Browse NME8

Summary
SymbolNME8
NameNME/NM23 family member 8
Aliases CILD6; SPTRX2; NM23-H8; sperm-specific thioredoxin 2; TXNDC3; thioredoxin domain containing 3 (spermatozoa); ......
Chromosomal Location7p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm
Domain PF00334 Nucleoside diphosphate kinase
PF00085 Thioredoxin
Function

Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds.

> Gene Ontology
 
Biological Process GO:0000302 response to reactive oxygen species
GO:0006164 purine nucleotide biosynthetic process
GO:0006165 nucleoside diphosphate phosphorylation
GO:0006183 GTP biosynthetic process
GO:0006213 pyrimidine nucleoside metabolic process
GO:0006220 pyrimidine nucleotide metabolic process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0006228 UTP biosynthetic process
GO:0006241 CTP biosynthetic process
GO:0006979 response to oxidative stress
GO:0007283 spermatogenesis
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0009116 nucleoside metabolic process
GO:0009119 ribonucleoside metabolic process
GO:0009132 nucleoside diphosphate metabolic process
GO:0009141 nucleoside triphosphate metabolic process
GO:0009142 nucleoside triphosphate biosynthetic process
GO:0009144 purine nucleoside triphosphate metabolic process
GO:0009145 purine nucleoside triphosphate biosynthetic process
GO:0009147 pyrimidine nucleoside triphosphate metabolic process
GO:0009148 pyrimidine nucleoside triphosphate biosynthetic process
GO:0009150 purine ribonucleotide metabolic process
GO:0009152 purine ribonucleotide biosynthetic process
GO:0009163 nucleoside biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0009199 ribonucleoside triphosphate metabolic process
GO:0009201 ribonucleoside triphosphate biosynthetic process
GO:0009205 purine ribonucleoside triphosphate metabolic process
GO:0009206 purine ribonucleoside triphosphate biosynthetic process
GO:0009208 pyrimidine ribonucleoside triphosphate metabolic process
GO:0009209 pyrimidine ribonucleoside triphosphate biosynthetic process
GO:0009218 pyrimidine ribonucleotide metabolic process
GO:0009220 pyrimidine ribonucleotide biosynthetic process
GO:0009260 ribonucleotide biosynthetic process
GO:0010927 cellular component assembly involved in morphogenesis
GO:0030031 cell projection assembly
GO:0030317 flagellated sperm motility
GO:0034599 cellular response to oxidative stress
GO:0034614 cellular response to reactive oxygen species
GO:0036473 cell death in response to oxidative stress
GO:0042278 purine nucleoside metabolic process
GO:0042384 cilium assembly
GO:0042451 purine nucleoside biosynthetic process
GO:0042455 ribonucleoside biosynthetic process
GO:0044782 cilium organization
GO:0045454 cell redox homeostasis
GO:0046036 CTP metabolic process
GO:0046039 GTP metabolic process
GO:0046051 UTP metabolic process
GO:0046128 purine ribonucleoside metabolic process
GO:0046129 purine ribonucleoside biosynthetic process
GO:0046131 pyrimidine ribonucleoside metabolic process
GO:0046132 pyrimidine ribonucleoside biosynthetic process
GO:0046134 pyrimidine nucleoside biosynthetic process
GO:0046390 ribose phosphate biosynthetic process
GO:0046939 nucleotide phosphorylation
GO:0048232 male gamete generation
GO:0060271 cilium morphogenesis
GO:0072522 purine-containing compound biosynthetic process
GO:0072527 pyrimidine-containing compound metabolic process
GO:0072528 pyrimidine-containing compound biosynthetic process
GO:0097193 intrinsic apoptotic signaling pathway
GO:0097722 sperm motility
GO:1900407 regulation of cellular response to oxidative stress
GO:1900408 negative regulation of cellular response to oxidative stress
GO:1901068 guanosine-containing compound metabolic process
GO:1901070 guanosine-containing compound biosynthetic process
GO:1901293 nucleoside phosphate biosynthetic process
GO:1901657 glycosyl compound metabolic process
GO:1901659 glycosyl compound biosynthetic process
GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:1902532 negative regulation of intracellular signal transduction
GO:1902882 regulation of response to oxidative stress
GO:1902883 negative regulation of response to oxidative stress
GO:1903201 regulation of oxidative stress-induced cell death
GO:1903202 negative regulation of oxidative stress-induced cell death
GO:2001233 regulation of apoptotic signaling pathway
GO:2001234 negative regulation of apoptotic signaling pathway
GO:2001242 regulation of intrinsic apoptotic signaling pathway
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Molecular Function GO:0004550 nucleoside diphosphate kinase activity
GO:0008017 microtubule binding
GO:0015631 tubulin binding
GO:0016776 phosphotransferase activity, phosphate group as acceptor
GO:0019205 nucleobase-containing compound kinase activity
Cellular Component GO:0005858 axonemal dynein complex
GO:0005875 microtubule associated complex
GO:0005929 cilium
GO:0005930 axoneme
GO:0030286 dynein complex
GO:0031514 motile cilium
GO:0036126 sperm flagellum
GO:0036157 outer dynein arm
GO:0044441 ciliary part
GO:0044447 axoneme part
GO:0097014 ciliary plasm
GO:0097223 sperm part
GO:0097228 sperm principal piece
GO:0097598 sperm cytoplasmic droplet
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolNME8
NameNME/NM23 family member 8
Aliases CILD6; SPTRX2; NM23-H8; sperm-specific thioredoxin 2; TXNDC3; thioredoxin domain containing 3 (spermatozoa); ......
Chromosomal Location7p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between NME8 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolNME8
NameNME/NM23 family member 8
Aliases CILD6; SPTRX2; NM23-H8; sperm-specific thioredoxin 2; TXNDC3; thioredoxin domain containing 3 (spermatozoa); ......
Chromosomal Location7p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of NME8 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolNME8
NameNME/NM23 family member 8
Aliases CILD6; SPTRX2; NM23-H8; sperm-specific thioredoxin 2; TXNDC3; thioredoxin domain containing 3 (spermatozoa); ......
Chromosomal Location7p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of NME8 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)141201
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-1.0880.0376
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.9990.339
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-1.2030.322
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.880.17
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15111.8830.0804
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.2440.831
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.5870.459
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.1460.886
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.4170.0404
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of NME8 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277304.1-4.10.561
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275903.4-3.41
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)2117195.913.10.355
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)86250250.473
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131115.49.16.31
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38277.914.8-6.90.437
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.17.71.41
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.221.4-15.20.315
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolNME8
NameNME/NM23 family member 8
Aliases CILD6; SPTRX2; NM23-H8; sperm-specific thioredoxin 2; TXNDC3; thioredoxin domain containing 3 (spermatozoa); ......
Chromosomal Location7p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NME8. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolNME8
NameNME/NM23 family member 8
Aliases CILD6; SPTRX2; NM23-H8; sperm-specific thioredoxin 2; TXNDC3; thioredoxin domain containing 3 (spermatozoa); ......
Chromosomal Location7p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NME8. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NME8.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolNME8
NameNME/NM23 family member 8
Aliases CILD6; SPTRX2; NM23-H8; sperm-specific thioredoxin 2; TXNDC3; thioredoxin domain containing 3 (spermatozoa); ......
Chromosomal Location7p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NME8. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolNME8
NameNME/NM23 family member 8
Aliases CILD6; SPTRX2; NM23-H8; sperm-specific thioredoxin 2; TXNDC3; thioredoxin domain containing 3 (spermatozoa); ......
Chromosomal Location7p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of NME8 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolNME8
NameNME/NM23 family member 8
Aliases CILD6; SPTRX2; NM23-H8; sperm-specific thioredoxin 2; TXNDC3; thioredoxin domain containing 3 (spermatozoa); ......
Chromosomal Location7p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between NME8 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolNME8
NameNME/NM23 family member 8
Aliases CILD6; SPTRX2; NM23-H8; sperm-specific thioredoxin 2; TXNDC3; thioredoxin domain containing 3 (spermatozoa); ......
Chromosomal Location7p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting NME8 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.