Summary | |
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Symbol | NME7 |
Name | NME/NM23 family member 7 |
Aliases | FLJ37194; NM23-H7; CFAP67; cilia and flagella associated protein 67; non-metastatic cells 7, protein express ...... |
Chromosomal Location | 1q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF06565 DUF1126 PH-like domain PF00334 Nucleoside diphosphate kinase |
Function |
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. |
Biological Process |
GO:0006164 purine nucleotide biosynthetic process GO:0006165 nucleoside diphosphate phosphorylation GO:0006183 GTP biosynthetic process GO:0006213 pyrimidine nucleoside metabolic process GO:0006220 pyrimidine nucleotide metabolic process GO:0006221 pyrimidine nucleotide biosynthetic process GO:0006228 UTP biosynthetic process GO:0006241 CTP biosynthetic process GO:0009116 nucleoside metabolic process GO:0009119 ribonucleoside metabolic process GO:0009132 nucleoside diphosphate metabolic process GO:0009141 nucleoside triphosphate metabolic process GO:0009142 nucleoside triphosphate biosynthetic process GO:0009144 purine nucleoside triphosphate metabolic process GO:0009145 purine nucleoside triphosphate biosynthetic process GO:0009147 pyrimidine nucleoside triphosphate metabolic process GO:0009148 pyrimidine nucleoside triphosphate biosynthetic process GO:0009150 purine ribonucleotide metabolic process GO:0009152 purine ribonucleotide biosynthetic process GO:0009163 nucleoside biosynthetic process GO:0009165 nucleotide biosynthetic process GO:0009199 ribonucleoside triphosphate metabolic process GO:0009201 ribonucleoside triphosphate biosynthetic process GO:0009205 purine ribonucleoside triphosphate metabolic process GO:0009206 purine ribonucleoside triphosphate biosynthetic process GO:0009208 pyrimidine ribonucleoside triphosphate metabolic process GO:0009209 pyrimidine ribonucleoside triphosphate biosynthetic process GO:0009218 pyrimidine ribonucleotide metabolic process GO:0009220 pyrimidine ribonucleotide biosynthetic process GO:0009260 ribonucleotide biosynthetic process GO:0042278 purine nucleoside metabolic process GO:0042451 purine nucleoside biosynthetic process GO:0042455 ribonucleoside biosynthetic process GO:0046036 CTP metabolic process GO:0046039 GTP metabolic process GO:0046051 UTP metabolic process GO:0046128 purine ribonucleoside metabolic process GO:0046129 purine ribonucleoside biosynthetic process GO:0046131 pyrimidine ribonucleoside metabolic process GO:0046132 pyrimidine ribonucleoside biosynthetic process GO:0046134 pyrimidine nucleoside biosynthetic process GO:0046390 ribose phosphate biosynthetic process GO:0046939 nucleotide phosphorylation GO:0072522 purine-containing compound biosynthetic process GO:0072527 pyrimidine-containing compound metabolic process GO:0072528 pyrimidine-containing compound biosynthetic process GO:1901068 guanosine-containing compound metabolic process GO:1901070 guanosine-containing compound biosynthetic process GO:1901293 nucleoside phosphate biosynthetic process GO:1901657 glycosyl compound metabolic process GO:1901659 glycosyl compound biosynthetic process |
Molecular Function |
GO:0004550 nucleoside diphosphate kinase activity GO:0016776 phosphotransferase activity, phosphate group as acceptor GO:0019205 nucleobase-containing compound kinase activity |
Cellular Component |
GO:0005813 centrosome |
KEGG |
hsa00230 Purine metabolism hsa00240 Pyrimidine metabolism hsa01100 Metabolic pathways |
Reactome | - |
Summary | |
---|---|
Symbol | NME7 |
Name | NME/NM23 family member 7 |
Aliases | FLJ37194; NM23-H7; CFAP67; cilia and flagella associated protein 67; non-metastatic cells 7, protein express ...... |
Chromosomal Location | 1q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between NME7 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | NME7 |
Name | NME/NM23 family member 7 |
Aliases | FLJ37194; NM23-H7; CFAP67; cilia and flagella associated protein 67; non-metastatic cells 7, protein express ...... |
Chromosomal Location | 1q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of NME7 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | NME7 |
Name | NME/NM23 family member 7 |
Aliases | FLJ37194; NM23-H7; CFAP67; cilia and flagella associated protein 67; non-metastatic cells 7, protein express ...... |
Chromosomal Location | 1q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of NME7 in various data sets.
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Points in the above scatter plot represent the mutation difference of NME7 in various data sets.
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Summary | |
---|---|
Symbol | NME7 |
Name | NME/NM23 family member 7 |
Aliases | FLJ37194; NM23-H7; CFAP67; cilia and flagella associated protein 67; non-metastatic cells 7, protein express ...... |
Chromosomal Location | 1q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NME7. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | NME7 |
Name | NME/NM23 family member 7 |
Aliases | FLJ37194; NM23-H7; CFAP67; cilia and flagella associated protein 67; non-metastatic cells 7, protein express ...... |
Chromosomal Location | 1q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NME7. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NME7. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | NME7 |
Name | NME/NM23 family member 7 |
Aliases | FLJ37194; NM23-H7; CFAP67; cilia and flagella associated protein 67; non-metastatic cells 7, protein express ...... |
Chromosomal Location | 1q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NME7. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | NME7 |
Name | NME/NM23 family member 7 |
Aliases | FLJ37194; NM23-H7; CFAP67; cilia and flagella associated protein 67; non-metastatic cells 7, protein express ...... |
Chromosomal Location | 1q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of NME7 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | NME7 |
Name | NME/NM23 family member 7 |
Aliases | FLJ37194; NM23-H7; CFAP67; cilia and flagella associated protein 67; non-metastatic cells 7, protein express ...... |
Chromosomal Location | 1q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between NME7 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | NME7 |
Name | NME/NM23 family member 7 |
Aliases | FLJ37194; NM23-H7; CFAP67; cilia and flagella associated protein 67; non-metastatic cells 7, protein express ...... |
Chromosomal Location | 1q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting NME7 collected from DrugBank database. |
There is no record. |