Browse OSR1

Summary
SymbolOSR1
Nameodd-skipped related transciption factor 1
Aliases odd-skipped (Drosophila) homolog; odd-skipped related 1 (Drosophila); odd-skipped homolog; odd-skipped relat ......
Chromosomal Location2p24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus
Domain -
Function

Transcription factor that plays a role in the regulation of embryonic heart and urogenital development.

> Gene Ontology
 
Biological Process GO:0001101 response to acid chemical
GO:0001501 skeletal system development
GO:0001503 ossification
GO:0001655 urogenital system development
GO:0001656 metanephros development
GO:0001657 ureteric bud development
GO:0001822 kidney development
GO:0001823 mesonephros development
GO:0001838 embryonic epithelial tube formation
GO:0002028 regulation of sodium ion transport
GO:0002062 chondrocyte differentiation
GO:0003002 regionalization
GO:0006814 sodium ion transport
GO:0006970 response to osmotic stress
GO:0007231 osmosensory signaling pathway
GO:0007369 gastrulation
GO:0007379 segment specification
GO:0007389 pattern specification process
GO:0007423 sensory organ development
GO:0007498 mesoderm development
GO:0007507 heart development
GO:0007548 sex differentiation
GO:0008406 gonad development
GO:0009952 anterior/posterior pattern specification
GO:0009954 proximal/distal pattern formation
GO:0010463 mesenchymal cell proliferation
GO:0010470 regulation of gastrulation
GO:0010766 negative regulation of sodium ion transport
GO:0010959 regulation of metal ion transport
GO:0015672 monovalent inorganic cation transport
GO:0016331 morphogenesis of embryonic epithelium
GO:0018107 peptidyl-threonine phosphorylation
GO:0018210 peptidyl-threonine modification
GO:0022898 regulation of transmembrane transporter activity
GO:0023016 signal transduction by trans-phosphorylation
GO:0030278 regulation of ossification
GO:0030282 bone mineralization
GO:0030326 embryonic limb morphogenesis
GO:0030500 regulation of bone mineralization
GO:0030501 positive regulation of bone mineralization
GO:0030856 regulation of epithelial cell differentiation
GO:0030857 negative regulation of epithelial cell differentiation
GO:0031214 biomineral tissue development
GO:0032409 regulation of transporter activity
GO:0032410 negative regulation of transporter activity
GO:0032412 regulation of ion transmembrane transporter activity
GO:0032413 negative regulation of ion transmembrane transporter activity
GO:0032526 response to retinoic acid
GO:0032835 glomerulus development
GO:0034762 regulation of transmembrane transport
GO:0034763 negative regulation of transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0034766 negative regulation of ion transmembrane transport
GO:0035107 appendage morphogenesis
GO:0035108 limb morphogenesis
GO:0035113 embryonic appendage morphogenesis
GO:0035115 embryonic forelimb morphogenesis
GO:0035116 embryonic hindlimb morphogenesis
GO:0035136 forelimb morphogenesis
GO:0035137 hindlimb morphogenesis
GO:0035148 tube formation
GO:0035239 tube morphogenesis
GO:0035282 segmentation
GO:0035725 sodium ion transmembrane transport
GO:0035850 epithelial cell differentiation involved in kidney development
GO:0036022 limb joint morphogenesis
GO:0036023 embryonic skeletal limb joint morphogenesis
GO:0040019 positive regulation of embryonic development
GO:0042471 ear morphogenesis
GO:0042474 middle ear morphogenesis
GO:0042476 odontogenesis
GO:0042733 embryonic digit morphogenesis
GO:0043271 negative regulation of ion transport
GO:0043583 ear development
GO:0045137 development of primary sexual characteristics
GO:0045778 positive regulation of ossification
GO:0045995 regulation of embryonic development
GO:0048389 intermediate mesoderm development
GO:0048562 embryonic organ morphogenesis
GO:0048568 embryonic organ development
GO:0048608 reproductive structure development
GO:0048704 embryonic skeletal system morphogenesis
GO:0048705 skeletal system morphogenesis
GO:0048706 embryonic skeletal system development
GO:0048736 appendage development
GO:0048745 smooth muscle tissue development
GO:0048762 mesenchymal cell differentiation
GO:0048793 pronephros development
GO:0048863 stem cell differentiation
GO:0050673 epithelial cell proliferation
GO:0050678 regulation of epithelial cell proliferation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051051 negative regulation of transport
GO:0051216 cartilage development
GO:0060021 palate development
GO:0060173 limb development
GO:0060272 embryonic skeletal joint morphogenesis
GO:0060485 mesenchyme development
GO:0060537 muscle tissue development
GO:0060562 epithelial tube morphogenesis
GO:0060993 kidney morphogenesis
GO:0061004 pattern specification involved in kidney development
GO:0061005 cell differentiation involved in kidney development
GO:0061227 pattern specification involved in mesonephros development
GO:0061326 renal tubule development
GO:0061333 renal tubule morphogenesis
GO:0061437 renal system vasculature development
GO:0061440 kidney vasculature development
GO:0061448 connective tissue development
GO:0061458 reproductive system development
GO:0070167 regulation of biomineral tissue development
GO:0070169 positive regulation of biomineral tissue development
GO:0071214 cellular response to abiotic stimulus
GO:0071229 cellular response to acid chemical
GO:0071300 cellular response to retinoic acid
GO:0071396 cellular response to lipid
GO:0071470 cellular response to osmotic stress
GO:0072001 renal system development
GO:0072006 nephron development
GO:0072007 mesangial cell differentiation
GO:0072009 nephron epithelium development
GO:0072012 glomerulus vasculature development
GO:0072028 nephron morphogenesis
GO:0072047 proximal/distal pattern formation involved in nephron development
GO:0072048 renal system pattern specification
GO:0072071 kidney interstitial fibroblast differentiation
GO:0072073 kidney epithelium development
GO:0072074 kidney mesenchyme development
GO:0072075 metanephric mesenchyme development
GO:0072078 nephron tubule morphogenesis
GO:0072079 nephron tubule formation
GO:0072080 nephron tubule development
GO:0072081 specification of nephron tubule identity
GO:0072087 renal vesicle development
GO:0072088 nephron epithelium morphogenesis
GO:0072098 anterior/posterior pattern specification involved in kidney development
GO:0072111 cell proliferation involved in kidney development
GO:0072131 kidney mesenchyme morphogenesis
GO:0072132 mesenchyme morphogenesis
GO:0072133 metanephric mesenchyme morphogenesis
GO:0072141 renal interstitial fibroblast development
GO:0072143 mesangial cell development
GO:0072160 nephron tubule epithelial cell differentiation
GO:0072161 mesenchymal cell differentiation involved in kidney development
GO:0072162 metanephric mesenchymal cell differentiation
GO:0072163 mesonephric epithelium development
GO:0072164 mesonephric tubule development
GO:0072165 anterior mesonephric tubule development
GO:0072166 posterior mesonephric tubule development
GO:0072167 specification of mesonephric tubule identity
GO:0072168 specification of anterior mesonephric tubule identity
GO:0072169 specification of posterior mesonephric tubule identity
GO:0072170 metanephric tubule development
GO:0072171 mesonephric tubule morphogenesis
GO:0072172 mesonephric tubule formation
GO:0072175 epithelial tube formation
GO:0072176 nephric duct development
GO:0072177 mesonephric duct development
GO:0072178 nephric duct morphogenesis
GO:0072180 mesonephric duct morphogenesis
GO:0072182 regulation of nephron tubule epithelial cell differentiation
GO:0072183 negative regulation of nephron tubule epithelial cell differentiation
GO:0072184 renal vesicle progenitor cell differentiation
GO:0072185 metanephric cap development
GO:0072186 metanephric cap morphogenesis
GO:0072189 ureter development
GO:0072190 ureter urothelium development
GO:0072194 kidney smooth muscle tissue development
GO:0072202 cell differentiation involved in metanephros development
GO:0072203 cell proliferation involved in metanephros development
GO:0072207 metanephric epithelium development
GO:0072208 metanephric smooth muscle tissue development
GO:0072210 metanephric nephron development
GO:0072224 metanephric glomerulus development
GO:0072234 metanephric nephron tubule development
GO:0072239 metanephric glomerulus vasculature development
GO:0072243 metanephric nephron epithelium development
GO:0072258 metanephric interstitial fibroblast differentiation
GO:0072259 metanephric interstitial fibroblast development
GO:0072268 pattern specification involved in metanephros development
GO:0072498 embryonic skeletal joint development
GO:0090094 metanephric cap mesenchymal cell proliferation involved in metanephros development
GO:0090183 regulation of kidney development
GO:0090185 negative regulation of kidney development
GO:0090596 sensory organ morphogenesis
GO:1902305 regulation of sodium ion transmembrane transport
GO:1902306 negative regulation of sodium ion transmembrane transport
GO:1904062 regulation of cation transmembrane transport
GO:1904063 negative regulation of cation transmembrane transport
GO:1904238 pericyte cell differentiation
GO:1905407 regulation of creatine transmembrane transporter activity
GO:1905408 negative regulation of creatine transmembrane transporter activity
GO:2000543 positive regulation of gastrulation
GO:2000649 regulation of sodium ion transmembrane transporter activity
GO:2000650 negative regulation of sodium ion transmembrane transporter activity
GO:2000696 regulation of epithelial cell differentiation involved in kidney development
GO:2000697 negative regulation of epithelial cell differentiation involved in kidney development
GO:2001012 mesenchymal cell differentiation involved in renal system development
Molecular Function GO:0004674 protein serine/threonine kinase activity
Cellular Component GO:0019898 extrinsic component of membrane
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolOSR1
Nameodd-skipped related transciption factor 1
Aliases odd-skipped (Drosophila) homolog; odd-skipped related 1 (Drosophila); odd-skipped homolog; odd-skipped relat ......
Chromosomal Location2p24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between OSR1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolOSR1
Nameodd-skipped related transciption factor 1
Aliases odd-skipped (Drosophila) homolog; odd-skipped related 1 (Drosophila); odd-skipped homolog; odd-skipped relat ......
Chromosomal Location2p24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of OSR1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolOSR1
Nameodd-skipped related transciption factor 1
Aliases odd-skipped (Drosophila) homolog; odd-skipped related 1 (Drosophila); odd-skipped homolog; odd-skipped relat ......
Chromosomal Location2p24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of OSR1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.9720.0262
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.8820.00751
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.3070.63
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.2040.765
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.2380.895
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.1430.937
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.270.729
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.6770.599
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.4110.739
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.2890.575
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.3420.618
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.1790.488
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of OSR1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.703.70.27
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.703.70.314
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolOSR1
Nameodd-skipped related transciption factor 1
Aliases odd-skipped (Drosophila) homolog; odd-skipped related 1 (Drosophila); odd-skipped homolog; odd-skipped relat ......
Chromosomal Location2p24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of OSR1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolOSR1
Nameodd-skipped related transciption factor 1
Aliases odd-skipped (Drosophila) homolog; odd-skipped related 1 (Drosophila); odd-skipped homolog; odd-skipped relat ......
Chromosomal Location2p24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of OSR1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by OSR1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolOSR1
Nameodd-skipped related transciption factor 1
Aliases odd-skipped (Drosophila) homolog; odd-skipped related 1 (Drosophila); odd-skipped homolog; odd-skipped relat ......
Chromosomal Location2p24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of OSR1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolOSR1
Nameodd-skipped related transciption factor 1
Aliases odd-skipped (Drosophila) homolog; odd-skipped related 1 (Drosophila); odd-skipped homolog; odd-skipped relat ......
Chromosomal Location2p24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of OSR1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolOSR1
Nameodd-skipped related transciption factor 1
Aliases odd-skipped (Drosophila) homolog; odd-skipped related 1 (Drosophila); odd-skipped homolog; odd-skipped relat ......
Chromosomal Location2p24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between OSR1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolOSR1
Nameodd-skipped related transciption factor 1
Aliases odd-skipped (Drosophila) homolog; odd-skipped related 1 (Drosophila); odd-skipped homolog; odd-skipped relat ......
Chromosomal Location2p24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting OSR1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.