Browse NRXN1

Summary
SymbolNRXN1
Nameneurexin 1
Aliases KIAA0578; Hs.22998; PTHSL2; SCZD17; neurexin I; Neurexin I-beta; Neurexin-1-beta
Chromosomal Location2p16.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane; Single-pass type I membrane protein. Cell junction, synapse. Note=Localized on the pre-synaptic membrane.
Domain PF02210 Laminin G domain
PF01034 Syndecan domain
Function

Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis (By similarity).

> Gene Ontology
 
Biological Process GO:0001505 regulation of neurotransmitter levels
GO:0001678 cellular glucose homeostasis
GO:0001941 postsynaptic membrane organization
GO:0001964 startle response
GO:0002790 peptide secretion
GO:0002791 regulation of peptide secretion
GO:0006836 neurotransmitter transport
GO:0007158 neuron cell-cell adhesion
GO:0007269 neurotransmitter secretion
GO:0007270 neuron-neuron synaptic transmission
GO:0007409 axonogenesis
GO:0007411 axon guidance
GO:0007416 synapse assembly
GO:0007611 learning or memory
GO:0007612 learning
GO:0007625 grooming behavior
GO:0007638 mechanosensory behavior
GO:0009306 protein secretion
GO:0009612 response to mechanical stimulus
GO:0009743 response to carbohydrate
GO:0009746 response to hexose
GO:0009749 response to glucose
GO:0009914 hormone transport
GO:0010817 regulation of hormone levels
GO:0010996 response to auditory stimulus
GO:0015833 peptide transport
GO:0021700 developmental maturation
GO:0023061 signal release
GO:0030072 peptide hormone secretion
GO:0030073 insulin secretion
GO:0030534 adult behavior
GO:0031223 auditory behavior
GO:0032102 negative regulation of response to external stimulus
GO:0032844 regulation of homeostatic process
GO:0033500 carbohydrate homeostasis
GO:0034284 response to monosaccharide
GO:0035176 social behavior
GO:0035249 synaptic transmission, glutamatergic
GO:0035418 protein localization to synapse
GO:0035773 insulin secretion involved in cellular response to glucose stimulus
GO:0042297 vocal learning
GO:0042391 regulation of membrane potential
GO:0042593 glucose homeostasis
GO:0042886 amide transport
GO:0043113 receptor clustering
GO:0044089 positive regulation of cellular component biogenesis
GO:0044091 membrane biogenesis
GO:0044708 single-organism behavior
GO:0046879 hormone secretion
GO:0046883 regulation of hormone secretion
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0050708 regulation of protein secretion
GO:0050795 regulation of behavior
GO:0050796 regulation of insulin secretion
GO:0050803 regulation of synapse structure or activity
GO:0050804 modulation of synaptic transmission
GO:0050806 positive regulation of synaptic transmission
GO:0050807 regulation of synapse organization
GO:0050808 synapse organization
GO:0050885 neuromuscular process controlling balance
GO:0050890 cognition
GO:0050905 neuromuscular process
GO:0051668 localization within membrane
GO:0051703 intraspecies interaction between organisms
GO:0051705 multi-organism behavior
GO:0051962 positive regulation of nervous system development
GO:0051963 regulation of synapse assembly
GO:0051965 positive regulation of synapse assembly
GO:0051966 regulation of synaptic transmission, glutamatergic
GO:0051968 positive regulation of synaptic transmission, glutamatergic
GO:0060074 synapse maturation
GO:0060078 regulation of postsynaptic membrane potential
GO:0060079 excitatory postsynaptic potential
GO:0060134 prepulse inhibition
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0061564 axon development
GO:0071322 cellular response to carbohydrate stimulus
GO:0071326 cellular response to monosaccharide stimulus
GO:0071331 cellular response to hexose stimulus
GO:0071333 cellular response to glucose stimulus
GO:0071625 vocalization behavior
GO:0071709 membrane assembly
GO:0072657 protein localization to membrane
GO:0090087 regulation of peptide transport
GO:0090128 regulation of synapse maturation
GO:0090129 positive regulation of synapse maturation
GO:0090276 regulation of peptide hormone secretion
GO:0097104 postsynaptic membrane assembly
GO:0097106 postsynaptic density organization
GO:0097107 postsynaptic density assembly
GO:0097116 gephyrin clustering involved in postsynaptic density assembly
GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly
GO:0097119 postsynaptic density protein 95 clustering
GO:0097485 neuron projection guidance
GO:0098596 imitative learning
GO:0098597 observational learning
GO:0098598 learned vocalization behavior or vocal learning
GO:0098815 modulation of excitatory postsynaptic potential
GO:0099068 postsynapse assembly
GO:0099531 presynaptic process involved in chemical synaptic transmission
GO:0099565 chemical synaptic transmission, postsynaptic
GO:0099643 signal release from synapse
GO:1904861 excitatory synapse assembly
GO:2000463 positive regulation of excitatory postsynaptic potential
GO:2000821 regulation of grooming behavior
Molecular Function GO:0005246 calcium channel regulator activity
GO:0016247 channel regulator activity
GO:0033130 acetylcholine receptor binding
GO:0050839 cell adhesion molecule binding
GO:0097109 neuroligin family protein binding
Cellular Component GO:0005635 nuclear envelope
GO:0031965 nuclear membrane
GO:0042734 presynaptic membrane
GO:0043025 neuronal cell body
GO:0044297 cell body
GO:0097060 synaptic membrane
GO:0098793 presynapse
> KEGG and Reactome Pathway
 
KEGG hsa04514 Cell adhesion molecules (CAMs)
Reactome R-HSA-1474244: Extracellular matrix organization
R-HSA-6794361: Interactions of neurexins and neuroligins at synapses
R-HSA-112316: Neuronal System
R-HSA-3000171: Non-integrin membrane-ECM interactions
R-HSA-6794362: Protein-protein interactions at synapses
Summary
SymbolNRXN1
Nameneurexin 1
Aliases KIAA0578; Hs.22998; PTHSL2; SCZD17; neurexin I; Neurexin I-beta; Neurexin-1-beta
Chromosomal Location2p16.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between NRXN1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolNRXN1
Nameneurexin 1
Aliases KIAA0578; Hs.22998; PTHSL2; SCZD17; neurexin I; Neurexin I-beta; Neurexin-1-beta
Chromosomal Location2p16.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of NRXN1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolNRXN1
Nameneurexin 1
Aliases KIAA0578; Hs.22998; PTHSL2; SCZD17; neurexin I; Neurexin I-beta; Neurexin-1-beta
Chromosomal Location2p16.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of NRXN1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)141201
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.3660.45
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.1680.925
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.6130.789
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.4160.667
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.5530.674
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.2530.883
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.0990.786
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.0170.975
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.5890.106
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of NRXN1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141714.3014.30.196
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103200201
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277325.96.819.10.0153
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275925.98.517.40.0441
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.823.5-18.70.152
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.516.7-4.21
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)1311027.3-27.30.0815
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91622.26.2160.53
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 592011.18.91
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 382713.211.12.11
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221322.77.7150.377
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1614014.3-14.30.209
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11139.109.10.458
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 512200200.294
Summary
SymbolNRXN1
Nameneurexin 1
Aliases KIAA0578; Hs.22998; PTHSL2; SCZD17; neurexin I; Neurexin I-beta; Neurexin-1-beta
Chromosomal Location2p16.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NRXN1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolNRXN1
Nameneurexin 1
Aliases KIAA0578; Hs.22998; PTHSL2; SCZD17; neurexin I; Neurexin I-beta; Neurexin-1-beta
Chromosomal Location2p16.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NRXN1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NRXN1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolNRXN1
Nameneurexin 1
Aliases KIAA0578; Hs.22998; PTHSL2; SCZD17; neurexin I; Neurexin I-beta; Neurexin-1-beta
Chromosomal Location2p16.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NRXN1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolNRXN1
Nameneurexin 1
Aliases KIAA0578; Hs.22998; PTHSL2; SCZD17; neurexin I; Neurexin I-beta; Neurexin-1-beta
Chromosomal Location2p16.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of NRXN1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolNRXN1
Nameneurexin 1
Aliases KIAA0578; Hs.22998; PTHSL2; SCZD17; neurexin I; Neurexin I-beta; Neurexin-1-beta
Chromosomal Location2p16.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between NRXN1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolNRXN1
Nameneurexin 1
Aliases KIAA0578; Hs.22998; PTHSL2; SCZD17; neurexin I; Neurexin I-beta; Neurexin-1-beta
Chromosomal Location2p16.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting NRXN1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.