Summary | |
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Symbol | OR11H4 |
Name | olfactory receptor, family 11, subfamily H, member 4 |
Aliases | OR14-36; olfactory receptor OR14-36; Olfactory receptor 11H4 |
Chromosomal Location | 14q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Domain |
PF13853 Olfactory receptor |
Function |
Odorant receptor. |
Biological Process |
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007192 adenylate cyclase-activating serotonin receptor signaling pathway GO:0007210 serotonin receptor signaling pathway GO:0007608 sensory perception of smell GO:0050907 detection of chemical stimulus involved in sensory perception GO:0050911 detection of chemical stimulus involved in sensory perception of smell |
Molecular Function |
GO:0004984 olfactory receptor activity GO:0004993 G-protein coupled serotonin receptor activity GO:0008227 G-protein coupled amine receptor activity GO:0030594 neurotransmitter receptor activity GO:0099589 serotonin receptor activity |
Cellular Component |
GO:0030425 dendrite |
KEGG |
hsa04740 Olfactory transduction |
Reactome |
R-HSA-388396: GPCR downstream signaling R-HSA-381753: Olfactory Signaling Pathway R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR |
Summary | |
---|---|
Symbol | OR11H4 |
Name | olfactory receptor, family 11, subfamily H, member 4 |
Aliases | OR14-36; olfactory receptor OR14-36; Olfactory receptor 11H4 |
Chromosomal Location | 14q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between OR11H4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | OR11H4 |
Name | olfactory receptor, family 11, subfamily H, member 4 |
Aliases | OR14-36; olfactory receptor OR14-36; Olfactory receptor 11H4 |
Chromosomal Location | 14q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of OR11H4 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | OR11H4 |
Name | olfactory receptor, family 11, subfamily H, member 4 |
Aliases | OR14-36; olfactory receptor OR14-36; Olfactory receptor 11H4 |
Chromosomal Location | 14q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of OR11H4 in various data sets.
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Points in the above scatter plot represent the mutation difference of OR11H4 in various data sets.
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Summary | |
---|---|
Symbol | OR11H4 |
Name | olfactory receptor, family 11, subfamily H, member 4 |
Aliases | OR14-36; olfactory receptor OR14-36; Olfactory receptor 11H4 |
Chromosomal Location | 14q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of OR11H4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | OR11H4 |
Name | olfactory receptor, family 11, subfamily H, member 4 |
Aliases | OR14-36; olfactory receptor OR14-36; Olfactory receptor 11H4 |
Chromosomal Location | 14q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of OR11H4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by OR11H4. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | OR11H4 |
Name | olfactory receptor, family 11, subfamily H, member 4 |
Aliases | OR14-36; olfactory receptor OR14-36; Olfactory receptor 11H4 |
Chromosomal Location | 14q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of OR11H4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | OR11H4 |
Name | olfactory receptor, family 11, subfamily H, member 4 |
Aliases | OR14-36; olfactory receptor OR14-36; Olfactory receptor 11H4 |
Chromosomal Location | 14q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of OR11H4 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | OR11H4 |
Name | olfactory receptor, family 11, subfamily H, member 4 |
Aliases | OR14-36; olfactory receptor OR14-36; Olfactory receptor 11H4 |
Chromosomal Location | 14q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between OR11H4 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | OR11H4 |
Name | olfactory receptor, family 11, subfamily H, member 4 |
Aliases | OR14-36; olfactory receptor OR14-36; Olfactory receptor 11H4 |
Chromosomal Location | 14q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting OR11H4 collected from DrugBank database. |
There is no record. |