Browse P2RX7

Summary
SymbolP2RX7
Namepurinergic receptor P2X, ligand gated ion channel, 7
Aliases P2X7; MGC20089; purinergic receptor P2X, ligand-gated ion channel, 7; P2X7 receptor; P2Z receptor; purinergi ......
Chromosomal Location12q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Multi-pass membrane protein
Domain PF00864 ATP P2X receptor
Function

Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. In the absence of its natural ligand, ATP, functions as a scavenger receptor in the recognition and engulfment of apoptotic cells (PubMed:21821797, PubMed:23303206).

> Gene Ontology
 
Biological Process GO:0000187 activation of MAPK activity
GO:0001501 skeletal system development
GO:0001503 ossification
GO:0001505 regulation of neurotransmitter levels
GO:0001776 leukocyte homeostasis
GO:0001819 positive regulation of cytokine production
GO:0001845 phagolysosome assembly
GO:0001894 tissue homeostasis
GO:0001906 cell killing
GO:0001909 leukocyte mediated cytotoxicity
GO:0001910 regulation of leukocyte mediated cytotoxicity
GO:0001912 positive regulation of leukocyte mediated cytotoxicity
GO:0001913 T cell mediated cytotoxicity
GO:0001914 regulation of T cell mediated cytotoxicity
GO:0001916 positive regulation of T cell mediated cytotoxicity
GO:0001933 negative regulation of protein phosphorylation
GO:0002028 regulation of sodium ion transport
GO:0002237 response to molecule of bacterial origin
GO:0002250 adaptive immune response
GO:0002260 lymphocyte homeostasis
GO:0002443 leukocyte mediated immunity
GO:0002449 lymphocyte mediated immunity
GO:0002456 T cell mediated immunity
GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
GO:0002697 regulation of immune effector process
GO:0002699 positive regulation of immune effector process
GO:0002703 regulation of leukocyte mediated immunity
GO:0002705 positive regulation of leukocyte mediated immunity
GO:0002706 regulation of lymphocyte mediated immunity
GO:0002708 positive regulation of lymphocyte mediated immunity
GO:0002709 regulation of T cell mediated immunity
GO:0002711 positive regulation of T cell mediated immunity
GO:0002819 regulation of adaptive immune response
GO:0002821 positive regulation of adaptive immune response
GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
GO:0003254 regulation of membrane depolarization
GO:0006090 pyruvate metabolic process
GO:0006091 generation of precursor metabolites and energy
GO:0006096 glycolytic process
GO:0006109 regulation of carbohydrate metabolic process
GO:0006110 regulation of glycolytic process
GO:0006140 regulation of nucleotide metabolic process
GO:0006165 nucleoside diphosphate phosphorylation
GO:0006509 membrane protein ectodomain proteolysis
GO:0006643 membrane lipid metabolic process
GO:0006649 phospholipid transfer to membrane
GO:0006665 sphingolipid metabolic process
GO:0006672 ceramide metabolic process
GO:0006732 coenzyme metabolic process
GO:0006733 oxidoreduction coenzyme metabolic process
GO:0006757 ATP generation from ADP
GO:0006814 sodium ion transport
GO:0006816 calcium ion transport
GO:0006820 anion transport
GO:0006835 dicarboxylic acid transport
GO:0006836 neurotransmitter transport
GO:0006862 nucleotide transport
GO:0006869 lipid transport
GO:0006874 cellular calcium ion homeostasis
GO:0006875 cellular metal ion homeostasis
GO:0006884 cell volume homeostasis
GO:0006887 exocytosis
GO:0006900 membrane budding
GO:0006909 phagocytosis
GO:0007009 plasma membrane organization
GO:0007033 vacuole organization
GO:0007040 lysosome organization
GO:0007159 leukocyte cell-cell adhesion
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007269 neurotransmitter secretion
GO:0007586 digestion
GO:0007596 blood coagulation
GO:0007599 hemostasis
GO:0008361 regulation of cell size
GO:0009116 nucleoside metabolic process
GO:0009118 regulation of nucleoside metabolic process
GO:0009119 ribonucleoside metabolic process
GO:0009123 nucleoside monophosphate metabolic process
GO:0009126 purine nucleoside monophosphate metabolic process
GO:0009132 nucleoside diphosphate metabolic process
GO:0009135 purine nucleoside diphosphate metabolic process
GO:0009141 nucleoside triphosphate metabolic process
GO:0009144 purine nucleoside triphosphate metabolic process
GO:0009150 purine ribonucleotide metabolic process
GO:0009161 ribonucleoside monophosphate metabolic process
GO:0009167 purine ribonucleoside monophosphate metabolic process
GO:0009179 purine ribonucleoside diphosphate metabolic process
GO:0009185 ribonucleoside diphosphate metabolic process
GO:0009199 ribonucleoside triphosphate metabolic process
GO:0009205 purine ribonucleoside triphosphate metabolic process
GO:0009306 protein secretion
GO:0009612 response to mechanical stimulus
GO:0009894 regulation of catabolic process
GO:0009896 positive regulation of catabolic process
GO:0009991 response to extracellular stimulus
GO:0010035 response to inorganic substance
GO:0010038 response to metal ion
GO:0010043 response to zinc ion
GO:0010522 regulation of calcium ion transport into cytosol
GO:0010524 positive regulation of calcium ion transport into cytosol
GO:0010876 lipid localization
GO:0010959 regulation of metal ion transport
GO:0014047 glutamate secretion
GO:0014048 regulation of glutamate secretion
GO:0014049 positive regulation of glutamate secretion
GO:0014051 gamma-aminobutyric acid secretion
GO:0014052 regulation of gamma-aminobutyric acid secretion
GO:0014054 positive regulation of gamma-aminobutyric acid secretion
GO:0014074 response to purine-containing compound
GO:0015672 monovalent inorganic cation transport
GO:0015711 organic anion transport
GO:0015718 monocarboxylic acid transport
GO:0015732 prostaglandin transport
GO:0015748 organophosphate ester transport
GO:0015812 gamma-aminobutyric acid transport
GO:0015908 fatty acid transport
GO:0015914 phospholipid transport
GO:0015931 nucleobase-containing compound transport
GO:0016050 vesicle organization
GO:0016052 carbohydrate catabolic process
GO:0016079 synaptic vesicle exocytosis
GO:0016485 protein processing
GO:0017121 phospholipid scrambling
GO:0017156 calcium ion regulated exocytosis
GO:0019233 sensory perception of pain
GO:0019362 pyridine nucleotide metabolic process
GO:0019835 cytolysis
GO:0023061 signal release
GO:0030031 cell projection assembly
GO:0030148 sphingolipid biosynthetic process
GO:0030278 regulation of ossification
GO:0030282 bone mineralization
GO:0030500 regulation of bone mineralization
GO:0030501 positive regulation of bone mineralization
GO:0031214 biomineral tissue development
GO:0031329 regulation of cellular catabolic process
GO:0031331 positive regulation of cellular catabolic process
GO:0031341 regulation of cell killing
GO:0031343 positive regulation of cell killing
GO:0031346 positive regulation of cell projection organization
GO:0031640 killing of cells of other organism
GO:0031668 cellular response to extracellular stimulus
GO:0032060 bleb assembly
GO:0032147 activation of protein kinase activity
GO:0032303 regulation of icosanoid secretion
GO:0032305 positive regulation of icosanoid secretion
GO:0032306 regulation of prostaglandin secretion
GO:0032308 positive regulation of prostaglandin secretion
GO:0032309 icosanoid secretion
GO:0032310 prostaglandin secretion
GO:0032368 regulation of lipid transport
GO:0032370 positive regulation of lipid transport
GO:0032496 response to lipopolysaccharide
GO:0032535 regulation of cellular component size
GO:0032610 interleukin-1 alpha production
GO:0032611 interleukin-1 beta production
GO:0032612 interleukin-1 production
GO:0032635 interleukin-6 production
GO:0032650 regulation of interleukin-1 alpha production
GO:0032651 regulation of interleukin-1 beta production
GO:0032652 regulation of interleukin-1 production
GO:0032675 regulation of interleukin-6 production
GO:0032730 positive regulation of interleukin-1 alpha production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032732 positive regulation of interleukin-1 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032844 regulation of homeostatic process
GO:0032845 negative regulation of homeostatic process
GO:0032846 positive regulation of homeostatic process
GO:0032943 mononuclear cell proliferation
GO:0032963 collagen metabolic process
GO:0033198 response to ATP
GO:0033619 membrane protein proteolysis
GO:0033674 positive regulation of kinase activity
GO:0034103 regulation of tissue remodeling
GO:0034104 negative regulation of tissue remodeling
GO:0034204 lipid translocation
GO:0034405 response to fluid shear stress
GO:0034762 regulation of transmembrane transport
GO:0034764 positive regulation of transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0034767 positive regulation of ion transmembrane transport
GO:0035587 purinergic receptor signaling pathway
GO:0035590 purinergic nucleotide receptor signaling pathway
GO:0035821 modification of morphology or physiology of other organism
GO:0042098 T cell proliferation
GO:0042110 T cell activation
GO:0042268 regulation of cytolysis
GO:0042278 purine nucleoside metabolic process
GO:0042326 negative regulation of phosphorylation
GO:0042391 regulation of membrane potential
GO:0042493 response to drug
GO:0042742 defense response to bacterium
GO:0043029 T cell homeostasis
GO:0043132 NAD transport
GO:0043270 positive regulation of ion transport
GO:0043331 response to dsRNA
GO:0043405 regulation of MAP kinase activity
GO:0043406 positive regulation of MAP kinase activity
GO:0043409 negative regulation of MAPK cascade
GO:0043410 positive regulation of MAPK cascade
GO:0043467 regulation of generation of precursor metabolites and energy
GO:0043470 regulation of carbohydrate catabolic process
GO:0043900 regulation of multi-organism process
GO:0044070 regulation of anion transport
GO:0044089 positive regulation of cellular component biogenesis
GO:0044236 multicellular organism metabolic process
GO:0044243 multicellular organism catabolic process
GO:0044254 multicellular organismal protein catabolic process
GO:0044256 protein digestion
GO:0044259 multicellular organismal macromolecule metabolic process
GO:0044266 multicellular organismal macromolecule catabolic process
GO:0044268 multicellular organismal protein metabolic process
GO:0044364 disruption of cells of other organism
GO:0044723 single-organism carbohydrate metabolic process
GO:0044724 single-organism carbohydrate catabolic process
GO:0045055 regulated exocytosis
GO:0045124 regulation of bone resorption
GO:0045332 phospholipid translocation
GO:0045453 bone resorption
GO:0045778 positive regulation of ossification
GO:0045779 negative regulation of bone resorption
GO:0045794 negative regulation of cell volume
GO:0045821 positive regulation of glycolytic process
GO:0045860 positive regulation of protein kinase activity
GO:0045913 positive regulation of carbohydrate metabolic process
GO:0045919 positive regulation of cytolysis
GO:0045979 positive regulation of nucleoside metabolic process
GO:0045981 positive regulation of nucleotide metabolic process
GO:0046031 ADP metabolic process
GO:0046034 ATP metabolic process
GO:0046128 purine ribonucleoside metabolic process
GO:0046467 membrane lipid biosynthetic process
GO:0046496 nicotinamide nucleotide metabolic process
GO:0046513 ceramide biosynthetic process
GO:0046651 lymphocyte proliferation
GO:0046683 response to organophosphorus
GO:0046717 acid secretion
GO:0046849 bone remodeling
GO:0046850 regulation of bone remodeling
GO:0046851 negative regulation of bone remodeling
GO:0046931 pore complex assembly
GO:0046939 nucleotide phosphorylation
GO:0046942 carboxylic acid transport
GO:0048489 synaptic vesicle transport
GO:0048705 skeletal system morphogenesis
GO:0048771 tissue remodeling
GO:0048871 multicellular organismal homeostasis
GO:0048872 homeostasis of number of cells
GO:0048873 homeostasis of number of cells within a tissue
GO:0050663 cytokine secretion
GO:0050701 interleukin-1 secretion
GO:0050702 interleukin-1 beta secretion
GO:0050703 interleukin-1 alpha secretion
GO:0050704 regulation of interleukin-1 secretion
GO:0050705 regulation of interleukin-1 alpha secretion
GO:0050706 regulation of interleukin-1 beta secretion
GO:0050707 regulation of cytokine secretion
GO:0050708 regulation of protein secretion
GO:0050714 positive regulation of protein secretion
GO:0050715 positive regulation of cytokine secretion
GO:0050716 positive regulation of interleukin-1 secretion
GO:0050717 positive regulation of interleukin-1 alpha secretion
GO:0050718 positive regulation of interleukin-1 beta secretion
GO:0050817 coagulation
GO:0050830 defense response to Gram-positive bacterium
GO:0050878 regulation of body fluid levels
GO:0051047 positive regulation of secretion
GO:0051181 cofactor transport
GO:0051186 cofactor metabolic process
GO:0051193 regulation of cofactor metabolic process
GO:0051194 positive regulation of cofactor metabolic process
GO:0051196 regulation of coenzyme metabolic process
GO:0051197 positive regulation of coenzyme metabolic process
GO:0051208 sequestering of calcium ion
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051222 positive regulation of protein transport
GO:0051235 maintenance of location
GO:0051238 sequestering of metal ion
GO:0051259 protein oligomerization
GO:0051282 regulation of sequestering of calcium ion
GO:0051283 negative regulation of sequestering of calcium ion
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0051493 regulation of cytoskeleton organization
GO:0051495 positive regulation of cytoskeleton organization
GO:0051592 response to calcium ion
GO:0051602 response to electrical stimulus
GO:0051604 protein maturation
GO:0051640 organelle localization
GO:0051648 vesicle localization
GO:0051650 establishment of vesicle localization
GO:0051656 establishment of organelle localization
GO:0051709 regulation of killing of cells of other organism
GO:0051881 regulation of mitochondrial membrane potential
GO:0051882 mitochondrial depolarization
GO:0051899 membrane depolarization
GO:0051900 regulation of mitochondrial depolarization
GO:0051901 positive regulation of mitochondrial depolarization
GO:0051924 regulation of calcium ion transport
GO:0051928 positive regulation of calcium ion transport
GO:0055074 calcium ion homeostasis
GO:0060249 anatomical structure homeostasis
GO:0060401 cytosolic calcium ion transport
GO:0060402 calcium ion transport into cytosol
GO:0060491 regulation of cell projection assembly
GO:0070167 regulation of biomineral tissue development
GO:0070169 positive regulation of biomineral tissue development
GO:0070227 lymphocyte apoptotic process
GO:0070228 regulation of lymphocyte apoptotic process
GO:0070230 positive regulation of lymphocyte apoptotic process
GO:0070486 leukocyte aggregation
GO:0070489 T cell aggregation
GO:0070509 calcium ion import
GO:0070588 calcium ion transmembrane transport
GO:0070661 leukocyte proliferation
GO:0070838 divalent metal ion transport
GO:0071359 cellular response to dsRNA
GO:0071407 cellular response to organic cyclic compound
GO:0071496 cellular response to external stimulus
GO:0071593 lymphocyte aggregation
GO:0071715 icosanoid transport
GO:0071887 leukocyte apoptotic process
GO:0071900 regulation of protein serine/threonine kinase activity
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0072503 cellular divalent inorganic cation homeostasis
GO:0072507 divalent inorganic cation homeostasis
GO:0072511 divalent inorganic cation transport
GO:0072524 pyridine-containing compound metabolic process
GO:0072593 reactive oxygen species metabolic process
GO:0080171 lytic vacuole organization
GO:0090066 regulation of anatomical structure size
GO:0090382 phagosome maturation
GO:0097035 regulation of membrane lipid distribution
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097479 synaptic vesicle localization
GO:0097480 establishment of synaptic vesicle localization
GO:0097553 calcium ion transmembrane import into cytosol
GO:0098542 defense response to other organism
GO:0099003 vesicle-mediated transport in synapse
GO:0099504 synaptic vesicle cycle
GO:0099531 presynaptic process involved in chemical synaptic transmission
GO:0099643 signal release from synapse
GO:1900542 regulation of purine nucleotide metabolic process
GO:1900544 positive regulation of purine nucleotide metabolic process
GO:1901657 glycosyl compound metabolic process
GO:1902532 negative regulation of intracellular signal transduction
GO:1902656 calcium ion import into cytosol
GO:1903532 positive regulation of secretion by cell
GO:1903578 regulation of ATP metabolic process
GO:1903580 positive regulation of ATP metabolic process
GO:1903793 positive regulation of anion transport
GO:1904170 regulation of bleb assembly
GO:1904172 positive regulation of bleb assembly
GO:1904181 positive regulation of membrane depolarization
GO:1904951 positive regulation of establishment of protein localization
GO:1990267 response to transition metal nanoparticle
GO:2000021 regulation of ion homeostasis
GO:2000106 regulation of leukocyte apoptotic process
GO:2000108 positive regulation of leukocyte apoptotic process
GO:2000191 regulation of fatty acid transport
GO:2000193 positive regulation of fatty acid transport
Molecular Function GO:0001530 lipopolysaccharide binding
GO:0001614 purinergic nucleotide receptor activity
GO:0004931 extracellular ATP-gated cation channel activity
GO:0005216 ion channel activity
GO:0005230 extracellular ligand-gated ion channel activity
GO:0005231 excitatory extracellular ligand-gated ion channel activity
GO:0005261 cation channel activity
GO:0015267 channel activity
GO:0015276 ligand-gated ion channel activity
GO:0016502 nucleotide receptor activity
GO:0022803 passive transmembrane transporter activity
GO:0022834 ligand-gated channel activity
GO:0022836 gated channel activity
GO:0022838 substrate-specific channel activity
GO:0035381 ATP-gated ion channel activity
GO:0035586 purinergic receptor activity
Cellular Component GO:0005635 nuclear envelope
GO:0005637 nuclear inner membrane
GO:0005639 integral component of nuclear inner membrane
GO:0009897 external side of plasma membrane
GO:0031229 intrinsic component of nuclear inner membrane
GO:0031300 intrinsic component of organelle membrane
GO:0031301 integral component of organelle membrane
GO:0031594 neuromuscular junction
GO:0031965 nuclear membrane
GO:0032059 bleb
GO:0043025 neuronal cell body
GO:0044297 cell body
GO:0044453 nuclear membrane part
GO:0098552 side of membrane
GO:0098793 presynapse
> KEGG and Reactome Pathway
 
KEGG hsa04020 Calcium signaling pathway
hsa04080 Neuroactive ligand-receptor interaction
hsa04621 NOD-like receptor signaling pathway
Reactome R-HSA-139853: Elevation of cytosolic Ca2+ levels
R-HSA-109582: Hemostasis
R-HSA-168256: Immune System
R-HSA-622312: Inflammasomes
R-HSA-168249: Innate Immune System
R-HSA-168643: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
R-HSA-418360: Platelet calcium homeostasis
R-HSA-418346: Platelet homeostasis
R-HSA-844456: The NLRP3 inflammasome
Summary
SymbolP2RX7
Namepurinergic receptor P2X, ligand gated ion channel, 7
Aliases P2X7; MGC20089; purinergic receptor P2X, ligand-gated ion channel, 7; P2X7 receptor; P2Z receptor; purinergi ......
Chromosomal Location12q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between P2RX7 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between P2RX7 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
25542861MelanomaPromote immunityOverall, our results showed that host P2X7R expression was critical to support an antitumor immune response, and to restrict tumor growth and metastatic diffusion.
23562161Colon CarcinomaPromote immunity (infiltration)Manipulations preventing tumor infiltration by CD11c(+)CD11b(+)Ly6C(hi) cells,?such as the local overexpression of ectonucleotidases, the blockade of purinergic receptors, or the neutralization of CD11b, abolished the immune?system-dependent antitumor activity of anthracyclines.
Summary
SymbolP2RX7
Namepurinergic receptor P2X, ligand gated ion channel, 7
Aliases P2X7; MGC20089; purinergic receptor P2X, ligand-gated ion channel, 7; P2X7 receptor; P2Z receptor; purinergi ......
Chromosomal Location12q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of P2RX7 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolP2RX7
Namepurinergic receptor P2X, ligand gated ion channel, 7
Aliases P2X7; MGC20089; purinergic receptor P2X, ligand-gated ion channel, 7; P2X7 receptor; P2Z receptor; purinergi ......
Chromosomal Location12q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of P2RX7 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.3330.455
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.3850.803
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.2910.812
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.2620.412
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.6020.647
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.1680.919
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.2370.572
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.720.652
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.3730.842
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.0560.315
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 282.0820.14
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.1190.505
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of P2RX7 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141705.9-5.91
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 41407.1-7.11
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolP2RX7
Namepurinergic receptor P2X, ligand gated ion channel, 7
Aliases P2X7; MGC20089; purinergic receptor P2X, ligand-gated ion channel, 7; P2X7 receptor; P2Z receptor; purinergi ......
Chromosomal Location12q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of P2RX7. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolP2RX7
Namepurinergic receptor P2X, ligand gated ion channel, 7
Aliases P2X7; MGC20089; purinergic receptor P2X, ligand-gated ion channel, 7; P2X7 receptor; P2Z receptor; purinergi ......
Chromosomal Location12q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of P2RX7. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by P2RX7.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolP2RX7
Namepurinergic receptor P2X, ligand gated ion channel, 7
Aliases P2X7; MGC20089; purinergic receptor P2X, ligand-gated ion channel, 7; P2X7 receptor; P2Z receptor; purinergi ......
Chromosomal Location12q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of P2RX7. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolP2RX7
Namepurinergic receptor P2X, ligand gated ion channel, 7
Aliases P2X7; MGC20089; purinergic receptor P2X, ligand-gated ion channel, 7; P2X7 receptor; P2Z receptor; purinergi ......
Chromosomal Location12q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of P2RX7 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolP2RX7
Namepurinergic receptor P2X, ligand gated ion channel, 7
Aliases P2X7; MGC20089; purinergic receptor P2X, ligand-gated ion channel, 7; P2X7 receptor; P2Z receptor; purinergi ......
Chromosomal Location12q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between P2RX7 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolP2RX7
Namepurinergic receptor P2X, ligand gated ion channel, 7
Aliases P2X7; MGC20089; purinergic receptor P2X, ligand-gated ion channel, 7; P2X7 receptor; P2Z receptor; purinergi ......
Chromosomal Location12q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting P2RX7 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.