation of proteasomal protein catabolic process GO:0070613 regulation of protein processing GO:0072657 protein localization to membrane GO:0072659 protein localization to plasma membrane GO:0072661 protein targeting to plasma membrane GO:0090002 establishment of protein localization to plasma membrane GO:0090003 regulation of establishment of protein localization to plasma membrane GO:0090004 positive regulation of establishment of protein localization to plasma membrane GO:0090090 negative regulation of canonical Wnt signaling pathway GO:0090150 establishment of protein localization to membrane GO:0090174 organelle membrane fusion GO:0198738 cell-cell signaling by wnt GO:1901800 positive regulation of proteasomal protein catabolic process GO:1903050 regulation of proteolysis involved in cellular protein catabolic process GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process GO:1903076 regulation of protein localization to plasma membrane GO:1903078 positive regulation of protein localization to plasma membrane GO:1903317 regulation of protein maturation GO:1903319 positive regulation of protein maturation GO:1903362 regulation of cellular protein catabolic process GO:1903364 positive regulation of cellular protein catabolic process GO:1903729 regulation of plasma membrane organization GO:1903829 positive regulation of cellular protein localization GO:1904375 regulation of protein localization to cell periphery GO:1904377 positive regulation of protein localization to cell periphery GO:1904951 positive regulation of establishment of protein localization GO:1990778 protein localization to cell periphery
Molecular Function	GO:0019838 growth factor binding GO:0031625 ubiquitin protein ligase binding GO:0044389 ubiquitin-like protein ligase binding
Cellular Component	GO:0016323 basolateral plasma membrane GO:0016328 lateral plasma membrane

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04310 Wnt signaling pathway
Reactome	-

Summary
Symbol	NKD2
Name	naked cuticle homolog 2 (Drosophila)
Aliases	Naked2; naked cuticle-2; Dvl-binding protein NKD2; hNkd2; Naked-2; Protein naked cuticle homolog 2
Chromosomal Location	5p15.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between NKD2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	NKD2
Name	naked cuticle homolog 2 (Drosophila)
Aliases	Naked2; naked cuticle-2; Dvl-binding protein NKD2; hNkd2; Naked-2; Protein naked cuticle homolog 2
Chromosomal Location	5p15.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of NKD2 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	NKD2
Name	naked cuticle homolog 2 (Drosophila)
Aliases	Naked2; naked cuticle-2; Dvl-binding protein NKD2; hNkd2; Naked-2; Protein naked cuticle homolog 2
Chromosomal Location	5p15.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of NKD2 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.568	0.19
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-1.663	0.0285
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.224	0.754
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	1.087	0.0344
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.882	0.613
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	1.347	0.54
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.296	0.634
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.124	0.892
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.36	0.704
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	-0.887	0.348
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	-0.295	0.81
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.171	0.434

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of NKD2 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	1.4	-1.4	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	1.7	-1.7	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	1

Summary
Symbol	NKD2
Name	naked cuticle homolog 2 (Drosophila)
Aliases	Naked2; naked cuticle-2; Dvl-binding protein NKD2; hNkd2; Naked-2; Protein naked cuticle homolog 2
Chromosomal Location	5p15.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NKD2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	NKD2
Name	naked cuticle homolog 2 (Drosophila)
Aliases	Naked2; naked cuticle-2; Dvl-binding protein NKD2; hNkd2; Naked-2; Protein naked cuticle homolog 2
Chromosomal Location	5p15.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NKD2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NKD2. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	NKD2
Name	naked cuticle homolog 2 (Drosophila)
Aliases	Naked2; naked cuticle-2; Dvl-binding protein NKD2; hNkd2; Naked-2; Protein naked cuticle homolog 2
Chromosomal Location	5p15.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NKD2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	NKD2
Name	naked cuticle homolog 2 (Drosophila)
Aliases	Naked2; naked cuticle-2; Dvl-binding protein NKD2; hNkd2; Naked-2; Protein naked cuticle homolog 2
Chromosomal Location	5p15.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of NKD2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	NKD2
Name	naked cuticle homolog 2 (Drosophila)
Aliases	Naked2; naked cuticle-2; Dvl-binding protein NKD2; hNkd2; Naked-2; Protein naked cuticle homolog 2
Chromosomal Location	5p15.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between NKD2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	NKD2
Name	naked cuticle homolog 2 (Drosophila)
Aliases	Naked2; naked cuticle-2; Dvl-binding protein NKD2; hNkd2; Naked-2; Protein naked cuticle homolog 2
Chromosomal Location	5p15.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting NKD2 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

Browse NKD2