Browse NRP1

Summary
SymbolNRP1
Nameneuropilin 1
Aliases VEGF165R; CD304; BDCA4; transmembrane receptor; vascular endothelial cell growth factor 165 receptor; CD ant ......
Chromosomal Location10p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: Isoform 2: Secreted.
Domain PF00431 CUB domain
PF11980 C-terminal domain of neuropilin glycoprotein
PF00754 F5/8 type C domain
PF00629 MAM domain
Function

The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF165 isoform of VEGFA and VEGFB. Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulate VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). ; FUNCTION: The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.

> Gene Ontology
 
Biological Process GO:0001525 angiogenesis
GO:0001558 regulation of cell growth
GO:0001569 patterning of blood vessels
GO:0001654 eye development
GO:0001655 urogenital system development
GO:0001667 ameboidal-type cell migration
GO:0001708 cell fate specification
GO:0001755 neural crest cell migration
GO:0001763 morphogenesis of a branching structure
GO:0001764 neuron migration
GO:0001822 kidney development
GO:0001935 endothelial cell proliferation
GO:0001936 regulation of endothelial cell proliferation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002040 sprouting angiogenesis
GO:0002042 cell migration involved in sprouting angiogenesis
GO:0003002 regionalization
GO:0003158 endothelium development
GO:0006929 substrate-dependent cell migration
GO:0007350 blastoderm segmentation
GO:0007389 pattern specification process
GO:0007409 axonogenesis
GO:0007411 axon guidance
GO:0007413 axonal fasciculation
GO:0007423 sensory organ development
GO:0007431 salivary gland development
GO:0007435 salivary gland morphogenesis
GO:0007507 heart development
GO:0008037 cell recognition
GO:0008038 neuron recognition
GO:0008045 motor neuron axon guidance
GO:0008361 regulation of cell size
GO:0009880 embryonic pattern specification
GO:0010594 regulation of endothelial cell migration
GO:0010595 positive regulation of endothelial cell migration
GO:0010631 epithelial cell migration
GO:0010632 regulation of epithelial cell migration
GO:0010634 positive regulation of epithelial cell migration
GO:0010720 positive regulation of cell development
GO:0010721 negative regulation of cell development
GO:0010769 regulation of cell morphogenesis involved in differentiation
GO:0010770 positive regulation of cell morphogenesis involved in differentiation
GO:0010771 negative regulation of cell morphogenesis involved in differentiation
GO:0010975 regulation of neuron projection development
GO:0010976 positive regulation of neuron projection development
GO:0010977 negative regulation of neuron projection development
GO:0014031 mesenchymal cell development
GO:0014032 neural crest cell development
GO:0014033 neural crest cell differentiation
GO:0014812 muscle cell migration
GO:0014909 smooth muscle cell migration
GO:0014910 regulation of smooth muscle cell migration
GO:0014911 positive regulation of smooth muscle cell migration
GO:0016049 cell growth
GO:0016358 dendrite development
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0018212 peptidyl-tyrosine modification
GO:0021536 diencephalon development
GO:0021537 telencephalon development
GO:0021543 pallium development
GO:0021545 cranial nerve development
GO:0021559 trigeminal nerve development
GO:0021561 facial nerve development
GO:0021562 vestibulocochlear nerve development
GO:0021602 cranial nerve morphogenesis
GO:0021604 cranial nerve structural organization
GO:0021610 facial nerve morphogenesis
GO:0021612 facial nerve structural organization
GO:0021636 trigeminal nerve morphogenesis
GO:0021637 trigeminal nerve structural organization
GO:0021648 vestibulocochlear nerve morphogenesis
GO:0021649 vestibulocochlear nerve structural organization
GO:0021675 nerve development
GO:0021761 limbic system development
GO:0021783 preganglionic parasympathetic fiber development
GO:0021785 branchiomotor neuron axon guidance
GO:0021795 cerebral cortex cell migration
GO:0021800 cerebral cortex tangential migration
GO:0021824 cerebral cortex tangential migration using cell-axon interactions
GO:0021825 substrate-dependent cerebral cortex tangential migration
GO:0021828 gonadotrophin-releasing hormone neuronal migration to the hypothalamus
GO:0021854 hypothalamus development
GO:0021855 hypothalamus cell migration
GO:0021856 hypothalamic tangential migration using cell-axon interactions
GO:0021872 forebrain generation of neurons
GO:0021879 forebrain neuron differentiation
GO:0021884 forebrain neuron development
GO:0021885 forebrain cell migration
GO:0021886 hypothalamus gonadotrophin-releasing hormone neuron differentiation
GO:0021888 hypothalamus gonadotrophin-releasing hormone neuron development
GO:0021953 central nervous system neuron differentiation
GO:0021954 central nervous system neuron development
GO:0021979 hypothalamus cell differentiation
GO:0021987 cerebral cortex development
GO:0022029 telencephalon cell migration
GO:0022604 regulation of cell morphogenesis
GO:0022612 gland morphogenesis
GO:0030307 positive regulation of cell growth
GO:0030308 negative regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0030516 regulation of axon extension
GO:0030517 negative regulation of axon extension
GO:0030900 forebrain development
GO:0031290 retinal ganglion cell axon guidance
GO:0031345 negative regulation of cell projection organization
GO:0031346 positive regulation of cell projection organization
GO:0032092 positive regulation of protein binding
GO:0032102 negative regulation of response to external stimulus
GO:0032103 positive regulation of response to external stimulus
GO:0032535 regulation of cellular component size
GO:0035239 tube morphogenesis
GO:0035272 exocrine system development
GO:0035282 segmentation
GO:0035290 trunk segmentation
GO:0035728 response to hepatocyte growth factor
GO:0035729 cellular response to hepatocyte growth factor stimulus
GO:0035767 endothelial cell chemotaxis
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0036010 protein localization to endosome
GO:0036484 trunk neural crest cell migration
GO:0036486 ventral trunk neural crest cell migration
GO:0038084 vascular endothelial growth factor signaling pathway
GO:0038189 neuropilin signaling pathway
GO:0038190 VEGF-activated neuropilin signaling pathway
GO:0040013 negative regulation of locomotion
GO:0040017 positive regulation of locomotion
GO:0043010 camera-type eye development
GO:0043393 regulation of protein binding
GO:0043410 positive regulation of MAPK cascade
GO:0043523 regulation of neuron apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0043534 blood vessel endothelial cell migration
GO:0043542 endothelial cell migration
GO:0045165 cell fate commitment
GO:0045446 endothelial cell differentiation
GO:0045665 negative regulation of neuron differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045773 positive regulation of axon extension
GO:0045926 negative regulation of growth
GO:0045927 positive regulation of growth
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048012 hepatocyte growth factor receptor signaling pathway
GO:0048483 autonomic nervous system development
GO:0048485 sympathetic nervous system development
GO:0048486 parasympathetic nervous system development
GO:0048514 blood vessel morphogenesis
GO:0048532 anatomical structure arrangement
GO:0048588 developmental cell growth
GO:0048638 regulation of developmental growth
GO:0048639 positive regulation of developmental growth
GO:0048640 negative regulation of developmental growth
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0048675 axon extension
GO:0048732 gland development
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048762 mesenchymal cell differentiation
GO:0048841 regulation of axon extension involved in axon guidance
GO:0048842 positive regulation of axon extension involved in axon guidance
GO:0048843 negative regulation of axon extension involved in axon guidance
GO:0048844 artery morphogenesis
GO:0048846 axon extension involved in axon guidance
GO:0048863 stem cell differentiation
GO:0048864 stem cell development
GO:0050673 epithelial cell proliferation
GO:0050678 regulation of epithelial cell proliferation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050768 negative regulation of neurogenesis
GO:0050769 positive regulation of neurogenesis
GO:0050770 regulation of axonogenesis
GO:0050771 negative regulation of axonogenesis
GO:0050772 positive regulation of axonogenesis
GO:0050918 positive chemotaxis
GO:0050920 regulation of chemotaxis
GO:0050921 positive regulation of chemotaxis
GO:0050922 negative regulation of chemotaxis
GO:0051098 regulation of binding
GO:0051099 positive regulation of binding
GO:0051271 negative regulation of cellular component movement
GO:0051272 positive regulation of cellular component movement
GO:0051402 neuron apoptotic process
GO:0051961 negative regulation of nervous system development
GO:0051962 positive regulation of nervous system development
GO:0060041 retina development in camera-type eye
GO:0060300 regulation of cytokine activity
GO:0060301 positive regulation of cytokine activity
GO:0060326 cell chemotaxis
GO:0060384 innervation
GO:0060385 axonogenesis involved in innervation
GO:0060445 branching involved in salivary gland morphogenesis
GO:0060485 mesenchyme development
GO:0060560 developmental growth involved in morphogenesis
GO:0060562 epithelial tube morphogenesis
GO:0060600 dichotomous subdivision of an epithelial terminal unit
GO:0060627 regulation of vesicle-mediated transport
GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching
GO:0060837 blood vessel endothelial cell differentiation
GO:0060839 endothelial cell fate commitment
GO:0060840 artery development
GO:0060846 blood vessel endothelial cell fate commitment
GO:0060847 endothelial cell fate specification
GO:0060976 coronary vasculature development
GO:0060977 coronary vasculature morphogenesis
GO:0060978 angiogenesis involved in coronary vascular morphogenesis
GO:0060982 coronary artery morphogenesis
GO:0061138 morphogenesis of a branching epithelium
GO:0061298 retina vasculature development in camera-type eye
GO:0061299 retina vasculature morphogenesis in camera-type eye
GO:0061387 regulation of extent of cell growth
GO:0061437 renal system vasculature development
GO:0061438 renal system vasculature morphogenesis
GO:0061439 kidney vasculature morphogenesis
GO:0061440 kidney vasculature development
GO:0061441 renal artery morphogenesis
GO:0061548 ganglion development
GO:0061549 sympathetic ganglion development
GO:0061550 cranial ganglion development
GO:0061551 trigeminal ganglion development
GO:0061552 ganglion morphogenesis
GO:0061564 axon development
GO:0070371 ERK1 and ERK2 cascade
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070997 neuron death
GO:0071526 semaphorin-plexin signaling pathway
GO:0071679 commissural neuron axon guidance
GO:0071696 ectodermal placode development
GO:0072001 renal system development
GO:0072148 epithelial cell fate commitment
GO:0072665 protein localization to vacuole
GO:0090066 regulation of anatomical structure size
GO:0090130 tissue migration
GO:0090132 epithelium migration
GO:0090259 regulation of retinal ganglion cell axon guidance
GO:0097101 blood vessel endothelial cell fate specification
GO:0097102 endothelial tip cell fate specification
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097374 sensory neuron axon guidance
GO:0097485 neuron projection guidance
GO:0097490 sympathetic neuron projection extension
GO:0097491 sympathetic neuron projection guidance
GO:1900120 regulation of receptor binding
GO:1900122 positive regulation of receptor binding
GO:1901166 neural crest cell migration involved in autonomic nervous system development
GO:1901214 regulation of neuron death
GO:1901215 negative regulation of neuron death
GO:1901998 toxin transport
GO:1902284 neuron projection extension involved in neuron projection guidance
GO:1902285 semaphorin-plexin signaling pathway involved in neuron projection guidance
GO:1902287 semaphorin-plexin signaling pathway involved in axon guidance
GO:1902336 positive regulation of retinal ganglion cell axon guidance
GO:1902378 VEGF-activated neuropilin signaling pathway involved in axon guidance
GO:1902667 regulation of axon guidance
GO:1902668 negative regulation of axon guidance
GO:1902669 positive regulation of axon guidance
GO:1902946 protein localization to early endosome
GO:1903375 facioacoustic ganglion development
GO:1904835 dorsal root ganglion morphogenesis
GO:1905040 otic placode development
GO:1990138 neuron projection extension
GO:1990791 dorsal root ganglion development
GO:2000147 positive regulation of cell motility
GO:2001233 regulation of apoptotic signaling pathway
GO:2001234 negative regulation of apoptotic signaling pathway
GO:2001236 regulation of extrinsic apoptotic signaling pathway
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Molecular Function GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005021 vascular endothelial growth factor-activated receptor activity
GO:0005539 glycosaminoglycan binding
GO:0008201 heparin binding
GO:0015026 coreceptor activity
GO:0017154 semaphorin receptor activity
GO:0019199 transmembrane receptor protein kinase activity
GO:0019838 growth factor binding
GO:0019955 cytokine binding
GO:0038085 vascular endothelial growth factor binding
GO:1901681 sulfur compound binding
Cellular Component GO:0002116 semaphorin receptor complex
GO:0005769 early endosome
GO:0005882 intermediate filament
GO:0005883 neurofilament
GO:0005924 cell-substrate adherens junction
GO:0005925 focal adhesion
GO:0030055 cell-substrate junction
GO:0030424 axon
GO:0030426 growth cone
GO:0030427 site of polarized growth
GO:0043025 neuronal cell body
GO:0043235 receptor complex
GO:0044297 cell body
GO:0045111 intermediate filament cytoskeleton
GO:0097443 sorting endosome
> KEGG and Reactome Pathway
 
KEGG hsa04360 Axon guidance
Reactome R-HSA-422475: Axon guidance
R-HSA-447041: CHL1 interactions
R-HSA-399956: CRMPs in Sema3A signaling
R-HSA-1266738: Developmental Biology
R-HSA-373760: L1CAM interactions
R-HSA-194306: Neurophilin interactions with VEGF and VEGFR
R-HSA-399955: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-HSA-399954: Sema3A PAK dependent Axon repulsion
R-HSA-373755: Semaphorin interactions
R-HSA-162582: Signal Transduction
R-HSA-445144: Signal transduction by L1
R-HSA-194138: Signaling by VEGF
Summary
SymbolNRP1
Nameneuropilin 1
Aliases VEGF165R; CD304; BDCA4; transmembrane receptor; vascular endothelial cell growth factor 165 receptor; CD ant ......
Chromosomal Location10p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between NRP1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between NRP1 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
23045606MelanomaInhibit immunity (T cell function)We provide evidence that Neuropilin 1 (Nrp-1), highly expressed by Foxp3(+) T reg cells, regulates the immunological anti-tumor control by guiding T reg cells into the tumor in response to tumor-derived vascular endothelial growth factor (VEGF).
28552348Melanoma; Head and Neck Squamous Cell Carcinoma.Inhibit immunity (T cell function)Using a mouse model of melanoma where Nrp1-deficient (Nrp1-/-) and wild-type (Nrp1+/+) Tregscan be assessed in a competitive environment, we find that a high proportion of intratumoral Nrp1-/-Tregsproduce interferon-γ (IFNγ), which drives the fragility of surrounding wild-type Tregs, boosts anti-tumor immunity, and facilitates tumor clearance.
23447383Chronic Lymphocytic LeukemiaInhibit immunity (T cell function)In our study, we characterized mRNA levels of VEGF receptors including NRP1 in a large cohort of CLL patients (n = 114), additionally we performed a detailed characterization of NRP1 expression on B cells, plasmacytoid dendritic cells (PDCs) and regulatory T cells (Tregs). The expression of NRP1 was significantly higher on leukemic lymphocytes compared to control B lymphocytes on mRNA and protein levels (22.72% vs. 0.2%, p = 0.0003, respectively), Tregs (42.6% vs. 16.05%, p = 0.0003) and PDCs (100% vs. 98% p < 0.0001). In functional studies, we found higher NRP1 expression on CLL cells after stimulation with VEGF. The correlation between expression of VEGF receptors: FLT1, NRP1 and FOXP3 expression (r(2) = 0.53, p < 0.0001 and r(2) = 0.49, p < 0.0001, respectively) was observed.
29097606GliomaInhibit immunityMice that lack the transmembrane receptor neuropilin-1 (Nrp1), which modulates GAM immune polarization, exhibit a decrease in glioma volumes and neoangiogenesis and an increase in antitumorigenic GAM infiltrate. Mice with Nrp1-deficient microglia and wild-type peripheral macrophages showed resistance to glioma development and had higher microglial infiltrate than mice with wild-type GAMs.
Summary
SymbolNRP1
Nameneuropilin 1
Aliases VEGF165R; CD304; BDCA4; transmembrane receptor; vascular endothelial cell growth factor 165 receptor; CD ant ......
Chromosomal Location10p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of NRP1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolNRP1
Nameneuropilin 1
Aliases VEGF165R; CD304; BDCA4; transmembrane receptor; vascular endothelial cell growth factor 165 receptor; CD ant ......
Chromosomal Location10p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of NRP1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-1.070.0197
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.8430.646
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-1.2270.32
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.2670.394
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.3190.892
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.2010.947
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.2970.619
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.2040.915
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.4580.823
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.8230.669
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.7840.533
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.350.0076
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of NRP1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.74.1-0.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.75.1-1.41
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.811.8-70.577
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)86016.7-16.70.429
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.79.1-1.41
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38277.907.90.26
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.109.10.519
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolNRP1
Nameneuropilin 1
Aliases VEGF165R; CD304; BDCA4; transmembrane receptor; vascular endothelial cell growth factor 165 receptor; CD ant ......
Chromosomal Location10p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NRP1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolNRP1
Nameneuropilin 1
Aliases VEGF165R; CD304; BDCA4; transmembrane receptor; vascular endothelial cell growth factor 165 receptor; CD ant ......
Chromosomal Location10p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NRP1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NRP1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolNRP1
Nameneuropilin 1
Aliases VEGF165R; CD304; BDCA4; transmembrane receptor; vascular endothelial cell growth factor 165 receptor; CD ant ......
Chromosomal Location10p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NRP1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolNRP1
Nameneuropilin 1
Aliases VEGF165R; CD304; BDCA4; transmembrane receptor; vascular endothelial cell growth factor 165 receptor; CD ant ......
Chromosomal Location10p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of NRP1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolNRP1
Nameneuropilin 1
Aliases VEGF165R; CD304; BDCA4; transmembrane receptor; vascular endothelial cell growth factor 165 receptor; CD ant ......
Chromosomal Location10p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between NRP1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolNRP1
Nameneuropilin 1
Aliases VEGF165R; CD304; BDCA4; transmembrane receptor; vascular endothelial cell growth factor 165 receptor; CD ant ......
Chromosomal Location10p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting NRP1 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting NRP1.
ID Name Drug Type Targets #Targets
DB00039PaliferminBiotechFGFR1, FGFR2, FGFR3, FGFR4, HSPG2, NRP16
DB04895PegaptanibBiotechNRP11