TISIDB

Summary
Symbol	NUMBL
Name	numb homolog (Drosophila)-like
Aliases	NUMB-R; CTG3a; CAG3A; TNRC23; NUMBR; NUMBLIKE; numb (Drosophila) homolog-like; NBL; NUMB-RIKE; numb homolog- ......
Chromosomal Location	19q13.13-q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cytoplasm Note=Symmetrically distributed throughout the cytoplasm in non dividing neuroblasts of the CNS.
Domain	PF06311 NUMB domain PF00640 Phosphotyrosine interaction domain (PTB/PID)
Function	Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.

> Gene Ontology [ TOP ]
Biological Process	GO:0007405 neuroblast proliferation GO:0007409 axonogenesis GO:0010720 positive regulation of cell development GO:0017145 stem cell division GO:0021537 telencephalon development GO:0021591 ventricular system development GO:0021670 lateral ventricle development GO:0021846 cell proliferation in forebrain GO:0021849 neuroblast division in subventricular zone GO:0021872 forebrain generation of neurons GO:0021873 forebrain neuroblast division GO:0030900 forebrain development GO:0034330 cell junction organization GO:0034332 adherens junction organization GO:0036445 neuronal stem cell division GO:0045216 cell-cell junction organization GO:0048103 somatic stem cell division GO:0048667 cell morphogenesis involved in neuron differentiation GO:0050769 positive regulation of neurogenesis GO:0051962 positive regulation of nervous system development GO:0055057 neuroblast division GO:0061351 neural precursor cell proliferation GO:0061564 axon development GO:0072089 stem cell proliferation
Molecular Function	-
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04330 Notch signaling pathway
Reactome	-

Summary
Symbol	NUMBL
Name	numb homolog (Drosophila)-like
Aliases	NUMB-R; CTG3a; CAG3A; TNRC23; NUMBR; NUMBLIKE; numb (Drosophila) homolog-like; NBL; NUMB-RIKE; numb homolog- ......
Chromosomal Location	19q13.13-q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between NUMBL and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	NUMBL
Name	numb homolog (Drosophila)-like
Aliases	NUMB-R; CTG3a; CAG3A; TNRC23; NUMBR; NUMBLIKE; numb (Drosophila) homolog-like; NBL; NUMB-RIKE; numb homolog- ......
Chromosomal Location	19q13.13-q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of NUMBL in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	NUMBL
Name	numb homolog (Drosophila)-like
Aliases	NUMB-R; CTG3a; CAG3A; TNRC23; NUMBR; NUMBLIKE; numb (Drosophila) homolog-like; NBL; NUMB-RIKE; numb homolog- ......
Chromosomal Location	19q13.13-q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the expression difference of NUMBL in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.791	0.0222
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-1.123	0.453
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.548	0.627
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.332	0.37
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.139	0.948
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-0.572	0.835
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.138	0.676
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.201	0.854
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.546	0.641
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.646	0.542
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	1.031	0.482
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.082	0.361

> Mutation difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the mutation difference of NUMBL in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	7.1	0	7.1	0.452
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	10	0	10	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	3.7	0	3.7	0.27
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	3.7	0	3.7	0.314
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	4.8	11.8	-7	0.577
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	7.7	18.2	-10.5	0.576
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	11.1	6.2	4.9	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	11.1	-11.1	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	25	0	25	0.364
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	5.3	0	5.3	0.507
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	9.1	0	9.1	0.519
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	NUMBL
Name	numb homolog (Drosophila)-like
Aliases	NUMB-R; CTG3a; CAG3A; TNRC23; NUMBR; NUMBLIKE; numb (Drosophila) homolog-like; NBL; NUMB-RIKE; numb homolog- ......
Chromosomal Location	19q13.13-q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NUMBL. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	NUMBL
Name	numb homolog (Drosophila)-like
Aliases	NUMB-R; CTG3a; CAG3A; TNRC23; NUMBR; NUMBLIKE; numb (Drosophila) homolog-like; NBL; NUMB-RIKE; numb homolog- ......
Chromosomal Location	19q13.13-q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NUMBL. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NUMBL. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	NUMBL
Name	numb homolog (Drosophila)-like
Aliases	NUMB-R; CTG3a; CAG3A; TNRC23; NUMBR; NUMBLIKE; numb (Drosophila) homolog-like; NBL; NUMB-RIKE; numb homolog- ......
Chromosomal Location	19q13.13-q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NUMBL. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	NUMBL
Name	numb homolog (Drosophila)-like
Aliases	NUMB-R; CTG3a; CAG3A; TNRC23; NUMBR; NUMBLIKE; numb (Drosophila) homolog-like; NBL; NUMB-RIKE; numb homolog- ......
Chromosomal Location	19q13.13-q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of NUMBL expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	NUMBL
Name	numb homolog (Drosophila)-like
Aliases	NUMB-R; CTG3a; CAG3A; TNRC23; NUMBR; NUMBLIKE; numb (Drosophila) homolog-like; NBL; NUMB-RIKE; numb homolog- ......
Chromosomal Location	19q13.13-q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between NUMBL and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	NUMBL
Name	numb homolog (Drosophila)-like
Aliases	NUMB-R; CTG3a; CAG3A; TNRC23; NUMBR; NUMBLIKE; numb (Drosophila) homolog-like; NBL; NUMB-RIKE; numb homolog- ......
Chromosomal Location	19q13.13-q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting NUMBL collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

Browse NUMBL