Browse NMT2

Summary
SymbolNMT2
NameN-myristoyltransferase 2
Aliases NMT 2; glycylpeptide N-tetradecanoyltransferase 2 variant 3; glycylpeptide N-tetradecanoyltransferase 2 vari ......
Chromosomal Location10p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm Membrane Peripheral membrane protein
Domain PF01233 Myristoyl-CoA
PF02799 Myristoyl-CoA
Function

Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.

> Gene Ontology
 
Biological Process GO:0006497 protein lipidation
GO:0006498 N-terminal protein lipidation
GO:0006499 N-terminal protein myristoylation
GO:0007602 phototransduction
GO:0007603 phototransduction, visible light
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0009314 response to radiation
GO:0009416 response to light stimulus
GO:0009581 detection of external stimulus
GO:0009582 detection of abiotic stimulus
GO:0009583 detection of light stimulus
GO:0009584 detection of visible light
GO:0016056 rhodopsin mediated signaling pathway
GO:0018008 N-terminal peptidyl-glycine N-myristoylation
GO:0018201 peptidyl-glycine modification
GO:0018377 protein myristoylation
GO:0019058 viral life cycle
GO:0022400 regulation of rhodopsin mediated signaling pathway
GO:0031365 N-terminal protein amino acid modification
GO:0042157 lipoprotein metabolic process
GO:0042158 lipoprotein biosynthetic process
GO:0043543 protein acylation
GO:0044766 multi-organism transport
GO:0046794 transport of virus
GO:0071214 cellular response to abiotic stimulus
GO:0071478 cellular response to radiation
GO:0071482 cellular response to light stimulus
GO:0075733 intracellular transport of virus
GO:1902579 multi-organism localization
GO:1902581 multi-organism cellular localization
GO:1902583 multi-organism intracellular transport
Molecular Function GO:0004379 glycylpeptide N-tetradecanoyltransferase activity
GO:0016410 N-acyltransferase activity
GO:0016746 transferase activity, transferring acyl groups
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
GO:0019107 myristoyltransferase activity
Cellular Component GO:0019898 extrinsic component of membrane
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-175474: Assembly Of The HIV Virion
R-HSA-1643685: Disease
R-HSA-162906: HIV Infection
R-HSA-162587: HIV Life Cycle
R-HSA-2514859: Inactivation, recovery and regulation of the phototransduction cascade
R-HSA-5663205: Infectious disease
R-HSA-162599: Late Phase of HIV Life Cycle
R-HSA-174490: Membrane binding and targetting of GAG proteins
R-HSA-162582: Signal Transduction
R-HSA-174495: Synthesis And Processing Of GAG, GAGPOL Polyproteins
R-HSA-2514856: The phototransduction cascade
R-HSA-2187338: Visual phototransduction
Summary
SymbolNMT2
NameN-myristoyltransferase 2
Aliases NMT 2; glycylpeptide N-tetradecanoyltransferase 2 variant 3; glycylpeptide N-tetradecanoyltransferase 2 vari ......
Chromosomal Location10p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between NMT2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolNMT2
NameN-myristoyltransferase 2
Aliases NMT 2; glycylpeptide N-tetradecanoyltransferase 2 variant 3; glycylpeptide N-tetradecanoyltransferase 2 vari ......
Chromosomal Location10p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of NMT2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell logFC: -1.58; FDR: 0.04220 Resistant to T cell-mediated killing
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolNMT2
NameN-myristoyltransferase 2
Aliases NMT 2; glycylpeptide N-tetradecanoyltransferase 2 variant 3; glycylpeptide N-tetradecanoyltransferase 2 vari ......
Chromosomal Location10p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of NMT2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.1950.475
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.5210.493
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.7210.243
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.0230.935
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.2750.882
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.3980.864
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.4780.151
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.5430.644
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.3970.764
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.1490.9
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.7050.667
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.2050.0838
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolNMT2
NameN-myristoyltransferase 2
Aliases NMT 2; glycylpeptide N-tetradecanoyltransferase 2 variant 3; glycylpeptide N-tetradecanoyltransferase 2 vari ......
Chromosomal Location10p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NMT2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolNMT2
NameN-myristoyltransferase 2
Aliases NMT 2; glycylpeptide N-tetradecanoyltransferase 2 variant 3; glycylpeptide N-tetradecanoyltransferase 2 vari ......
Chromosomal Location10p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NMT2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NMT2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolNMT2
NameN-myristoyltransferase 2
Aliases NMT 2; glycylpeptide N-tetradecanoyltransferase 2 variant 3; glycylpeptide N-tetradecanoyltransferase 2 vari ......
Chromosomal Location10p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NMT2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolNMT2
NameN-myristoyltransferase 2
Aliases NMT 2; glycylpeptide N-tetradecanoyltransferase 2 variant 3; glycylpeptide N-tetradecanoyltransferase 2 vari ......
Chromosomal Location10p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of NMT2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolNMT2
NameN-myristoyltransferase 2
Aliases NMT 2; glycylpeptide N-tetradecanoyltransferase 2 variant 3; glycylpeptide N-tetradecanoyltransferase 2 vari ......
Chromosomal Location10p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between NMT2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolNMT2
NameN-myristoyltransferase 2
Aliases NMT 2; glycylpeptide N-tetradecanoyltransferase 2 variant 3; glycylpeptide N-tetradecanoyltransferase 2 vari ......
Chromosomal Location10p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting NMT2 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting NMT2.
ID Name Drug Type Targets #Targets
DB02180Myristoyl-CoaSmall MoleculeNMT21
DB02271S-(2-Oxo)PentadecylcoaSmall MoleculeNMT21
DB070611-(CYCLOHEXYLAMINO)-3-(6-METHYL-3,4-DIHYDRO-1H-CARBAZOL-9(2H)-YL)PROPAN-2-OLSmall MoleculeNMT21
DB07838(Z)-3-BENZYL-5-(2-HYDROXY-3-NITROBENZYLIDENE)-2-THIOXOTHIAZOLIDIN-4-ONESmall MoleculeNMT21